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1. 发明申请

WO2021248124A1 AUTOMATED ONLINE CHROMATOGRAPHIC SAMPLE DILUTION AND PREPARATION SYSTEM 审中-公开
公开(公告)号：WO2021248124A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/036194
申请日：2021-06-07
申请人： SNAPDRAGON CHEMISTRY, INC.
发明人： AMADOR, Adrian G. , FANG, Yuanqing , FORD, David D. , GONCHARUK, Mikhail V. , RUSSELL, Grace
IPC分类号： G01N30/06 , G01N1/38 , G01N30/88 , G01N30/20 , G01N1/2035 , G01N2001/205 , G01N2030/027 , G01N2030/324 , G01N2030/8435 , G01N2030/8804 , G01N2030/8809 , G01N2030/8886 , G01N30/04 , G01N30/30 , G01N30/32 , G01N30/84 , G01N30/8658
摘要： The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 µL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.

2. 发明申请

WO2021122376A1 A BIOPROCESS FLUID MIXING SYSTEM 审中-公开
公开(公告)号：WO2021122376A1
公开(公告)日：2021-06-24
申请号：PCT/EP2020/085767
申请日：2020-12-11
申请人： CYTIVA SWEDEN AB
发明人： GEBAUER, Klaus
IPC分类号： G05D11/13 , G01N30/02 , G01N2030/8809 , G01N30/32 , G01N30/34 , G05D11/139
摘要： A bioprocess fluid mixing system (3; 3'; 3''; 103; 103'), said fluid mixing system (3; 3'; 3''; 103; 103') comprising: - at least two fluid inlets (5a, 5b, 5c, 5d, 5e), configured for providing a first fluid into the fluid mixing system through a first fluid inlet (5a) and for providing a second fluid into the fluid mixing system through a second fluid inlet (5b); - at least one valve arrangement (13a, 13b, 13c, 13a'), where a first valve arrangement (13a; 13a') is in fluid communication with at least both the first fluid inlet (5a) and the second fluid inlet (5b); - at least two pumps (11a, 11b, 11c, 11d, 11e), where a first pump (11a) is in selective fluid communication with at least both the first and the second fluid inlets (5a, 5b) via the first valve arrangement (13a; 13a') and a second pump (11b) is in fluid communication with at least one of the first and second fluid inlet (5b); and - a common fluid outlet (14) which is in fluid communication with both an outlet (15a) of the first pump (11a) and an outlet (15b) of the second pump (11b), wherein pump rates of the at least two pumps (11a, 11b) and valve positions in the at least one valve arrangement (13a; 13a'; 13b, 13c) are configured to be controllable by a control system (21) such that mixing of at least a first fluid from the first fluid inlet (5a) and a second fluid from the second fluid inlet (5b) can be performed to a requested mixing of the at least two fluids and to a requested combined fluid flow rate at the common fluid outlet (14).

3. 发明申请

WO2021147275A1 电子鼻仪器气敏-色谱多信息融合和风味物质现场检测与分析方法审中-公开
公开(公告)号：WO2021147275A1
公开(公告)日：2021-07-29
申请号：PCT/CN2020/102886
申请日：2020-07-18
申请人：高大启
发明人：王泽建 , 张小勤 , 李建华 , 盛明健
IPC分类号： G01N33/00 , G01N30/88 , G06N3/04 , G01N2030/8804 , G01N2030/8809 , G01N33/0032 , G01N33/0034 , G01N33/0062 , G06N3/0454
摘要：一种电子鼻仪器气敏-色谱多信息融合和风味物质现场检测分析方法，电子鼻仪器包括气敏传感器阵列模块（I），毛细管气相色谱柱模块（II），气体自动顶空进样魔窟（III），计算机控制与分析模块（IV），自动顶空进样升降装置（V），大容量顶空挥发气发生模块（VI），以及辅助气源（VII-1，VII-2）。电子鼻仪器检测多个样品，建立气味大数据，经归一化融合预处理，机器学习级联模型通过学习实现食品及调味品、香料香精、石蜡的现场识别和气味质量等级与多成分浓度量化预测。

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