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1. 发明申请

WO9934400A9 DIRECT INJECTION HIGH EFFICIENCY NEBULIZER FOR ANALYTICAL SPECTROMETRY 审中-公开
标题翻译：直接喷射高效喷雾器用于分析光谱测定
公开(公告)号：WO9934400A9
公开(公告)日：1999-09-30
申请号：PCT/US9827797
申请日：1998-12-28
申请人： UNIV GEORGE WASHINGTON
发明人： MONTASER AKBAR , MCLEAN JOHN A , KACSIR JEROLD M
IPC分类号： G01N21/71 , G01N21/73 , H01J49/04 , H01J49/12
CPC分类号： H01J49/105 , G01N21/714 , H01J49/045
摘要： A direct injection nebulizer (18) is disclosed. The nebulizer (18) comprises an elongate tubular shell (20) having a gas input port (28) and a gas output port (30) located at a terminus (38) of the shell (20). The shell (20) surrounds a capillary tube (24) having a sample input port (42) and a sample output port (46) which is substantially at or proximal to the shell terminus (38) in which the gas output port (30) is located. Each of the input ports (28, 42) is separated from both of the output ports (30, 46) by at least 10 cm so that the nebulizer (18) can be inserted into a torch for direct injection of aerosol towards an interaction region. The shell (20) and the capillary tube (24) are sized to form a nozzle (52) comprising an annular region (56) between the shell (20) and the capillary tube (24) through which gas can flow at a rate of 1 liter/minute when argon is input at a pressure in the range of 20 to 300 psi.
摘要翻译：公开了直接注射雾化器（18）。喷雾器（18）包括具有气体输入端口（28）和位于壳体（20）的末端（38）处的气体输出端口（30）的细长管状壳体（20）。外壳（20）围绕具有样品输入端口（42）和样品输出端口（46）的毛细管（24），样品输出端口（46）基本位于壳体终端（38）处或其附近，其中气体输出端口（30）位于。每个输入端口（28,42）与两个输出端口（30,46）分开至少10cm，使得喷雾器（18）可以插入喷枪中，以将气雾剂直接喷射到相互作用区域。壳体（20）和毛细管（24）的尺寸被确定为形成喷嘴（52），该喷嘴包括壳体（20）和毛细管（24）之间的环形区域（56），气体可以通过该环形区域当在20至300psi范围内的压力下输入氩气时为1升/分钟。

2. 发明申请

WO2021110542A1 A SYSTEM AND METHOD FOR DETECTING ANALYTES DISSOLVED IN LIQUIDS BY PLASMA IONISATION MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2021110542A1
公开(公告)日：2021-06-10
申请号：PCT/EP2020/083559
申请日：2020-11-26
申请人： MICROSAIC SYSTEMS PLC
发明人： WRIGHT, Steven , YEATMAN, Eric , CRICHTON, Edward
IPC分类号： H01J49/04 , H01J49/10 , H01J49/12 , H01J49/16
摘要： Bubble plasma ionisation probe for analysing liquids by mass spectrometry A means of a detecting analytes dissolved in a liquid by mass spectrometry is described. Gas flows from a source through a first conduit 105 and thereafter through a coaxial second conduit 103 that also serves as the inlet to the mass spectrometer 102. The coaxial arrangement of conduits is submerged in the liquid to be analysed 301. Using a feedback loop, the gas pressure is adjusted and controlled such that an attached bubble 302 forms at the open end of the first conduit 105. A plasma 305 is provided in the bubble. The plasma is preferably generated by a dielectric barrier discharge between a collar electrode 107 and mass spectrometer inlet 103. Analytes dissolved in the liquid are both desorbed form the gas-liquid interface and ionised by the action of the plasma. Ions formed in this way become entrained in the gas flow and are consequently transferred to the mass spectrometer, where they are analysed.

