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1. 发明申请

WO2010141920A3 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：WO2010141920A3
公开(公告)日：2011-01-27
申请号：PCT/US2010037544
申请日：2010-06-04
申请人： GENOMATICA INC , VAN DIEN STEPHEN J , BURGARD ANTHONY P , HASELBECK ROBERT , PUJOL-BAXLEY CATHERINE J , NIU WEI , TRAWICK JOHN D , YIM HARRY , BURK MARK J , OSTERHOUT ROBIN E , SUN JUN
发明人： VAN DIEN STEPHEN J , BURGARD ANTHONY P , HASELBECK ROBERT , PUJOL-BAXLEY CATHERINE J , NIU WEI , TRAWICK JOHN D , YIM HARRY , BURK MARK J , OSTERHOUT ROBIN E , SUN JUN
IPC分类号： C12P7/16
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

2. 发明申请

WO02086097A8 METHODS FOR IDENTIFYING THE TARGET OF A COMPOUND WHICH INHIBITS CELLULAR PROLIFERATION 审中-公开
标题翻译：识别抑制细胞增殖的化合物的目标的方法
公开(公告)号：WO02086097A8
公开(公告)日：2004-11-25
申请号：PCT/US0203987
申请日：2002-02-08
申请人： ELITRA PHARMACEUTICALS INC , CARR GRANT J , XU HOWARD H , FOULKES GORDON J , ZAMUDIO CARLOS , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , YAMAMOTO ROBERT T , ROEMER TERRY , JIANG BO , BOONE CHARLES , BUSSEY HOWARD
发明人： CARR GRANT J , XU HOWARD H , FOULKES GORDON J , ZAMUDIO CARLOS , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , YAMAMOTO ROBERT T , ROEMER TERRY , JIANG BO , BOONE CHARLES , BUSSEY HOWARD
IPC分类号： G01N33/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/10 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C12P19/34 , C12N1/000
CPC分类号： C12N15/1034
摘要： The present invention relates to cultures or collections of strains which overexpress or underexpress gene products required for the proliferation of an organism. The present invention also includes methods for identifying the target on which a compound which inhibits the proliferation of an organims acts and methods for identifying the extent to which a strain is present in a culture or collection of strains.
摘要翻译：本发明涉及过表达或低表达生物体增殖所需基因产物的菌株的培养物或收集品。本发明还包括用于鉴定抑制组织的增殖的化合物作用的靶标的方法以及用于鉴定菌株存在于培养物或菌株集合中的程度的方法。

3. 发明申请

WO2002086097A2 METHODS FOR IDENTIFYING THE TARGET OF A COMPOUND WHICH INHIBITS CELLULAR PROLIFERATION 审中-公开
标题翻译：识别抑制细胞增殖的化合物的目标的方法
公开(公告)号：WO2002086097A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/003987
申请日：2002-02-08
申请人： ELITRA PHARMACEUTICALS, INC. , CARR, Grant, J. , XU, Howard, H. , FOULKES, Gordon, J. , ZAMUDIO, Carlos , HASELBECK, Robert , OHLSEN, Kari, L. , ZYSKIND, Judith, W. , WALL, Daniel , TRAWICK, John, D. , YAMAMOTO, Robert, T. , ROEMER, Terry , JIANG, Bo , BOONE, Charles , BUSSEY, Howard
发明人： CARR, Grant, J. , XU, Howard, H. , FOULKES, Gordon, J. , ZAMUDIO, Carlos , HASELBECK, Robert , OHLSEN, Kari, L. , ZYSKIND, Judith, W. , WALL, Daniel , TRAWICK, John, D. , YAMAMOTO, Robert, T. , ROEMER, Terry , JIANG, Bo , BOONE, Charles , BUSSEY, Howard
IPC分类号： C12N
CPC分类号： C12N15/1034
摘要： The present invention relates to cultures or collections of strains which overexpress or underexpress gene products required for the proliferation of an organism. The present invention also includes methods for identifying the target on which a compound which inhibits the proliferation of an organims acts and methods for identifying the extent to which a strain is present in a culture or collection of strains.
摘要翻译：本发明涉及过表达或低表达生物体增殖所需基因产物的菌株的培养物或收集品。本发明还包括用于鉴定抑制组织的增殖的化合物作用的靶标的方法以及用于鉴定菌株存在于培养物或菌株集合中的程度的方法。

