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1. 发明申请

WO2010118016A3 DIGITAL QUANTIFICATION OF DNA METHYLATION 审中-公开
标题翻译： DNA甲基化的数字量化
公开(公告)号：WO2010118016A3
公开(公告)日：2011-04-07
申请号：PCT/US2010030084
申请日：2010-04-06
申请人： UNIV JOHNS HOPKINS , UNIV CASE WESTERN RESERVE , VOGELSTEIN BERT , KINZLER KENNETH W , LI MENG , DIAZ LUIS , PAPADOPOULOS NICKOLAS , MARKOWITZ SANFORD
发明人： VOGELSTEIN BERT , KINZLER KENNETH W , LI MENG , DIAZ LUIS , PAPADOPOULOS NICKOLAS , MARKOWITZ SANFORD
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/52
CPC分类号： C12Q1/6816 , C12Q1/6886 , C12Q2600/154 , C12Q2565/501 , C12Q2527/125 , C12Q2523/125
摘要： Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads, resulting in a population of beads each containing thousands of copies of the template molecule. After hybridization with probes specific for methylated sequences, the beads can be analyzed by flow cytometry. This approach enables detection and enumeration of one methylated molecule in a population of ~5000 unmethylated molecules. Methyl-BEAMing provides digital quantification of rare methylation events and is generally applicable to the assessment of methylated genes in clinical samples.
摘要翻译： DNA甲基化异常可用作癌症患者的生物标志物。为此目的，重要的是精确测定分析样品中甲基化分子的分数。我们称之为甲基BEAMing的技术实现了这一目标。单独的亚硫酸氢盐处理的DNA分子可以在含有珠粒的含水纳米间隔内进行PCR扩增，导致每个珠粒群含有数千份拷贝的模板分子。与特异于甲基化序列的探针杂交后，可以通过流式细胞术分析珠粒。这种方法能够检测和计数一个约5000个非甲基化分子的一个甲基化分子。甲基BEAMing提供罕见甲基化事件的数字量化，通常适用于临床样品中甲基化基因的评估。

2. 发明申请

WO2012064721A2 MEDULLOBLASTOMA GENES AS TARGETS FOR DIAGNOSIS AND THERAPEUTICS 审中-公开
标题翻译：作为诊断和治疗目标的MEDLOBLASTOMA基因
公开(公告)号：WO2012064721A2
公开(公告)日：2012-05-18
申请号：PCT/US2011059751
申请日：2011-11-08
申请人： UNIV JOHNS HOPKINS , UNIV DUKE , VOGELSTEIN BERT , KINZLER KENNETH W , PAPADOPOULOS NICKOLAS , PARSONS DONALD WILLIAMS , LEARY REBECCA J , LI MENG , ZHANG XIAOSONG , JONES SIAN , RIGGINS GREGORY J , VELCULESCU VICTOR , BIGNER DARELL , YAN HAI
发明人： VOGELSTEIN BERT , KINZLER KENNETH W , PAPADOPOULOS NICKOLAS , PARSONS DONALD WILLIAMS , LEARY REBECCA J , LI MENG , ZHANG XIAOSONG , JONES SIAN , RIGGINS GREGORY J , VELCULESCU VICTOR , BIGNER DARELL , YAN HAI
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57407
摘要： Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.
摘要翻译：髓母细胞瘤（MB）是儿童最常见的恶性脑肿瘤。为了鉴定这种肿瘤类型的遗传改变，我们使用高密度微阵列搜索拷贝数改变，并使用Sanger测序对所有已知的蛋白质编码基因和miRNA基因进行测序。我们发现平均而言，每个肿瘤有11个基因改变，明显少于常见的成人癌症。除了Hedgehog和Wnt途径的改变之外，我们的分析还导致发现以前不知道在MB中改变的基因。最值得注意的是，在16％的MB患者中鉴定出组蛋白H3K4三甲基化酶基因MLL2或MLL3的失活突变。这些结果表明成人和儿童癌症的遗传景观之间的主要区别，突出发展途径的失调作为潜在的MB的重要机制，并确定在人类肿瘤特定类型的组蛋白甲基化的作用。

3. 发明公开

EP2417270A4 DIGITAL QUANTIFICATION OF DNA METHYLATION 有权
标题翻译：数字量化DNA甲基化
公开(公告)号：EP2417270A4
公开(公告)日：2012-09-12
申请号：EP10762298
申请日：2010-04-06
申请人： UNIV JOHNS HOPKINS , UNIV CASE WESTERN RESERVE
发明人： VOGELSTEIN BERT , KINZLER KENNETH W , LI MENG , DIAZ LUIS , PAPADOPOULOS NICKOLAS , MARKOWITZ SANFORD
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/52
CPC分类号： C12Q1/6816 , C12Q1/6886 , C12Q2600/154 , C12Q2565/501 , C12Q2527/125 , C12Q2523/125

