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1. 发明申请

WO2005112670A8 MOLECULARLY IMPRINTED POLYMERS SELECTIVE FOR NITROSAMINES AND METHODS OF USING THE SAME 审中-公开
标题翻译：选择用于硝基胺的分子内置聚合物及其使用方法
公开(公告)号：WO2005112670A8
公开(公告)日：2006-08-24
申请号：PCT/SE2005000773
申请日：2005-05-24
申请人： MIP TECHNOLOGIES AB , BRITISH AMERICAN TOBACCO CO , BHATTACHARYYA SUMITA , MCADAM KEVIN , REES ANTHONY , SELLERGREN BOERJE , WIDSTRAND CHRISTINE
发明人： BHATTACHARYYA SUMITA , MCADAM KEVIN , REES ANTHONY , SELLERGREN BOERJE , WIDSTRAND CHRISTINE
IPC分类号： C07B63/00 , A24B15/18 , A24B15/24 , A24D3/12 , C07C243/06 , C07D213/42 , C08F236/02
CPC分类号： A24B15/245 , A24B15/24 , A24D3/02 , A24D3/067 , A24D3/08 , B01D15/3852 , B01J20/268 , C08F222/14 , G01N33/0098
摘要： A class of molecularly imprinted polymers that specifically recognizes and binds to nitrosamines members of which class are useful, for example, in analysis and separation of nitrosamines from biological fluids. Such molecularly imprinted polymers are also useful in methods of treating and manufacturing tobacco products and materials.
摘要翻译：一类分子印迹聚合物，其特异性识别并结合亚硝胺成员，其中可用于例如亚硝胺与生物流体的分析和分离。这种分子印迹聚合物也可用于治疗和制造烟草制品和材料的方法。

2. 发明申请

WO2005051896A1 NITROSO DERIVATIVES OF DIPHENYLAMINE 审中-公开
标题翻译：二苯胺的硝基衍生物
公开(公告)号：WO2005051896A1
公开(公告)日：2005-06-09
申请号：PCT/EP2004/014892
申请日：2004-11-17
申请人： MERCK PATENT GMBH , LARDY, Claude , GUEDAT, Philippe , CAPUTO, Lidia
发明人： LARDY, Claude , GUEDAT, Philippe , CAPUTO, Lidia
IPC分类号： C07C243/06
CPC分类号： A61K31/165 , A61K31/135 , A61K31/275 , A61K31/655 , C07C243/06 , C07C255/63 , C07C317/34 , C07C317/36 , C07C323/48
摘要： The invention relates to a compound of the formula (I) in which: - R 1 represents, independently of each other, a halogen atom; an aliphatic hydrocarbon-based group optionally substituted and/or optionally interrupted by one or more oxygen or sulfur atoms; a nitro group; a cyano group; an amino group; a mono- or dialkylamino group; an alkylcarbonyl group; a carboxyl group; an alkylcarbonylamino group; an alkylsulfonyl group; - R 2 represents, independently of each other, a cyano group; a hydroxyl group, an alkylcarbonyl group; a carboxyl group; an alkoxycarbonyl group; an unsubstituted amide group; or a linear or branched alkyl group substituted by a cyano, hydroxyl, carboxyl, alkoxycarbonyl or unsubstituted amide group; - i and j independently being 1 to 5, with the exclusion of the compound for which i and j = 1 and R 1 = carboxyl and R 2 = alkoxycarbonyl or R 1 = CF 3 and R 2 = carboxyl, and also the pharmaceutically acceptable derivatives, salts, solvates and stereoisomers thereof, including mixtures thereof in all proportions.
摘要翻译：本发明涉及式（I）的化合物，其中：-R 1彼此独立地表示卤素原子; 任选被一个或多个氧或硫原子取代和/或任选地中断的脂族烃基; 硝基; 氰基; 氨基; 单或二烷基氨基; 烷基羰基; 羧基; 烷基羰基氨基; 烷基磺酰基; -R 2彼此独立地表示氰基; 羟基，烷基羰基; 羧基; 烷氧基羰基; 未取代的酰胺基; 或被氰基，羟基，羧基，烷氧基羰基或未取代的酰胺基取代的直链或支链烷基; - i和j独立地为1至5，排除i和j = 1且R1 =羧基和R2 =烷氧基羰基或R1 = CF3和R2 =羧基的化合物，以及其药学上可接受的衍生物，盐，溶剂合物其立体异构体，包括其各种比例的混合物。

