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1. 发明申请

US20130095134A1 STABILIZED VIRUS LIKE PARTICLES HAVING ENHANCED MUCOSAL IMMUNOGENICITY 有权
标题翻译：具有增强的粘膜免疫原性的稳定的病毒颗粒
公开(公告)号：US20130095134A1
公开(公告)日：2013-04-18
申请号：US13518504
申请日：2010-12-23
申请人： Charles J. Arntzen , Melissa Herbst-Kralovetz
发明人： Charles J. Arntzen , Melissa Herbst-Kralovetz
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K9/0043 , A61K9/1652 , A61K9/1694 , A61K39/00 , A61K39/125 , A61K2039/5258 , A61K2039/53 , A61K2039/542 , A61K2039/543 , C12N7/00 , C12N2770/16023 , C12N2770/16034 , C12N2770/16051
摘要： This disclosure relates to compositions and methods for inducing immune response. Specifically, the disclosure relates to a composition comprising a subunit antigen stabilized by a polysaccharide-containing plant extract, in which the antigen consists of virus-like particles that have enhanced mucosal immuno-genicity as a result of the stabilization.
摘要翻译：本公开涉及用于诱导免疫应答的组合物和方法。具体地，本公开涉及包含由含多糖植物提取物稳定的亚单位抗原的组合物，其中抗原由作为稳定性结果而具有增强的粘膜免疫原性的病毒样颗粒组成。

2. 发明授权

US08217228B2 Down-regulation and silencing of allergen genes in transgenic peanut seeds 有权
标题翻译：转基因花生种子中过敏原基因的下调和沉默
公开(公告)号：US08217228B2
公开(公告)日：2012-07-10
申请号：US12770435
申请日：2010-04-29
申请人： Hortense W. Dodo , Charles J. Arntzen , Olga Martha Viquez , Koffi N'da Konan
发明人： Hortense W. Dodo , Charles J. Arntzen , Olga Martha Viquez , Koffi N'da Konan
IPC分类号： C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8251 , C07K14/415 , C12N15/8242
摘要： An allergen-free transgenic peanut seed is produced by recombinant methods. Peanut plants are transformed with multiple copies of each of the allergen genes, or fragments thereof, to suppress gene expression and allergen protein production. Alternatively, peanut plants are transformed with peanut allergen antisense genes introduced into the peanut genome as antisense fragments, sense fragments, or combinations of both antisense and sense fragments. Peanut transgenes are under the control of the 35S promoter, or the promoter of the Ara h2 gene to produce antisense RNAs, sense RNAs, and double-stranded RNAs for suppressing allergen protein production in peanut plants. A full length genomic clone for allergen Ara h2 is isolated and sequenced. The ORF is 622 nucleotides long. The predicted encoded protein is 207 amino acids long and includes a putative transit peptide of 21 residues. One polyadenilation signal is identified at position 951. Six additional stop codons are observed. A promoter region was revealed containing a putative TATA box located at position −72. Homologous regions were identified between Ara h2, h6, and h7, and between Ara h3 and h4, and between Ara h1P41B and Ara h1P17. The homologous regions will be used for the screening of peanut genomic library to isolate all peanut allergen genes and for down-regulation and silencing of multiple peanut allergen genes.
摘要翻译：通过重组方法产生无过敏原的转基因花生种子。每个变应原基因或其片段的多个拷贝转化花生植物以抑制基因表达和变应原蛋白质的产生。或者，用作为反义片段，有义片段或反义片段和有义片段的组合引入花生基因组的花生过敏原反义基因转化花生植物。花生转基因由35S启动子或Ara h2基因的启动子控制，以产生用于抑制花生植物中过敏原蛋白质产生的反义RNA，有义RNA和双链RNA。分离和测序过敏原Ara h2的全长基因组克隆。 ORF为622个核苷酸长。预测编码的蛋白质是207个氨基酸长，并且包含21个残基的推定转运肽。在951位点识别出一种多聚增生信号。观察到另外六个终止密码子。揭示了一个启动子区域，其中包含位于-72位置的推定TATA盒。在Ara h2，h6和h7之间以及Ara h3和h4之间以及Ara h1P41B和Ara h1P17之间鉴定了同源区域。同源区域将用于筛选花生基因组文库，以分离所有花生过敏原基因并降低多个花生过敏原基因的沉默。

