基本信息:
- 专利标题： 클로피도그렐 및 아스피린의 복합제제
- 专利标题（英）：Combination of Clopidogrel and Aspirin
- 专利标题（中）：氯吡格雷和阿司匹林联合应用
- 申请号：KR1020130049002 申请日：2013-05-01
- 公开(公告)号：KR101502588B1 公开(公告)日：2015-03-16
- 发明人： 최연웅 , 민병구 , 하대철 , 조상민 , 송희용 , 박희찬 , 곽신영 , 이성능 , 권인호 , 김아영 , 강준혁 , 박진아
- 申请人： 한국유나이티드제약 주식회사
- 申请人地址： 세종특별자치시 전동면 노장공단길 **-** ( )
- 专利权人： 한국유나이티드제약 주식회사
- 当前专利权人： 한국유나이티드제약 주식회사
- 当前专利权人地址： 세종특별자치시 전동면 노장공단길 **-** ( )
- 代理人： 김홍균
- 主分类号： A61K9/48
- IPC分类号： A61K9/48 ; A61K9/16 ; A61K31/4365 ; A61K31/616
또한, 수분에 민감한 클로피도그렐 및 그의 염의 안정성 향상을 위해 방습코팅기재를 포함하여 클로피도그렐 용출량에는 변화없이 클로피도그렐 유연물질의 생성을 최소화하였다.
The present invention relates to a combined preparation that, a combined preparation containing the aspirin granules coated with a coating layer aspirin granules and a clopidogrel layer sokbang protective layer with an enteric layer in the capsules of the containing clopidogrel and aspirin. Present invention by blocking the physical contact of clopidogrel and aspirin, a eutectic (eutectic) to fundamentally blocked by the developer, the short term, the content of the preparation, dissolution characteristics, prevents a change in the bioequivalence (bioequivalence), and the stability of the long-term preparation as well as to increase, there is an effect to prevent damage to the stomach wall by coating the aspirin with the enteric layer.
In addition, clopidogrel elution there was minimal generation of clopidogrel related substances without change, including the moisture barrier coated substrate for a sensitive and improved clopidogrel salt thereof is stable in water.
公开/授权文献:
- KR1020140130579A 클로피도그렐 및 아스피린의 복합제제 公开/授权日：2014-11-11
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/48 | .胶囊制剂，例如用明胶、巧克力制造的 |