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1. 发明申请

WO2021257706A1 RECOMBINANT HVT VECTORS EXPRESSING INFLUENZA HEMAGGLUTININ AND IMMUNOGENIC COMPOSITIONS, AND PRODUCTION AND USES THEREOF 审中-公开
公开(公告)号：WO2021257706A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037631
申请日：2021-06-16
申请人： BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. , MEBATSION, Teshome
发明人： KASSA, Aemro
IPC分类号： A61K39/12 , A61K39/155 , A61K39/17 , A61K39/245 , A61K39/255 , A61K39/295 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61P31/22 , A61K39/00 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N2710/16311 , C12N2710/16334 , C12N2710/16341 , C12N2710/16343 , C12N2720/10011 , C12N2720/10022 , C12N2720/10034 , C12N2720/10071 , C12N2760/16111 , C12N2760/16122 , C12N2760/16134 , C12N2760/16334 , C12N2760/18111 , C12N2760/18122 , C12N2760/18134
摘要： Recombinant viral vectors and compositions that include them for use as vehicles to induce an immunological response. Multivalent viral vectors may be used in compositions or vaccines containing one or more recombinant viral vectors for protection against a variety of pathogens. Formation of these viral vectors may include insertion and expression of foreign genes to protect against a variety of pathogens. Further provided are methods of making and using the recombinant viral vectors, as well as immunogenic compositions that include the vectors and/or antigens. In particular, immunogenic compositions may include recombinant viral vectors such as vHVT509, vHVT522, and/or vHVT523.

2. 发明申请

WO2014077096A1 ベクターワクチンおよび生ワクチンの併用による感染症の予防方法审中-公开
标题翻译：使用载体疫苗和活体疫苗组合预防感染的方法
公开(公告)号：WO2014077096A1
公开(公告)日：2014-05-22
申请号：PCT/JP2013/078719
申请日：2013-10-23
申请人：一般財団法人化学及血清療法研究所
发明人：末永　清剛 , 坂口　正士 , 岡村　宏
IPC分类号： A61K39/145 , A61K39/00 , A61K39/155 , A61K39/17 , A61K39/205 , A61K39/215 , A61K39/235 , A61K39/245 , A61K39/255 , A61K39/275 , A61K39/295 , C12N15/09
CPC分类号： A61K39/12 , A61K2039/522 , A61K2039/53 , A61K2039/545 , C12N2710/16334 , C12N2760/18134 , C12N2770/20034
摘要：　ベクターワクチン及び生ワクチンの併用による感染症の予防方法を提供する。遺伝子組み換え技術により、ウイルスや細菌等の動物感染因子由来の感染防御抗原をコードするDNA断片がウイルスゲノムに組み込まれた組換えベクターウイルス（ベクターワクチン）、該感染因子を弱毒化して得られる弱毒化感染因子（生ワクチン）、及び該ベクターワクチンと該生ワクチンとを併用することを特徴とするヒト以外の動物感染症を予防する方法、並びに該ベクターワクチン及び該生ワクチンを有効成分として用いることを特徴とするワクチン。
摘要翻译：提供了使用载体疫苗和活疫苗的组合来预防感染的方法。通过基因重组技术将来自病毒，细菌等的动物感染因子的编码感染保护性抗原的DNA片段整合到病毒基因组中而生成的重组载体病毒（载体疫苗）通过减弱感染因子产生的减毒感染因子（活疫苗）; 一种预防非人动物感染的方法，其特征在于使用载体疫苗和活疫苗组合使用; 以及使用载体疫苗和活疫苗作为活性成分生产的疫苗。

3. 发明申请

WO2006012092A2 SAFER ATTENUATED VIRUS VACCINES WITH MISSING OR DIMINISHED LATENCY OF INFECTION 审中-公开
标题翻译：更安全的病毒疫苗缺乏或减少感染时间
公开(公告)号：WO2006012092A2
公开(公告)日：2006-02-02
申请号：PCT/US2005021788
申请日：2005-06-22
申请人： US HEALTH , COHEN JEFFREY I , COX JR EDWARD M , PESNICAK LESLEY M
发明人： COHEN JEFFREY I , COX JR EDWARD M , PESNICAK LESLEY M
IPC分类号： A61K39/245 , A61K39/25 , A61K39/255 , A61K39/265 , A61K39/27
CPC分类号： A61K39/25 , A61K39/12 , C12N7/00 , C12N2710/16734 , C12N2710/16761 , C12N2710/16762
摘要： Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
摘要翻译：描述了建立和/或维持潜伏期的能力减弱的病毒及其作为活疫苗的用途。疫苗在提供持续病毒复制但抑制潜伏期的基因中具有一个或多个改变。疫苗材料及其构建方法以水痘带状疱疹病毒为例。显示水痘带状疱疹基因ORF63的两个拷贝中显着部分的缺失显示抑制了该病毒的活疫苗形式的潜伏感染的建立。插入ORF63缺失部分截短的另外的ORF62基因抑制潜伏期的建立并允许病毒正常生长。其它理想的病毒抗原编码序列和/或细胞因子基因可以有利地替代缺失的遗传物质以增强所需的免疫应答。该发现的方面涉及其他病毒的活疫苗，并且可以提供具有更高安全性的各种疫苗。

