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    • 7. 发明授权
    • Palatable arginine compounds and uses thereof for cardiovascular health
    • 可口的精氨酸化合物及其用于心血管健康的用途
    • US06794375B2
    • 2004-09-21
    • US10181655
    • 2002-07-19
    • Robert Joseph SaramaRaymond Louis Niehoff
    • Robert Joseph SaramaRaymond Louis Niehoff
    • A61K3156
    • C07D311/72A23G1/305A23G2200/10A23L33/11A23L33/175A23L33/26A23V2002/00C07C279/14C07J41/00A23V2250/5114A23V2250/606A23V2250/0606A23V2250/032A23V2250/702A23V2250/708A23V2250/5488
    • The present invention is directed to a compound having the structure (I): and acceptable salts, polypeptides, and pro-forms thereof, wherein R is selected from the group consisting of: (a) substituted glycerols; wherein n is an integer from 1 to 2; (b) vitamins; wherein n is 1; (c) sterols; wherein n is 1; (d) stanols; wherein n is 1; and (e) C6-C32 alkyl; and (f) C6-C32 alkenyl; wherein n is 1. The present invention is further directed to compositions and kits comprising these compounds as well as methods of using the compounds. The compounds, compositions, kits, and methods herein are useful for providing general health benefits to the consumer, particularly cardiovascular benefits, anti-menopausal benefits and/or treating sexual dysfunction (particularly, erectile dysfunction). Most particularly, the compounds, compositions, kits, and methods herein are useful for providing cardiovascular benefits, including lowering cholesterol in the consumer, treating, preventing, and/or inhibiting heart disease (e.g., atherosclerosis, restenosis, thrombosis) and, for example, treating other conditions such as hypercholesterolemia, hypertension, poor circulation, and complications associated with diabetes.
    • 本发明涉及具有结构(I)的化合物及其可接受的盐,多肽及其前体,其中R选自:(a)取代的甘油; 其中n是1至2的整数; (b)维生素; 其中n为1; (c)甾醇; 其中n为1; (d)甾烷醇; 其中n为1; 和(e)C 6 -C 32烷基; 和(f)C 6 -C 32烯基; 其中n为1.本发明还涉及包含这些化合物的组合物和试剂盒以及使用该化合物的方法。 本文的化合物,组合物,试剂盒和方法可用于向消费者提供一般健康益处,特别是心血管益处,抗绝经益处和/或治疗性功能障碍(特别是勃起功能障碍)。 最特别地,本文的化合物,组合物,试剂盒和方法可用于提供心血管益处,包括降低消费者的胆固醇,治疗,预防和/或抑制心脏病(例如动脉粥样硬化,再狭窄,血栓形成),以及例如 治疗高胆固醇血症,高血压,循环不良,糖尿病并发症等其他病症。
    • 9. 发明授权
    • Reduced calorie cooking and frying oils having improved hydrolytic stability, and process for preparing
    • 具有改善的水解稳定性的减少热量烹饪和煎炸油以及制备方法
    • US06310227B1
    • 2001-10-30
    • US09355543
    • 1999-10-06
    • Robert Joseph SaramaJohn Keeney HowieReginald Sebastian Clay
    • Robert Joseph SaramaJohn Keeney HowieReginald Sebastian Clay
    • C11B300
    • C07H13/06A23D9/007A23D9/013A23L33/26C07H15/04
    • The present invention relates to a process for preparing calorie cooking and frying oils, containing nondigestable polyol polyesters, and having improved color and improved stability against hydrolysis during frying. The process comprises, as a first step, treating a crude polyol polyester with an ion exchange ligand in an aqueous phase to convert diavalent metal soaps present in the crude polyol polyester to monovalent soaps. The monovalent soaps and ion exchange ligands are then removed from the treated polyol polyester to provide a cooking and frying oil which contains less than about 550 ppb divalent metal ions. Said oil, when further processed according to conventional industry standards will have a free fatty acid content of less than about 500 ppm. Preferably, the cooking and frying oils prepared according to the process of the present invention will further have a Lovibond red color of less than about 6, preferably less than about 4.
    • 本发明涉及一种制备含有不易消化的多元醇多酯的热量烹调和煎炸油的方法,并且具有改进的颜色和改善油炸期间的水解稳定性。 该方法包括作为第一步骤,在水相中用离子交换配体处理粗多元醇多酯以将存在于粗多元醇多酯中的二价金属皂转化成单价皂。 然后从经处理的多元醇多元醇中除去一价皂和离子交换配体,以提供包含小于约550ppb二价金属离子的烹饪油炸油。 当根据常规工业标准进一步加工时,所述油将具有小于约500ppm的游离脂肪酸含量。 优选地,根据本发明的方法制备的烹饪和油炸油将进一步具有小于约6,优选小于约4的Lovibond红色。