3. 发明申请

WO2017223182A1 NITRIC OXIDE DONORS 审中-公开
标题翻译：氧化氮供体
公开(公告)号：WO2017223182A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038509
申请日：2017-06-21
申请人： MEDCHEM PARTNERS, LLC.
发明人： RIESINGER, Steven , LAZAROVA, Tsvetelina , RIBOVSKAIA, Zinadia
IPC分类号： C07C243/06 , A61K31/15 , C07C243/42 , C07C29/08
摘要： The present invention provides, in part a novel class of nonoate compounds which exhibit nitric oxide releasing activity and their pharmaceutically acceptable salts, esters and prodrugs. The compounds release nitric oxide upon activation by contact with plasma. The present invention also relates to the use of the disclosed compounds to deliver nitric oxide to treat disorders arising from nitric oxide dysregulation.
摘要翻译：本发明部分地提供了一类新型的表现出一氧化氮释放活性的无酸化合物及其药学上可接受的盐，酯和前体药物。该化合物通过与血浆接触而活化后释放一氧化氮。本发明还涉及所公开的化合物递送一氧化氮以治疗由一氧化氮调节异常引起的病症的用途。

4. 发明申请

WO2007117404A2 METHODS AND MATERIALS FOR PREPARING ORGANIC COMPOUNDS FROM PRIMARY AMINES 审中-公开
标题翻译：从主要原料制备有机化合物的方法和材料
公开(公告)号：WO2007117404A2
公开(公告)日：2007-10-18
申请号：PCT/US2007008221
申请日：2007-03-30
申请人： UNIV VIRGINIA , GEYSEN H MARIO , GINESTE CYRILLE
发明人： GEYSEN H MARIO , GINESTE CYRILLE
IPC分类号： C07C243/06
CPC分类号： C07C17/093 , C07C19/075
摘要： Methods are disclosed for the conversion of primary amines to other functional groups. The methods can be used to prepare chiral organic compounds, including organic alcohols and organic halides. The methods can be carried out by treating a primary amine with an activating agent and a nitrosyl agent to produce the transformed compound along with nitrous oxide.
摘要翻译：公开了将伯胺转化成其它官能团的方法。该方法可用于制备手性有机化合物，包括有机醇和有机卤化物。该方法可以通过用活化剂和亚硝酰基试剂处理伯胺以与一氧化二氮一起生产转化的化合物来进行。

5. 发明申请

WO2020002338A1 PROCESS FOR THE PREPARATION OF CYCLOPROPANE COMPOUNDS USING DIAZO-COM POUNDS 审中-公开
公开(公告)号：WO2020002338A1
公开(公告)日：2020-01-02
申请号：PCT/EP2019/066849
申请日：2019-06-25
申请人： GIVAUDAN SA
发明人： SCHRÖDER, Fridtjof , STECK, Marcel
IPC分类号： C07C2/86 , C07C13/04 , C07C221/00 , C07C225/06 , C07C241/00 , C07C243/06
摘要： A process for the continuous production of a reaction product of a diazo‐compound and a substrate in a multi‐stage flow reactor is disclosed.

6. 发明申请

WO2012099770A3 DIAZENIUMDIOLATE DERIVATIVES 审中-公开
标题翻译： DIAZENIUMDOLATE DERIVATIVES
公开(公告)号：WO2012099770A3
公开(公告)日：2012-11-15
申请号：PCT/US2012021048
申请日：2012-01-12
申请人： MERCK SHARP & DOHME , ALI AMJAD , LO MICHAEL MAN-CHU , METZGER EDWARD , SHAH SHRENIK K , DELLUREFICIO JAMES
发明人： ALI AMJAD , LO MICHAEL MAN-CHU , METZGER EDWARD , SHAH SHRENIK K , DELLUREFICIO JAMES
IPC分类号： C07C245/04 , A61K31/04 , A61P9/12 , C07C243/06
CPC分类号： C07C291/02 , A61K45/06 , C07C291/08
摘要： A compound having the structure (I) useful for treating hypertension, pulmonary arterial hypertension, congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
摘要翻译：具有用于治疗高血压，肺动脉高压，充血性心力衰竭，由过度保水，心血管疾病，糖尿病，氧化应激，内皮功能障碍，肝硬化，先兆子痫，骨质疏松症或肾病引起的病症的结构（I）的化合物。

