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1. 发明申请

WO2022226009A1 SINGLE STEP PROCESS FOR PRODUCTION OF 2-METHYLTETRAHYDROFURAN FROM FURFURYL ALCOHOL 审中-公开
公开(公告)号：WO2022226009A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025457
申请日：2022-04-20
申请人： PENN A KEM, LLC
发明人： ENYONG, Arrey, B. , HEGDE, Shridhar, G.
IPC分类号： B01J23/00 , B01J23/38 , B01J23/40 , C07D307/06 , C07D307/08 , C07D307/10
摘要： The invention is a single step process for producing 2-methyltetrahydrofuran from furfuryl alcohol with high conversion rate and high selectivity towards 2-methyltetrahydrofuran.

2. 发明申请

WO2014104400A1 ACTINIC-RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC-RAY- OR RADIATION-SENSITIVE FILM AND METHOD OF FORMING PATTERN 审中-公开
标题翻译：抗紫外线或辐射敏感性树脂组合物，抗紫外线或辐射敏感膜和形成图案的方法
公开(公告)号：WO2014104400A1
公开(公告)日：2014-07-03
申请号：PCT/JP2013/085328
申请日：2013-12-25
申请人： FUJIFILM CORPORATION
发明人： KAWABATA, Takeshi , TAKIZAWA, Hiroo , SHIBUYA, Akinori , GOTO, Akiyoshi , KOJIMA, Masafumi , KATO, Keita
IPC分类号： G03F7/004 , C07C309/17 , C07C309/19 , C07C309/24 , C07C311/48 , C07C317/04 , C07D211/06 , C07D307/10 , C07J31/00 , G03F7/038 , G03F7/039
CPC分类号： G03F7/0045 , C07C309/06 , C07C309/12 , C07C309/17 , C07C309/29 , C07C311/48 , C07C317/04 , C07C381/12 , C07C2601/14 , C07C2603/74 , C07D217/06 , C07D295/185 , C07D327/06 , C07D333/46 , C07D333/48 , C07D333/76 , C07D335/02 , C07J9/005 , C07J17/00 , C07J31/006 , G03F7/038 , G03F7/039 , G03F7/20
摘要： Provided is an actinic-ray- or radiation-sensitive resin composition including a resin (A) and any of compounds (B) of general formula (I) below. (In general formula (I), Rf represents a fluorine atom or a monovalent organic group containing at least one fluorine atom; R 1 represents a hydrogen atom or a monovalent substituent containing no fluorine atom; X 1 represents a monovalent organic group having at least two carbon atoms, or a methyl group in which a substituent other than a fluorine atom is optionally introduced, provided that X 1 may be bonded to R 1 to thereby form a ring; and Z represents a moiety that when exposed to actinic rays or radiation, is converted to a sulfonic acid group, an imidic acid group or a methide acid group.)
摘要翻译：本发明提供一种包含树脂（A）和下述通式（I）的任何化合物（B））的光化射线或辐射敏感性树脂组合物。（通式（I）中，Rf表示氟原子或含有至少一个氟原子的一价有机基团; R1表示氢原子或不含氟原子的一价取代基; X1表示具有至少2个碳原子的1价有机基团原子或其中任选地引入除氟原子以外的取代基的甲基，条件是X1可以与R 1键合，从而形成环; Z表示当暴露于光化射线或辐射时被转化为磺酸基，亚氨基酸基或甲基酸基）。

