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1. 发明申请

WO1984002478A1 END CLOSURE FOR TUBULAR HOUSING 审中-公开
标题翻译：用于管状住宅的封闭
公开(公告)号：WO1984002478A1
公开(公告)日：1984-07-05
申请号：PCT/US1983001628
申请日：1983-10-17
申请人： BAXTER TRAVENOL LABORATORIES, INC.
发明人： BAXTER TRAVENOL LABORATORIES, INC. , TOBIASZ, Henry, E.
IPC分类号： B01D31/00
CPC分类号： F28F21/067 , B01D63/02 , B01D63/021 , B01D2313/04 , B01D2313/21 , B29C65/00 , B29C66/1162 , B29C66/5344 , F28F9/0219
摘要： An end closure for a tubular housing (12) comprises an end cap (22) fitting over the end of the tubular housing, the end cap defining an internal annular face (28) defining, in turn, an angle of essentially 5 to 70 to the axis of the tubular housing. The end of the tubular housing is positioned in bonded relationship with the annular face.
摘要翻译：用于管状壳体（12）的端盖包括装配在管状壳体的端部上的端盖（22），端盖限定内部环形面（28），所述内部环形面（28）又基本上限定为5° 至70°至管状壳体的轴线。管状壳体的端部与环形面接合。

2. 发明申请

WO1985002554A1 CONTROLLING TRANSMEMBRANE PRESSURE IN MEMBRANE PLASMA FILTRATION 审中-公开
标题翻译：控制薄膜等离子体过滤中的转印膜压力
公开(公告)号：WO1985002554A1
公开(公告)日：1985-06-20
申请号：PCT/US1984001800
申请日：1984-11-05
申请人： BAXTER TRAVENOL LABORATORIES, INC.
发明人： BAXTER TRAVENOL LABORATORIES, INC. , BILSTAD, Arnold, C. , BROWN, Richard, I.
IPC分类号： B01D31/00
CPC分类号： B01D61/22 , A61M1/3496 , B01D63/02 , B01D2313/19
摘要： Method and apparatus for controlling the pressure differential across the filter membrane (14) in membrane plasma filtration apparatus (12). Control means (26) in fluid communication with a plasma-containing fluid flow path (30) up-stream of the filter membrane (14) and cooperatively associated with the plasma filtrate flow path (32), is operable to vary the size of the plasma filtrate flow path (32) inversely with respect to changes in the pressure in the plasma-containing fluid, thereby maintaining the differential pressure substantially constant. The control means includes a movable surface (34) disposed for contact with fluid in the fluid flow path (30) upstream of the membrane (14), the surface (34) being movable upon pressure changes in the blood flow path (30) to vary the size of the plasma filtrate flow path (32). The movable surface (34) is biased to a normally open plasma filtrate flow path condition by a force of selected amount corresponding to the desired pressure differential.
摘要翻译：用于控制膜等离子体过滤装置（12）中的过滤膜（14）上的压力差的方法和装置。与过滤膜（14）上游的等离子体流体流动路径（30）流体连通并与血浆滤液流路（32）协作地相关联的控制装置（26）可操作以改变血浆滤液流路（32）相对于等离子体流体中的压力变化相反，从而保持差压基本恒定。所述控制装置包括可移动表面（34），所述可移动表面（34）设置成与所述流体流动路径（30）中的流体在所述膜（14）上游相接触，所述表面（34）可在所述血液流路（30）中的压力变化改变血浆滤液流路（32）的大小。可移动表面（34）通过对应于期望压力差的选定量的力而被偏压到常开的等离子体滤液流路条件。

3. 发明申请

WO1984001522A1 FILTER 审中-公开
标题翻译：过滤
公开(公告)号：WO1984001522A1
公开(公告)日：1984-04-26
申请号：PCT/US1983001340
申请日：1983-09-01
申请人： BAXTER TRAVENOL LABORATORIES, INC.
发明人： BAXTER TRAVENOL LABORATORIES, INC. , SHAH, Dilip, H. , KOPP, Clinton
IPC分类号： B01D31/00
CPC分类号： B01D63/04 , B01D63/02 , B01D2313/125
摘要： A filter (10) and a method of filtering fluids. In the filter (10), a plurality of porous, hollow fibers (20) surround a central tube (18) and are contained by a housing (12). The ends of the assembly are potted with a sealant to define first and second sealant-impregnated ends (22, 24) having open flow paths through the hollow fibers (20) and central tube (18) from one end to the other. A manifold (16) defining a typically closed chamber covers one end of the assembly and another manifold (14) covers the other end and defines a fluid portal (26) to the tube (18) and hollow fibers (20). Fluid may be filtered by passing it through the pores of the hollow fibers (20) from the outside to the inside and draining fluid from the portal (26). Alternatively, filtering of a fluid may be accomplished by introducing fluid through the portal (26) and passing it through the pores of the hollow fibers (20) from inside to out.
摘要翻译：过滤器（10）和过滤流体的方法。在过滤器（10）中，多个中空纤维（20）围绕中心管（18）并由壳体（12）容纳。组件的端部用密封剂封装以限定具有从一端到另一端穿过中空纤维（20）和中心管（18）的开放流动路径的第一和第二密封剂浸渍端部（22,24）。限定通常封闭的腔室的歧管（16）覆盖组件的一端，另一个歧管（14）覆盖另一端并且限定到管（18）和中空纤维（20）的流体入口（26）。可以通过将中空纤维（20）的孔从外部传递到内部并从入口（26）排出流体来将流体过滤。或者，流体的过滤可以通过将流体引入入口（26）并将其从内向外通过中空纤维（20）的孔而实现。