7. 发明申请

WO00078711A1 STABILIZATION OF N-NITROSOHYDROXYLAMINES BY USE OF ABSORPTIVE MATERIAL 审中-公开
标题翻译：使用吸收材料稳定N-硝基甲硅烷基胺
公开(公告)号：WO00078711A1
公开(公告)日：2000-12-28
申请号：PCT/US2000/016058
申请日：2000-06-12
IPC分类号： C07C243/06 , C07C243/04 , C07F5/06 , C08F2/40
CPC分类号： C08F2/40 , C07C243/04
摘要： N-Nitrosohydroxylamine compounds exhibiting minimal or no degradation are disclosed. The N-nitrosohydroxylamines can be stabilized in the presence of a compound capable of removing water from the environment.
摘要翻译：公开了表现出最小或不降解的N-亚硝基羟胺化合物。在能够从环境中除去水的化合物的存在下，N-亚硝基羟胺可以被稳定化。

8. 发明申请

WO2017046122A1 PROCESS FOR THE CYCLOPROPANATION OF OLEFINS USING N-METHYL-N-NITROSO COMPOUNDS 审中-公开
标题翻译：使用N-甲基-N-硝基化合物的烯烃的环化方法
公开(公告)号：WO2017046122A1
公开(公告)日：2017-03-23
申请号：PCT/EP2016/071630
申请日：2016-09-14
申请人： GIVAUDAN SA
发明人： SCHROEDER, Fridtjof , STECK, Marcel
IPC分类号： C07C2/86 , C07C13/04 , C07C241/00 , C07C243/06
CPC分类号： C07C241/00 , C07C2/86 , C07C2523/44 , C07C2531/20 , C07C2601/02 , C07C13/04 , C07C243/06
摘要： A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.
摘要翻译：将底物上的碳 - 碳双键转化为环丙烷环的方法，该方法包括用N-烷基-N-亚硝基化合物，过渡金属催化剂和碱水溶液处理底物的步骤，其中N - 烷基-N-亚硝基化合物是通过在单碱式或二碱性或其混合物存在下使烷基胺与碱金属亚硝酸盐反应形成的，其中N-烷基-N-亚硝基化合物是在与底物，催化剂和碱混合之前不蒸馏。

9. 发明申请

WO2012099770A2 DIAZENIUMDIOLATE DERIVATIVES 审中-公开
标题翻译： DIAZENIUMOOLOLA衍生物
公开(公告)号：WO2012099770A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021048
申请日：2012-01-12
申请人： MERCK SHARP & DOHME CORP. , ALI, Amjad , LO, Michael Man-Chu , METZGER, Edward , SHAH, Shrenik, K. , DELLUREFICIO, James
发明人： ALI, Amjad , LO, Michael Man-Chu , METZGER, Edward , SHAH, Shrenik, K. , DELLUREFICIO, James
IPC分类号： C07C245/04 , C07C243/06 , A61K31/04 , A61P9/12
CPC分类号： C07C291/02 , A61K45/06 , C07C291/08
摘要： A compound having the structure (I) useful for treating hypertension, pulmonary arterial hypertension, congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
摘要翻译：具有结构（I）的化合物，其可用于治疗高血压，肺动脉高压，充血性心力衰竭，由过度保水引起的病症，心血管疾病，糖尿病，氧化应激，内皮功能障碍，肝硬化，先兆子痫，骨质疏松症或肾病。

10. 发明申请

WO2007117404A9 METHODS AND MATERIALS FOR PREPARING ORGANIC COMPOUNDS FROM PRIMARY AMINES 审中-公开
标题翻译：从原始胺制备有机化合物的方法和材料
公开(公告)号：WO2007117404A9
公开(公告)日：2007-11-29
申请号：PCT/US2007008221
申请日：2007-03-30
申请人： UNIV VIRGINIA , GEYSEN H MARIO , GINESTE CYRILLE
发明人： GEYSEN H MARIO , GINESTE CYRILLE
IPC分类号： C07C243/06
CPC分类号： C07C17/093 , C07C19/075
摘要： Methods are disclosed for the conversion of primary amines to other functional groups. The methods can be used to prepare chiral organic compounds, including organic alcohols and organic halides. The methods can be carried out by treating a primary amine with an activating agent and a nitrosyl agent to produce the transformed compound along with nitrous oxide.
摘要翻译：公开了将伯胺转化为其他官能团的方法。该方法可用于制备手性有机化合物，包括有机醇和有机卤化物。该方法可以通过用活化剂和亚硝基试剂处理伯胺以产生转化的化合物以及氧化亚氮来进行。

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