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1. 发明申请

WO0170955A8 IDENTIFICATION OF ESSENTIAL GENES IN PROKARYOTES 审中-公开
标题翻译：鉴定基因组中的基因
公开(公告)号：WO0170955A8
公开(公告)日：2004-04-15
申请号：PCT/US0109180
申请日：2001-03-21
申请人： ELITRA PHARMACEUTICALS INC , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD , FORSYTH R ALLYN
发明人： HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD , FORSYTH R ALLYN
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/31 , C12P21/02 , C12Q1/06 , C12Q1/68 , G01N33/15 , C12N15/11 , C07K14/195
CPC分类号： C12N15/1079 , A61K31/7088 , A61K48/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N15/1034
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸也可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯菌和铜绿假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

2. 发明申请

WO0170955A3 IDENTIFICATION OF ESSENTIAL GENES IN PROKARYOTES 审中-公开
标题翻译：鉴定基因组中的基因
公开(公告)号：WO0170955A3
公开(公告)日：2002-08-01
申请号：PCT/US0109180
申请日：2001-03-21
申请人： ELITRA PHARMACEUTICALS INC , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD
发明人： HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/31 , C12P21/02 , C12Q1/06 , C12Q1/68 , G01N33/15 , C12N15/11 , C07K14/195
CPC分类号： C12N15/1079 , A61K31/7088 , A61K48/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N15/1034
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa . The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸还可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯杆菌和绿脓假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

3. 发明申请

WO02077183A2 IDENTIFICATION OF ESSENTIAL GENES IN MICROORGANISMS 审中-公开
标题翻译：鉴定微生物中的基因
公开(公告)号：WO02077183A2
公开(公告)日：2002-10-03
申请号：PCT/US0209107
申请日：2002-03-21
申请人： ELITRA PHARMACEUTICALS INC , WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
发明人： WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
IPC分类号： C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40 , C12N
CPC分类号： C07K14/212 , C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/3156 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸也可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯菌和铜绿假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

4. 发明申请

WO02086097A8 METHODS FOR IDENTIFYING THE TARGET OF A COMPOUND WHICH INHIBITS CELLULAR PROLIFERATION 审中-公开
标题翻译：识别抑制细胞增殖的化合物的目标的方法
公开(公告)号：WO02086097A8
公开(公告)日：2004-11-25
申请号：PCT/US0203987
申请日：2002-02-08
申请人： ELITRA PHARMACEUTICALS INC , CARR GRANT J , XU HOWARD H , FOULKES GORDON J , ZAMUDIO CARLOS , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , YAMAMOTO ROBERT T , ROEMER TERRY , JIANG BO , BOONE CHARLES , BUSSEY HOWARD
发明人： CARR GRANT J , XU HOWARD H , FOULKES GORDON J , ZAMUDIO CARLOS , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , YAMAMOTO ROBERT T , ROEMER TERRY , JIANG BO , BOONE CHARLES , BUSSEY HOWARD
IPC分类号： G01N33/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/10 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C12P19/34 , C12N1/000
CPC分类号： C12N15/1034
摘要： The present invention relates to cultures or collections of strains which overexpress or underexpress gene products required for the proliferation of an organism. The present invention also includes methods for identifying the target on which a compound which inhibits the proliferation of an organims acts and methods for identifying the extent to which a strain is present in a culture or collection of strains.
摘要翻译：本发明涉及过表达或低表达生物体增殖所需基因产物的菌株的培养物或收集品。本发明还包括用于鉴定抑制组织的增殖的化合物作用的靶标的方法以及用于鉴定菌株存在于培养物或菌株集合中的程度的方法。

5. 发明申请

WO2010141920A3 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：WO2010141920A3
公开(公告)日：2011-01-27
申请号：PCT/US2010037544
申请日：2010-06-04
申请人： GENOMATICA INC , VAN DIEN STEPHEN J , BURGARD ANTHONY P , HASELBECK ROBERT , PUJOL-BAXLEY CATHERINE J , NIU WEI , TRAWICK JOHN D , YIM HARRY , BURK MARK J , OSTERHOUT ROBIN E , SUN JUN
发明人： VAN DIEN STEPHEN J , BURGARD ANTHONY P , HASELBECK ROBERT , PUJOL-BAXLEY CATHERINE J , NIU WEI , TRAWICK JOHN D , YIM HARRY , BURK MARK J , OSTERHOUT ROBIN E , SUN JUN
IPC分类号： C12P7/16
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

