专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2021098737A1 稠和杂环类衍生物及其应用审中-公开
公开(公告)号：WO2021098737A1
公开(公告)日：2021-05-27
申请号：PCT/CN2020/129850
申请日：2020-11-18
申请人：上海枢境生物科技有限公司 , 江苏恩华药业股份有限公司
发明人：靖鹏 , 郭强 , 窦飞 , 万泽红 , 胡志京
IPC分类号： C07D455/04 , C07D471/06 , A61K31/4745 , A61K31/496 , A61P25/18
摘要：本发明属于医疗领域，具体涉及一种稠和杂环类衍生物及其应用，其具有如式(I)所示化合物结构，该类化合物可用于制备治疗神经精神类疾病的药物。

2. 发明申请

WO2008015516A1 FUSED TRICYCLIC HETEROCYCLES FOR THE TREATMENT OF SCHIZOPHRENIA 审中-公开
标题翻译：用于治疗SCHIZOPHRENIA的融合三聚异体体
公开(公告)号：WO2008015516A1
公开(公告)日：2008-02-07
申请号：PCT/IB2007/002031
申请日：2007-07-16
申请人： PFIZER PRODUCTS INC. , AWASTHI, Alok Kumar , CHO, Stephen, Sung, Yong , GRAHAM, James Michael , NIKAM, Sham Shridhar
发明人： AWASTHI, Alok Kumar , CHO, Stephen, Sung, Yong , GRAHAM, James Michael , NIKAM, Sham Shridhar
IPC分类号： C07D455/04 , C07D471/06 , C07D487/06 , A61K31/4375 , A61P25/18
CPC分类号： C07D471/06 , C07D455/04 , C07D487/06
摘要： Disclosed are compounds of Formula (1), pharmaceutical compositions containing compounds of Formula (1), and the use of compounds of Formula (1) to treat central nervous system disorders, including schizophrenia and other psychotic disorders, wherein L, Z 1 , Z 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 R 8 , R 9 and R 10 in Formula (1) are defined in the specification.
摘要翻译：公开了式（1）的化合物，含有式（1）化合物的药物组合物和式（1）化合物用于治疗中枢神经系统疾病，包括精神分裂症和其他精神病性障碍的用途，其中L，Z < 1，Z 2，R 1，R 2，R 3，R 3， R 4，R 5，R 6，R 7，R 8，R 9，式（1）中的和R 10定义在说明书中。

3. 发明申请

WO0185095A3 CHIRAL FLUOROQUINOLIZINONE ARGININE SALT FORMS 审中-公开
标题翻译： CHIRAL FLOOROQUINOLIZINONE ARGININE SALT FORMS
公开(公告)号：WO0185095A3
公开(公告)日：2002-10-03
申请号：PCT/IN0100097
申请日：2001-05-03
申请人： DE SOUZA NOEL JOHN , WOCKHARDT LTD , AGARWAL SHIV KUMAR , PATEL MAHESH VITHALBHAI , BHAWSAR SATISH BALIRAM , BERI RUPINDER KAUR , YEOLE RAVINDRA DATTATRAYA , SHETTY NITIN , KHORAKIWALA HABIL FAKHRUDDIN
发明人： DE SOUZA NOEL JOHN , AGARWAL SHIV KUMAR , PATEL MAHESH VITHALBHAI , BHAWSAR SATISH BALIRAM , BERI RUPINDER KAUR , YEOLE RAVINDRA DATTATRAYA , SHETTY NITIN , KHORAKIWALA HABIL FAKHRUDDIN
IPC分类号： A61K45/06 , A61P31/00 , C07C279/14 , C07D215/22 , C07D215/233 , C07D401/04 , C07D401/14 , C07D455/04 , C07D471/04 , C07D471/08 , C07D519/00 , A61K31/4375
CPC分类号： C07D215/233 , A61K45/06 , C07B2200/07 , C07C279/14 , C07D401/04 , C07D401/14 , C07D455/04 , C07D471/04 , C07D471/08
摘要： The invention relates to the new arginine salt forms of S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating antimicrobial infections.
摘要翻译：本发明涉及新的精氨酸盐形式的S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H，5H- 苯并[i，j]喹嗪-2-羧酸，其制备方法和药物制剂，其包含这些精氨酸盐形式作为其用于治疗抗微生物感染的活性成分。