4. 发明申请

WO1981001800A1 FLOW REVERSING MECHANISM FOR USE IN A DIALYSIS MACHINE 审中-公开
标题翻译：流动反转机构用于透析机
公开(公告)号：WO1981001800A1
公开(公告)日：1981-07-09
申请号：PCT/US1980000952
申请日：1980-07-28
申请人： BAXTER TRAVENOL LAB INC , SCHNELL W
发明人： BAXTER TRAVENOL LAB INC
IPC分类号： B01D31/00
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/3334
摘要： Dialysis machine (10) adapted for operation with a negative-pressure-type dialyzer (12, 200). The machine (10) includes a flow system (14, 16, 26, 34, 36, 100, 46, 48, 52, 56, 58) having a negative pressure pump (56) for drawing fresh dialysis solution through a dialyzer (12, 200) under a controllable negative pressure and for discharging spent dialysis solution to a drain (58). A flow reversing valve system (100, 102, 104, 106, 108) is positioned in the flow system for cooperation with the dialyzer (12, 200) to selectively control the direction of dialysis solution flow within the dialyzer (12, 200) in either a first direction or a second reverse direction. The flow reversing valve system (100) is operative in a first mode to control direction of flow to and from the dialyzer in a first direction and in a second mode to reverse the direction of flow. The dialysis machine (10) also includes a very effective degassing system (16, 18, 20, 22, 56) which minimizes gas build-up on the dialysis solution side of the dialyzer (12, 200) so that when a hollow-fiber dialyzer (12) is used the normal dialysis solution flow is in a downward direction and blood flow is in an upward direction. The flow reversing system (100) may be integral with the machine (10) or may be a separate component for use with machines that do not include an integral or built-in flow reversing system. Finally, a method is disclosed herein for operating such a system which avoids the previous requirements for positioning and repositioning of the dialyzer during dialysis set-up.
摘要翻译：适用于负压型透析器（12,200）的透析机（10）。机器（10）包括具有负压泵（56）的流动系统（14,16,26,34,36,100,46,48,52,56,58），用于将新鲜的透析溶液通过透析器（12 ，200），并且用于将废透析溶液排放到排水口（58）。流量换向阀系统（100,102,104,106,108）定位在流动系统中，用于与透析器（12,200）配合，以选择性地控制渗透溶液在透析器（12,200）内的流动方向第一方向或第二反向方向。流动换向阀系统（100）以第一模式操作以控制在第一方向和第二模式中从透析器流出的流动方向以逆转流动方向。透析机（10）还包括非常有效的脱气系统（16,18,20,22,56），其最小化透析器（12,200）的透析溶液侧上的气体积聚，使得当中空纤维使用透析器（12），正常透析液流向下方，血流呈向上方向。流动反向系统（100）可以与机器（10）成一体，或者可以是与不包括整体或内置的流动反向系统的机器一起使用的单独组件。最后，本文公开了用于操作这样的系统的方法，其避免了在透析设置期间对透析器的定位和重新定位的先前要求。