4. 发明申请

WO2009094485A1 METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL 审中-公开
标题翻译：使用合成气或其他气体碳源和甲醇的方法和有机体
公开(公告)号：WO2009094485A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031737
申请日：2009-01-22
申请人： GENOMATICA, INC. , BURK, Mark , SCHILLING, Christophe, H. , BURGARD, Anthony , TRAWICK, John, D.
发明人： BURK, Mark , SCHILLING, Christophe, H. , BURGARD, Anthony , TRAWICK, John, D.
IPC分类号： C12N1/20 , C12P21/06 , C12P11/00
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl- CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO 2 and/or H 2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydro folate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO 2 and H 2 to acetyl- CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO 2 and/or H 2 , alone or in combination with methanol, to produce acetyl- CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
摘要翻译：本发明提供了具有乙酰辅酶A途径和利用合成气或合成气和甲醇的能力的非天然存在的微生物。在一个实施方案中，本发明提供非天然存在的微生物，其包含一种或多种外源蛋白质，赋予微生物将CO，CO 2和/或H 2转化为乙酰辅酶A（乙酰辅酶A），甲基四氢叶酸（甲基-THF）或其它所需产物，其中微生物缺乏在不存在一种或多种外源蛋白的情况下将CO或CO 2和H 2转化为乙酰辅酶A或甲基-THF的能力。例如，微生物生物体可以含有至少一种编码乙酰辅酶A途径中的酶或蛋白质的外源核酸。微生物生物能够单独或与甲醇组合使用包含CO，CO 2和/或H 2的合成气体，以产生乙酰辅酶A。本发明另外提供了生产乙酰辅酶A的方法，例如通过培养产生乙酰辅酶A的微生物，其中微生物生物体表达至少一种编码乙酰辅酶A途径酶或蛋白质的外源核酸，其量足够在条件和足够的时间内产生乙酰辅酶A产生乙酰辅酶A。

5. 发明申请

WO2011066076A1 MICROORGANISMS AND METHODS FOR THE COPRODUCTION OF 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE 审中-公开
标题翻译：共聚1,4-丁二醇和γ-丁内酯的微生物和方法
公开(公告)号：WO2011066076A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/055524
申请日：2010-11-04
申请人： GENOMATICA, INC. , SUN, Jun , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , NIU, Wei , TRAWICK, John, D. , HASELBECK, Robert
发明人： SUN, Jun , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , NIU, Wei , TRAWICK, John, D. , HASELBECK, Robert
IPC分类号： C12P7/38 , C12P7/16 , C12N1/20
CPC分类号： C12P17/04 , C12N1/20 , C12N15/52 , C12P7/18
摘要： The invention provides non-naturally occurring microbial organisms comprising 1,4- butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
摘要翻译：本发明提供包含1,4-丁二醇（14-BDO）和γ-丁内酯（GBL）途径的非天然存在的微生物生物，其包含至少一种编码14-BDO和GBL途径酶的外源核酸，其以足够的量表达，生产14-BDO和GBL。本发明另外提供了使用这种微生物生物来生产14-BDO和GBL的方法。

6. 发明申请

WO2010071697A1 MICROORGANISMS AND METHODS FOR CONVERSION OF SYNGAS AND OTHER CARBON SOURCES TO USEFUL PRODUCTS 审中-公开
标题翻译：将有关产品转化为基质和其他碳源的微生物和方法
公开(公告)号：WO2010071697A1
公开(公告)日：2010-06-24
申请号：PCT/US2009/050757
申请日：2009-07-15
申请人： GENOMATICA, INC. , TRAWICK, John, D. , BURK, Mark, J. , BURGARD, Anthony, P.
发明人： TRAWICK, John, D. , BURK, Mark, J. , BURGARD, Anthony, P.
IPC分类号： C12N1/00 , C12N1/21 , C12P5/00
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/10 , C12N9/1029 , C12N9/88 , C12N15/52 , C12P7/04 , C12P7/42
摘要： An exemplary non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme expressed in a sufficient amount to produce isopropanol and includes a succinyl-CoA:3-ketoacid-CoA transferase. Another organism having a 4-hydroxybutryate pathway includes at least one exogenous nucleic acid including an acetoacetyl-CoA thiolase, a 3-hydroxybutyryl-CoA dehydrogenase, a crotonase, a crotonyl-CoA hydratase, a 4-hydroxybutyryl-CoA transferase, a phosphotrans-4-hydroxybutyrylase, and a 4-hydroxybutyrate kinase. An exemplary organism having a 1,4-butanediol pathway includes an acetoacetyl-CoA thiolase, a 3-Hydroxybutyryl-CoA dehydrogenase, a crotonase, a crotonyl-CoA hydratase, a 4-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA reductase (aldehyde forming), and a 1,4-butanediol dehydrogenase. Such an organism further comprising an acetyl-CoA pathway. Any of the aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4- butanediol.
摘要翻译：具有异丙醇途径的示例性非天然存在的微生物生物体包括至少一种编码异丙醇途径酶的外源核酸，其以足以产生异丙醇的量表达，并且包括琥珀酰-CoA：3-酮酸 - 辅酶A转移酶。具有4-羟基丁酸酯途径的另一种生物体包括至少一种外源核酸，包括乙酰乙酰辅酶A硫解酶，3-羟基丁酰辅酶A脱氢酶，巴豆酸酶，巴豆酰辅酶A水合酶，4-羟基丁酰辅酶A转移酶， 4-羟基丁酸酯酶和4-羟基丁酸酯激酶。具有1,4-丁二醇途径的示例性生物体包括乙酰乙酰辅酶A硫解酶，3-羟基丁酰辅酶A脱氢酶，巴豆酸酶，巴豆酰辅酶A水合酶，4-羟基丁酰辅酶A还原酶（醇形成），4- 羟基丁酰辅酶A还原酶（醛形成）和1,4-丁二醇脱氢酶。这种生物体还包含乙酰辅酶A途径。任何上述生物被培养以产生异丙醇，4-羟基丁酸酯或1,4-丁二醇。

