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1. 发明公开

CN1893966A 在神经胶质瘤细胞的快速复制和在流感流行中的复制素肽无效
公开(公告)号：CN1893966A
公开(公告)日：2007-01-10
申请号：CN03810902.6
申请日：2003-03-25
申请人：塞缪尔·博戈奇 , 埃伦诺尔S·博戈奇
发明人：塞缪尔·博戈奇 , 埃伦诺尔S·博戈奇
IPC分类号： A61K38/00 , C07K14/11
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要：公开了流感病毒血细胞凝集素蛋白质和恶性疟原虫疟疾抗原的肽、所述肽的特异性抗体、流感疫苗、疟疾疫苗以及激发受试者的免疫反应以产生抗流感病毒或疟疾的抗体的方法。另外公开了配制针对流感病毒的疫苗的方法。

2. 发明公开

CN101805393A REPLIKIN肽及其应用无效
公开(公告)号：CN101805393A
公开(公告)日：2010-08-18
申请号：CN200910266227.X
申请日：2002-03-26
申请人：塞缪尔·博戈奇 , 埃伦诺尔S·博戈奇
发明人：塞缪尔·博戈奇 , 埃伦诺尔S·博戈奇
IPC分类号： C07K7/06 , C07K7/08 , C07K14/11 , C07K16/10 , A61K39/42 , A61K39/145 , A61P31/16 , C12N15/113 , G01N33/68 , G01N33/569 , A61K39/015 , A61P33/06 , C07K14/445 , C07K16/20 , A61K39/395 , C12Q1/70 , C12Q1/68 , C12N15/82 , C07K14/32 , C07K14/07 , C07K16/12 , C07K16/08 , A61K39/07 , A61K39/285 , A61P31/04 , A61P31/20 , C07K14/00 , C07K16/00 , A61K39/00 , A61K48/00 , C07K14/405 , C07K14/39 , C07K14/415 , C07K14/195 , C07K14/005 , C07K14/435 , C07K14/44 , C07K16/14 , C07K16/16 , C07K16/18 , C12R1/93
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要：本发明公开了流感病毒血凝素蛋白和恶性疟原虫(Plasmodiumfalciparum)疟疾抗原的肽、对所述肽特异性的抗体、流感疫苗、疟疾疫苗以及刺激患者产生抗流感病毒或疟疾的抗体的免疫反应的方法。本发明也公开了用于配制针对流感病毒的疫苗的方法。本发明公开了炭疽芽孢杆菌(Bacillus anthracis)炭疽毒素致死因子蛋白pX01-107的分离的肽、对所述肽特异性的抗体以及刺激患者产生抗炭疽芽孢杆菌炭疽毒素致死因子蛋白pX01-107的抗体的免疫反应的方法。本发明也公开了天花病毒表面抗原S前体蛋白的分离的肽、对所述肽特异性的抗体以及以及刺激患者产生抗天花病毒表面抗原S前体蛋白的抗体的免疫反应的方法。

3. 发明公开

EP2327715A1 Replikin peptides and uses thereof 审中-公开
公开(公告)号：EP2327715A1
公开(公告)日：2011-06-01
申请号：EP10012947.7
申请日：2002-03-26
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

4. 发明申请

WO02077183A2 IDENTIFICATION OF ESSENTIAL GENES IN MICROORGANISMS 审中-公开
标题翻译：鉴定微生物中的基因
公开(公告)号：WO02077183A2
公开(公告)日：2002-10-03
申请号：PCT/US0209107
申请日：2002-03-21
申请人： ELITRA PHARMACEUTICALS INC , WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
发明人： WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
IPC分类号： C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40 , C12N
CPC分类号： C07K14/212 , C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/3156 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸也可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯菌和铜绿假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

5. 发明公开

EP2345664A2 Replikin peptides and uses thereof 审中-公开
标题翻译： Replikin-Peptide和Verwendung davon
公开(公告)号：EP2345664A2
公开(公告)日：2011-07-20
申请号：EP10012944.4
申请日：2002-07-09
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N9/93 , C12N15/8261 , C12N2740/16022 , C12N2760/16122 , C12N2770/32122 , Y02A40/146 , Y02A50/412
摘要： The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
摘要翻译：本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