5. 发明申请

WO1981001247A1 INTEGRAL ARTIFICIAL KIDNEY UNIT 审中-公开
标题翻译：综合人造犬科
公开(公告)号：WO1981001247A1
公开(公告)日：1981-05-14
申请号：PCT/US1979000966
申请日：1979-11-01
申请人： NEWHART R
发明人： NEWHART R , NEWHART E
IPC分类号： B01D31/00
CPC分类号： B01D61/28 , B01D63/06 , B01D63/08 , B01D2313/10 , B01D2313/12
摘要： An integral artificial kidney unit (and a process of making); formed of four opposed plastic sheets bonded together, the composition of the inner second pair of opposed thin sheets being selected for their high permeability to blood waste products in hemodialysis; is relatively easily made and has good diffusion characteristics. The inner second pair of bonded sheets provides an integral perfusion unit. The outer first pair of plastic sheets are bonded at their exterior edges, forming a dialyzate chamber (20), having an inlet port (22) and an outlet port (23), and also are bonded to a blood inlet tube (31) and a blood outlet tube (32) of the enclosed integral perfusion unit. More than one perfusion unit can be interconnected in parallel to a common blood inlet tube and a common blood outlet tube. Each integral perfusion unit has a single blood inlet port symmetrically disposed and interconnected to a blood inlet manifold, the inlet manifold disposed across and interconnected to multiple parallel blood tubules having small diameters. The blood outlet manifold is disposed across and interconnected to the termini of the multiple blood tubules opposite the blood inlet manifold. A blood outlet port is interconnected to the blood outlet manifold.
摘要翻译：一个完整的人造肾单位（和一个制作过程）; 由连接在一起的四个相对的塑料片形成，内部第二对相对薄片的组成被选择用于其对血液透析中血液废物的高渗透性; 相对容易制造并具有良好的扩散特性。内部的第二对粘合片提供了一体的灌注单元。外部第一对塑料片在其外部边缘处接合，形成具有入口端口（22）和出口（23）的透析液室（20），并且还结合到血液入口管（31）和封闭整体灌注单元的出血管（32）。可以将多于一个的灌注单元并联到共同的血液入口管和共同的血液出口管。每个整体灌注单元具有对称地设置并互连到血液入口歧管的单一血液入口端口，入口歧管布置成跨越并互连到具有小直径的多个平行的血管。血液出口歧管布置在与血液入口歧管相对的多个血液小管的末端并互连。血液出口与血液出口歧管相互连接。

6. 发明申请

WO1985004341A1 INTERNAL DIALYZER WITH WEARABLE EXTERNAL REGENERATION 审中-公开
标题翻译：内部DIALYZER具有外部再生能力
公开(公告)号：WO1985004341A1
公开(公告)日：1985-10-10
申请号：PCT/US1985000522
申请日：1985-03-26
申请人： RESEARCH DEVELOPMENT SYSTEMS, INC.
发明人： RESEARCH DEVELOPMENT SYSTEMS, INC. , SCOTT, Robert, D.
IPC分类号： B01D31/00
CPC分类号： A61M1/1696 , A61M1/1678 , A61M1/28 , A61M1/284 , A61M2209/088 , A61M2210/1017
摘要： Wearable, continuously internally operable, externally regenerable dialysis system in which body fluids are dialyzed against a first dialysis fluid within a chamber (24) in the body without invasion of veins or arteries, the chamber (24) being a body cavity or a semi-permeable wall within the body, the dialysis fluid being regenerated in a chamber (26) outside the body against a second dialysis fluid which is continuously regenerated in a belt supported apparatus (22), the internal and external chambers being in fluid communication.

7. 发明申请

WO1984000015A1 WETTABLE HYDROPHOBIC HOLLOW FIBERS 审中-公开
标题翻译：可湿式疏水中空纤维
公开(公告)号：WO1984000015A1
公开(公告)日：1984-01-05
申请号：PCT/US1983000495
申请日：1983-04-06
申请人： BAXTER TRAVENOL LABORATORIES, INC.
发明人： BAXTER TRAVENOL LABORATORIES, INC. , BOGGS, Daniel, R. , McGLOTHLIN, Mark, W.
IPC分类号： B01D31/00
CPC分类号： B01D67/0088 , B01D63/021
摘要： A bundle (12) of hydrophobic membranes (18) made of hydrophobic plastic containing micropores of less than 10 microns in diameter is treated with an organic solvent containing monoester-type surface active agent to coat the micropores, to permit aqueous liquid to easily flow through the micropores. The coated membranes (18) are not toxic and are particularly compatible with blood, exhibiting very low hemolysis.
摘要翻译：用含有直径小于10微米的微孔的疏水性塑料制成的疏水膜（18）束（12）用含有单酯型表面活性剂的有机溶剂进行处理以涂覆微孔，以使含水液体容易地流过微孔。涂膜（18）无毒性，与血液特别相容，表现出非常低的溶血。

8. 发明申请

WO1982000775A1 FLUID TREATMENT APPARATUS 审中-公开
标题翻译：流体处理设备
公开(公告)号：WO1982000775A1
公开(公告)日：1982-03-18
申请号：PCT/AU1981000126
申请日：1981-09-03
申请人： MEMTEC LAB PTY LTD , LEFEBVRE M
发明人： MEMTEC LAB PTY LTD
IPC分类号： B01D31/00
CPC分类号： B01D65/08 , B01D61/18 , B01D63/084 , B01D2313/02 , B01D2321/02 , B01D2321/10
摘要： Apparatus for altering the concentration of a pre-selected component (11) of a feedstock (12) wherein the feedstock (12) flows through flow paths bounded by overlying barriers (13) which selectively pass the component (11). Flow of feedstock (12) elastically separates the barriers (13) to maintain laminar now therebetween. The preselected component (11) may be routed to flow selectively through the barriers (13) either into or out of the feedstock (12).
摘要翻译：用于改变原料（12）的预先选择的组分（11）的浓度的装置，其中原料（12）流过选择性地通过组分（11）的上覆障碍物（13）限定的流动路径。原料（12）的流动弹性地分离阻挡层（13）以保持其间的层流。预选组分（11）可以被选择性地通过阻挡层（13）流入或流出原料（12）。

