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1. 发明申请

WO2022162014A1 AZA-CRYPTOPHANES, PROCESSES FOR PREPARATION THEREOF, AND THEIR USES 审中-公开
公开(公告)号：WO2022162014A1
公开(公告)日：2022-08-04
申请号：PCT/EP2022/051781
申请日：2022-01-26
申请人： UNIVERSITE DE CAEN NORMANDIE
发明人： DUBOST, Emmanuelle , CAILLY, Thomas , FABIS, Frédéric , VIGIER, Clément , MALZERT-FREON, Aurélie , GROO, Anne-Claire
IPC分类号： C07D225/04 , C07D245/04 , C07D255/04 , C07D498/22 , A61K49/10
摘要： The present invention concerns aza-cryptophanes, processes for preparation thereof, and their uses, in particular as in vivo diagnostic tools when complexing a hyperpolarized noble element, or in nanoemulsions.

2. 发明申请

WO2006036395A3 INHIBITORS OF AKT ACTIVITY 审中-公开
标题翻译： AKT活动的抑制剂
公开(公告)号：WO2006036395A3
公开(公告)日：2007-12-21
申请号：PCT/US2005029941
申请日：2005-08-19
申请人： MERCK & CO INC , BILODEAU MARK T , COSFORD NICHOLAS D P , HARTNETT JOHN C , LIANG JUN , MANLEY PETER J , NEILSON LOU ANNE , SIU TONY , WU ZHICAI , LI YIWEI
发明人： BILODEAU MARK T , COSFORD NICHOLAS D P , HARTNETT JOHN C , LIANG JUN , MANLEY PETER J , NEILSON LOU ANNE , SIU TONY , WU ZHICAI , LI YIWEI
IPC分类号： A61K31/519 , A61K31/397 , C07D225/04 , C07D403/14 , C07D471/14 , C07D487/14
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
摘要翻译：本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-去氮萘啶部分的化合物。本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。

3. 发明申请

WO99001434A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE 审中-公开
标题翻译：番茄红素转移酶抑制剂
公开(公告)号：WO99001434A1
公开(公告)日：1999-01-14
申请号：PCT/US1998/012549
申请日：1998-06-16
IPC分类号： C07D403/08 , A61K31/4709 , A61K31/55 , A61P35/00 , A61P37/02 , A61P43/00 , C07D233/54 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/14 , C07D233/02 , A61K31/33 , A61K31/395 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61K31/54 , C07D215/16 , C07D215/38 , C07D215/44 , C07D217/22 , C07D217/26 , C07D221/02 , C07D223/10 , C07D223/14 , C07D225/00 , C07D225/04 , C07D233/04 , C07D235/02 , C07D237/30 , C07D239/00 , C07D239/72 , C07D249/00 , C07D249/16 , C07D251/00 , C07D257/04 , C07D257/08 , C07D257/10 , C07D271/02 , C07D271/04 , C07D271/08 , C07D285/02 , C07D285/04 , C07D295/00 , C07D401/00 , C07D403/00 , C07D403/02 , C07D417/00 , C07D453/02 , C07D453/04 , C07D471/02 , C07D475/00 , C07D487/00 , C07D491/00 , C07D491/02 , C07D498/00 , C07D513/00 , C07D513/02 , C07D513/12 , C07D513/22
CPC分类号： C07D401/06 , C07D403/06 , C07D403/12 , C07D409/14
摘要： Disclosed are quinoline and benzazepine derivatives that inhibit farnesylprotein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.
摘要翻译：公开了抑制法呢基蛋白转移酶（FTase）和致癌蛋白Ras的法呢基化的喹啉和苯并氮杂衍生物。因此，这些化合物可用作抗癌剂。所述化合物还可用于治疗除癌症以外的疾病。

4. 发明申请

WO2020055113A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME 审中-公开
公开(公告)号：WO2020055113A1
公开(公告)日：2020-03-19
申请号：PCT/KR2019/011745
申请日：2019-09-10
申请人： ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.
发明人： OH, Hong-Se , LEE, Ga-Won , LEE, Tae-Jin
IPC分类号： C07D225/04 , C07D313/06 , C07D337/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/10 , C07D471/04 , C07D498/04 , H01L51/00
摘要： The present disclosure relates to an organic electroluminescent compound represented by formula 1 and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, an organic electroluminescent device having improved driving voltage and/or luminous efficiency characteristics can be provided.

