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1. 发明申请

WO2023009184A1 ADAPTIVE SEARCH MASS SPECTROMETER SPECTRAL ANALYSIS 审中-公开
公开(公告)号：WO2023009184A1
公开(公告)日：2023-02-02
申请号：PCT/US2022/023485
申请日：2022-04-05
申请人： JOHN WILEY & SONS, INC.
发明人： NEDWED, Karl , D'SOUZA, Michelle , ABSHEAR, Ty
IPC分类号： G01N21/31 , G01N27/62 , G01N27/623 , G16C20/20 , G01J3/28
摘要： A method for analyzing spectra comprises identifying a set of sample peaks in a sample spectrum, where the sample peaks are associated with fragments of a sample, each having a sample fragment mass. A reference spectrum is selected with one or more reference peaks corresponding to fragments of a reference, each having a reference fragment mass. A mass difference can be determined between selected sample and reference peaks, and a group exchange can be selected based on the mass difference; e.g., where the group exchange represents a change in the sample or reference fragment masses associated with the selected peaks. The selected peaks can be shifted by the mass difference, and a fit value can be determined with respect to the reference spectrum. The fit value characterizes similarity between the respective sets of sample and reference peaks, responsive to the group exchange and corresponding peak shift.

2. 发明申请

WO2023288179A1 METHOD OF OPTIMIZING GEOMETRIC AND ELECTROSTATIC PARAMETERS OF AN ELECTROSTATIC LINEAR ION TRAP (ELIT) 审中-公开
公开(公告)号：WO2023288179A1
公开(公告)日：2023-01-19
申请号：PCT/US2022/073503
申请日：2022-07-07
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： JARROLD, Martin, F. , BOTAMANENKO, Daniel, Y.
IPC分类号： H01J49/42 , G01N27/623 , G06F30/27
摘要： A method for optimizing an electrostatic linear ion trap (ELIT) for mass-to-charge (m/z) measurement resolution may include determining initial electrostatic and geometric parameters of the ELIT, modifying at least one of the initial electrostatic parameters to produce a resulting set of modified electrostatic parameters with which m/z measurements made by the ELIT are independent of a trajectory of ions moving within the ELIT relative to a longitudinal axis of the ELIT, modifying at least one of the initial geometric parameters to produce a resulting set of modified geometric parameters with which m/z measurements made by the ELIT are independent of energy of ions moving within the ELIT, and constructing the ELIT using the modified sets of electrostatic and geometric parameters.

3. 发明申请

WO2021076735A1 METHODS FOR CHARACTERIZING HOST-CELL PROTEINS 审中-公开
公开(公告)号：WO2021076735A1
公开(公告)日：2021-04-22
申请号：PCT/US2020/055744
申请日：2020-10-15
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： ZHENG, Xiaojing , O'BRIEN JOHNSON, Reid , GREER, Tyler
IPC分类号： G01N33/68 , G01N30/88 , G01N30/72 , B01D15/38 , G01N27/623 , G01N27/624
摘要： Methods for characterizing host-cell proteins in a sample matrix are provided.

4. 发明申请

WO2022136881A1 CHARACTERISATION OF HIGH MASS PARTICLES 审中-公开
公开(公告)号：WO2022136881A1
公开(公告)日：2022-06-30
申请号：PCT/GB2021/053426
申请日：2021-12-23
申请人： MICROMASS UK LIMITED
发明人： UJMA, Jakub , LANGRIDGE, David , WILDGOOSE, Jason , RICHARDSON, Keith , GILES, Kevin
IPC分类号： H01J49/42 , G01N27/623
摘要： A method of analysing high-mass (> 1 MDa) particles comprises ionising particles to as to produce ions, separating the ions according to mass to charge ratio by passing the ions through an ion separation device in which one or more time-varying electric fields is used to urge ions through a gas such that ions are separated according to mass to charge ratio, measuring the transit time of the ions through the ion separation device, and determining a drift time or mass to charge ratio distribution of the ions therefrom. The method further comprises identifying one or more charge envelopes in the drift time or mass to charge ratio distribution, and using the one or more charge envelopes to characterise the particles.