4. 发明专利

IL279647D0 Dosing regimens for targeted tgf-β inhibition for use in treating biliary tract cancer 未知
公开(公告)号：IL279647D0
公开(公告)日：2021-03-01
申请号：IL27964720
申请日：2020-12-21
申请人： MERCK PATENT GMBH , EL BAWAB SAMER , VUGMEYSTER YULIA , KHANDELWAL AKASH , DUSSAULT ISABELLE , CHRISTENSEN OLAF , OSADA MOTONOBU , LI MENG
发明人： EL BAWAB SAMER , VUGMEYSTER YULIA , KHANDELWAL AKASH , DUSSAULT ISABELLE , CHRISTENSEN OLAF , OSADA MOTONOBU , LI MENG
IPC分类号： A61K39/00 , C07K14/71 , C07K16/28
摘要： This disclosure relates to dosage regimens for targeted TGF-β inhibition with a bi-functional fusion protein for use in a method of treating biliary tract cancer or inhibiting biliary tract tumor growth in treatment naïve patients, or patients with locally advanced or metastatic BTC who have failed or are intolerant to first-line systemic chemotherapy.

5. 发明申请

WO0223221A2 METHOD AND APPARATUS FOR IDENTIFYING THE SOURCE OF AN IMPULSIVE OR EXPLOSIVE EVENT 审中-公开
标题翻译：识别爆炸事件的来源的方法和装置
公开(公告)号：WO0223221A2
公开(公告)日：2002-03-21
申请号：PCT/GB0104086
申请日：2001-09-11
申请人： SERCO LTD , DREW RODERICK CHARLES , LI MENG
发明人： DREW RODERICK CHARLES , LI MENG
IPC分类号： F41H11/00 , G01S5/18 , G01V1/00
CPC分类号： G01V1/00 , F41H11/00 , G01S5/18
摘要： This invention consists of a system with the capability of acquiring an acoustic signature with high precision, which can be used to identify artillery or other sources of explosive shock waves from their acoustic signatures. It includes two high-performance microphones (20, 22), one of which acts as a triggering microphone (22). This microphone (22) is harboured within a special chamber (12) containing a floating panel or wall (14), which is inserted in such a way that it is free to vibrate slightly. Any impulsive acoustic signal causes an internal impulse pressure to be built up, causing data acquisition to commence. The anti-alias filtered, digitised signal from the measurement microphone (20) is then processed in such a manner that certain parameters can be extracted. The most significant of these parameters are the "Modified Mach Number", the "Sound Intensity Level", the "Acoustic Shock Wave Energy Potential" and the "Decision Pattern" and two- or three-dimensional "Decision Function", which can be used to identify the origin of the explosive or impulsive shock wave.
摘要翻译：本发明由具有高精度获取声学特征的能力的系统组成，可用于从其声学特征识别火炮或其他爆炸冲击波源。它包括两个高性能麦克风（20,22），其中一个用作触发麦克风（22）。该麦克风（22）包含在包含浮动面板或壁（14）的特殊室（12）内，该浮动面板或壁以这样一种方式被插入以使得其稍微振动。任何脉冲声信号都会产生内部脉冲压力，从而开始数据采集。然后，以可以提取某些参数的方式处理来自测量麦克风（20）的经滤波的抗混叠数字化信号。这些参数中最重要的是“改进马赫数”，“声强级”，“声波冲击波能量”和“决策模式”以及二维或三维“决策函数” 用于识别爆炸或脉冲冲击波的起源。

6. 发明申请

WO2005025816A8 A ROBOT WITH FIVE-FREEDOM MIX COUPLE STRUCTURE 审中-公开
标题翻译：一种具有五自由度混合连接结构的机器人
公开(公告)号：WO2005025816A8
公开(公告)日：2005-07-14
申请号：PCT/CN2004000479
申请日：2004-05-14
申请人： UNIV TIANJIN , HUANG TIAN , LI MENG , LI ZHANXIAN , MEI JIANGPING , ZHAO XUEMAN , ZHANG DAWEI
发明人： HUANG TIAN , LI MENG , LI ZHANXIAN , MEI JIANGPING , ZHAO XUEMAN , ZHANG DAWEI
IPC分类号： B25J17/02 , B25J9/06 , B25J18/04
CPC分类号： B25J17/0266 , B25J9/0069
摘要： A robot with five-freedom mix couple structure is disclosed, which comprises a fixed frame, a first setting adjustable in length, a second setting adjustable in length, a third setting adjustable in length, a positioning head, a movable table. Thereinto, a first hinge is provided in the middle of the fixed frame. The top of the first setting is mounted on the fixed frame via the first hinge and a shift pair that is formed by the first setting and the first hinge, the end of which connects the movable table. A second hinge and a third hinge are provided symmetrically on an end face of the fixed frame, the tops of them are mounted respectively and symmetrically on the end face of the fixed frame, and the ends connect apart with the movable table. The invention can be designed in modularization and used conveniently; the amount of moving components can be reduced, which can avoid the interference among moving components. The end performer can move with five-freedom and holds the performance of high speed, high precision, high rigidity and the trait of broad working space.
摘要翻译：本发明公开了一种具有五自由度混合联接结构的机器人，其包括固定框架，可调整长度的第一设定，可调整长度的第二设定，可调整长度的第三设定，定位头，可动台。其中，第一铰链设置在固定框架的中间。第一设置的顶部通过第一铰链和由第一设置和第一铰链形成的换挡对安装在固定框架上，换挡对的一端连接可动台。第二铰链和第三铰链对称地设置在固定框架的端面上，它们的顶部分别对称地安装在固定框架的端面上，并且端部与可移动台分开连接。本发明可以模块化设计，使用方便; 移动部件的数量可以减少，这可以避免移动部件之间的干扰。最终演员能够以五自由度运动，并具备高速，高精度，高刚性和广阔工作空间的特点。