4. 发明申请

WO2005010173A3 KERATINOCYTE CULTURING METHOD AND THE USE THEREOF 审中-公开
标题翻译：杀菌素培养方法及其用途
公开(公告)号：WO2005010173A3
公开(公告)日：2005-05-26
申请号：PCT/FR2004001864
申请日：2004-07-15
申请人： CENTRE NAT RECH SCIENT , DJIAN PHILIPPE , VANHOUTTEGHEM AMANDINE LAETITI
发明人： DJIAN PHILIPPE , VANHOUTTEGHEM AMANDINE LAETITI
IPC分类号： A61K39/12 , A61K39/255 , A61K39/275 , C12N5/071 , C12N7/00 , C12N7/02 , C12N5/06
CPC分类号： C12N7/00 , C12N5/0629 , C12N2500/80 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39 , C12N2501/395 , C12N2502/13 , C12N2710/16351
摘要： The invention relates to keratinocyte culture, a keratinocyte culturing method and the use thereof for spreading living attenuated viruses. The inventive method makes it possible to obtain living attenuated viruses and vaccines containing said viruses.
摘要翻译：本发明涉及角质形成细胞培养，角质形成细胞培养方法及其用于扩散活的减毒病毒的用途。本发明的方法使得可以获得包含所述病毒的减毒病毒和疫苗。

5. 发明申请

WO2005009372A3 MAREK'S DISEASE VIRUS VACCINE 审中-公开
标题翻译： MAREK'S病毒病毒疫苗
公开(公告)号：WO2005009372A3
公开(公告)日：2005-04-14
申请号：PCT/US2004023424
申请日：2004-07-20
申请人： US AGRICULTURE , REDDY SANJAY M , LUPIANI BLANCA M , WITTER RICHARD L
发明人： REDDY SANJAY M , LUPIANI BLANCA M , WITTER RICHARD L
IPC分类号： A61K39/255 , C12N7/01 , A61K39/27
CPC分类号： A61K39/255 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2710/16321 , C12N2710/16334 , C12N2740/13022 , C12N2820/60 , C12N2830/60
摘要： An effective vaccine for Marek's disease may be prepared using a recombinant Marek's disease virus CVI 988 transformed with a foreign DNA construct which includes a long terminal repeat sequence of a reticuloendotheliosis virus. This viral agent is effective to elicit an immune response in a chicken to Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.
摘要翻译：利用包含网状内皮组织增生病毒的长末端重复序列的外源DNA构建体转化的重组马立克氏病病毒CVI 988可以制备马立克氏病的有效疫苗。该病毒剂有效引发鸡对马立克氏病病毒的免疫应答，而不会在接种的禽类中引起显着程度的致病性。适用于鸡的疫苗的合适制剂包括这种新型病毒剂与药学上可接受的载体或稀释剂的有效免疫剂量。

6. 发明申请

WO0061736A3 RECOMBINANT AND MUTANT MAREK'S DISEASE VIRUS 审中-公开
标题翻译：重组和突变MAREK病毒病毒
公开(公告)号：WO0061736A3
公开(公告)日：2001-02-01
申请号：PCT/US0009518
申请日：2000-04-07
申请人： SCHERING PLOUGH LTD , JUNKER DAVID E
发明人： JUNKER DAVID E
IPC分类号： C12N15/09 , A61K35/76 , A61K39/17 , A61K39/255 , A61K39/265 , A61K48/00 , A61P31/12 , A61P37/04 , C12N7/00 , C12N15/869 , C12R1/93 , C12N15/38 , A61K39/215 , C12N15/45 , C12N15/50
CPC分类号： C12N15/86 , A61K2039/525 , C12N2710/16343
摘要： The present invention provides methods and reagents for inducing active immunity in animals. In particular, the present invention provides recombinant herpesviruses having foreign DNA that are capable of inducing immunity to the herpesvirus and/or the source of the foreigh DNA. The present invention also provides mutant herpesviruses having portions of their genome deleted. Preferably, foreign DNA is introduced, or portions of the genome are deleted, in the UL54.5 open reading frame of avian herperviruses or the UL43 open reading frame of Marek's disease virus.
摘要翻译：本发明提供用于诱导动物中的主动免疫的方法和试剂。特别地，本发明提供具有能够诱导对疱疹病毒和/或甲状腺源的免疫的外源DNA的重组疱疹病毒。本发明还提供具有其基因组部分缺失的突变疱疹病毒。优选地，在禽类疫苗的UL54.5开放阅读框或马立克氏病病毒的UL43开放阅读框中，引入外来DNA或基因组的部分缺失。