6. 发明专利

AU2002241706A1 Bacterial promoters and methods of use 未知
公开(公告)号：AU2002241706A1
公开(公告)日：2002-07-08
申请号：AU2002241706
申请日：2001-12-21
申请人： ELITRA PHARMACEUTICALS INC , HASELBECK ROBERT , WALL DAN , GROSS MOLLY
发明人： HASELBECK ROBERT , WALL DAN , GROSS MOLLY
IPC分类号： C12N15/74

7. 发明申请

WO02051982A2 BACTERIAL PROMOTERS AND METHODS OF USE 审中-公开
标题翻译：细菌促进剂和使用方法
公开(公告)号：WO02051982A2
公开(公告)日：2002-07-04
申请号：PCT/US0150250
申请日：2001-12-21
申请人： ELITRA PHARMACEUTICALS INC , HASELBECK ROBERT , WALL DAN , GROSS MOLLY
发明人： HASELBECK ROBERT , WALL DAN , GROSS MOLLY
IPC分类号： C12N15/74 , C12N
CPC分类号： C12N15/74
摘要： Compositions and methods are disclosed herein that relate to the development of fusion promoters for regulating gene expression in bacteria. Embodiments include fusion promoters comprising one or more operators linked to a promoter that is modified to have altered activity in Gram-positive organisms. Vectors and cells containing these fusion promoters are also described. Other embodiments include, methods of using these fusion promoters to regulate nucleic acid and/or polypeptide expression, methods of using these fusion promoters to identify proliferation-required genes, and methods of using these fusion promoters to identify molecules having potential antibiotic activity.
摘要翻译：本文公开了与用于调节细菌中的基因表达的融合启动子的开发有关的组合物和方法。实施方案包括融合启动子，其包含连接到启动子的一个或多个操纵子，所述启动子被修饰以在革兰氏阳性生物中具有改变的活性。也描述了含有这些融合启动子的载体和细胞。其他实施方案包括使用这些融合启动子调节核酸和/或多肽表达的方法，使用这些融合启动子来鉴定增殖需要的基因的方法，以及使用这些融合启动子鉴定具有潜在抗生素活性的分子的方法。

8. 发明专利

CA2436216A1 METHODS FOR IDENTIFYING THE TARGET OF A COMPOUND WHICH INHIBITS CELLULAR PROLIFERATION 未知
公开(公告)号：CA2436216A1
公开(公告)日：2002-10-31
申请号：CA2436216
申请日：2002-02-08
申请人： ELITRA PHARMACEUTICALS INC
发明人： TRAWICK JOHN D , YAMAMOTO ROBERT T , BUSSEY HOWARD , CARR GRANT J , XU HOWARD H , BOONE CHARLES , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , JIANG BO , HASELBECK ROBERT , ZAMUDIO CARLOS , FOULKES GORDON J , ROEMER TERRY
IPC分类号： G01N33/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/10 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C12P19/34
摘要： The present invention relates to cultures or collections of strains which overexpress or underexpress gene products required for the proliferation of an organism. The present invention also includes methods for identifying the target on which a compound which inhibits the proliferation of an organims acts and methods for identifying the extent to which a strain is present in a culture or collection of strains.

9. 发明专利

AU4934501A Identification of essential genes in prokaryotes 未知
公开(公告)号：AU4934501A
公开(公告)日：2001-10-03
申请号：AU4934501
申请日：2001-03-21
申请人： ELITRA PHARMACEUTICALS INC
发明人： HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT T , XU H HOWARD
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/31 , C12P21/02 , C12Q1/06 , C12Q1/68 , G01N33/15 , C12N15/11 , C07K14/195
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.

10. 发明专利

CA2404260A1 IDENTIFICATION OF ESSENTIAL GENES IN PROKARYOTES 未知
公开(公告)号：CA2404260A1
公开(公告)日：2001-09-27
申请号：CA2404260
申请日：2001-03-21
申请人： ELITRA PHARMACEUTICALS INC
发明人： YAMAMOTO ROBERT T , WALL DANIEL , CARR GRANT J , OHLSEN KARI L , XU H HOWARD , TRAWICK JOHN D , FORSYTH ALLYN R , ZYSKIND JUDITH W , HASELBECK ROBERT
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/21 , C07K14/255 , C07K14/26 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/31 , C12P21/02 , C12Q1/06 , C12Q1/68 , G01N33/15 , C12N15/11 , C07K14/195
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, a nd Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.

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