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1. 发明申请

US20100167285A1 METHODS AND AGENTS FOR EVALUATING INFLAMMATORY BOWEL DISEASE, AND TARGETS FOR TREATMENT 审中-公开
标题翻译：用于评估炎症性皮肤病的方法和试剂以及治疗目标
公开(公告)号：US20100167285A1
公开(公告)日：2010-07-01
申请号：US12450478
申请日：2008-03-26
申请人： Stefan Schreiber , Philip Rosenstiel , Andreas Ruether , Andre Franke , John Raelson , Randall D. Little , Tim Keith , Helene Fournier
发明人： Stefan Schreiber , Philip Rosenstiel , Andreas Ruether , Andre Franke , John Raelson , Randall D. Little , Tim Keith , Helene Fournier
IPC分类号： C12Q1/68 , C07K2/00 , C12N5/10 , C07K16/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.
摘要翻译：本发明提供了用于评估肠易激综合征（IBD）的方法，包括克罗恩病和溃疡性结肠炎，用于确定患者对发展IBD的易感性的方法以及确定患者IBD基因型的方法。本发明包括与nel样1前体（NELL1）的公开变体和多态性相关的方法，多核苷酸，多肽和抗体，以及5p13.1基因座以及本文公开的与IBD相关的其他基因。因此，本发明提供了用于IBD的诊断和/或治疗靶标，以及用于IBD的诊断和治疗剂。

2. 发明授权

US08574845B2 Method for identifying an increased susceptibility to ulcerative colitis 有权
标题翻译：鉴定溃疡性结肠炎易感性增加的方法
公开(公告)号：US08574845B2
公开(公告)日：2013-11-05
申请号：US12746419
申请日：2008-10-08
申请人： Stefan Schreiber , Andre Franke
发明人： Stefan Schreiber , Andre Franke
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/172
摘要： A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.
摘要翻译：提供了一种通过确定其中C被T取代的rs3024505的核苷酸序列的256位的多态性的存在或rs12612347的核苷酸序列的位置501处的多态性的存在来检测对溃疡性结肠炎的敏感性增加的方法其中G被A代替。

3. 发明申请

US20100099083A1 CROHN DISEASE SUSCEPTIBILITY GENE 审中-公开
标题翻译：高蛋白病可溶性基因
公开(公告)号：US20100099083A1
公开(公告)日：2010-04-22
申请号：US12309635
申请日：2007-07-26
申请人： John Verner Raelson , Stefan Schreiber , Randall David Little , Andre Franke , Jochen Hampe , Tim Keith , Vanessa Bruat , Abdelmajid Belouchi
发明人： John Verner Raelson , Stefan Schreiber , Randall David Little , Andre Franke , Jochen Hampe , Tim Keith , Vanessa Bruat , Abdelmajid Belouchi
IPC分类号： C12Q1/68 , G01N33/53 , C40B20/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , Y10T436/143333
摘要： The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.
摘要翻译：本发明涉及ATG161基因和与克罗恩病相关的遗传变异体。特别地，本发明涉及药物基因组学，诊断学，患者治疗和使用遗传单倍型信息来预测个体对克罗恩病的易感性和/或其对特定药物或药物的反应的领域。

4. 发明申请

US20090222134A1 CAMERA-BASED MONITORING OF MACHINES WITH MOBILE MACHINE ELEMENTS FOR COLLISION PREVENTION 有权
标题翻译：用于冲突防护的机器移动机器的基于摄像机的监控
公开(公告)号：US20090222134A1
公开(公告)日：2009-09-03
申请号：US12362733
申请日：2009-01-30
申请人： Andre Franke , Lars Krueger , Christian Woehler
发明人： Andre Franke , Lars Krueger , Christian Woehler
IPC分类号： G05B19/4061
CPC分类号： G05B19/4061 , G05B2219/39098 , G05B2219/49137
摘要： In modern industrial robots which move at considerable speeds, collisions generally cause serious damage to the robots and the collision objects. This can lead to injuries and expensive production stoppages. In a method for collision-free interaction between a machine having mobile machine elements and objects in its vicinity, safety regions are established and monitored using the knowledge of the current position and the dynamic behavior. In particular, image data of the mobile machine element are recorded by means of an image acquisition system and are correlated with a database, which has been compiled in a training phase with image data of at least one mobile machine element. The database contains image data relating to a plurality of movement phases within the movement process of the machine. In the scope of correlating the currently recorded image data with this database, both the current position of the mobile machine element is ascertained and a future position, reachable within the stopping time, is estimated. The dynamic behavior of the machine in the event of collision risk is optimized on the basis of this estimation.
摘要翻译：在以相当大的速度移动的现代工业机器人中，碰撞通常会对机器人和碰撞物体造成严重损害。这可能导致人身伤害和昂贵的生产停产。在具有移动机器元件的机器和其附近的物体之间的无碰撞交互的方法中，使用当前位置和动态行为的知识来建立和监视安全区域。特别地，通过图像采集系统记录移动机器元件的图像数据，并将其与已经在训练阶段编译的数据库相关联，该数据库具有至少一个移动机器元件的图像数据。数据库包含与机器运动过程中的多个移动阶段有关的图像数据。在将当前记录的图像数据与该数据库相关联的范围中，确定移动机器元件的当前位置，并且估计在停止时间内可到达的未来位置。在碰撞风险的情况下机器的动态特性在此估计的基础上得到优化。

