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1. 发明申请

WO2013076226A1 PROCESS FOR PREPARING 3-SUBSTITUTED 2-ALKENALS, IN PARTICULAR PRENAL 审中-公开
标题翻译：制备3-取代的2-ALKENALS，特别是预处理的方法
公开(公告)号：WO2013076226A1
公开(公告)日：2013-05-30
申请号：PCT/EP2012/073422
申请日：2012-11-23
申请人： BASF SE
发明人： SCHAUB, Thomas , BRUNNER, Bernhard , EBEL, Klaus , PACIELLO, Rocco
IPC分类号： C07C45/00 , C07C35/04 , C07C47/20 , C07C47/21 , C07C45/29
CPC分类号： C07C45/66 , C07C45/002 , C07C45/29 , C07C47/21 , C07C47/20
摘要： The present invention to a process for preparing 2-alkenals of the formula (I) in which R 1 is selected from hydrogen and C 1 -C 4 -alkyl; and R 2 is selected from hydrogen, C 1 -C 12 -alkyl, C 2 -C 12 -alkenyl, C 4 -C 8 -cycloalkyl and C 6 -C- 10 aryl, wherein C 1 -C 12 -alkyl and C 1 -C 12 -alkenyl may be substituted with C 5 -C 7 -cycloalkyl or C 5 -C 7 -cylcoalkenyl; comprising dehydrogenating an alkenol of the formula (II), an alkenol of the formula (III) or a mixture thereof, wherein R 1 and R 2 are each as defined above, wherein the alkenol II, the alkenol III or a mixture thereof is brought into contact with a catalytic system comprising at least one ligand and a metal compound selected from ruthenium(II) compounds and iridium(I) compounds, and wherein the hydrogen formed during the dehydrogenation is removed from the reaction mixture by: i) reaction with a reoxidant selected from C 3 -C 12 -alkanones, C 4 -C 9 -cycoalkanones, benzaldehyde and mixtures thereof; and/or ii) purely physical means.
摘要翻译：本发明涉及一种制备式（I）的2-烯烃的方法，其中R 1选自氢和C 1 -C 4 - 烷基; 并且R 2选自氢，C 1 -C 12 - 烷基，C 2 -C 12 - 链烯基，C 4 -C 8 - 环烷基和C 6 -C 10芳基，其中C 1 -C 12 - 烷基和C 1 -C 12 - 烯基可以被C 5- C7-环烷基或C5-C7-环烯基; 包括使式（II）的烯醇，式（III）的烯醇或其混合物脱氢，其中R 1和R 2各自如上所定义，其中链烯醇II，链烯醇III或其混合物接触具有包含至少一种配体和选自钌（II）化合物和铱（I））化合物的金属化合物的催化体系，并且其中通过以下步骤从反应混合物中除去脱氢过程中形成的氢：i）与选择的再氧化剂反应 C 3 -C 12烷基酮，C 4 -C 9 - 环烷基酮，苯甲醛及其混合物; 和/或ii）纯粹的物理手段。