3. 发明申请

WO2009094059A3 SENSITIVE ION DETECTION DEVICE AND METHOD FOR ANALYSIS OF COMPOUNDS AS VAPORS IN GASES 审中-公开
标题翻译：灵敏离子检测装置和用于分析气体中的化合物作为蒸气的方法
公开(公告)号：WO2009094059A3
公开(公告)日：2009-12-30
申请号：PCT/US2008082589
申请日：2008-11-06
申请人： UNIV ARIZONA STATE , DENTON BONNER M , SPERLINE ROGER P
发明人： DENTON BONNER M , SPERLINE ROGER P
IPC分类号： H01J49/12
CPC分类号： G01N27/622 , H01J49/02 , H01J49/10
摘要： An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm3 and preferably greater than 100 cm3. The larger size ionizers of this invention enable analysis of trace (
摘要翻译：用于检测溶解或悬浮在载气中，尤其是在环境空气中的痕量气态分子化合物的离子迁移谱仪（IMS），无需预浓缩或捕获分析物颗粒。本发明的IMS包含大于5立方厘米且优选大于100立方厘米的电离体积。本发明的较大尺寸的离子发生器能够分析气相中痕量（<1ppb）的样品化合物。为了促进通过IMS的大体积电离和反应区域的高效离子运动，可以在电离区域中或者在电离区域和反应区域中提供电场梯度。该系统可以用放射性电离源来实现，电晕放电离子源或离子可以通过光电离形成。在特定实施例中，特别是当样本气体是环境空气时，样本气体在进入仪器之前是加热器，仪器在高于环境温度的温度下运行，并且可以通过与离开仪器的加热样本气体接触来加热仪器。

4. 发明申请

WO2009094059A2 SENSITIVE ION DETECTION DEVICE AND METHOD FOR ANALYSIS OF COMPOUNDS AS VAPORS IN GASES 审中-公开
标题翻译：敏感离子检测装置和气体分析化合物的方法
公开(公告)号：WO2009094059A2
公开(公告)日：2009-07-30
申请号：PCT/US2008/082589
申请日：2008-11-06
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , DENTON, Bonner, M. , SPERLINE, Roger, P.
发明人： DENTON, Bonner, M. , SPERLINE, Roger, P.
IPC分类号： H01J49/12
CPC分类号： G01N27/622 , H01J49/02 , H01J49/10
摘要： An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm 3 and preferably greater than 100 cm 3 . The larger size ionizers of this invention enable analysis of trace (
摘要翻译：用于检测溶解或悬浮在载气中的痕量气态分子化合物的离子迁移谱仪（IMS），特别是在环境空气中，没有预浓缩或捕获分析物颗粒。本发明的IMS包括大于5cm 3，优选大于100cm 3的电离体积。本发明的较大尺寸的离子发生器能够分析气相中痕量（<1ppb）的样品化合物。为了促进通过IMS的大体积电离和反应区域的有效离子运动，可以在电离区域或电离和反应区域中提供电场梯度。该系统可以用放射性离子源实现，可以通过光电离形成电晕放电离子源或离子。在具体实施方案中，特别是当样品气体是环境空气时，样品气体在进入仪器之前是加热器，仪器在高于环境温度的温度下运行，并且可以通过与离开仪器的加热样品气体接触来加热仪器。

