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1. 发明申请

WO2013071097A1 2,5-DISUBSTITUTED-PYRIDYL NICOTINIC LIGANDS, AND METHODS OF USE THEREOF 审中-公开
标题翻译： 2,5-DISUBSTITUTED-PYRIDYL NICOTINIC LIGANDS，及其使用方法
公开(公告)号：WO2013071097A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064438
申请日：2012-11-09
申请人： GEORGETOWN UNIVERSITY , DUKE UNIVERSITY
发明人： XIAO, Yingxian , KELLAR, Kenneth, J. , BROWN, Milton, L. , PAIGE, Mikell, A. , LIU, Yong , LEVIN, Edward, D. , REZVANI, Amir, H.
IPC分类号： A61K31/44
CPC分类号： A61K31/4427 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K31/4439 , C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

2. 发明申请

WO2014160783A1 2-HALO-5-ALKYNYL-PYRIDYL NICOTINIC LIGANDS 审中-公开
标题翻译： 2-羟基-5-烷基 - 吡啶基尼古丁配体
公开(公告)号：WO2014160783A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031873
申请日：2014-03-26
申请人： GEORGETOWN UNIVERSITY
发明人： XIAO, Yingxian , KELLAR, Kenneth, J. , BROWN, Milton, L. , PAIGE, Mikell, A. , LIU, Yong
IPC分类号： A61K31/44 , A61K31/397 , C07D205/02
CPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

3. 发明申请

WO2012027482A2 COMPOUNDS, COMPOSITIONS AND METHODS RELATED TO PPAR ANTAGONISTS 审中-公开
标题翻译：与PPAR拮抗剂有关的化合物，组合物和方法
公开(公告)号：WO2012027482A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048981
申请日：2011-08-24
申请人： GEORGETOWN UNIVERSITY , BROWN, Milton, Lang , KONG, Yali , LIU, Yong , GLAZER, Robert , TOMITA, York
发明人： BROWN, Milton, Lang , KONG, Yali , LIU, Yong , GLAZER, Robert , TOMITA, York
IPC分类号： C07C311/49 , C07C243/18 , A61K31/18 , A61P35/00 , A61P3/00
CPC分类号： C07C311/51 , A61K31/18 , C07C243/38 , C07C311/49 , C07D213/82 , C07D263/48 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders.
摘要翻译：公开了与PPAR拮抗剂有关的化合物，组合物和方法。某些化合物可有效抑制PPARs。该组合物可用于抑制PPARs，治疗癌症和治疗代谢紊乱。

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