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1. 发明申请

US20130245958A1 ACCURATE COMPARISON AND VALIDATION OF SINGLE NUCLEOTIDE VARIANTS 审中-公开
标题翻译：准确的比较和验证单核苷酸变体
公开(公告)号：US20130245958A1
公开(公告)日：2013-09-19
申请号：US13795492
申请日：2013-03-12
申请人： Michael FORSTER , Andre FRANKE , Andreas KELLER
发明人： Michael FORSTER , Andre FRANKE , Andreas KELLER
IPC分类号： G06F19/22
CPC分类号： G16B30/00
摘要： A method is disclosed for validation of single nucleotide variants (SNV) in a sequence of interest. In at least one embodiment, the method includes: interrogating a BAM-file of the sequence of interest and a reference sequence file and producing a summary table for genomic coordinates of interest; generating a plurality of sequence reads from a sample of said sequence of interest; filtering sequence reads using a plurality of filter levels; extracting SNV counts for each strand for a genomic region of interest within the sequence of interest, resulting in ten SNV counts; for each genomic region of interest determining a rule based genotype decision and inferring a best genotype from the 10 counts; and creating a single consensus file for said sequence of interest including information of best genotype and a best quality for each genomic region of interest.
摘要翻译：公开了一种在感兴趣的序列中验证单核苷酸变体（SNV）的方法。在至少一个实施例中，所述方法包括：询问感兴趣序列的BAM文件和参考序列文件，并产生用于感兴趣的基因组坐标的汇总表; 从所述感兴趣的序列的样本生成多个序列读数; 过滤序列使用多个滤波器级别读取; 提取感兴趣序列中感兴趣的基因组区域的每条链的SNV计数，得到十个SNV计数; 对于每个感兴趣的基因组区域，确定基于规则的基因型决定并从10个计数推断最佳基因型; 以及为所述感兴趣的序列创建单一的共同文件，包括针对感兴趣的每个基因组区域的最佳基因型和最佳质量的信息。

2. 发明申请

US20120004498A1 DEVICE AND METHOD FOR REDUCING TENSION AND STRESS IN A SUBJECT 审中-公开
标题翻译：减少主体张力和应力的装置和方法
公开(公告)号：US20120004498A1
公开(公告)日：2012-01-05
申请号：US13162067
申请日：2011-06-16
申请人： Dolores MALASPINA , Andreas KELLER , Daniel ANTONIUS
发明人： Dolores MALASPINA , Andreas KELLER , Daniel ANTONIUS
IPC分类号： A61M21/00
CPC分类号： A61M21/00 , A61M2021/0016
摘要： The present invention relates to a sensory device for reducing tension in a subject. The device includes an elastic covering, a filling material inside the elastic covering, an openable sealed reservoir located within the filling, an absorbent material surrounding the reservoir, and a calming odor releasing substance sealed within the reservoir. The present invention also relates to a method of reducing tension in a subject. This method involves providing a subject in need of tension relief with the device of the present invention. The device is manipulated to break open the reservoir and release the calming odor releasing substance. The released calming odor is inhaled in an amount sufficient to lower salivary cortisol levels in the subject and thereby reduce tension in the subject.
摘要翻译：本发明涉及用于减轻受试者的张力的感觉装置。该装置包括弹性覆盖物，弹性覆盖物内部的填充材料，位于填充物内的可打开的密封储存器，围绕储存器的吸收材料以及密封在贮存器内的平静的气味释放物质。本发明还涉及减少受试者的张力的方法。该方法涉及通过本发明的装置提供需要张力释放的对象。操作该装置以打开储存器并释放镇静的气味释放物质。释放的镇静气味的吸入量足以降低受试者的唾液皮质醇水平，从而降低受试者的张力。

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