5. 发明申请

WO2014202892A1 PROCÉDÉ ET DISPOSITIF DE SPECTROMÉTRIE DE MASSE À DÉCHARGE LUMINESCENTE 审中-公开
标题翻译： GLOW放射性质谱方法和装置
公开(公告)号：WO2014202892A1
公开(公告)日：2014-12-24
申请号：PCT/FR2014/051493
申请日：2014-06-17
申请人： HORIBA JOBIN YVON SAS
发明人： CHAPON, Patrick , LEGENDRE, Sébastien
IPC分类号： H01J49/12 , H01J37/32
CPC分类号： H01J49/12 , H01J37/32018 , H01J37/32862 , H01J49/0031 , H01J49/40
摘要： La présente invention concerne un dispositif et procédé de spectrométrie de masse à décharge luminescente, le dispositif comprenant une lampe à décharge luminescente (1), des moyens d'injection d'un flux de gaz, ladite lampe à décharge luminescente étant adaptée pour former un plasma d'ablation en présence d'un gaz de plasma et un spectromètre de masse. Selon l'invention, le dispositif comporte des moyens de chauffage (30, 31) adaptés pour chauffer un flux de gaz (38) en amont de ladite cellule (2), les moyens d'injection de gaz étant adaptés pour injecter, dans la cellule de décharge luminescente, un flux de gaz (38) chauffé à une température T pendant une durée D, et en ce que les moyens de pompage (7, 27) sont configurés pour pomper un flux d'espèces gazeuses (17, 37) hors de ladite cellule pendant la durée D, de manière à décontaminer la surface de l'échantillon (4) et/ou les parois internes de la cellule (2) de décharge luminescente avant l'allumage d'un plasma d'ablation (5).
摘要翻译：本发明涉及辉光放电质谱装置和方法，该装置包括辉光放电灯（1），气流注入装置，辉光放电灯适用于在等离子体气体存在下形成消融等离子体，以及质谱仪根据本发明，该装置包括适于加热电池（2）上游的气流（38）的加热装置（30,31），气体注入装置适合于向辉光放电室注入气流 38）被加热到温度T持续持续时间D，并且泵送装置（7,27）被设计成将气态物质（17,37）的流动泵出电池持续时间D，以便净化表面在消融等离子体（5）被点燃之前的辉光放电单元（2）的样品（4）和/或内壁。

6. 发明申请

WO2006081075A3 CORRECTING PHASES FOR ION POLARITY IN ION TRAP MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2006081075A3
公开(公告)日：2006-08-03
申请号：PCT/US2006/001062
申请日：2006-01-12
申请人： VARIAN INC. , MARQUETTE, Edward, G.
发明人： MARQUETTE, Edward, G.
IPC分类号： H01J49/12
摘要： In a method and apparatus for adjusting a composite electric field to be applied to an ion trap to accommodate switching the operation of the ion trap between a positive ion mode and a negative ion mode, the composite electric field includes a plurality of component fields including at least one AC trapping field and one or more supplemental AC fields. A phase of one or more of the component fields is adjusted such that a force imparted by the composite field to a negative ion in the ion trap will be substantially the same as the force imparted by the composite field to a positive ion in the ion trap.

7. 发明申请

WO2006081075A2 CORRECTING PHASES FOR ION POLARITY IN TRAP MASS SPECTROMETRY 审中-公开
标题翻译：在轨道质谱中校正离子极化的相位
公开(公告)号：WO2006081075A2
公开(公告)日：2006-08-03
申请号：PCT/US2006001062
申请日：2006-01-12
申请人： VARIAN INC , MARQUETTE EDWARD G
发明人： MARQUETTE EDWARD G
IPC分类号： H01J49/12
CPC分类号： H01J49/4295 , H01J49/0095 , H01J49/424
摘要： In a method and apparatus for adjusting a composite electric field to be applied to an ion trap to accommodate switching the operation of the ion trap between a positive ion mode and a negative ion mode, the composite electric field includes a plurality of component fields including at least one AC trapping field and one or more supplemental AC fields. A phase of one or more of the component fields is adjusted such that a force imparted by the composite field to a negative ion in the ion trap will be substantially the same as the force imparted by the composite field to a positive ion in the ion trap.
摘要翻译：在用于调整施加到离子阱的复合电场以适应在正离子模式和负离子模式之间切换离子阱的操作的方法和装置中，复合电场包括多个分量场，包括在至少一个AC捕获场和一个或多个补充AC场。调整一个或多个分量场的相位，使得由离子阱中的负离子复合场所赋予的力与由离子阱中的正离子产生的复合场所施加的力基本相同。