2. 发明申请

WO2006091005A1 METHOD OF PRODUCING UNSATURATED ALDEHYDE AND/OR UNSATURATED ACID 审中-公开
标题翻译：生产不饱和醛和/或不饱和酸的方法
公开(公告)号：WO2006091005A1
公开(公告)日：2006-08-31
申请号：PCT/KR2006/000596
申请日：2006-02-22
申请人： LG CHEM, LTD.
发明人： YOO, Yeon-shick , SHIN, Hyun-jong , CHOI, Byung-yul , CHOI, Young-hyun , CHO, Young-jin , KIM, Duk-ki , PARK, Joo-yeon , PARK, Kwang-ho
IPC分类号： C07C47/20 , C07C51/145
CPC分类号： B01J35/0006 , B01J8/0453 , B01J8/0457 , B01J8/0496 , B01J8/067 , B01J23/002 , B01J23/8876 , B01J23/8885 , B01J23/8892 , B01J23/8898 , B01J35/10 , B01J35/1009 , B01J35/1014 , B01J2208/025 , B01J2219/0004 , B01J2523/00 , C07C45/34 , C07C45/35 , C07C51/252 , C07C47/21 , C07C47/22 , C07C57/04 , B01J2523/13 , B01J2523/3712 , B01J2523/54 , B01J2523/68 , B01J2523/72 , B01J2523/842 , B01J2523/845 , B01J2523/31 , B01J2523/17 , B01J2523/24 , B01J2523/55 , B01J2523/69 , B01J2523/847
摘要： Disclosed is a shell-and-tube reactor that may be used for fixed-bed catalytic partial oxidation, the reactor being characterized by including at least one reaction zone of a first-step reaction zone for mainly- producing unsaturated aldehydes and a second-step reaction zone for mainly producing unsaturated acids, wherein at least one reaction zone of the above reaction zones comprises two or more catalytic layers; each of the catalytic layers is packed with a formed product of catalyst that is different in pore density and/or pore size in a catalytically active component; and the pore density and/or pore size is controlled in such a manner that specific surface area of the catalytically active component increases from the inlet of the reactor to the outlet of the reactor. A method for producing unsaturated aldehydes and/or unsaturated fatty acids from olefins using the same reactor is also disclosed. According to the present invention, it is possible to control the temperature efficiently at a hot spot, thereby permitting stable use of a catalyst, and to produce unsaturated aldehydes and/or unsaturated fatty acids with high yield.
摘要翻译：公开了可用于固定床催化部分氧化的管壳式反应器，反应器的特征在于包括至少一个用于主要产生不饱和醛的第一步反应区的反应区和第二步用于主要生产不饱和酸的反应区，其中上述反应区的至少一个反应区包含两个或多个催化层; 每个催化层用催化活性组分中孔密度和/或孔径不同的催化剂形成产物填充; 并且以使得催化活性组分的比表面积从反应器的入口增加到反应器的出口的方式来控制孔密度和/或孔径。还公开了使用相同的反应器由烯烃生产不饱和醛和/或不饱和脂肪酸的方法。根据本发明，可以在热点有效地控制温度，从而可以稳定地使用催化剂，并以高产率生产不饱和醛和/或不饱和脂肪酸。

3. 发明申请

WO2010022881A1 HYDROFORMYLATION PROCESS INCLUDING CATALYST RECYCLE 审中-公开
标题翻译：包括催化回收的水解方法
公开(公告)号：WO2010022881A1
公开(公告)日：2010-03-04
申请号：PCT/EP2009/005996
申请日：2009-08-19
申请人： EXXONMOBIL CHEMICAL PATENTS INC. , GARTON, Ronald, D. , VAN DRIESSCHE, Eddy, T. , REED, Corey, W.
发明人： GARTON, Ronald, D. , VAN DRIESSCHE, Eddy, T. , REED, Corey, W.
IPC分类号： C07C45/50 , C07C47/02 , C07C47/20
CPC分类号： C07C45/50 , C07C45/80 , Y02P20/584 , C07C47/02
摘要： An improved hydroformylation catalyst cycle is disclosed wherein the cobalt catalyst is recycled to the hydroformylation reaction mainly as a water soluble carbonyl salt, obtained from extraction of the acidic form of the homogeneous cobalt carbonyl catalyst from the hydroformylation product with an aqueous solution of a salt of a weaker acid. The organic product after extraction is submitted to a further demetalling step in the presence of a dilute acid and an oxidant. The water from this further demetalling step is suitable for use in the upstream extraction step. A free water phase present in the hydroformylation reaction product may be separated upstream from the extraction step and is suitable for use in the further demetalling step, such that the catalyst cycle has no waste water stream.
摘要翻译：公开了一种改进的加氢甲酰化催化剂循环，其中主要以水溶性羰基盐将钴催化剂再循环至加氢甲酰化反应，该水溶性羰基盐是从加氢甲酰化产物中提取酸性形式的均匀钴羰基催化剂得到的，酸弱。提取后的有机产物在稀酸和氧化剂存在下进一步脱金属步骤。来自该进一步脱金属步骤的水适用于上游萃取步骤。存在于加氢甲酰化反应产物中的游离水相可以从萃取步骤的上游分离，并且适合用于进一步脱金属步骤，使得催化剂循环不含废水流。

