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    • 91. 发明申请
    • Skin coating with microbial indicator
    • 皮肤涂层微生物指示剂
    • US20080145316A1
    • 2008-06-19
    • US11639833
    • 2006-12-14
    • John Gavin MacDonaldStephanie MartinMolly K. SmithJason Lye
    • John Gavin MacDonaldStephanie MartinMolly K. SmithJason Lye
    • A61K49/00C12Q1/04C12Q1/70
    • A61L26/0061A61L24/001
    • Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. A skin coating is provided that has an indicator that gives a visible color change upon contact with microbes or microbial by-products and so provides an early warning of infection. The coating is a curable coating composition that may also be used without skin preps and may be used to protect other disruptions in the skin like wounds, bruises, abrasions, burns, acne, blisters, bites, stings, punctures and cuts. It may also be used to close wounds or provide an additional barrier to other parts of the skin, such as the nails and mucosa.
    • 皮肤密封剂通常用于皮肤制服上以密封皮肤,并且在手术切口之前将任何残留的细菌保持在适当位置。 这种密封剂通常在手术后留在皮肤上。 提供皮肤涂层,其具有指示剂,其在与微生物或微生物副产物接触时产生可见的颜色变化,因此提供感染的早期预警。 该涂层是可固化的涂料组合物,其也可以不使用皮肤制剂使用,并且可以用于保护皮肤中的其它中断,例如伤口,瘀伤,擦伤,烧伤,痤疮,水疱,叮咬,叮咬,刺穿和切口。 它还可以用于闭合伤口或提供对皮肤其他部分(例如指甲和粘膜)的额外屏障。
    • 92. 发明授权
    • Solvatochromatic bacterial detection
    • 溶剂色素细菌检测
    • US07282349B2
    • 2007-10-16
    • US10737574
    • 2003-12-16
    • Jason LyeJohn Gavin MacDonaldNing Wei
    • Jason LyeJohn Gavin MacDonaldNing Wei
    • C12Q1/22
    • C12Q1/04
    • Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. A lateral flow device incorporating solvatochromic dyes and a method of detecting bacteria are also included.
    • 溶剂化色素染料在本文中用于通过将它们并入各种底物如薄膜,机织和非织造织物,纸巾,共成型和气流成网材料和粘合梳理纤维网中来表示细菌的存在。 这些染料响应于环境极性的变化而改变颜色。 由于水是极性溶剂,大多数细菌都是由非极性物质制成的,所以细菌的存在会改变环境的极性,引发肉眼可见的变化。 还包括含有溶剂化色素染料的侧流装置和检测细菌的方法。