5. 发明申请

WO2006098761A3 HSP90 INHIBITORS, METHODS OF MAKING AND USES THEREFOR 审中-公开
标题翻译： HSP90抑制剂，其制备方法及其用途
公开(公告)号：WO2006098761A3
公开(公告)日：2007-07-05
申请号：PCT/US2005031524
申请日：2005-08-31
申请人： UNIV COLORADO , ROSS DAVID , REIGAN PHILIP , GUO WENCHANG , SIEGEL DAVID , GUSTAFSON DANIEL L
发明人： ROSS DAVID , REIGAN PHILIP , GUO WENCHANG , SIEGEL DAVID , GUSTAFSON DANIEL L
IPC分类号： C07D225/04 , A61K31/33 , A61K31/395 , A61K31/40 , C07D225/06
CPC分类号： C07D225/02 , C07D225/06 , C07H17/02 , C07H19/00
摘要： The invention provides purified 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the treatment and/or the amelioration of symptoms of cancer and other proliferative tissue disorders.
摘要翻译：本发明提供了纯化的18,21-二脱氢-18,21-二脱氧-18,21-二羟基 - 格尔德霉素衍生物，其药学上可接受的盐和其前体药物，其是有效的Hsp90结合剂，其可用于治疗和/或改善癌症和其他增生性组织疾病的症状。

6. 发明申请

WO2006036941A3 SPECIFIC KINASE INHIBITORS 审中-公开
标题翻译：特异性激酶抑制剂
公开(公告)号：WO2006036941A3
公开(公告)日：2006-10-26
申请号：PCT/US2005034537
申请日：2005-09-26
申请人： KOSAN BIOSCIENCES INC , SANTI DANIEL V , REID RALPH C , HUTCHINSON RICHARD C , SUNDERMANN KURT F , LAU JANICE
发明人： SANTI DANIEL V , REID RALPH C , HUTCHINSON RICHARD C , SUNDERMANN KURT F , LAU JANICE
IPC分类号： C07D267/22 , C07D225/04 , C07D245/00 , C07D281/18 , C07D291/00 , C07D313/00 , C07D321/00 , C07D321/10 , C07D321/12 , C07D323/00 , C07D327/00 , C07D337/12 , C07D337/16 , C07D339/00 , C07D341/00 , C07D343/00 , C07D405/00 , C07D407/00 , C07D409/00 , C07D411/00 , C07D487/00 , C07D493/00 , C07D495/00 , C07D497/00 , C07D513/00
CPC分类号： A61K31/33 , A61K31/365 , A61K31/4178 , A61K31/5377 , C07D493/04
摘要： Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.
摘要翻译：具有C 5 -C 6顺式双键和在C7上的酮和能够形成迈克尔加合物的其它化合物的间苯二甲酸内酯是在ATP结合位点具有特异性半胱氨酸残基的蛋白激酶子集的有效且稳定的抑制剂。

7. 发明申请

WO98052925A1 ANALOGS OF DUOCARMYCIN AND CC-1065 审中-公开
标题翻译： DUOCARMYCIN和CC-1065的模拟物
公开(公告)号：WO98052925A1
公开(公告)日：1998-11-26
申请号：PCT/US1998/010535
申请日：1998-05-22
IPC分类号： A61K31/475 , A61K31/55 , A61P35/00 , A61P43/00 , C07D223/14 , C07D223/32 , C07D225/04 , C07D401/06 , C07D487/04 , C07D487/10 , C07D519/00
CPC分类号： C07D487/04 , C07D223/14 , C07D223/32 , C07D225/04 , C07D487/10
摘要： Analogs and derivatives of duocarmycin and CC-1065 are provided. The compounds have use as antitumor antibiotics and as cell toxicity agents. The compounds have sequences specific DNA alkylating activity.
摘要翻译：提供了杜卡霉素和CC-1065的类似物和衍生物。该化合物可用作抗肿瘤抗生素和细胞毒性剂。该化合物具有序列特异性DNA烷基化活性。