7. 发明申请

WO2002086097A3 METHODS FOR IDENTIFYING THE TARGET OF A COMPOUND WHICH INHIBITS CELLULAR PROLIFERATION 审中-公开
公开(公告)号：WO2002086097A3
公开(公告)日：2002-10-31
申请号：PCT/US2002/003987
申请日：2002-02-08
申请人： ELITRA PHARMACEUTICALS, INC. , CARR, Grant, J. , XU, Howard, H. , FOULKES, Gordon, J. , ZAMUDIO, Carlos , HASELBECK, Robert , OHLSEN, Kari, L. , ZYSKIND, Judith, W. , WALL, Daniel , TRAWICK, John, D. , YAMAMOTO, Robert, T. , ROEMER, Terry , JIANG, Bo , BOONE, Charles , BUSSEY, Howard
发明人： CARR, Grant, J. , XU, Howard, H. , FOULKES, Gordon, J. , ZAMUDIO, Carlos , HASELBECK, Robert , OHLSEN, Kari, L. , ZYSKIND, Judith, W. , WALL, Daniel , TRAWICK, John, D. , YAMAMOTO, Robert, T. , ROEMER, Terry , JIANG, Bo , BOONE, Charles , BUSSEY, Howard
IPC分类号： C12Q1/68
摘要： The present invention relates to cultures or collections of strains which overexpress or underexpress gene products required for the proliferation of an organism. The present invention also includes methods for identifying the target on which a compound which inhibits the proliferation of an organims acts and methods for identifying the extent to which a strain is present in a culture or collection of strains.

8. 发明申请

WO02077183A2 IDENTIFICATION OF ESSENTIAL GENES IN MICROORGANISMS 审中-公开
标题翻译：鉴定微生物中的基因
公开(公告)号：WO02077183A2
公开(公告)日：2002-10-03
申请号：PCT/US0209107
申请日：2002-03-21
申请人： ELITRA PHARMACEUTICALS INC , WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
发明人： WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
IPC分类号： C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40 , C12N
CPC分类号： C07K14/212 , C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/3156 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸也可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯菌和铜绿假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

9. 发明申请

WO0170955A3 IDENTIFICATION OF ESSENTIAL GENES IN PROKARYOTES 审中-公开
标题翻译：鉴定基因组中的基因
公开(公告)号：WO0170955A3
公开(公告)日：2002-08-01
申请号：PCT/US0109180
申请日：2001-03-21
申请人： ELITRA PHARMACEUTICALS INC , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD
发明人： HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/31 , C12P21/02 , C12Q1/06 , C12Q1/68 , G01N33/15 , C12N15/11 , C07K14/195
CPC分类号： C12N15/1079 , A61K31/7088 , A61K48/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N15/1034
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa . The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸还可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯杆菌和绿脓假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

10. 发明申请

WO2011047101A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,4-丁二醇，4-羟基吡啶，4-羟基丁酰氯，聚氨酯和相关化合物的微生物及其相关方法
公开(公告)号：WO2011047101A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052570
申请日：2010-10-13
申请人： GENOMATICA, INC. , HASELBECK, Robert , TRAWICK, John, D. , NIU, Wei , BURGARD, Anthony, P.
发明人： HASELBECK, Robert , TRAWICK, John, D. , NIU, Wei , BURGARD, Anthony, P.
IPC分类号： C12P7/26 , C12N1/20
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4- butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, A- hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A， - 羟基丁醛或腐胺途径酶以足够的量表达以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺，并进一步优化BDO的表达。本发明另外提供了使用这种微生物生物制备BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

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