基本信息:
- 专利标题： CHEMICAL AMPLIFICATION FOR THE SYNTHESIS OF PATTERNED ARRAYS
- 专利标题（中）：用于合成图案阵列的化学放大
- 申请号：PCT/US1997021209 申请日：1997-11-13
- 公开(公告)号：WO1998020967A1 公开(公告)日：1998-05-22
- 发明人： AFFYMETRIX, INC.
- 申请人： AFFYMETRIX, INC. , BEECHER, Jody, E. , GOLDBERG, Martin, J. , MCGALL, Glenn, H.
- 专利权人： AFFYMETRIX, INC.,BEECHER, Jody, E.,GOLDBERG, Martin, J.,MCGALL, Glenn, H.
- 当前专利权人： AFFYMETRIX, INC.,BEECHER, Jody, E.,GOLDBERG, Martin, J.,MCGALL, Glenn, H.
- 优先权： US60/030,826 19961114
- 主分类号： B01J19/00
- IPC分类号： B01J19/00
摘要：
Radiation-activated catalyst (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要（中）：
使用辐射活化催化剂（RAC），自催化反应和保护基团来实现多种聚合物图案阵列的高灵敏度，高分辨率的辐射导向组合合成。 当照射时，RAC产生可与增强剂反应的催化剂，例如参与自催化反应的那些。 自催化反应产生至少一种从合成中间体中除去保护基的产物。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。