3. 发明授权

US07927833B2 Composition and method for enhancing immune response 有权
标题翻译：用于增强免疫应答的组合物和方法
公开(公告)号：US07927833B2
公开(公告)日：2011-04-19
申请号：US12211544
申请日：2008-09-16
申请人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
发明人： Tsafrir S. Mor , Nobuyuki Matoba , Charles J. Arntzen
IPC分类号： C12N15/00 , A61K39/395
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/541 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C12N2740/16122
摘要： A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.
摘要翻译：公开了一种增强活体内免疫应答的组合物和方法。特别地，本公开提供了用于提高对抗原的免疫应答的佐剂肽。佐剂肽选自具有HIV相关序列的肽组。另外，佐剂肽可以包含充当粘膜佐剂的融合蛋白。辅助肽可以转化成一个或多个活细胞，使得粘膜佐剂可以在活细胞中产生，然后通过全身，粘膜或表皮递送进行施用。

4. 发明授权

US07670632B2 Triterpene compositions and methods for use thereof 失效
标题翻译：三萜组合物及其使用方法
公开(公告)号：US07670632B2
公开(公告)日：2010-03-02
申请号：US11295189
申请日：2005-12-06
申请人： Charles J. Arntzen , Mary E. Blake , Jordan U. Gutterman
发明人： Charles J. Arntzen , Mary E. Blake , Jordan U. Gutterman
IPC分类号： A61K35/78 , A61P9/10
CPC分类号： A61K41/0038 , A01H4/005 , A23L33/105 , A61K31/70 , A61K31/704 , A61K36/48 , C12N5/04 , Y10S514/821 , Y10S514/886 , Y10S514/887 , A61K2300/00
摘要： The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
摘要翻译：本发明提供了从相思树种分离的皂苷混合物和化合物及其使用方法。这些化合物可以含有寡糖和单萜部分所连接的三萜部分，例如酸性或齐墩果酸。混合物和化合物具有与细胞凋亡和细胞毒性的调节相关的性质，并且对各种肿瘤细胞表现出有效的抗肿瘤作用。

5. 发明授权

US07094606B2 Use of mixed duplex oligonucleotides to effect localized genetic changes in plants 有权
标题翻译：使用混合双重寡核苷酸来实现植物的局部遗传变化
公开(公告)号：US07094606B2
公开(公告)日：2006-08-22
申请号：US09129298
申请日：1998-08-05
申请人： Charles J. Arntzen , Peter B. Kipp , Ramesh Kumar , Gregory D. May
发明人： Charles J. Arntzen , Peter B. Kipp , Ramesh Kumar , Gregory D. May
IPC分类号： C12N15/82
CPC分类号： C12N15/8213 , C07K14/43595 , C12N15/102 , C12N15/8207 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/8251 , C12N15/8274 , C12N15/8289
摘要： The invention concerns the use of duplex oligonucleotides about 25 to 30 base pairs to introduce site specific genetic alterations in plant cells. The oligonucleotides can be delivered by mechanical (biolistic) systems or by electrpoporation of plant protoplasts. Thereafter plants having the genetic alteration can be generated from the altered cells. In specific embodiments the invention concerns alteration in the gene that encode acid invertase, UDP-glucose pyrophosphorylase, polyphenol oxidase, O-methyl transferase, cinnamyl alcohol dehydrogenase, ACC synthase and ACC oxidase or etr-1 or a homolog of etr-1, and plants having isolated point mutations in such genes.
摘要翻译：本发明涉及使用双链寡核苷酸约25至30个碱基对来引入植物细胞中的位点特异性遗传改变。寡核苷酸可以通过机械（生物弹道）系统或通过植物原生质体的播种递送。此后可以从改变的细胞产生具有遗传改变的植物。在具体实施方案中，本发明涉及编码酸转化酶，UDP-葡萄糖焦磷酸化酶，多酚氧化酶，O-甲基转移酶，肉桂醇脱氢酶，ACC合酶和ACC氧化酶或etr-1或etr-1的同系物的基因的改变，以及在这些基因中具有孤立点突变的植物。