5. 发明申请

WO2022093468A1 RESISTIVE COATING FOR A CAPILLARY 审中-公开
公开(公告)号：WO2022093468A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/052605
申请日：2021-09-29
申请人： AGILENT TECHNOLOGIES, INC.
发明人： CARR, Elizabeth , CLOSSER, Richard
IPC分类号： B01L3/00 , G01N27/623 , C23C16/455 , C23C16/40 , C23C16/06 , C23C16/04 , G01N30/72
摘要： A coated capillary tube having a tunable resistance in an ion transfer device, including an inlet end in communication with an atmospheric-pressure ion source, an outlet end in communication with a vacuum region of a mass spectrometer, a body elongated along an axis from the inlet end to the outlet end, and an inside surface defining a bore having an inner diameter is disclosed. The coated capillary tube also includes a resistive coating on the inside surface of the capillary tube, in which the resistive coating includes at least one layer comprising oxides or nitrides of a metal and discrete metal particles of a different metal embedded therein.

6. 发明申请

WO2022029424A1 ION IDENTIFICATION USING ION MOBILITY SPECTROMETRY 审中-公开
公开(公告)号：WO2022029424A1
公开(公告)日：2022-02-10
申请号：PCT/GB2021/052008
申请日：2021-08-04
申请人： MICROMASS UK LIMITED
发明人： GREEN, Martin Raymond , WILDGOOSE, Jason Lee
IPC分类号： G01N27/623 , H01J49/00 , H01J49/26
摘要： A method of analysing ions is disclosed comprising: (i) subjecting ions of an analyte molecule to different activation levels at different times so as to cause the ions to have different mobilities at said different times, wherein the activation level is varied in a plurality of cycles, and wherein the activation level is varied between said different levels during each of the cycles. The method uses an ion mobility separator or scanned ion mobility filter to determine the mobilities of the ions for said different activation levels; and correlates the determined mobilities with their respective activation levels so as to thereby obtain a fingerprint for the analyte molecule.

7. 发明申请

WO2023091594A1 SYSTEMS AND METHODS FOR TWO-DIMENSIONAL MOBILITY BASED FILTERING OF IONS 审中-公开
公开(公告)号：WO2023091594A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050293
申请日：2022-11-17
申请人： MOBILION SYSTEMS, INC.
发明人： DEBORD, John Daniel , DENG, Liulin , BUTTRILL, Jr., Sidney E.
IPC分类号： H01J49/06 , G01N27/623 , H01J49/02
摘要： A system for separating ions includes first and second surfaces extending along first and second perpendicular directions, an ion channel defined between the surfaces and configured to receive a stream of ions, first and second electrode arrays each including a plurality of electrodes extending in a third direction and respectively associated with the first and second surfaces, means for causing gas to flow across the ion channel in a fourth direction substantially opposite the first direction, and a controller configured to apply a DC voltage gradient to the electrode arrays. The electrode arrays are configured to generate an electric field based on the DC voltage gradient. The electric field and the flow of gas are configured to direct ions having mobilities in a first mobility range along a first path and ions having mobilities in a second mobility range along a second path.

8. 发明申请

WO2022243896A1 SYSTEMS AND METHODS FOR PERFORMING A CHECK OF A DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开
公开(公告)号：WO2022243896A1
公开(公告)日：2022-11-24
申请号：PCT/IB2022/054620
申请日：2022-05-18
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BEDFORD, Leigh , SCHNEIDER, Bradley B. , DUCHOSLAV, Eva , TATE, Stephen
IPC分类号： G01N27/623 , G01N27/624 , H01J49/00
摘要： A method of operating a system including a differential mobility spectrometer (DMS) and a mass spectrometer. A sample is introduced to the DMS. The sample is analyzed with the DMS. Data is generated based at least in part on an analyte ion generated from the sample and at least one transport gas composition. Library data of the analyte ion is accessed from a library. The generated data is compared to the library data. A signal is sent when the generated data deviates from the library data by more than a predetermined threshold.

