会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明申请
    • SAFER ATTENUATED VIRUS VACCINES WITH MISSING OR DIMINISHED LATENCY OF INFECTION
    • 更安全的病毒疫苗缺乏或减少感染时间
    • WO2006012092A2
    • 2006-02-02
    • PCT/US2005021788
    • 2005-06-22
    • US HEALTHCOHEN JEFFREY ICOX JR EDWARD MPESNICAK LESLEY M
    • COHEN JEFFREY ICOX JR EDWARD MPESNICAK LESLEY M
    • A61K39/245A61K39/25A61K39/255A61K39/265A61K39/27
    • A61K39/25A61K39/12C12N7/00C12N2710/16734C12N2710/16761C12N2710/16762
    • Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
    • 描述了建立和/或维持潜伏期的能力减弱的病毒及其作为活疫苗的用途。 疫苗在提供持续病毒复制但抑制潜伏期的基因中具有一个或多个改变。 疫苗材料及其构建方法以水痘带状疱疹病毒为例。 显示水痘带状疱疹基因ORF63的两个拷贝中显着部分的缺失显示抑制了该病毒的活疫苗形式的潜伏感染的建立。 插入ORF63缺失部分截短的另外的ORF62基因抑制潜伏期的建立并允许病毒正常生长。 其它理想的病毒抗原编码序列和/或细胞因子基因可以有利地替代缺失的遗传物质以增强所需的免疫应答。 该发现的方面涉及其他病毒的活疫苗,并且可以提供具有更高安全性的各种疫苗。