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1. 发明专利

DK3155024T3 OPHOLDSSTRUKTURER OG RELATEREDE FREMGANGSMÅDER 未知
公开(公告)号：DK3155024T3
公开(公告)日：2020-11-23
申请号：DK15806017
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI , DICICCIO ANGELA
IPC分类号： A61K9/00

2. 发明专利

AU2019232862A1 RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：AU2019232862A1
公开(公告)日：2019-10-10
申请号：AU2019232862
申请日：2019-09-19
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： - 1 Abstract Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal 5 to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, 10 mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the 15 structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure 20 comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. WO 2015/191920 5/52 PCT/US2OlS/035423 >13 I~ 120 13512 I* ~ 110 \ 130 FIG.lBE

3. 发明专利

AU2015274451C1 Residence structures and related methods 未知
公开(公告)号：AU2015274451C1
公开(公告)日：2019-09-12
申请号：AU2015274451
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

4. 发明专利

AU2021203086A1 RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：AU2021203086A1
公开(公告)日：2021-06-10
申请号：AU2021203086
申请日：2021-05-14
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： - 1 Abstract Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal 5 to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, 10 mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the 15 structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure 20 comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

5. 发明专利

SG10201912100SA RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：SG10201912100SA
公开(公告)日：2020-02-27
申请号：SG10201912100S
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO , LANGER ROBERT , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN , DICICCIO ANGELA , WOOD LOWELL , ECKHOFF PHILIP
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

6. 发明专利

BR122021018078B1 Artigo e estrutura de residência gástrica 未知
公开(公告)号：BR122021018078B1
公开(公告)日：2022-02-08
申请号：BR122021018078
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , DICICCIO ANGELA , CARLO GIOVANNI TRAVERSO , DEAN LIANG GLETTIG , LOWELL L WOOD JR , JAFARI MOUSA , PHILIP A ECKHOFF , ROBERT S LANGER , ZHANG SHIYI , MO STACY , GRANT TYLER
IPC分类号： C08F8/00 , C08G63/682
摘要： a presente revelação refere-se a estrutura de residência, sistemas, e métodos relativos que são geralmente providos. certas modalidades compreendem administrar uma estrutura de residência para uma pessoa de modo que a estrutura de residência fique retida em uma localização interna ao paciente por uma quantidade de tempo específica antes de ser liberada. a estrutura de residência pode ser uma estrutura de residência gástrica. em algumas modalidades, as estruturas e sistemas aqui descritos compreendem um ou mais materiais configurados para altos níveis de carregamento de substância ativas, alta estabilidade de substância ativa e/ou estrutura em ambientes ácidos, flexibilidade mecânica e resistência em um orifício interno, fácil passagem através do trato gi até fornecimento em um orifício interno desejado, e/ou dissolução / degradação rápida em um ambiente fisiológico e/ou em resposta a um estimulante químico. em certas modalidades, a estrutura tem um projeto modular, combinando um material configurado para liberação controlada de agentes terapêuticos, de diagnóstico, e/ou de melhoramentos com um material estrutural necessário para residência gástrica, mas configurado para uma degradação/dissolução controlada e/ou sintonizável para determinar o tempo no qual a integridade de forma de retenção é perdida e a estrutura passe para fora da cavidade gástrica.

7. 发明专利

ES2832334T3 Estructuras de permanencia y métodos relacionados 未知
公开(公告)号：ES2832334T3
公开(公告)日：2021-06-10
申请号：ES15806017
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO , LANGER ROBERT , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： A61K9/00
摘要： Estructura de permanencia, que comprende: un componente polimérico cargable; un segundo componente polimérico acoplado con el componente polimérico cargable; y al menos un conector degradable que comprende al menos una porción del componente polimérico cargable y/o el segundo componente polimérico o acoplado con el mismo, en la que i) el conector está configurado para disolverse, degradarse, debilitarse mecánicamente y/o separarse mecánicamente de al menos uno del uno o más componentes poliméricos, o ii) el conector degradable está configurado para degradarse de tal manera que la estructura de permanencia se rompa, o iii) el segundo componente polimérico es diferente del componente polimérico cargable, o iv) el conector degradable es un material conector independiente, y en la que para cada uno de i) a iv) o bien a) el segundo componente polimérico se acopla al componente polimérico cargable mediante el al menos un conector degradable; en la que al menos uno del componente polimérico cargable, el segundo componente polimérico y el conector degradable comprende un componente polimérico elástico; en la que el componente polimérico cargable comprende al menos aproximadamente el 60% en peso del peso total de la estructura; en la que la estructura de permanencia tiene una fuerza de plegado de al menos aproximadamente 0,2 N, en la que la fuerza de plegado se determina colocando la estructura en un embudo que tiene un diámetro superior de 20 cm y un diámetro inferior de 2 cm y midiendo las fuerzas requeridas para mover la estructura a través del diámetro inferior de 2 cm conectando un émbolo a la cruceta de tensión de una máquina de carga de tracción y el embudo a una abrazadera, y empujando la estructura a través del embudo a una velocidad de 10 mm/min, mientras se mide la fuerza y el desplazamiento, en la que la fuerza de plegado se determina midiendo la fuerza a la que la estructura se pliega y entra en el tubo de diámetro inferior de 2 cm; y en la que la estructura de permanencia tiene una dimensión de sección transversal sin comprimir de al menos aproximadamente 2 cm, y en la que la estructura de permanencia está configurada de tal manera que se retiene en una ubicación interna de un sujeto; o bien b) la estructura de permanencia está configurada de tal manera que se retiene en una ubicación interna de un sujeto durante al menos aproximadamente 24 horas; o bien c) el componente polimérico cargable comprende un principio activo; la estructura de permanencia está configurada de tal manera que el principio activo se libere del material polimérico cargable a una velocidad promedio inicial particular determinada a lo largo de las primeras 24 horas de liberación; y en la que se libera el principio activo a una velocidad promedio de al menos aproximadamente el 1% de la velocidad promedio inicial a lo largo de un periodo de 24 horas después de las primeras 24 horas de liberación.

8. 发明专利

AU2015274451B2 Residence structures and related methods 未知
公开(公告)号：AU2015274451B2
公开(公告)日：2019-06-20
申请号：AU2015274451
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

9. 发明申请

WO2015191920A8 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A8
公开(公告)日：2016-02-04
申请号：PCT/US2015035423
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , TOKITAE LLC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

10. 发明专利

SG11201610246PA RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：SG11201610246PA
公开(公告)日：2017-01-27
申请号：SG11201610246P
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

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