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1. 发明专利

SG10201912100SA RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：SG10201912100SA
公开(公告)日：2020-02-27
申请号：SG10201912100S
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO , LANGER ROBERT , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN , DICICCIO ANGELA , WOOD LOWELL , ECKHOFF PHILIP
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

2. 发明专利

NZ727659A Residence structures and related methods 未知
公开(公告)号：NZ727659A
公开(公告)日：2021-12-24
申请号：NZ72765915
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , THE BRIGHAM AND WOMEN’S HOSPITAL INC
发明人： LANGER ROBERT , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN , DICICCIO ANGELA , WOOD LOWELL , ECKHOFF PHILIP
IPC分类号： C08F8/00 , A61K9/00 , A61K31/00 , A61K47/00 , A61M31/00 , C08G63/682 , C08G83/00
摘要： In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). The invention relates to a gastric residence structure comprising an active substance, the gastric residence structure comprising: one or more arms comprising a loadable polymeric component, wherein the loadable polymeric component comprises the active substance, and the active substance is a therapeutic agent or a diagnostic agent; an elastic polymeric component; and a separate linker component. The linker connects the one or more arms with the elastic polymeric component, the gastric residence structure is configured to be folded and physically constrained during administration and is configured to assume an open retention shape upon removal of a constraint. A change between the folded shape and the open retention shape is mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape. The linker degrades, dissolves, disassociates, or mechanically weakens in a gastric environment which results in loss of retention shape integrity and passage out of a gastric cavity.

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