3. 发明申请

WO2007072782A1 カルボン酸誘導体又はその塩审中-公开
标题翻译：羧酸衍生物或其盐
公开(公告)号：WO2007072782A1
公开(公告)日：2007-06-28
申请号：PCT/JP2006/325197
申请日：2006-12-18
申请人：アステラス製薬株式会社 , 久保田秀樹 , 塚本一成 , 加藤浩二 , 福田悠太 , 上條一紀 , 大貫圭 , 平野雄介 , 渡邉亨
发明人：久保田秀樹 , 塚本一成 , 加藤浩二 , 福田悠太 , 上條一紀 , 大貫圭 , 平野雄介 , 渡邉亨
IPC分类号： C07D213/42 , A61K31/337 , A61K31/341 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/497 , A61P13/02 , A61P13/08 , A61P13/10 , A61P43/00 , C07D213/71 , C07D213/80 , C07D277/20 , C07D277/36 , C07D305/12 , C07D307/10 , C07D401/12 , C07D405/12 , C07D407/12 , C07D417/12 , C07D417/14
CPC分类号： C07D213/42 , C07D213/71 , C07D213/80 , C07D277/20 , C07D277/36 , C07D305/12 , C07D307/10 , C07D401/12 , C07D405/12 , C07D407/12 , C07D417/12 , C07D417/14
摘要：【課題】EP1受容体が関与する疾患、特に過活動膀胱に伴う頻尿・尿意切迫感や尿失禁、膀胱炎、間質性膀胱炎、前立腺炎などの下部尿路疾患の治療薬に用いることができる化合物の提供。【解決手段】スルホンアミド構造を有し、かつ、当該スルホンアミドのＮ原子上の置換基として、置換されていてもよいヘテロ環基で置換された低級アルキル基を有することを構造上の特徴とするカルボン酸誘導体又はその塩が強力なEP1受容体拮抗作用を有することを確認し、本発明を完成した。本発明化合物は、強力なEP1受容体拮抗作用を有することから、EP1受容体が関与する疾患、特に過活動膀胱に伴う頻尿・尿失禁、前立腺肥大症に伴う下部尿路症状、間質性膀胱炎、前立腺炎などの下部尿路疾患治療薬として有用である。
摘要翻译： [问题]提供一种化合物，其可用作与EP1受体相关疾病的治疗剂，特别是下尿路疾病，例如伴随膀胱膀胱过度活动，膀胱炎，间质性膀胱炎的小便或尿失禁的急性尿急或前列腺炎。解决问题的方法公开了一种羧酸衍生物，其特征在于其具有磺酰胺结构，并且还具有被可被磺酰胺结构中的N-原子取代的杂环基取代的低级烷基，或衍生物的盐。发现羧酸衍生物或其盐对EP1受体具有有效的拮抗活性。因此，该化合物可用作下尿路疾病的治疗剂，例如伴有膀胱活动过度的尿频/尿失禁，伴有前列腺炎的下尿路症状，间质性膀胱炎或前列腺炎。

4. 发明申请

WO01078733A1 ALPHA,BETA-UNSATURATED SULFONES FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增生性疾病的ALPHA，硫酸不饱和磺酸
公开(公告)号：WO01078733A1
公开(公告)日：2001-10-25
申请号：PCT/US2001/012133
申请日：2001-04-13
IPC分类号： C07D295/04 , A61K31/10 , A61K31/381 , A61K31/40 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61P7/00 , A61P9/10 , A61P17/02 , A61P19/08 , A61P25/00 , A61P35/00 , A61P35/02 , C07C317/10 , C07D207/32 , C07D207/333 , C07D213/32 , C07D213/34 , C07D277/26 , C07D277/36 , C07D307/10 , C07D307/38 , C07D333/18 , C07D333/28 , C07D333/42 , C07D333/48 , A61K31/275 , A61K31/385 , A61K31/435 , C07D207/08 , C07D211/70 , C07D241/04 , C07D307/02 , C07D355/02
CPC分类号： C07D207/333 , C07C317/10 , C07D213/34 , C07D277/36 , C07D307/10 , C07D333/18 , C07D333/42 , C07D333/48
摘要： Sulfones of formula (I) are useful as antiproliferative agents, including, for example, anticancer agents, wherein Q1' is selected from the group consisting of: (a) a phenyl radical according to formula (II), wherein R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl; (b) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl; and (c) an aromatic radical according to formula (III), wherein n1 is 1 or 2, Y1 and Y2 are independently selected from the group consisting of hydrogen, halogen, and nitro, and X1 is selected from the group consisting of oxygen, nitrogen, sulfur; and (F2); and Q2 is selected from the group consisting of: (d) a phenyl radical according to formula (II), as defined above; (e) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl; (f) an aromatic radical according to formula (IV) wherein n1 is 1 or 2, Y3 and Y4 are independently selected from the group consisting of hydrogen, halogen, and nitro, and X2, X3 and X4 are independently selected from the group consisting of carbon, oxygen, nitrogen, sulfur and (F2) provided that not all of X2, X3 and X4 may be carbon; and (g) 1-piperazinyl; provided that at least one of Q1 or Q2 is other than a phenyl radical according to formula (II); or a pharmaceutically acceptable salt thereof. Sulfones of formula (V) are also useful as antiproliferative agents, including, for example, anticancer agents, wherein X is sulfur or oxygen; Ya and Yb are independently selected from the group consisting of hydrogen, halogen, and nitro; and R1-R5 are defined as above; or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）的砜可用作抗增殖剂，包括例如抗癌剂，其中Q 1'选自：（a）根据式（II）的苯基，其中R 1，R 2，R 3 R 4和R 5独立地选自氢，卤素，C 1 -C 6烷基，C 1 -C 6烷氧基，硝基，氰基，羧基，羟基，氨基，C 1 -C 6三氟烷氧基和三氟甲基; （b）选自1-萘基，2-萘基和9-蒽基的芳族基团; 和（c）根据式（III）的芳族基团，其中n1是1或2，Y1和Y2独立地选自氢，卤素和硝基，X1选自氧，氮，硫; 和（F2）; 和Q2选自：（d）如上定义的根据式（II）的苯基; （e）选自1-萘基，2-萘基和9-蒽基的芳族基团; （f）根据式（IV）的芳基，其中n1是1或2，Y3和Y4独立地选自氢，卤素和硝基，X2，X3和X4独立地选自的碳，氧，氮，硫和（F2），条件是不是全部的X 2，X 3和X 4可以是碳; 和（g）1-哌嗪基; 条件是Q1或Q2中的至少一个不是根据式（II）的苯基; 或其药学上可接受的盐。式（V）的砜也可用作抗增殖剂，包括例如抗癌剂，其中X是硫或氧; Ya和Yb独立地选自氢，卤素和硝基; 和R 1 -R 5如上定义; 或其药学上可接受的盐。