4. 发明申请

WO02004445A1 HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS 审中-公开
标题翻译：杂环羧酰胺作为抗病毒剂
公开(公告)号：WO02004445A1
公开(公告)日：2002-01-17
申请号：PCT/US2001/016494
申请日：2001-06-25
IPC分类号： C07D455/04 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/5395 , A61K31/5513 , A61K31/553 , A61P31/12 , A61P31/22 , A61P43/00 , C07D471/06 , C07D498/06 , A61K31/435 , A61K31/535 , A61K31/54 , C07D471/16 , C07D513/06
CPC分类号： C07D471/06
摘要： The present invention provides a compound of formula (I) which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
摘要翻译：本发明提供了可用作抗病毒剂的式（I）化合物，特别是作为抗疱疹家族病毒的药剂。

5. 发明申请

WO00053598A1 PYRAN DERIVATIVES 审中-公开
标题翻译：派兰衍生物
公开(公告)号：WO00053598A1
公开(公告)日：2000-09-14
申请号：PCT/JP2000/001437
申请日：2000-03-09
IPC分类号： H01L51/50 , C07C211/54 , C07C211/58 , C07C211/61 , C07D407/06 , C07D407/14 , C07D417/06 , C07D491/16 , C07F3/06 , C07F5/06 , C08F2/50 , C09B57/02 , C09K3/00 , C09K11/06 , G03C1/73 , G03F7/031 , C07D405/14 , C07D417/14 , C07D455/04 , G03H1/02
CPC分类号： G03C1/73 , C09B57/02 , G03F7/031
摘要： Novel organic compounds which have remarkable sensitivity to visible light and remarkable luminescent performance and are useful in photochemical polymerization, dye lasers, and organic electroluminescence. The compounds are pyran derivatives having a skeleton represented by the formula (1) or (2). Also provided are: a photosensitizer comprising any of the pyran derivatives; a photopolymerizable composition; a substance functioning in lasers; a luminescent agent for organic electroluminescent elements; an organic electroluminescent element; and a process for producing the pyran derivatives which contains the step of reacting a compound having a 4-cyanomethylene-2-methyl-4H-pyran skeleton with a compound having a 3-formylcoumarin skeleton.
摘要翻译：对可见光具有显着的敏感性和显着的发光性能的新型有机化合物，可用于光化学聚合，染料激光和有机电致发光。该化合物是具有由式（1）或（2）表示的骨架的吡喃衍生物。还提供：包含任何吡喃衍生物的光敏剂; 光聚合组合物; 在激光器中起作用的物质; 用于有机电致发光元件的发光剂; 有机电致发光元件; 以及包含使具有4-氰基亚甲基-2-甲基-4H-吡喃骨架的化合物与具有3-甲酰基香豆素骨架的化合物反应的步骤的吡喃衍生物的制造方法。

6. 发明申请

WO00008019A1 PROCESS FOR THE SYNTHESIS OF (1H)-BENZO[C]QUINOLIZIN-3-ONES DERIVATIVES 审中-公开
标题翻译：合成（1H） - 苯并[C]喹啉-3-酮衍生物的方法
公开(公告)号：WO00008019A1
公开(公告)日：2000-02-17
申请号：PCT/EP1999/005277
申请日：1999-07-23
IPC分类号： C07D455/02 , C07D455/04
CPC分类号： C07D455/04
摘要： The present invention refers to a process for the preparation of (1H)-benzo[c]quinolizin-3-ones derivatives of general formula (I) which involves only three steps and the use, as starting products, of commercially available, or easily preparable, compounds. The compounds of formula (I) are useful as inhibitors of 5 alpha -reductases.
摘要翻译：本发明涉及一种制备通式（I）的（1H） - 苯并[c]喹嗪啉-3-酮衍生物的方法，该方法仅涉及三个步骤，并用作市售的或容易的起始产物可制成，化合物。式（I）化合物可用作5α-还原酶的抑制剂。