6. 发明申请

US20130045205A1 Methods and Compositions Related to Glycoprotein-Immunoglobulin Fusions 审中-公开
标题翻译：与糖蛋白免疫球蛋白融合相关的方法和组合物
公开(公告)号：US20130045205A1
公开(公告)日：2013-02-21
申请号：US13578575
申请日：2011-02-11
申请人： Hugh S. Mason , Seong Hee Bhoo , Sun Hee Rosenthal , Charles J. Arntzen
发明人： Hugh S. Mason , Seong Hee Bhoo , Sun Hee Rosenthal , Charles J. Arntzen
IPC分类号： A61K39/42 , C12N15/62 , A61P31/14 , C12N5/10 , C07K19/00 , A01H5/00 , C12P21/02 , C12N15/82
CPC分类号： A61K39/29 , A61K38/00 , A61K39/12 , A61K2039/55566 , C07K16/10 , C07K19/00 , C07K2317/13 , C07K2317/24 , C07K2319/30 , C12N2760/14134 , C12N2770/24234 , Y02A50/397
摘要： Disclosed herein are compositions and methods for eliciting immune responses against HCV antigens. In particular embodiments, the compounds and methods elicit immune responses against all or a segment of HCV glycoprotein E1 and/or HCV glycoprotein E2.
摘要翻译：本文公开了用于引发针对HCV抗原的免疫应答的组合物和方法。在具体实施方案中，化合物和方法引起针对HCV糖蛋白E1和/或HCV糖蛋白E2的全部或一部分的免疫应答。

7. 发明授权

US06943010B1 Down-regulation and silencing of allergen genes in transgenic peanut seeds 有权
标题翻译：转基因花生种子中过敏原基因的下调和沉默
公开(公告)号：US06943010B1
公开(公告)日：2005-09-13
申请号：US09715036
申请日：2000-11-20
申请人： Hortense W. Dodo , Charles J. Arntzen , Olga Martha Viquez , Koffi N'da Konan
发明人： Hortense W. Dodo , Charles J. Arntzen , Olga Martha Viquez , Koffi N'da Konan
IPC分类号： C07K14/415 , C12N15/82 , C12N15/00
CPC分类号： C12N15/8251 , C07K14/415 , C12N15/8242
摘要： An allergen-free transgenic peanut seed is produced by recombinant methods. Peanut plants are transformed with multiple copies of each of the allergen genes, or fragments thereof, to suppress gene expression and allergen protein production. Alternatively, peanut plants are transformed with peanut allergen antisense genes introduced into the peanut genome as antisense fragments, sense fragments, or combinations of both antisense and sense fragments. Peanut transgenes are under the control of the 35S promoter, or the promoter of the Ara h2 gene to produce antisense RNAs, sense RNAs, and double-stranded RNAs for suppressing allergen protein production in peanut plants. A full length genomic clone for allergen Ara h2 is isolated and sequenced. The ORF is 622 nucleotides long. The predicted encoded protein is 207 amino acids long and includes a putative transit peptide of 21 residues. One polyadenilation signal is identified at position 951. Six additional stop codons are observed. A promoter region was revealed containing a putative TATA box located at position −72. Homologous regions were identified between Ara h2, h6, and h7, and between Ara h3 and h4, and between Ara h1P41B and Ara h1P17. The homologous regions will be used for the screening of peanut genomic library to isolate all peanut allergen genes and for down-regulation and silencing of multiple peanut allergen genes.
摘要翻译：通过重组方法产生无过敏原的转基因花生种子。每个变应原基因或其片段的多个拷贝转化花生植物以抑制基因表达和变应原蛋白质的产生。或者，用作为反义片段，有义片段或反义片段和有义片段的组合引入花生基因组的花生过敏原反义基因转化花生植物。花生转基因由35S启动子或Ara h2基因的启动子控制，以产生用于抑制花生植物中过敏原蛋白质产生的反义RNA，有义RNA和双链RNA。分离和测序过敏原Ara h2的全长基因组克隆。 ORF为622个核苷酸长。预测编码的蛋白质是207个氨基酸长，并且包含21个残基的推定转运肽。在951位点识别出一种多聚增生信号。观察到另外六个终止密码子。揭示了一个启动子区域，其中包含位于-72位置的推定TATA盒。在Ara h2，h6和h7之间以及Ara h3和h4之间以及Ara h1P41B和Ara h1P17之间鉴定了同源区域。同源区域将用于筛选花生基因组文库，以分离所有花生过敏原基因并降低多个花生过敏原基因的沉默。