5. 发明申请

WO2013169651A1 DIRECT ANTI-MARKOVNIKOV ADDITION OF ACIDS TO ALKENES 审中-公开
标题翻译：直接的抗马尔可维尔添加酸对阿尔卑斯
公开(公告)号：WO2013169651A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/039707
申请日：2013-05-06
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： NICEWICZ, David A. , HAMILTON, David S. , PERKOWSKI, Andrew J.
IPC分类号： C07D307/10 , C07D309/04 , C07D307/33 , B01J31/12
CPC分类号： C07D307/12 , B01J31/0235 , B01J31/0239 , B01J31/0244 , B01J35/004 , B01J2231/324 , B01J2531/002 , B01J2531/008 , C07D307/06 , C07D309/04 , C07D313/04
摘要： A method of making an anti-Markovnikov addition product is carried out by reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Compositions useful for carrying out such methods are also described.
摘要翻译：通过在双重催化剂反应体系中使酸与烯烃或炔烃反应，除去氧以产生所述抗马尔科夫尼科夫加成产物，从而制备抗马尔可夫尼科夫加成产物的方法; 双重催化剂反应体系包括与氢原子供体催化剂组合的单电子氧化催化剂。还描述了用于实施这些方法的组合物。

6. 发明申请

WO2009131246A1 SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS 审中-公开
标题翻译：用于预防或治疗致病微生物引起的感染性疾病的西他灵衍生物
公开(公告)号：WO2009131246A1
公开(公告)日：2009-10-29
申请号：PCT/JP2009/058437
申请日：2009-04-22
申请人： Astellas Pharma Inc. , WASHIZUKA, Kenichi , TOMISHIMA, Masaki , HANADATE, Tadaatsu , SHIRAISHI, Nobuyuki , MATSUYA, Takahiro , MORIKAWA, Hiroshi , TODA, Ayako , TANABE, Daisuke , OKADA, Akihiro , MAKI, Katsuyuki , MATSUMOTO, Satoru , OHTAKE, Hiroaki
发明人： WASHIZUKA, Kenichi , TOMISHIMA, Masaki , HANADATE, Tadaatsu , SHIRAISHI, Nobuyuki , MATSUYA, Takahiro , MORIKAWA, Hiroshi , TODA, Ayako , TANABE, Daisuke , OKADA, Akihiro , MAKI, Katsuyuki , MATSUMOTO, Satoru , OHTAKE, Hiroaki
IPC分类号： C07D307/10 , C07D307/12 , C07D307/54 , C07D307/87 , C07D309/04 , C07D307/30 , C07D405/12 , C07D405/14 , C07D407/08 , C07D413/06 , C07D413/12 , C07D487/10 , C07D491/10 , C07F7/18 , C07C255/47
CPC分类号： C07D317/30 , C07C255/47 , C07C2603/86 , C07D307/10 , C07D307/12 , C07D307/52 , C07D307/54 , C07D307/58 , C07D307/87 , C07D309/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/08 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D453/02 , C07D471/02 , C07D487/02 , C07D487/10 , C07D491/10 , C07D513/04 , C07F7/1848 , C07F7/1856
摘要： This invention relates to a new sordarin derivative or a pharmaceutically acceptable salt thereof, which has antimicrobial activities (especially, antifungal activities), to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases in a human being or an animal.
摘要翻译：本发明涉及一种具有抗微生物活性（特别是抗真菌活性）的新型sordarin衍生物或其药学上可接受的盐，其制备方法涉及含有该化合物的药物组合物，以及一种预防和/或治疗方法治疗人或动物中的传染病。

7. 发明申请

WO2003070714A1 FLUOROUS ACETYLATION 审中-公开
标题翻译：荧光素酶
公开(公告)号：WO2003070714A1
公开(公告)日：2003-08-28
申请号：PCT/AU2003/000218
申请日：2003-02-20
申请人： UNISEARCH LIMITED , READ, Roger
发明人： READ, Roger
IPC分类号： C07D307/10
CPC分类号： C07D319/08 , C07C31/42 , C07C69/675 , C07C255/19 , C07C309/66 , C07C327/22 , C07D307/10 , C07D317/16 , C07D317/20 , C07D319/06 , C07D321/06 , C07D339/04 , C07D339/08 , C07F7/1852