6. 发明公开

EP1419175A2 REPLIKIN PEPTIDES AND USES THEREOF 有权
标题翻译：复制素肽及其应用
公开(公告)号：EP1419175A2
公开(公告)日：2004-05-19
申请号：EP02736514.7
申请日：2002-03-26
申请人： Bogoch, Samuel, Dr. , Bogoch, Elenore, S.
发明人： Bogoch, Samuel, Dr. , Bogoch, Elenore, S.
IPC分类号： C07K14/005
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/415 , C07K14/44 , C07K14/445 , C12N2710/24122 , C12N2760/16122 , Y02A50/412
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

7. 发明授权

US07758863B2 Replikin peptides in rapid replication of glioma cells and in influenza epidemics 失效
标题翻译：复制素肽在胶质瘤细胞和流行性感冒流行中的快速复制
公开(公告)号：US07758863B2
公开(公告)日：2010-07-20
申请号：US12412888
申请日：2009-03-27
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： A61K39/145 , C07K4/00 , C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus.
摘要翻译：公开了流感病毒血凝素蛋白和恶性疟原虫疟疾抗原肽，肽特异性抗体，流感疫苗，疟疾疫苗和刺激受试者的免疫应答以产生抗流感病毒或疟疾的方法。还公开了用于制定用于流感病毒的疫苗的方法。

8. 发明申请

US20090137778A1 REPLIKIN PEPTIDES AND ANTIBODIES THEREFORE 审中-公开
标题翻译： REPLIKIN肽及其抗体
公开(公告)号：US20090137778A1
公开(公告)日：2009-05-28
申请号：US12252028
申请日：2008-10-15
申请人： Samuel BOGOCH , Elenore S. BOGOCH
发明人： Samuel BOGOCH , Elenore S. BOGOCH
IPC分类号： C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
摘要翻译：本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

9. 发明申请

US20060024669A1 System and method for identifying complex patterns of amino acids 有权
公开(公告)号：US20060024669A1
公开(公告)日：2006-02-02
申请号：US11116203
申请日：2005-04-28
申请人： Samuel Bogoch , Elenore Bogoch
发明人： Samuel Bogoch , Elenore Bogoch
IPC分类号： C12Q1/70 , G01N33/48 , C07H21/04 , G06F19/00 , G01N33/50 , C12N15/86
CPC分类号： G06F19/16 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , C40B30/02 , G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.

10. 发明授权

US06489290B2 Antiplatelet agent 失效
标题翻译：抗血小板药
公开(公告)号：US06489290B2
公开(公告)日：2002-12-03
申请号：US09381261
申请日：1999-12-07
申请人： Joseph Loscalzo , Aida Inbal
发明人： Joseph Loscalzo , Aida Inbal
IPC分类号： A61K3800
CPC分类号： C07K14/355 , A61K38/00
摘要： This invention combines the unique antiplatelet effects of S-nitrosothiols and the antiadhesive properties of fragments of von Willebrand (vWF) in the A1 domain to provide unique molecules that exploit both of these properties. Preferred molecules comprise a fragment of A1 (Ala 444-Asn 730) in which arginine at position 545 is replaced by cysteine (the most frequent von Willebrand disease type 2b mutation) that has been discovered to impair platelet adhesion, and to inhibit an antithrombotic activity in vivo. This cysteine residue may be S-nitrosated to produce a novel molecule that has the potential for impairing platelet adhesion as well as activation/aggregation, and such molecules form the basis of a novel therapeutic method for impairing platelet responses following vascular injury or in other thrombotic disorders according to this invention.
摘要翻译：本发明结合了S-亚硝基硫醇的独特的抗血小板作用和缬沙坦（vWF）片段在A1结构域中的抗粘附性，以提供独特的分子，利用这两种特性。优选的分子包含A1（Ala 444-Asn 730）的片段，其中545位的精氨酸被已被发现损伤血小板粘附的半胱氨酸（最常见的血管性血友病血型B型突变）代替，并且抑制抗血栓形成活性体内。该半胱氨酸残基可以被S-亚硝基化以产生具有损害血小板粘附和活化/聚集的潜力的新分子，并且这些分子形成用于损伤血管损伤或其它血栓形成后血小板反应的新型治疗方法的基础根据本发明的病症。

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