5. 发明授权

US09122266B2 Camera-based monitoring of machines with mobile machine elements for collision prevention 有权
标题翻译：具有移动机器元件的机器的基于摄像机的监控用于防止碰撞
公开(公告)号：US09122266B2
公开(公告)日：2015-09-01
申请号：US12362733
申请日：2009-01-30
申请人： Andre Franke , Lars Krueger , Christian Woehler
发明人： Andre Franke , Lars Krueger , Christian Woehler
IPC分类号： G05B19/4061
CPC分类号： G05B19/4061 , G05B2219/39098 , G05B2219/49137
摘要： In a method for collision-free interaction between a machine having mobile machine elements and objects in its vicinity, safety regions are established and monitored using the knowledge of the current position and the dynamic behavior. In particular, image data of the mobile machine element are recorded by means of an image acquisition system and are correlated with a database compiled in a training phase with image data of at least one mobile machine element. The database contains image data relating to a plurality of movement phases within the movement process of the machine. Using the database, both the current position of the mobile machine element is ascertained and a future position, reachable within the stopping time, is estimated. The dynamic behavior of the machine in the event of collision risk is optimized on the basis of this estimation.
摘要翻译：在具有移动机器元件的机器和其附近的物体之间的无碰撞交互的方法中，使用当前位置和动态行为的知识来建立和监视安全区域。特别地，移动机器元件的图像数据通过图像采集系统被记录，并且与在至少一个移动机器元件的图像数据的训练阶段中编译的数据库相关。数据库包含与机器运动过程中的多个移动阶段有关的图像数据。使用数据库，确定移动机器元件的当前位置，并且估计在停止时间内可到达的未来位置。在碰撞风险的情况下机器的动态特性在此估计的基础上得到优化。

6. 发明申请

US20130245958A1 ACCURATE COMPARISON AND VALIDATION OF SINGLE NUCLEOTIDE VARIANTS 审中-公开
标题翻译：准确的比较和验证单核苷酸变体
公开(公告)号：US20130245958A1
公开(公告)日：2013-09-19
申请号：US13795492
申请日：2013-03-12
申请人： Michael FORSTER , Andre FRANKE , Andreas KELLER
发明人： Michael FORSTER , Andre FRANKE , Andreas KELLER
IPC分类号： G06F19/22
CPC分类号： G16B30/00
摘要： A method is disclosed for validation of single nucleotide variants (SNV) in a sequence of interest. In at least one embodiment, the method includes: interrogating a BAM-file of the sequence of interest and a reference sequence file and producing a summary table for genomic coordinates of interest; generating a plurality of sequence reads from a sample of said sequence of interest; filtering sequence reads using a plurality of filter levels; extracting SNV counts for each strand for a genomic region of interest within the sequence of interest, resulting in ten SNV counts; for each genomic region of interest determining a rule based genotype decision and inferring a best genotype from the 10 counts; and creating a single consensus file for said sequence of interest including information of best genotype and a best quality for each genomic region of interest.
摘要翻译：公开了一种在感兴趣的序列中验证单核苷酸变体（SNV）的方法。在至少一个实施例中，所述方法包括：询问感兴趣序列的BAM文件和参考序列文件，并产生用于感兴趣的基因组坐标的汇总表; 从所述感兴趣的序列的样本生成多个序列读数; 过滤序列使用多个滤波器级别读取; 提取感兴趣序列中感兴趣的基因组区域的每条链的SNV计数，得到十个SNV计数; 对于每个感兴趣的基因组区域，确定基于规则的基因型决定并从10个计数推断最佳基因型; 以及为所述感兴趣的序列创建单一的共同文件，包括针对感兴趣的每个基因组区域的最佳基因型和最佳质量的信息。

7. 发明申请

US20100279297A1 Method for Identifying an Increased Susceptibility to Ulcerative Colitis 有权
标题翻译：识别溃疡性结肠炎易感性增加的方法
公开(公告)号：US20100279297A1
公开(公告)日：2010-11-04
申请号：US12746419
申请日：2008-10-08
申请人： Stefan Schreiber , Andre Franke
发明人： Stefan Schreiber , Andre Franke
IPC分类号： C12Q1/68 , C12N15/63
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/172
摘要： A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.
摘要翻译：提供了一种通过确定其中C被T取代的rs3024505的核苷酸序列的256位的多态性的存在或rs12612347的核苷酸序列的位置501处的多态性的存在来检测对溃疡性结肠炎的敏感性增加的方法其中G被A代替。

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