摘要： The present invention relates to a method for the synthesis of highly fluorinated compounds and to novel highly fluorinated compounds. In particular, the present invention relates to the synthesis of highly fluorinated acetals and ketals and their thio analogues and to novel highly fluorinated acetals and ketals and their thio analogues.
摘要翻译：本发明涉及高氟化合物的合成方法和新型高氟化合物。特别地，本发明涉及高度氟化的缩醛和缩酮及其硫代类似物的合成，以及新型高度氟化的缩醛和缩酮及其硫代类似物的合成。

8. 发明申请

WO98035937A1 CETP ACTIVITY INHIBITORS 审中-公开
标题翻译： CETP活性抑制剂
公开(公告)号：WO98035937A1
公开(公告)日：1998-08-20
申请号：PCT/JP1998/000542
申请日：1998-02-10
IPC分类号： C07D333/38 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61P3/06 , A61P9/10 , A61P43/00 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/63 , C07C323/65 , C07C327/30 , C07C329/10 , C07C329/20 , C07C333/08 , C07D207/16 , C07D207/28 , C07D211/34 , C07D211/62 , C07D213/81 , C07D213/82 , C07D307/10 , C07D307/68 , C07D521/00 , A61K31/255
CPC分类号： C07D307/10 , A61K31/164 , A61K31/18 , A61K31/33 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/435 , A61K31/44 , C07C311/14 , C07C311/15 , C07C311/21 , C07C323/40 , C07C323/41 , C07C323/42 , C07C327/30 , C07C329/10 , C07C329/20 , C07C333/04 , C07C333/08 , C07C333/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/22 , C07C2602/28 , C07C2603/74 , C07D211/34 , C07D213/80 , C07D213/81 , C07D307/68 , C07D333/38 , Y02P20/55
摘要： CETP activity inhitors containing as the active ingredient compounds represented by general formula (I), prodrug compounds thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these, (wherein R represents linear or branched alkyl, linear or branched alkenyl, lower haloalkyl, optionally substitued cycloalkyl, optionally substituted cycloalkenyl, optionally substituted cycloalkylalkyl, optionally substitued aryl or optionally substituted heterocycle; X1, X2, X3 and X4 may be the same or different from each other and each represents hydrogen, halogeno, lower alkyl, lower haloalkyl, lower alkoxy, cyano, nitro, acyl or aryl; Y represents -CO- or -SO2-; and Z represents hydrogen or a mercapto-protective group). The compounds represented by general formula (I) are expected to be useful as preventives or remedies of a novel type for arteriosclerosis or hyperlipemia, since they can selectively inhibit the CETP activity to thereby increase HDL and, at the same time, decrease LDL.
摘要翻译： CETP活性吸收剂，其含有作为活性成分的通式（I）表示的化合物，其前药化合物，其药学上可接受的盐或它们的水合物或溶剂合物，（其中R表示直链或支链烷基，直链或支链烯基，低级卤代烷基，任选取代的环烷基，任选取代的环烯基，任选取代的环烷基烷基，任选取代的芳基或任选取代的杂环; X 1，X 2，X 3和X 4可以彼此相同或不同，并且各自表示氢，卤代，低级烷基，低级卤代烷基，低级烷氧基，氰基，硝基，酰基或芳基; Y表示-CO-或-SO 2 - ; Z表示氢或巯基保护基）。预期由通式（I）表示的化合物可用作动脉硬化或高脂血症新型的预防剂或补救剂，因为它们可以选择性地抑制CETP活性从而增加HDL，同时降低LDL。