9. 发明申请

WO1982000102A1 MEMBRANE PLASMAPHERESIS MODULE 审中-公开
标题翻译：薄膜等离子体模块
公开(公告)号：WO1982000102A1
公开(公告)日：1982-01-21
申请号：PCT/US1981000527
申请日：1981-04-17
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , EDELMAN W , SCHNELL W , HITCHCOCK J
IPC分类号： B01D31/00
CPC分类号： B01D63/14 , B01D63/084 , Y10S128/03 , Y10S261/28
摘要： Un module de plasmapherese a membrane (10) comprend une membrane semipermeable (11) pouvant laisser passer du plasma sanguin au travers tout en empechant le passage de cellules sanguines, et une enceinte hermetique (18, 19) definissant un orifice d'entree du sang (43) et un orifice de sortie du sang (44) adjacents aux extremites opposees d'un premier chemin d'ecoulement (60) s'etendant le long d'un cote de la membrane (11). L'enceinte (18, 19) definit aussi un orifice de sortie du plasma (38) adjacent a une extremite de seconds passages separes d'ecoulement (62) s'etendant le long de l'autre cote de la membrane (11). La membrane (11) peut etre repliee suivant une ligne de pliage (12) pour definir une paire de portions de membrane (14, 16) reposant l'une contre l'autre. Le premier passage d'ecoulement (60) s'etend entre les portions de membrane (14, 16) et le second passage d'ecoulement (62) peut eventuellement s'etendre entre chaque portion de membrane (14, 16) et une paroi de l'enceinte hermetique (18, 19), ou alternativement un pli adjacent (12) de la portion de membrane. Un orifice de sortie du plasma (38) est defini au travers de l'enceinte (18, 19) en une position espacee de la membrane (11). Des canaux (21) sont definis dans la surface interieure de l'enceinte (18, 19) et positionnes face a la membrane (11) pour servir de collecteur de plasma sanguin provenant du second passage d'ecoulement (62). Le canal decrit ci-dessus (21) s'etend aussi au travers de la ligne de pliage (12) en communication d'ecoulement avec l'orifice de sortie de plasma (38). Egalement, les orifices d'entree et de sortie de sang (43, 44) peuvent s'etendre en relation telescopique avec les orifices d'ouverture (40, 42) dans l'enceinte pour la fixation des orifices d'entree et de sortie (43, 44).

10. 发明申请

WO1985004112A1 METHOD AND APPARATUS FOR FILTRATION 审中-公开
标题翻译：用于过滤的方法和装置
公开(公告)号：WO1985004112A1
公开(公告)日：1985-09-26
申请号：PCT/US1985000458
申请日：1985-03-20
申请人： McLAUGHLIN, William, Francis
发明人： McLAUGHLIN, William, Francis , SCHOENDORFER, Donald, W.
IPC分类号： B01D31/00
CPC分类号： A61M1/3496 , A61M1/265 , B01D61/025 , B01D63/062 , B01D63/16 , B01D65/02 , B01D2313/48 , B01D2313/90 , B01D2315/02 , B01D2321/02
摘要： A system for filtration of matter from a liquid suspension, for instance blood, through a membrane uses a rotor (22) within a concentric shell (24) rotating with a surface velocity which, together with the rotor-shell gap and suspension viscosity, establishes vigorous vortex cells about the rotor. At least one of the rotor and shell surfaces include a filter membrane (40). Tangential velocity components at the membrane surface constantly sweep the membrane surface to limit cell deposition tendencies while constantly replenishing the medium to be filtered. The vortex cells are established along the length of the membrane despite the constant extraction of filtrate and the resultant change in physical characteristics of the suspension.
摘要翻译：用于从液体悬浮液（例如血液）通过膜过滤物质的系统使用以表面速度旋转的同心壳体（24）内的转子（22），转子 - 壳体间隙和悬浮液粘度一起建立有力的漩涡细胞围绕转子。转子和壳体表面中的至少一个包括过滤膜（40）。膜表面的切向速度分量不断地扫描膜表面，以限制细胞沉积倾向，同时不断补充待过滤的介质。不管滤液的不断提取和悬浮液的物理特性的变化，沿着膜的长度建立涡旋细胞。

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