9. 发明申请

WO2022238566A1 METHOD AND APPARATUS FOR COMBINED ION MOBILITY AND MASS SPECTROMETRY ANALYSIS 审中-公开
公开(公告)号：WO2022238566A1
公开(公告)日：2022-11-17
申请号：PCT/EP2022/063054
申请日：2022-05-13
申请人： UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
发明人： TENZER, Stefan , DISTLER, Ute
IPC分类号： H01J49/00 , G01N27/623 , H01J49/0031 , H01J49/004
摘要： Disclosed herein is a method of and an apparatus for combined ion mobility and mass spectrometry analysis, the method comprising the following steps: introducing precursor ions (34) into a trap configured for trapping ions and for selectively ejecting trapped ions according to their m/z ratio, selectively ejecting precursor ions (34) having m/z values falling within at least one controllable ejection window from said trap (15), sequentially releasing precursor ions (34) from said IMS (16) according to their ion mobility, introducing said released precursor ions (34) into a mass filter (26) having a controllable mass window, fragmenting the precursor ions (34) transmitted through said mass filter (26) to generate fragment ions, and carrying out a mass spectrometry measurement on said fragment ions, wherein each fragment ion is associated with a mass window and an ion mobility (IM) range.

10. 发明申请

WO2022223232A1 VORRICHTUNG ZUR SPEKTROMETRISCHEN UNTERSUCHUNG EINES GASES UND LITHOGRAPHIEANLAGE 审中-公开
公开(公告)号：WO2022223232A1
公开(公告)日：2022-10-27
申请号：PCT/EP2022/057761
申请日：2022-03-24
申请人： CARL ZEISS SMT GMBH
发明人： ALIMAN, Michel , RANCK, Albrecht
IPC分类号： H01J49/40 , G01N27/623
摘要： Die Erfindung betrifft eine Vorrichtung (1) zur spektrometrischen Untersuchung eines Gases (2), umfassend: eine Extraktionseinrichtung (12) zur Extraktion von Ionen (11) des zu untersuchenden Gases (2) aus einer Ionenkammer (5), einen Ionen-Detektor (13) zur Detektion der Ionen (11), eine Ionen- Transfereinrichtung (14) zum Transfer der Ionen (11) von der Extraktionseinrichtung (12) zu dem Ionen-Detektor (13) entlang einer Ionen- Transferstrecke (Lm), eine Zuführungseinrichtung (16) zur Zuführung eines Bremsgases (17) zu der Ionen-Transferstrecke (Lm), sowie eine Auswerteeinrichtung (21) zur Bestimmung von Transportzeiten (tm) beim Transport der Ionen (11) von der Extraktionseinrichtung (12) zu dem Ionen- Detektor (13) entlang der Ionen-Transferstrecke (Lm). Die Vorrichtung (1) ist ausgebildet, einen Druck (pM) entlang der Ionen-Transferstrecke (Lm) zwischen einem ersten, niedrigeren Druckbereich (Δp1) und einem zweiten, höheren Druckbereich (Δp2) umzuschalten und die Auswerteeinrichtung (21) ist ausgebildet, in einem ersten Betriebszustand (MS) anhand der Transportzeiten (tm) der Ionen (11) bei dem Druck (pM) in dem ersten Druckbereich (Δp1) eine massenspektrometrische Untersuchung des Gases (2) durchzuführen und in einem zweiten Betriebszustand (IMS) anhand der Transportzeiten (tm) der Ionen (11) bei dem Druck (pM) in dem zweiten Druckbereich (Δp2) eine ionenmobilitäts-spektrometrische Untersuchung des Gases (2) durchzuführen. Die Erfindung betrifft auch eine Lithographieanlage, insbesondere eine EUV- Lithographieanlage, die mindestens eine solche Vorrichtung (1) aufweist.

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