9. 发明申请

WO2019096832A1 PHOTOCATALYST SYSTEM AND USE THEREOF IN A PHOTOCATALYTIC PROCESS 审中-公开
公开(公告)号：WO2019096832A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081203
申请日：2018-11-14
申请人： FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA)
发明人： MARTÍN ROMO, Rubén , SHEN, Yangyang , GU, Yiting
IPC分类号： C07D307/38 , B01J23/755 , B01J31/02 , C07B37/04 , C07D307/10
摘要： Photocatalyst system and use thereof in a photochemical process The invention relates to a photocatalyst system comprising, in the absence of a further photosensitizer other than the compound of formula (III) or a mixture thereof: (i) a nickel(II) salt, (ii) a compound of formula (III) or a mixture thereof (iii) optionally, a ligand; wherein, preferably, the molar ratio of the nickel (II) salt, the compound of formula (III) and, optionally, the ligand is 1:1:1; or, alternatively, wherein the molar ratio of the nickel (II) salt, the compound of formula (III) and, optionally, the ligand is 1:2:1. It also relates to the use of said photocatalyst system in combination with an external visible light source in photocatalytic cross- coupling reactions, and, more particularly to a process for the cross-coupling of bromide electrophiles with substrates comprising a C-H bond.

10. 发明申请

WO2017100268A1 COMBINATIONS FOR THE TREATMENT OF KIDNEY STONES 审中-公开
标题翻译：用于治疗肾结石的组合
公开(公告)号：WO2017100268A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065305
申请日：2016-12-07
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES , UAB RESEARCH FOUNDATION
发明人： LOWTHER, Todd, W. , HOLMES, Ross, P.
IPC分类号： C07D333/40 , C07D307/08 , C07D307/10
CPC分类号： C07D207/444 , C07D231/14 , C07D231/18 , C07D249/04 , C07D407/06 , C07D407/12
摘要： Provided herein are methods of treatment for kidney stones, e.g., for controlling or inhibiting the formation of calcium oxalate kidney stones by inhibiting the production of glyoxylate and/or oxalate, treatment of primary hyperoxaluria, etc. In some embodiments, methods comprise administering to a subject in need thereof, in combination, an inhibitor of hydroxyproline dehydrogenase (HYPDH), an inhibitor of glycolate oxidase (GO), and/or another agent for the treatment of kidney stones. Compositions for such use or the use of active agents in the manufacture of a medicament for the treatment of kidney stones are also provided.
摘要翻译：本文提供治疗肾结石的方法，例如通过抑制乙醛酸和/或草酸盐的产生，治疗原发性高草酸尿症等来控制或抑制草酸钙肾结石的形成。一些实施方案的方法包括向有需要的受试者联合施用羟脯氨酸脱氢酶（HYPDH）的抑制剂，乙醇酸氧化酶（GO）的抑制剂和/或另一种用于治疗肾结石的药剂。还提供了这种用途的组合物或活性剂在制造用于治疗肾结石的药物中的用途。

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