4. 发明申请

WO2006016912A3 SYNTHESIS OF (-)-BETA-ELEMENE, (-)-BETA-ELEMENAL, (-)-BETA-ELEMENOL, (-)-BETA-ELEMENE FLUORIDE AND THEIR ANALOGUES, INTERMEDIATES AND COMPOSITION AND USES THEREOF 审中-公开
标题翻译：（ - ） - BETA-ELEMENE，（ - ） - BETA-ELEMENOL，（ - ） - BETA-ELEMENE氟化物及其类似物，中间体和组合物的合成及其用途
公开(公告)号：WO2006016912A3
公开(公告)日：2007-02-15
申请号：PCT/US2005014699
申请日：2005-05-02
申请人： LONG RANGE INTERNAT USA LTD IN , HUANG LAN
发明人： HUANG LAN
IPC分类号： C07C13/19 , A61K31/015 , A61K31/025 , A61K31/045 , A61K31/11 , C07C21/18 , C07C35/17 , C07C47/20 , C07C47/21
CPC分类号： C07C49/647 , C07B2200/07 , C07C1/324 , C07C13/19 , C07C33/14 , C07C35/18 , C07C45/30 , C07C47/21 , C07C49/557 , C07C2601/14 , C07C2601/16
摘要： The present invention provides convergent processes for preparing (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, and (-)-beta-elemene fluoride and analogues thereof. Also provided are intermediates useful for preparing (-)-beta-elemene. The present invention further provides novel compositions based on analogues of (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and methods for the treatment of cancer, such as brain tumor, lung cancer, breast cancer, prostate cancer, ovarian cancer, colorectal cancer, gastric intestional cancer, and stomach cancer. The inventors propose a combination therapy using 1) one or more of the following anti-cancer agents: including, but not limited to, Cisplatin, 5-FU, Taxol, Taxol derivatives, and any anti-cancer agent, and 2) one or more of the following (-)-beta-elemene and its analogs, including (-)-beta-elemene, (-)-beta-elemenol, (-)-beta-elemenol, (-)-beta-elemene fluoride, and their analogs, and (-)-beta-elemene's intermediate in its chemical synthesis, for the treatment of cancer, especially for the treatment of brain tumor, lung cancer, ovarian cancer, bladder cancer, cervical cancer,. colon cancer, breast cancer, and prostate cancer.
摘要翻译：本发明提供（ - ） - β-榄香烯，（ - ） - β-元素，（ - ） - β-榄香烯和（ - ） - β-榄香烯氟化物及其类似物的收敛方法。还提供了可用于制备（ - ） - β-榄香烯的中间体。本发明还提供了基于（ - ） - β-榄香烯，（ - ） - β-元素，（ - ） - β-榄香烯，（ - ） - β-榄香烯氟化物类似物和治疗癌症的新方法，例如脑肿瘤，肺癌，乳腺癌，前列腺癌，卵巢癌，结肠直肠癌，胃肠癌和胃癌。本发明人提出了使用以下1种或多种抗癌药物的组合疗法：包括但不限于顺铂，5-FU，紫杉醇，紫杉醇衍生物和任何抗癌剂，以及2）一种或多种（ - ） - β-榄香烯，（ - ） - β-榄香烯，（ - ） - β-榄香烯，（ - ） - β-榄香烯氟化物和他们的类似物和（ - ） - β-榄香烯在其化学合成中的中间体，用于治疗癌症，特别是用于治疗脑肿瘤，肺癌，卵巢癌，膀胱癌，子宫颈癌。结肠癌，乳腺癌和前列腺癌。