7. 发明申请

WO00006572A1 BENSOQUINOLIZINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：苯并喹啉衍生物及其生产方法
公开(公告)号：WO00006572A1
公开(公告)日：2000-02-10
申请号：PCT/JP1999/004035
申请日：1999-07-28
IPC分类号： C07D471/06 , A61K31/435 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/08 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D455/04 , A61K31/47
CPC分类号： C07D455/04
摘要： Benzoquinolizine derivatives having tachykinin antagonism, in particular, substance P receptor antagonism. Namely, benzoquinolizine derivatives represented by general formula (1) and salts thereof and medicinal compositions containing these compounds or pharmaceutically useful salts thereof. In said formula, R , R and R are the same or different and each represents hydrogen or C1-6 alkyl; the ring A is a homocycle or a heterocycle optionally having 1 to 3 substituents selected independently (wherein 2 substituents adjacent to each other may be bonded together to form a ring); the ring B is a benzene ring optionally having 1 to 5 substituents (wherein 2 substituents adjacent to each other may be bonded together to form a ring); and the ring C is a benzene ring optionally having 1 to 3 substituents (wherein 2 substituents adjacent to each other may be bonded together to form a ring).
摘要翻译：具有速激肽拮抗作用的苯并喹嗪衍生物，特别是P受体拮抗作用。即，由通式（1）表示的苯并喹嗪衍生物及其盐和含有这些化合物的药物组合物或其药学上有用的盐。在所述式中，R 1，R 2和R 3相同或不同，各自表示氢或C 1-6烷基; 环A是任选具有1至3个独立选择的取代基的杂环或杂环（其中彼此相邻的2个取代基可以键合在一起形成环）; 环B是任选具有1至5个取代基的苯环（其中彼此相邻的2个取代基可以键合在一起形成环）; 并且环C是任选具有1至3个取代基的苯环（其中彼此相邻的2个取代基可以键合在一起形成环）。

8. 发明申请

WO99005913A1 USE OF BENZO[C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS 审中-公开
标题翻译：苯并[C]喹啉衍生物作为植物生长调节剂的应用
公开(公告)号：WO99005913A1
公开(公告)日：1999-02-11
申请号：PCT/EP1998/004737
申请日：1998-07-29
IPC分类号： A01N43/90 , C07D455/04 , C07D455/02
CPC分类号： C07D455/04 , A01N43/90
摘要： Described herein is the use of benzo[c]quinolizine derivatives of formula (I) as regulators of the growth of plants, and compositions for agricultural use containing the said derivatives or their salts.
摘要翻译：本文描述的是使用式（I）的苯并[c]喹嗪衍生物作为植物生长的调节剂，以及含有所述衍生物或其盐的农业用组合物的用途。

9. 发明申请

WO1997040046A1 BENZOQUINOLIZINE DERIVATIVES AND MEDICINAL COMPOSITIONS 审中-公开
标题翻译：苯并喹啉衍生物和药物组合物
公开(公告)号：WO1997040046A1
公开(公告)日：1997-10-30
申请号：PCT/JP1997001320
申请日：1997-04-17
申请人： NIPPON SHINYAKU CO., LTD. , YAMAMOTO, Osamu , SHIROUCHI, Yoshiaki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D455/04
CPC分类号： C07D455/06 , A61K31/473 , C07D455/04
摘要： Benzoquinolizine derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and medicinal compositions containing the same as the active ingredients, wherein R represents hydroxy or alkoxy; R represents hydrogen, hydroxy or alkoxy; R represents alkyl optionally substituted by hydroxy, alkoxy, amino, monoalkylamino or dialkylamino; and R represents alkyl optionally substituted by hydroxy or alkoxy, aryl optionally sustituted by alkyl, halogeno, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino, monoalkylamino or dialkylamino. Because of being capable of regulating the gastro-intestinal tract motion, these compounds are efficacious in the treatment of irritable bowel syndrome.
摘要翻译：由通式（1）表示的苯并喹嗪衍生物，其药学上可接受的盐和含有与活性成分相同的药物组合物，其中R 1表示羟基或烷氧基; R 2表示氢，羟基或烷氧基; R 3表示任选被羟基，烷氧基，氨基，单烷基氨基或二烷基氨基取代的烷基; 并且R 4表示任选被羟基或烷氧基取代的烷基，任选被烷基，卤代，羟基，烷氧基，氨基，单烷基氨基或二烷基氨基，单烷基氨基或二烷基氨基取代的芳基。由于能够调节胃肠道运动，这些化合物对肠易激综合征的治疗是有效的。

