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1. 发明申请

WO2023286053A1 METHOD OF PREPARING OF ARTHROPODICIDAL OXADIAZINE INTERMEDIATE 审中-公开
公开(公告)号：WO2023286053A1
公开(公告)日：2023-01-19
申请号：PCT/IL2022/050743
申请日：2022-07-11
申请人： ADAMA MAKHTESHIM LTD.
发明人： FOGLER, Eran , PEN, Liza , STRIZHIVER, Natalia , VAZANA, Chen
IPC分类号： C07C269/06 , C07C271/66 , C07D273/04
摘要： The present invention pertains to a process for preparing of methyl chloroformyl[4-(trifluoromethoxy)phenyl]carbamate of formula I as intermediate in the preparation of arthropodicidal indoxacarb, comprising reaction of compound of formula (IV) with phosgene or phosgene derivative in the presence of phase transfer catalyst, alkaline base and hydrocarbon organic solvent and in the absence of organic base and metal hydride. This invention also pertains to a telescopic process for preparation of methyl chloroformyl[4-(trifluoromethoxy)phenyl]carbamate of formula I comprising preparation of isocyanate of formula (II) by reaction of compound of aniline derivative of formula (III) with phosgene or phosgene derivative in the presence of dimethylcarbonate and hydrocarbon organic solvent; following the preparation of compound of formula (IV) by reaction of compound of formula (II) with methanol and distillation out of dimethylcarbonate and reaction of compound of formula (IV) with phosgene or phosgene derivative in the presence of phase transfer catalyst, alkaline base and hydrocarbon organic solvent.

2. 发明申请

WO2022069563A1 WATER-DISPERSIBLE MODIFIED POLYISOCYANATES 审中-公开
公开(公告)号：WO2022069563A1
公开(公告)日：2022-04-07
申请号：PCT/EP2021/076829
申请日：2021-09-29
申请人： COVESTRO DEUTSCHLAND AG
发明人： LIU, Hao , MA, Yaguang , XU, Na , XIA, Tian , DANIELMEIER, Karsten , PIRES, Raul , LAAS, Hans-Josef
IPC分类号： C08G18/16 , C07D251/34 , C07D273/04 , C08G18/18 , C08G18/78 , C08G18/79 , C08G18/80 , C08G18/08 , C08G18/12 , C08G18/68 , C09D175/00
摘要： The invention relates to a water-dispersible modified polyisocyanate and use thereof, especially as a crosslinking component in water-soluble or water-dispersible coating compositions. The water-dispersible modified polyisocyanate can be obtained by the reaction of a system comprising a water-dispersible polyisocyanate and an isocyanate-reactive component; wherein the viscosity of the water-dispersible modified polyisocyanate is 3000 mPa·s-11000 mPa·s, which is measured with a MV- DIN rotor according to DIN EN ISO 3219:1994-10 at 23°C and a shear rate of 10 s-1. The modified polyisocyanate according to the present invention has good manual stirring behavior and good dispersibility, and the coating formed by the coating composition containing the modified polyisocyanate has high gloss and good transparency.

3. 发明申请

WO2021047308A1 一种多异氰酸酯组合物及其制备方法审中-公开
公开(公告)号：WO2021047308A1
公开(公告)日：2021-03-18
申请号：PCT/CN2020/104738
申请日：2020-07-27
申请人：万华化学集团股份有限公司 , 万华化学（宁波）有限公司
发明人：刘伟 , 石滨 , 尚永华 , 辛光震 , 朱付林 , 薛勇勇 , 朱智诚 , 王丹 , 焦乾坤 , 黎源
IPC分类号： C08G18/79 , C08G18/02 , C08G18/78 , C07D251/34 , C07D273/04
摘要：一种多异氰酸酯组合物以及所述组合物的制备方法，该组合物由至少包含六亚甲基二异氰酸酯的脂肪族二异氰酸酯单体聚合而成，含有异氰脲酸酯基、脲二酮基、噁二嗪三酮基和亚氨基噁二嗪二酮基，且噁二嗪三酮基和异氰脲酸酯基的摩尔比率为(0.001-0.01):1，组合物中溴含量和氟含量之和不高于80ppm。上述多异氰酸酯组合物在低温下能稳定存储。

4. 发明申请

WO2016106284A3 CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译： CREATINE PRODRUGS，COMPOSITIONS AND METHODS OF USE THEREOF
公开(公告)号：WO2016106284A3
公开(公告)日：2016-10-13
申请号：PCT/US2015067283
申请日：2015-12-22
申请人： FARMINGTON PHARMA DEV
发明人： BRUBAKER WILLIAM F
IPC分类号： C07D273/04 , A61K31/4245 , A61K31/5395 , A61K31/551 , A61P25/00 , A61P25/28 , C07D271/07 , C07D273/06
CPC分类号： C07D273/06 , C07B2200/05 , C07C279/14 , C07C279/24 , C07D271/07 , C07D273/04
摘要： The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
摘要翻译：本发明描述了膜渗透性肌酸酐前药，包含膜可渗透性肌酸酐前药的药物组合物，以及治疗疾病如缺血，心力衰竭，神经变性疾病和影响肌酸激酶系统的遗传病症的方法，包括给予肌酸前药或其药物组合物。本发明还描述了治疗影响肌酸激酶系统的遗传疾病，例如肌酸转运蛋白紊乱或肌酸合成障碍，其包括施用肌酸前药或其药物组合物。