5. 发明申请

WO2016091894A1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的改善或有关
公开(公告)号：WO2016091894A1
公开(公告)日：2016-06-16
申请号：PCT/EP2015/079008
申请日：2015-12-08
申请人： GIVAUDAN SA
发明人： BAUMGARTNER, Corinne , FLACHSMANN, Felix
IPC分类号： C07C33/02 , C07C33/18 , C07C47/20 , C11B9/00
CPC分类号： C07C43/23 , C07C69/738 , C11B9/0003 , C11B9/0015
摘要： A fragrance precursor represented by the formula (1) wherein the wavy bond is indicating an unspecified configuration of the adjacent double bond, X and Y together represent a double bond to a carbon atom which is bearing R 1 and R 2 , with R 1 = H, methyl, acetyl or C 1 -C 3 alkoxycarbonyl (e.g. ethoxycarbonyl); and R 2 = phenyl optionally substituted with up to 3 (i.e. 0, 1, 2 or 3) groups selected from C 1 -C 4 alkyl (e.g. methyl, ethyl, iso-propyl, tert-butyl), vinyl, hydroxy, C 1 -C 3 alkoxy (e.g. ethoxy), and -O-CH 2 -O-, e.g. R 2 is benzo[d][1,3]dioxol-5-yl, 4-methylphenyl, 4-methoxyphenyl, 4-vinylphenyl or 3-ethoxy-4-hydroxyphenyl or R 2 = naphthyl, (naphthyl)methyl, 1,1,2,4,4,8-hexamethyl-1,2,3,4-tetrahydronaphthalen-7-yl, or 1,1,2,4,4,-pentamethyl-1,2,3,4-tetrahydronaphthalen-7-yl or R 2 = COR3, wherein R 3 is H, C 1 -C 10 alkoxy (e.g. ethoxy, 1-(3,3-dimethylcyclohexyl)ethoxy), C 1- C 4 alkyl (e.g. methyl, ethyl, propyl, iso-propyl, tert-butyl), e.g. R 2 is formyl, acetyl, ethoxycarbonyl, 1-(3,3-dimethylcyclohexyl)ethoxycarbonyl; or wherein X is OR 4 , with R 4 being H, alkyl or alkenyl, and Y is OR 5 , with R 5 being alkyl or alkenyl; the compound being useful as a perfume ingredient.
摘要翻译：由式（1）表示的香料前体，其中波状键表示相邻双键的未指定构型，X和Y一起表示与带有R 1和R 2的碳原子的双键，其中R 1 = H，甲基，乙酰基或C 1 -C 3烷氧基羰基（如乙氧羰基）; 并且R2 =任选被至多3个（即0,1,2或3）选自C 1 -C 4烷基（例如甲基，乙基，异丙基，叔丁基），乙烯基，羟基，C 1 -C 3烷氧基（例如乙氧基）和-O-CH2-O-，例如 R2是苯并[d] [1,3]二氧杂环戊烯-5-基，4-甲基苯基，4-甲氧基苯基，4-乙烯基苯基或3-乙氧基-4-羟基苯基或R 2 =萘基，（萘基）甲基， 2,4,4,8-六甲基-1,2,3,4-四氢萘-7-基或1,1,2,4,4 - 五甲基-1,2,3,4-四氢萘-7-酮，或R 2 = COR 3，其中R 3为H，C 1 -C 10烷氧基（例如乙氧基，1-（3,3-二甲基环己基）乙氧基），C 1 -C 4烷基（例如甲基，乙基，丙基，异丙基，叔丁基），例如 R2是甲酰基，乙酰基，乙氧基羰基，1-（3,3-二甲基环己基）乙氧基羰基; 或其中X为OR4，其中R4为H，烷基或烯基，Y为OR5，R5为烷基或烯基; 该化合物可用作香料成分。

