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1. 发明申请

WO2004042031A3 SAFER ATTENUATED VIRUS VACCINES WITH MISSING OR DIMINISHED LATENCY OF INFECTION 审中-公开
标题翻译：安全的病毒疫苗缺失或感染时间延长
公开(公告)号：WO2004042031A3
公开(公告)日：2004-09-16
申请号：PCT/US0335167
申请日：2003-11-05
申请人： US GOV HEALTH & HUMAN SERV , COHEN JEFFREY IRVINE , COX EDWARD MICHAEL , PESNICAK LESLEY M
发明人： COHEN JEFFREY IRVINE , COX EDWARD MICHAEL , PESNICAK LESLEY M
IPC分类号： C07K14/03 , C07K14/035 , C07K14/04 , C07K14/055 , C12N7/04 , C12N7/00 , A61K39/245 , C12N5/00
CPC分类号： C12N7/00 , A61K2039/5254 , C07K14/005 , C12N2710/16322 , C12N2710/16622 , C12N2710/16722 , C12N2710/16761
摘要： Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
摘要翻译：描述了具有削弱建立和/或维持延迟的能力及其作为活疫苗的用途的病毒。疫苗在提供持续病毒复制但抑制潜伏期的基因中具有一个或多个改变。用于其构建的疫苗材料和方法以水痘带状疱疹病毒为例。从水痘带状疱疹基因ORF63的两个拷贝中删除重要部分被证明可以抑制病毒活疫苗形式的潜伏感染的建立。其他所需的病毒抗原编码序列和/或细胞因子基因有利地可以代替缺失的遗传物质以增强所需的免疫应答。该发现的方面涉及其他病毒的活疫苗，并且可以提供具有更高安全性的多种疫苗。

2. 发明申请

WO2006012092A3 SAFER ATTENUATED VIRUS VACCINES WITH MISSING OR DIMINISHED LATENCY OF INFECTION 审中-公开
公开(公告)号：WO2006012092A3
公开(公告)日：2006-02-02
申请号：PCT/US2005/021788
申请日：2005-06-22
申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, DEPARTMENT OF HEALTH AND HUMAN SERVICES , COHEN, Jeffrey I. , COX, JR., Edward M. , PESNICAK, Lesley M.
发明人： COHEN, Jeffrey I. , COX, JR., Edward M. , PESNICAK, Lesley M.
IPC分类号： A61K39/245 , A61K39/25 , A61K39/255 , A61K39/27 , A61K39/265 , C07K14/04 , C12N7/04
摘要： Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.

3. 发明申请

WO2004042031A2 SAFER ATTENUATED VIRUS VACCINES WITH MISSING OR DIMINISHED LATENCY OF INFECTION 审中-公开
标题翻译：更安全的病毒疫苗缺乏或减少感染时间
公开(公告)号：WO2004042031A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/035167
申请日：2003-11-05
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , COHEN, Jeffrey, Irvine , COX, Edward, Michael , PESNICAK, Lesley, M.
发明人： COHEN, Jeffrey, Irvine , COX, Edward, Michael , PESNICAK, Lesley, M.
IPC分类号： C12N
CPC分类号： C12N7/00 , A61K2039/5254 , C07K14/005 , C12N2710/16322 , C12N2710/16622 , C12N2710/16722 , C12N2710/16761
摘要： Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
摘要翻译：描述了建立和/或维持潜伏期及其作为活疫苗使用的能力弱的病毒。疫苗在提供持续病毒复制但抑制潜伏期的基因中具有一个或多个改变。疫苗材料及其构建方法以水痘带状疱疹病毒为例。显示水痘带状疱疹基因ORF63的两个拷贝中显着部分的缺失显示抑制了该病毒的活疫苗形式的潜伏感染的建立。其它理想的病毒抗原编码序列和/或细胞因子基因可以有利地替代缺失的遗传物质以增强所需的免疫应答。该发现的方面涉及其他病毒的活疫苗，并且可以提供具有更高安全性的各种疫苗。

4. 发明申请

WO2006012092A2 SAFER ATTENUATED VIRUS VACCINES WITH MISSING OR DIMINISHED LATENCY OF INFECTION 审中-公开
标题翻译：更安全的病毒疫苗缺乏或减少感染时间
公开(公告)号：WO2006012092A2
公开(公告)日：2006-02-02
申请号：PCT/US2005021788
申请日：2005-06-22
申请人： US HEALTH , COHEN JEFFREY I , COX JR EDWARD M , PESNICAK LESLEY M
发明人： COHEN JEFFREY I , COX JR EDWARD M , PESNICAK LESLEY M
IPC分类号： A61K39/245 , A61K39/25 , A61K39/255 , A61K39/265 , A61K39/27
CPC分类号： A61K39/25 , A61K39/12 , C12N7/00 , C12N2710/16734 , C12N2710/16761 , C12N2710/16762
摘要： Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
摘要翻译：描述了建立和/或维持潜伏期的能力减弱的病毒及其作为活疫苗的用途。疫苗在提供持续病毒复制但抑制潜伏期的基因中具有一个或多个改变。疫苗材料及其构建方法以水痘带状疱疹病毒为例。显示水痘带状疱疹基因ORF63的两个拷贝中显着部分的缺失显示抑制了该病毒的活疫苗形式的潜伏感染的建立。插入ORF63缺失部分截短的另外的ORF62基因抑制潜伏期的建立并允许病毒正常生长。其它理想的病毒抗原编码序列和/或细胞因子基因可以有利地替代缺失的遗传物质以增强所需的免疫应答。该发现的方面涉及其他病毒的活疫苗，并且可以提供具有更高安全性的各种疫苗。

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