7. 发明申请

WO98037216A1 RECOMBINANT CHIMERIC VIRUSES AND USES THEREOF 审中-公开
标题翻译：重组的重要病毒及其用途
公开(公告)号：WO98037216A1
公开(公告)日：1998-08-27
申请号：PCT/US1998/003436
申请日：1998-02-20
IPC分类号： C12N15/09 , A61K39/00 , A61K39/245 , A61K39/255 , A61K39/295 , A61P31/12 , C12N7/04 , C12N15/869 , C12R1/93 , C12N15/85
CPC分类号： C12N7/00 , A61K39/00 , C12N15/86 , C12N2710/16343 , C12N2710/16361 , C12N2710/16362 , C12N2830/00 , C12N2830/60 , C12N2840/203
摘要： This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short viral genome region.
摘要翻译：本发明提供了包含火鸡独特长病毒基因组区域的疱疹病毒和马立克氏病病毒独特的短病毒基因组区域的火鸡 - 马立克氏病病毒嵌合体的重组疱疹病毒。

8. 发明申请

WO1985004588A1 LIVE PURIFIED MAREK'S DISEASE VACCINE AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：活血纯化马赛克病毒疫苗及其制备方法
公开(公告)号：WO1985004588A1
公开(公告)日：1985-10-24
申请号：PCT/NL1985000014
申请日：1985-03-27
申请人： CENTRAAL DIERGENEESKUNDIG INSTITUUT
发明人： CENTRAAL DIERGENEESKUNDIG INSTITUUT , DE BOER, Gerben, Foppe
IPC分类号： A61K39/255
CPC分类号： A61K39/255 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2710/16334 , Y10S424/816
摘要： A highly immunogenic virus preparation derived from a Marek's disease virus strain, belonging to Avian Herpesvirus serotype-1 by attenuation employing serial passages in Avian cell cultures and plaque purification. The preferred parent virus is the virus strain MDV CVI-988 which has been recovered from a healthy chicken (Avian diseases 16: 108-125, 1972). The live purified Marek's disease vaccine so obtained is innocuous for specific pathogen free Rhode Island Red chickens which are highly susceptible for development of Marek's disease tumours. The monovalent virus preparation according to the invention demonstrated, in comparison with Marek's disease vaccines based on the same strain, currently in use at lower cell passage level, an improved protective efficacy against challenge infection by two representatives of virulent Marek's disease virus. The monovalent vaccine preparation according to the invention provides solid protection to challenge infection with two representatives of the group of newly emerging biovariant very virulent strains of Marek's disease virus.

9. 发明申请

WO2021257492A1 CELL LINE FOR PRODUCTION OF MAREK'S DISEASE VIRUS VACCINE AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2021257492A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037306
申请日：2021-06-15
申请人： ZOETIS SERVICES LLC
发明人： AMEISS, Keith, Allen , ROSEY, Everett, Lee
IPC分类号： C12N7/00 , A61K39/12 , C12N5/07 , C12N15/86 , A61K39/255 , C12N15/111 , C12N2310/20 , C12N2710/16034 , C12N2710/16334 , C12N2710/16351 , C12N5/0602 , C12N5/10 , C12N9/22
摘要： The present application relates to an avian cell line capable of supporting viral growth of Marek's Disease Virus (MDV), including Herpes Virus of Turkeys (HVT), methods of producing such cell lines, and therapeutic uses of the cell lines and resulting vaccines.

10. 发明申请

WO2010119112A1 RECOMBINANT AVIAN HERPES VIRUS VECTORS AND VACCINE FOR IMMUNIZING WATERFOWL SPECIES 审中-公开
标题翻译：重组禽流感病毒载体和疫苗免疫水样
公开(公告)号：WO2010119112A1
公开(公告)日：2010-10-21
申请号：PCT/EP2010/054991
申请日：2010-04-15
申请人： CEVA SANTE ANIMALE , GARDIN, Yannick , PALYA, Vilmos
发明人： GARDIN, Yannick , PALYA, Vilmos
IPC分类号： A61K39/255
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/552 , A61K2039/55583 , C12N2710/16343 , C12N2760/16134 , C12N2760/18134 , Y02A50/467
摘要： The present invention relates to vaccines for waterfowl immunization based on live recombinant Marek's disease virus (hereinafter referred to as rMDV), and more specifically recombinant herpes virus of turkeys (hereinafter referred to as rHVT virus), which incorporates at least one nucleotide sequence encoding and expressing an antigenic peptide of a pathogenic agent of waterfowl. Methods of immunization are also provided.
摘要翻译：本发明涉及基于活重组马立克氏病病毒（以下称为rMDV）的水禽疫苗疫苗，更具体地涉及火鸡重组疱疹病毒（以下称为rHVT病毒），其包含至少一个编码和表达水禽病原体的抗原肽。还提供了免疫方法。

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