8. 发明申请

WO2017156071A1 CYCLIC KETO-AMIDE COMPOUNDS AS CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
标题翻译：作为CALPAIN调节剂的环状酮酰胺化合物及其生产和使用方法
公开(公告)号：WO2017156071A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021285
申请日：2017-03-08
申请人： BLADE THERAPEUTICS, INC.
发明人： BUCKMAN, Brad Owen , YUAN, Shendong
IPC分类号： C07K5/06 , C07K5/08 , C07D225/02 , C07D225/04 , C07D225/06 , A61K38/05 , A61K38/06 , A61P35/00 , A61P43/00
摘要： The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.
摘要翻译：本技术涉及通式I至XXXII的环酮酰胺化合物，其组合物和试剂盒作为钙蛋白酶调节剂和用于治疗各种疾病或病症如纤维化疾病或癌症的方法，其中由钙蛋白酶如CAPN1，CAPN2和/或CAPN9相关或介导。本技术也适用于抑制肌成纤维细胞分化的环酮酰胺化合物。

9. 发明申请

WO2007053284A3 METHOD OF TREATING BREAST CANCER USING 17-AAG OR 17-AG OR A PRODRUG OF EITHER IN COMBINATION WITH A HER2 INHIBITOR 审中-公开
标题翻译：使用17-AAG或17-AG治疗乳腺癌的方法或与HER2抑制剂组合的产品
公开(公告)号：WO2007053284A3
公开(公告)日：2009-04-30
申请号：PCT/US2006040139
申请日：2006-10-13
申请人： KOSAN BIOSCIENCES INC , JOHNSON ROBERT G JR , HANNAH ALISON L , CROPP GILLIAN F , ZHOU YIQING , SHERRILL MICHAEL J
发明人： JOHNSON ROBERT G JR , HANNAH ALISON L , CROPP GILLIAN F , ZHOU YIQING , SHERRILL MICHAEL J
IPC分类号： C07D225/04
CPC分类号： A61K31/395 , A61K39/39558 , A61K2039/545 , C07K16/32 , A61K2300/00
摘要： A method for treating a breast cancer in a subject by administering 17-allylamino-17-demethoxy-geldanamycin (17-AAG) or 17-amino-17-demethoxygeldanamycin (17-AG), or a prodrug of either 17-AAG or 17-AG, in combination with a HER2 inhibitor.
摘要翻译：通过给予17-烯丙基氨基-17-去甲氧基 - 格尔德霉素（17-AAG）或17-氨基-17-去甲氧基格尔德霉素（17-AG）或17-AAG或17 -AG，与HER2抑制剂组合。

10. 发明申请

WO2007133945A2 GEROTOR MOTOR AND BRAKE ASSEMBLY 审中-公开
标题翻译：电动马达和制动总成
公开(公告)号：WO2007133945A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068031
申请日：2007-05-02
申请人： WHITE DRIVE PRODUCTS, INC. , WHITE, Hollis, N., Jr.
发明人： WHITE, Hollis, N., Jr.
IPC分类号： C07D225/04
CPC分类号： F04C2/106 , F03C2/02 , F04C15/0084 , F04C2240/603
摘要： A hydraulic device includes a gerotor assembly, a wobble stick, an output shaft, a housing assembly, a first port in the housing assembly, a second port in the housing assembly, first brake disks, second brake disks, a piston, and a biasing member. The gerotor assembly includes a rotor and a stator. The wobble stick connects at a first end to the rotor. The output shaft connects to a second end of the wobble stick. The housing assembly receives the gerotor assembly, the wobble stick and the output shaft. The first port is in communication with the gerotor assembly. The second port is also in communication with the gerotor assembly. The first brake disks connect to the output shaft. The second brake disks connect to the housing assembly. The piston is disposed in the housing assembly adjacent at least one of the brake disks. The piston cooperates with the housing assembly to define a brake pressure chamber. The housing assembly and the first and second ports are configured such that pressurization of either port results in pressurization of the brake pressure chamber. The biasing member is disposed in the housing and contacts the piston. The biasing member urges the piston toward at least one of the brake disks.
摘要翻译：液压装置包括摆线组件，摆动杆，输出轴，壳体组件，壳体组件中的第一端口，壳体组件中的第二端口，第一制动盘，第二制动盘，活塞和偏压会员。摆线组件包括转子和定子。摆动杆在第一端连接到转子。输出轴连接到摆动杆的第二端。壳体组件接收摆线组件，摆动杆和输出轴。第一个端口与电动机组件通信。第二个端口也与电动机组件通信。第一个制动盘连接到输出轴。第二制动盘连接到壳体组件。活塞与至少一个制动盘相邻地设置在壳体组件中。活塞与壳体组件配合以限定制动压力室。壳体组件和第一和第二端口构造成使得任一端口的加压导致制动压力室的加压。偏置构件设置在壳体中并接触活塞。偏置构件朝向至少一个制动盘推动活塞。

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