8. 发明申请

WO0066265A9 PROBES FOR A GAS PHASE ION SPECTROMETER 审中-公开
标题翻译：气相离子光谱仪的探针
公开(公告)号：WO0066265A9
公开(公告)日：2001-09-07
申请号：PCT/US0011452
申请日：2000-04-27
申请人： CIPHERGEN BIOSYSTEMS INC , RICH WILLIAM E , UM PIL JE , VOIVODOV KAMEN , YIP TAI TUNG , BEECHER JODY
发明人： RICH WILLIAM E , UM PIL-JE , VOIVODOV KAMEN , YIP TAI-TUNG , BEECHER JODY
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将结合功能暴露于含有分析物的样品，并通过气体从探针解吸分析物相离子光谱法。

9. 发明申请

WO0066265A8 PROBES FOR A GAS PHASE ION SPECTROMETER 审中-公开
公开(公告)号：WO0066265A8
公开(公告)日：2001-03-15
申请号：PCT/US0011452
申请日：2000-04-27
申请人： CIPHERGEN BIOSYSTEMS INC , RICH WILLIAM E , UM PIL JE , VOIVODOV KAMEN , YIP TAI TUNG , BEECHER JODY
发明人： RICH WILLIAM E , UM PIL-JE , VOIVODOV KAMEN , YIP TAI-TUNG , BEECHER JODY
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12 , B01L
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.

10. 发明申请

WO00075953A2 DISCHARGE IONIZATION SOURCE 审中-公开
标题翻译：放电离子源
公开(公告)号：WO00075953A2
公开(公告)日：2000-12-14
申请号：PCT/US2000/015184
申请日：2000-06-02
IPC分类号： G01N27/64 , G01N27/70 , H01J49/10 , H01J49/12 , H01J27/02
CPC分类号： H01J49/12 , G01N27/622 , G01N27/70 , H01J49/165
摘要： A discharge ionization source, for use for example with an ion mobility spectrometer or atmospheric pressure ionization mass spectrometry. The source uses two or more electrodes for ionization and control, and solid state circuitry for operation. Inductive coupling of the discharge gap to the electronics is not necessary. The source can be operated as a continuous dc discharge, or as a pulsed discharge. The two-electrode configuration provides an anode and cathode with an optional adjustable gap. One of the electrodes can be hollow to enhance ionization efficiency (e.g., hollow cathode) and/or to accept effluent from a gas or liquid (including electrophoresis) chromatographic column. The three-electrode configuration adds a third or control electrode to additionally stabilize the discharge. The third electrode may be biased at the potential of the anode through a ballast resistor, and be located near the cathode. When used in this manner, the third electrode pre-ionizes the gas in the wider discharge gap, and initiates the discharge with a lower breakdown potential. The third electrode may also be used to switch the mode of operation of the discharge source from a gas phase ionizer to an electrospray ionizer. The discharge is pulsed and/or initiated by applying a potential (dc or pulsed) to the cathode. A transistor switch capacitively coupled to a negative diode clipping circuit may be used to double the potential applied across the discharge gap. The average power dissipation is less that a watt.
摘要翻译：放电电离源，例如用离子迁移谱仪或大气压电离质谱法使用。该源使用两个或多个电极进行电离和控制，以及用于操作的固态电路。放电间隙与电子设备的感应耦合是不必要的。源可以作为连续直流放电或脉冲放电来操作。双电极配置提供了具有可选可调间隙的阳极和阴极。其中一个电极可以是中空的以增强电离效率（例如空心阴极）和/或接受来自气体或液体（包括电泳）色谱柱的流出物。三电极配置增加了第三个或控制电极以额外地稳定放电。第三电极可以通过镇流电阻器在阳极的电位处被偏置，并且位于阴极附近。当以这种方式使用时，第三电极在较宽的放电间隙中预气化气体，并以较低的击穿电位启动放电。第三电极也可用于将放电源的工作模式从气相电离器切换到电喷雾离子发生器。通过向阴极施加电位（直流或脉冲）来对放电进行脉冲和/或启动。可以使用电容耦合到负二极管限幅电路的晶体管开关将跨越放电间隙施加的电位加倍。平均功耗小于瓦特。

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