6. 发明申请

WO2015160114A1 하이드록시피브알데히드의 제조방법 审中-公开
标题翻译：制备羟基戊酸的方法
公开(公告)号：WO2015160114A1
公开(公告)日：2015-10-22
申请号：PCT/KR2015/003185
申请日：2015-03-31
申请人： 한화케미칼 주식회사
发明人： 신연란 , 장남진 , 김지연 , 이선옥 , 조재억
IPC分类号： C07C45/78 , C07C47/20
CPC分类号： C07C45/78 , C07C47/19
摘要： 본 발명은 특정 농도의 파라포름알데히드 수용액을 이용한 하이드록시피브알데히드의 제조방법에 관한 것이다. 구체적으로, 본 발명에 따르면 파라포름알데히드를 특정 농도의 수용액으로 용해시켜 알돌 반응에 이용함으로써, 파라포름알데히드의 리사이클링이 가능하고 폐수 절감에 기여할 수 있는 하이드록시피브알데히드의 제조방법이 제공된다.
摘要翻译：本发明涉及使用特定浓度的多聚甲醛水溶液制备羟基甲醛的方法。具体地，根据本发明，提供了一种制备羟甲基甲醛的方法，其可以通过将多聚甲醛溶解在用于醛醇缩合反应的特定浓度的水溶液中来再循环多聚甲醛并有助于还原废水。

7. 发明申请

WO2017010618A1 인계 리간드를 포함하는 촉매 조성물 및 이를 이용한 하이드로포밀화 방법 审中-公开
标题翻译：含有磷基的配体的催化组合物和使用其的氢化方法
公开(公告)号：WO2017010618A1
公开(公告)日：2017-01-19
申请号：PCT/KR2015/011011
申请日：2015-10-19
申请人： (주) 엘지화학
发明人： 김미영 , 최민지 , 엄성식 , 고동현 , 정다원 , 김태윤
IPC分类号： B01J31/18 , C07C45/50 , C07C47/20
CPC分类号： B01J31/2404 , B01J31/185 , B01J31/20 , B01J31/2234 , B01J31/24 , B01J2231/321 , B01J2531/82 , B01J2531/822 , B01J2531/84 , C07C45/50 , C07C45/505 , C07C47/20
摘要： 본 발명은 본 발명은 인계 리간드를 포함하는 촉매 조성물 및 이를 이용한 하이드로포밀화 방법에 관한 것으로, 보다 상세하게는 일배위 포스파이트 리간드; 일배위 포스핀 리간드; 및 전이금속 촉매를 포함하되, 상기 일배위 포스파이트 리간드 및 일배위 포스핀 리간드를 합한 전체 리간드의 함량은 상기 전이금속 촉매 1몰을 기준으로 1 내지 33 몰인 촉매 조성물 및 이를 이용한 하이드로포밀화 방법에 관한 것이다. 본 발명에 따르면 본 발명에 따르면 올레핀계 화합물의 하이드로포밀화 반응 시, 생성되는 알데히드의 노르말/이소의 선택비(n/i ratio)를 낮추고, 촉매 활성 및 안정성이 우수한 촉매 조성물을 제공하고, 이를 이용한 올레핀계 화합물의 하이드로포밀화 방법을 제공하는 효과가 있다.
摘要翻译：本发明涉及含有磷系配体的催化剂组合物及其加氢甲酰化方法，更具体地说涉及含有：单齿亚磷酸酯配位体的催化剂组合物; 单齿膦配体; 和过渡金属催化剂，其中包括单齿亚磷酸酯配体和单齿膦配体的总体配体的含量为1摩尔过渡金属催化剂的1-33摩尔，以及使用其的加氢甲酰化方法。本发明具有以下效果：提供催化剂组合物，其在烯烃类化合物的加氢甲酰化时降低生成的醛中的正/异（n / i）比，并具有优异的催化活性和稳定性; 并提供使用其的烯烃类化合物的羰基化方法。