8. 发明授权

US06746696B2 Triterpene compositions and methods for use thereof 失效
标题翻译：三萜组合物及其使用方法
公开(公告)号：US06746696B2
公开(公告)日：2004-06-08
申请号：US09992837
申请日：2001-11-16
申请人： Charles J. Arntzen , Jordan U. Gutterman
发明人： Charles J. Arntzen , Jordan U. Gutterman
IPC分类号： A61K3578
CPC分类号： A61K41/0038 , A01H4/005 , A23L33/105 , A61K31/70 , A61K31/704 , A61K36/48 , C12N5/04 , Y10S514/821 , Y10S514/886 , Y10S514/887 , A61K2300/00
摘要： The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
摘要翻译：本发明提供了从相思树种分离的新颖的皂苷混合物和化合物及其使用方法。这些化合物可以含有寡糖和单萜部分所连接的三萜部分，例如酸性或齐墩果酸。混合物和化合物具有与细胞凋亡和细胞毒性的调节相关的性质，并且对各种肿瘤细胞表现出有效的抗肿瘤作用。

9. 发明授权

US5792935A Agrobacterium tumefaciens transformation of Musa species 失效
标题翻译：农杆菌根瘤土壤杆菌转化
公开(公告)号：US5792935A
公开(公告)日：1998-08-11
申请号：US652521
申请日：1996-06-05
申请人： Charles J. Arntzen , Gregory D. May
发明人： Charles J. Arntzen , Gregory D. May
IPC分类号： A01H5/00 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/18 , C12N15/24
CPC分类号： C12N15/8205 , C12N15/8242
摘要： Methods are provided for transforming Musa plants. In particular, methods for wounding meristematic Musa plant tissue to facilitate access of Agrobacterium tumefaciens comprising genetically-engineered T-DNA is provided. The methods may be used to transform the plant to produce pharmaceutical products or to alter the phenotypic trait of the fruit of the plant.
摘要翻译： PCT No.PCT / US94 / 14210 Sec。 371日期：1996年6月5日 102（e）日期1996年6月5日PCT 1994年12月9日PCT公布。出版物WO95 / 15678 日期：1995年6月15日提供了用于转化Musa植物的方法。特别地，提供了用于伤害分生孢子植物组织以促进包括遗传工程化T-DNA的根癌农杆菌接种的方法。该方法可用于转化植物以产生药物产品或改变植物果实的表型性状。

10. 发明授权

US08324177B2 Triterpene compositions and methods for use thereof 有权
标题翻译：三萜组合物及其使用方法
公开(公告)号：US08324177B2
公开(公告)日：2012-12-04
申请号：US13160144
申请日：2011-06-14
申请人： Charles J. Arntzen , Mary E. Blake , Jordan U. Gutterman , Joseph J. Hoffmann , Gamini S. Jayatilake , David T. Bailey
发明人： Charles J. Arntzen , Mary E. Blake , Jordan U. Gutterman , Joseph J. Hoffmann , Gamini S. Jayatilake , David T. Bailey
IPC分类号： A61K31/70 , C07H15/24
CPC分类号： A61K41/0038 , A01H4/005 , A23L33/105 , A61K31/70 , A61K31/704 , A61K36/48 , C12N5/04 , Y10S514/821 , Y10S514/886 , Y10S514/887 , A61K2300/00
摘要： The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
摘要翻译：本发明提供了从相思树种分离的皂苷混合物和化合物及其使用方法。这些化合物可以含有寡糖和单萜部分所连接的三萜部分，例如酸性或齐墩果酸。混合物和化合物具有与细胞凋亡和细胞毒性的调节相关的性质，并且对各种肿瘤细胞表现出有效的抗肿瘤作用。

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