10. 发明申请

WO1997031000A1 QUINOLONES AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：喹诺酮及其治疗用途
公开(公告)号：WO1997031000A1
公开(公告)日：1997-08-28
申请号：PCT/GB1997000492
申请日：1997-02-21
申请人： CHIROSCIENCE LIMITED
发明人： CHIROSCIENCE LIMITED , HAUGHAN, Alan, Findlay , BEASLEY, Steven, Colin , MONTANA, John, Gary , WATSON, Robert, John
IPC分类号： C07D455/04
CPC分类号： C07D455/04
摘要： A compound of formula (I) wherein n is an integer of up to 3; R represents cycloalkyl, aryl, heteroaryl or heterocyclo, any of which rings may be fused to a second ring selected from aryl, heteroaryl, to give a bicyclic structure, and in which the or each ring is optionally substituted by one or more substituents chosen from halo, C1-6 alkoxy, hydroxy, CN, CO2H (or C1-6 alkyl esters or C1-6 alkyl amides thereof), C1-6 alkyl, NR R and SO2NR R ; R , R and R are the same or different and represent H, halo, C1-6 alkoxy, hydroxy, CN, CO2H (or C1-6 alkyl esters or C1-6 alkyl amides thereof), NR R , SO2NR R or C1-6 alkyl in which alkyl is optionally substituted with halo, C1-6 alkoxy, hydroxy, CN, CO2H (or C1-6 alkyl esters or C1-6 alkyl amides thereof), NR R7 or SO2NR R , or any adjacent two substituents R -R are joined to form an optionally substituted carbocyclic aromatic, heteroaromatic, saturated carbocyclic or heterocyclic ring; R and R are the same or different and represent H, C1-6 alkyl, cycloalkyl, C1-6 alkylcarbonyl, arylcarbonyl, C1-6 alkoxycarbonyl, arylsulphonyl or C1-6 alkylsulphonyl, or NR R is a 5- or 6-membered ring such as pyrrolidine, piperidine, morpholine or piperazine; X represents a linking group selected from -(CR R )2-3-, -Y-(CR R )2-, -(CR R )2-Y-, -CR R -Y-CR R - and -Y-CR R -Z-, Y and Z being independently NR , O or S(O)0-2, provided that Y and Z are not both S(O)0-2; Q represents O or S; each R , each R and R are the same or different and are H or C1-6 alkyl; or a pharmaceutically-acceptable salt, solvate or hydrate thereof.
摘要翻译：式（I）的化合物，其中n为至多3的整数; R 1表示环烷基，芳基，杂芳基或杂环，其中任一个可以与选自芳基，杂芳基的第二个环稠合，得到双环结构，并且其中该环或每个环任选地被一个或多个选自卤素，C 1-6烷氧基，羟基，CN，CO 2 H（或其C 1-6烷基酯或其C 1-6烷基酰胺），C 1-6烷基，NR 6 R 7和SO 2 NR 6 R <7>; R 3，R 4和R 5相同或不同，表示H，卤素，C 1-6烷氧基，羟基，CN，CO 2 H（或其中C 1-6烷基酯或C 1-6烷基酰胺），NR 6 R 7，SO 2 NR 6 R 7或C 1-6烷基，其中烷基任选被卤素，C 1-6烷氧基，羟基，CN，CO 2 H（或C 1-6烷基酯或 C 6烷基酰胺），NR 6 R 7或SO 2 NR 6 R 7或任何相邻的两个取代基R 3 -R 5连接形成任选取代的碳环芳族杂芳族饱和碳环或杂环; R 6和R 7相同或不同，表示H，C 1-6烷基，环烷基，C 1-6烷基羰基，芳基羰基，C 1-6烷氧基羰基，芳基磺酰基或C 1-6烷基磺酰基，或NR 6 R 7是5-或6-元环，例如吡咯烷，哌啶，吗啉或哌嗪; 2-（CR 9 R 10）） - （CR 9 R 10）2 - ， - （CR 9 R 10） 2-Y-，-CR 9 R 10 -Y-CR 9 R 10和-Y-CR 9 R 10 -Z-，Y和Z独立地是NR 11 >，O或S（O）0-2，条件是Y和Z不同时为S（O）0-2; Q表示O或S; 每个R 9，每个R 10和R 11相同或不同，为H或C 1-6烷基; 或其药学上可接受的盐，溶剂合物或水合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式