7. 发明申请

WO2010136795A3 HEAT RECOVERY MODULE 审中-公开
标题翻译：热回收模块
公开(公告)号：WO2010136795A3
公开(公告)日：2011-10-06
申请号：PCT/GB2010050863
申请日：2010-05-26
申请人： DOOSAN POWER SYSTEMS LTD , CHEN CHAO HUI , LI MENG , SMITH MICHAEL
发明人： CHEN CHAO HUI , LI MENG , SMITH MICHAEL
IPC分类号： F22D1/02 , F22D1/36
CPC分类号： F22D1/36 , F22D1/02
摘要： A module for heat recovery from exhausted flue gas in a steam generator is described comprising a flue gas outlet conduit defining a flow path for flue gas from a flue gas outlet of a steam generator to a flue gas conduit junction; a first flue gas conduit defining a flow path for flue gas from the junction to a first air heater; a second flue gas conduit defining a flow path for flue gas from the junction to at least one high pressure and at least one low pressure process liquid economiser. A steam generator using the module, a method implementing the flow principles embodied in such a module, and a method of incorporation of such a module into a steam generator, especially by retrofit,are also described.
摘要翻译：描述了一种用于在蒸汽发生器中从排出的废气中回收热量的模块，其包括：烟道气出口导管，其限定用于从蒸汽发生器的烟道气出口到烟道气管道连接处的烟道气的流动路径; 第一烟气管道，其限定用于从所述连接点到第一空气加热器的烟道气的流动路径; 第二烟气管道，其限定用于从所述连接点到至少一个高压和至少一个低压过程液体节能器的烟道气的流动路径。还描述了使用该模块的蒸汽发生器，实现这种模块中实施的流程原理的方法，以及将这种模块并入蒸汽发生器，特别是通过改造的方法。

8. 发明申请

WO2010136797A3 SYSTEM FOR HEATING A PRIMARY AIR STREAM 审中-公开
标题翻译：加热一个主要空气流的系统
公开(公告)号：WO2010136797A3
公开(公告)日：2011-09-29
申请号：PCT/GB2010050867
申请日：2010-05-26
申请人： DOOSAN POWER SYSTEMS LTD , CHEN CHAO HUI , LI MENG , SMITH MICHAEL
发明人： CHEN CHAO HUI , LI MENG , SMITH MICHAEL
IPC分类号： F01K17/06
CPC分类号： F01K17/06
摘要： A system for heating a primary air stream in a steam generating process comprising at least one primary air heat exchanger to exchange heat between the primary air stream in the primary air heat exchanger(s) and a process fluid.
摘要翻译：一种用于在蒸汽发生方法中加热一次空气流的系统，包括至少一个一次空气热交换器以在一次空气热交换器中的一次空气流与过程流体之间进行热交换。

9. 发明申请

WO9953022A3 SELECTION OF LINEAGE SPECIFIC CELLS AFTER DIFFERENTIATION OF PROGENITOR CELLS 审中-公开
标题翻译：在分化细胞分化后选择线粒体特异性细胞
公开(公告)号：WO9953022A3
公开(公告)日：2001-04-19
申请号：PCT/GB9901136
申请日：1999-04-14
申请人： UNIV EDINBURGH , SMITH AUSTIN , LI MENG
发明人： SMITH AUSTIN , LI MENG
IPC分类号： C12N15/09 , A61K38/00 , C12N5/073 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N5/10 , C12Q1/00 , C12Q1/04 , C12N15/65 , C12N5/06 , C12N15/85
CPC分类号： C12N5/0603 , A61K38/00 , C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/385 , C12N2501/40 , C12N2501/70 , C12N2506/02 , C12N2506/03 , C12N2506/04 , C12N2510/00
摘要： A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which a selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and the multipotential cell is cultured to induce differentiation of the multipotential cell into a cell of the selected lineage or into a mixture of cells including cells of the selected lineage, or is cultured to induce preferential survival of cells of the selected lineage. Those cells that express the selectable marker are then selected for. Progenitors of selected lineage are also described as is the use of the method in assay techniques.
摘要翻译：描述了一种用于产生相对于所选谱系的细胞纯化或富集的培养物的方法，其中在所选择的谱系的细胞中与其在其它细胞中表达差异表达的选择性标记被引入多潜能培养细胞并使多潜能细胞诱导分化为所选谱系的细胞，或诱导包括所选谱系的细胞的细胞混合物，或培养以诱导所选谱系的细胞优先存活。然后选择表达可选择标记的那些细胞。选择谱系的祖细胞也被描述为在测定技术中使用该方法。

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