5. 发明申请

WO2014147231A1 VERFAHREN ZUR HERSTELLUNG VON POLYISOCYANATEN UND KATALYSATOR-KIT HIERFÜR 审中-公开
标题翻译：用于生产异氰酸酯和催化剂KIT THEREFOR
公开(公告)号：WO2014147231A1
公开(公告)日：2014-09-25
申请号：PCT/EP2014/055724
申请日：2014-03-21
申请人： BAYER MATERIALSCIENCE AG
发明人： RICHTER, Frank , BRAHM, Martin
IPC分类号： C08G18/78 , C07D273/04 , C08G18/02 , C08G18/08 , C08G18/16
CPC分类号： C08G18/022 , B01J31/0288 , B01J2231/20 , B01J2531/002 , C07D273/04 , C08G18/089 , C08G18/166 , C08G18/7887
摘要： Die Anmeldung betrifft ein Katalysator-Kit, umfassend einen Trimerisierungskatalysator für die asymmetrische Trimerisierung von Polyisocyanaten und ein Katalysatorgift des Trimerisierungskatalysators, welches dadurch gekennzeichnet ist, dass der Trimerisierungskatalysator und das Katalysatorgift jeweils einen Wassergehalt von höchstens 0,5 Gew.-% aufweisen. Die Anmeldung betrifft ferner die Verwendung des Katalysator-Kits zur Herstellung von Iminooxadiazindiongruppen enthaltenden Polyisocyanaten durch Oligomerisierung monomerer Di- und/oder Triisocyanate sowie ein Verfahren zur Herstellung von Iminooxadiazindiongruppen enthaltenden Polyisocyanaten.
摘要翻译：本申请涉及一种催化剂的试剂盒，其包括用于多异氰酸酯的不对称三聚和三聚催化剂，其特征在于，所述三聚催化剂和所述催化剂毒物各自具有至多0.5重量％的水含量的催化剂毒物三聚催化剂。本申请还涉及使用该催化剂的试剂盒用于制备由低聚单体二异氰酸和/或三异氰酸酯以及用于制备含有iminooxadiazinedione团多异氰酸酯的方法包含iminooxadiazinedione基异氰酸酯。

6. 发明申请

WO2010102717A1 OXO-HETEROCYCLISCH SUBSTITUIERTE ALKYLCARBONSÄUREN UND IHRE VERWENDUNG 审中-公开
标题翻译： OXO杂环取代的烷基羧酸及其用途
公开(公告)号：WO2010102717A1
公开(公告)日：2010-09-16
申请号：PCT/EP2010/001124
申请日：2010-02-24
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , HEITMEIER, Stefan , GRIEBENOW, Nils , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER, Eva-Maria , STOLL, Friederike , KNORR, Andreas
发明人： LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , HEITMEIER, Stefan , GRIEBENOW, Nils , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER, Eva-Maria , STOLL, Friederike , KNORR, Andreas
IPC分类号： C07D209/46 , C07D237/14 , C07D273/04 , A61K31/4035 , A61K31/50 , A61K31/5395 , A61P9/00
CPC分类号： C07D273/04 , A61K31/4035 , A61K31/495 , A61K31/50 , A61K31/5395 , C07D209/46 , C07D237/14
摘要： Die vorliegende Anmeldung betrifft neue Alkylcarbonsäuren mit einer oxo-substituierten azaheterocyclischen Partialstruktur, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen.
摘要翻译：本申请涉及新的烷基羧酸与氧代基取代的氮杂杂环部分结构，它们的制备方法，其用于疾病的治疗和/或预防和它们用于制备药物用于疾病的治疗和/或预防，特别是用于治疗和/ 或预防心血管疾病。