8. 发明申请

WO2010022880A1 OFFGAS CLEANUP IN OLEFIN HYDROFORMYLATION 审中-公开
标题翻译：在OLEFIN HYDROFORMYLATION的OFFGAS清洁
公开(公告)号：WO2010022880A1
公开(公告)日：2010-03-04
申请号：PCT/EP2009/005995
申请日：2009-08-19
申请人： EXXONMOBIL CHEMICAL PATENTS INC. , VAN DRIESSCHE, Eddy, T. , GARTON, Ronald, D. , CAERS, Raphael, Frans, Ivo
发明人： VAN DRIESSCHE, Eddy, T. , GARTON, Ronald, D. , CAERS, Raphael, Frans, Ivo
IPC分类号： C07C45/50 , C07C47/02 , C07C47/20
CPC分类号： C07C45/50 , C07C29/141 , C07C45/783 , C07C67/08 , C07C67/303 , C07C2601/14 , C07C69/82 , C07C69/75 , C07C47/02 , C07C31/125
摘要： In the hydroformylation of C5-C14 olefins with cobalt catalyst to produce C6-C15 oxygenates, where offgasses from the hydroformylation or cobalt removal step contain volatile cobalt compounds, the cobalt compounds are recovered by scrubbing the offgas with a liquid, and recycling the liquid to the cobalt removal step. Suitable scrubbing liquids are the organic cobalt-depleted hydroformylation reaction product or a downstream derivative thereof, or an aqueous solution of a Co 2+ salt, preferably such salt of formic acid.
摘要翻译：在用钴催化剂加氢甲酰化C5-C14烯烃以产生C6-C15含氧化合物，其中来自加氢甲酰化或脱钴步骤的废气含有挥发性钴化合物，通过用液体洗涤废气回收钴化合物，并将液体再循环至钴去除步骤。合适的洗涤液体是有机贫钴加氢甲酰化反应产物或其下游衍生物，或Co2 +盐的水溶液，优选甲酸盐。

9. 发明申请

WO2007006532A1 NEW PYROCATECHIN DERIVATIVES 审中-公开
标题翻译：新的吡咯烷酮衍生物
公开(公告)号：WO2007006532A1
公开(公告)日：2007-01-18
申请号：PCT/EP2006/006731
申请日：2006-07-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , SEDELMEIER, Gottfried , NEBEL, Kurt , VEENSTRA, Siem, Jacob , ZERGENYI, Janos
发明人： SEDELMEIER, Gottfried , NEBEL, Kurt , VEENSTRA, Siem, Jacob , ZERGENYI, Janos
IPC分类号： C07D307/32 , C07C47/20
CPC分类号： C07C69/96 , C07C45/676 , C07C45/71 , C07C49/84 , C07C68/06 , C07D307/33
摘要： Pyrocatechin derivatives of formula I wherein R illustrates a group of formulae Ia, Ib, Ic or Id R 1 is 4-halogen-but-2-enyl, R 2 is lower alkyl or cycloalkyl, R 3 is lower alkoxy and R 4 is lower alkoxy lower alkoxy, or, where R is a group of formula (Ia), it is hydroxy, hydroxy lower alkoxy or a group of formula Ie R 5 is reactive esterified hydroxy, R 6 is azido and R 7 is lower alkyl, lower alkenyl, cycloalkyl or aryl lower alkyl, and their salts, are valuable intermediates in the production of active ingredients for medicaments.
摘要翻译：其中R表示式Ia，Ib，Ic或Id R 1的基团的式I的焦儿茶酸衍生物是4-卤素 - 丁-2-烯基，R 2是较低的烷基或环烷基，R 3是低级烷氧基，R 4是低级烷氧基低级烷氧基，或其中R是式（Ia）的基团，它是羟基，羟基低级烷氧基或式Ie R 5的基团是反应性酯化羟基，R 6是叠氮基，R 7是低级烷基，低级烯基，环烷基或芳基低级烷基及其盐是制备药物活性成分的有价值的中间体。

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