7. 发明申请

WO99041245A1 INSECTICIDAL DIHYDRO-OXADIAZINES, -THIADIAZINES AND -TRIAZINES 审中-公开
标题翻译：杀虫剂二氢 - 氧化物，乙二胺四乙酸
公开(公告)号：WO99041245A1
公开(公告)日：1999-08-19
申请号：PCT/US1999/001245
申请日：1999-01-22
IPC分类号： A01N47/38 , A01N57/24 , C07D253/06 , C07D273/04 , C07D285/16 , C07D413/04 , C07D498/04 , C07F9/6533
CPC分类号： C07D253/06 , A01N47/38 , A01N57/24 , C07D273/04 , C07D285/16 , C07D413/04 , C07F9/6533
摘要： Insecticidal dihydro-oxadiazine compounds having formula (I): wherein X is O, N or S; R is a substituted or unsubstituted phenyl or C4-C5 heterocyclic group; R , R , R , and R are one of the following: a) R , R , and R are independently, hydrogen, alkyl, alkoxy, or furanyl; and R is nitro, cyano, alkyl, dialkylamino, alkylthio, alkoxy, haloalkoxy, phenoxy, phenylthio, or alkoxycarbonyl, wherein R and R together can form a ring; or b) R , R , and R are hydrogen; and R is alkylthio, alkylsulfinyl, alkylsulfonyl, nitroalkoxy, hydroxy, dialkoxyphosphinyl, cyano, acyloxy, alkoxy, haloalkoxy, cycloalkyl, or alkenyl; or R is a substituted or unsubstituted phenyl, phenylthio, phenylsulfinyl, phenylsulfonyl, pyrazolyl, furanyl, thienyl, phenylalkoxy, or benzoyloxy; and R is hydrogen alkyl, alkylthio, alkoxyalkyl, acyl, benzyl, or alkoxycarbonyl.
摘要翻译：具有式（I）的杀虫二氢 - 恶二嗪化合物：其中X是O，N或S; R是取代或未取代的苯基或C 4 -C 5杂环基; R 2，R 3，R 4和R 5是以下之一：a）R 2，R 3和R 4独立地是氢，烷基，烷氧基或呋喃基; R 5为硝基，氰基，烷基，二烷基氨基，烷硫基，烷氧基，卤代烷氧基，苯氧基，苯硫基或烷氧基羰基，其中R 3和R 5一起可以形成环; 或b）R 3，R 4和R 5是氢; R 2是烷硫基，烷基亚磺酰基，烷基磺酰基，硝基烷氧基，羟基，二烷氧基氧膦基，氰基，酰氧基，烷氧基，卤代烷氧基，环烷基或烯基; 或R 2是取代或未取代的苯基，苯硫基，苯基亚磺酰基，苯基磺酰基，吡唑基，呋喃基，噻吩基，苯基烷氧基或苯甲酰氧基; R 6是氢烷基，烷硫基，烷氧基烷基，酰基，苄基或烷氧基羰基。

8. 发明申请

WO1995018116A1 ARTHROPODICIDAL OXADIAZINE-, THIADIAZINE- OR TRIAZINE-CARBOXANILIDES 审中-公开
标题翻译：抗坏血酸OXADIAZINE-，THIADIAZINE-或TRIAZINE-CARBOXANILIDES
公开(公告)号：WO1995018116A1
公开(公告)日：1995-07-06
申请号：PCT/US1994014241
申请日：1994-12-21
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , STEVENSON, Thomas, Martin
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C07D273/04
CPC分类号： C07D253/06 , A01N43/88 , A01N47/20 , C07D273/04 , C07D285/16
摘要： Arthropodicidal compounds, compositions and use of compounds having formula (I) wherein A, E, X, Y, Z, R , R , R , R , R , n and m are as defined in the text.
摘要翻译：其中A，E，X，Y，Z，R 1，R 2，R 3，R 4，R 5，n，和m如文中所定义。

9. 发明申请

WO2022018651A2 SYNTHESIS OF HETEROCYCLIC COMPOUNDS FROM CARBOXAMIDE AND CARBOXAMIDE DERIVATIVES WITH HALOALKANOLS 审中-公开
公开(公告)号：WO2022018651A2
公开(公告)日：2022-01-27
申请号：PCT/IB2021/056583
申请日：2021-07-21
申请人： UNIVERSITY OF KWAZULU-NATAL
发明人： KARPOORMATH, Rajshekhar , SAYYAD, Nisar
IPC分类号： C07D263/12 , C07D273/04 , C07D265/10 , C07D273/00
摘要： The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.

10. 发明申请

WO2018178982A8 NEW CATALYTIC SYSTEM FOR SCALABLE PREPARATION OF INDOXACARB 审中-公开
公开(公告)号：WO2018178982A8
公开(公告)日：2018-10-04
申请号：PCT/IL2018/050356
申请日：2018-03-27
申请人： ADAMA MAKHTESHIM LTD.
发明人： VENKATARAMANA, Rajuri , BICIDI, Jayapal Reddy , PILLAI, Bijukumar Gopinathan , MANNAM, Sreedevi
IPC分类号： C07D273/04
摘要： It is an object of the present invention to provide a novel and advantageous process for commercially preparing of indoxacarb which is racemic or enantiomerically enriched at chiral center from its amide precursor using a new catalytic system. More particularly, it relates to an efficient method of preparation of indoxacarb which is racemic or enantiomerically enriched at chiral center from methyl-7-chloro-2,5-dihydro-2-[[[(4-trifluoromethoxy) phenyl]amino]carbonyl]-indeno[1,2-e][1,3,4]oxadiazine-4a(3H) carboxylate represented as formula (I) using methoxycarbonylation agent and metal salt of methylsulfinylmethylide in hydrocarbon solvent in the presence of organic base and phase transfer catalyst.

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