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1. 发明申请

WO2023057561A1 METHOD FOR SURVIVAL PREDICTION AND FOR DIAGNOSIS AND TREATMENT OF TYPE 2 DIABETES MELLITUS 审中-公开
公开(公告)号：WO2023057561A1
公开(公告)日：2023-04-13
申请号：PCT/EP2022/077801
申请日：2022-10-06
申请人： NORDISK HJERTECENTER APS
发明人： BALLEGAARD, Søren
IPC分类号： A61B5/00 , A61B5/4035 , A61B5/4824 , A61B5/4827
摘要： The present disclosure provides for a novel method of predicting life expectancy in persons, in particular in persons that have an a priori reduced life expectancy, for instance if they suffer from ischemic heart disease (IHD), IHD-related depression, ANSD, type 2 diabetes mellitus. Also disclosed is a related method for increasing life expectancy in human subjects, in particular in human subjects having an a priori reduced life expectancy. The disclosure also provides a method for evaluating the efficacy of drugs other treatment of ANSD. The present invention also provides a novel method for diagnosing and treating/preventing type 2 diabetes mellitus or IHD-related depression. Finally, the disclosure also provides a method for diagnosing autonomic homeostatic glucose dysregulation, and a novel method to re-establish normal homeostatic function, if disrupted, dysregulated or insufficient

2. 发明申请

WO2021245269A1 A METHOD AND SYSTEM FOR MONITORING A LEVEL OF MODIFIED CONSCIOUSNESS AND A LEVEL OF PAIN 审中-公开
公开(公告)号：WO2021245269A1
公开(公告)日：2021-12-09
申请号：PCT/EP2021/065063
申请日：2021-06-04
申请人： ONCOMFORT SA
发明人： JOORIS, Diane , HUYGHE, Mario , TOUSSAINT, Clémence
IPC分类号： A61B5/00 , A61B5/374 , A61B5/4821 , A61B5/4824 , A61B5/4839
摘要： There is described a computer-implemented method for measurement of a level of modified consciousness and a level of pain. The method comprises the steps of: - receiving measured data comprising electroencephalogram, EEG, data collected from one or more EEG electrodes; - extracting from the EEG data, a group indicators corresponding to: - a power, power (ta), associated with a theta-alpha frequency band, ta, within a theta-alpha frequency range; and - a power, F-power(dt) and/or P-power(dt), associated with a delta-theta frequency band, dt, within a delta-theta frequency range extracted from the at least one F- EEG and/or P- EEG electrode data; - determining, based on said group indicators, a depth of state, DoS, which is a value indicative for the level of a modified state of consciousness and a level of pain, LoP, which is a value indicative for the level of pain in the subject.

3. 发明申请

WO2021245268A1 A METHOD AND SYSTEM FOR MONITORING A LEVEL OF PAIN 审中-公开
公开(公告)号：WO2021245268A1
公开(公告)日：2021-12-09
申请号：PCT/EP2021/065061
申请日：2021-06-04
申请人： ONCOMFORT SA
发明人： JOORIS, Diane , HUYGHE, Mario , TOUSSAINT, Clémence
IPC分类号： A61B5/00 , A61B5/369 , A61B5/4824 , A61B5/7257 , A61B5/7264
摘要： There is described a computer-implemented method for measurement of a level of pain. The method comprises the steps of: - receiving measured data comprising electroencephalogram, EEG, data collected from one or more EEG electrodes; - extracting from the EEG data, a group 4 indicator corresponding to: - a power, power (ta), associated with a theta-alpha frequency band, ta, within a theta-alpha frequency range; and - determining, based on said group 4 indicator, a level of pain, LoP, which is a value indicative for the level of pain in the subject.

4. 发明申请

WO2021195138A1 SYSTEM AND METHOD FOR ASSESSING CONDITIONS OF VENTILATED PATIENTS 审中-公开
公开(公告)号：WO2021195138A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/023765
申请日：2021-03-23
申请人： VYAIRE MEDICAL, INC.
发明人： VARGA, Christopher M. , HASNAIN, Somji , VILLASMIL, Alejandro Jose , KUSLEIKA, Rich
IPC分类号： A61M16/00 , G16H20/10 , G16H20/40 , G16H40/63 , G16H50/20 , A61B2505/03 , A61B2562/0204 , A61B2562/0219 , A61B5/0036 , A61B5/0077 , A61B5/024 , A61B5/1101 , A61B5/1176 , A61B5/14542 , A61B5/165 , A61B5/225 , A61B5/346 , A61B5/4064 , A61B5/4088 , A61B5/412 , A61B5/4824 , A61B5/4839 , A61B5/4848 , A61B5/7264 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0465 , A61M16/06 , A61M2016/0015 , A61M2016/1025 , A61M2205/18 , A61M2205/3317 , A61M2205/332 , A61M2205/3368 , A61M2205/3375 , A61M2205/3553 , A61M2205/3592 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/80 , A61M2209/088 , A61M2230/04 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/432 , A61M2230/46 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M5/168 , G06K9/00302 , G06K9/00342 , G06K9/6271 , G16H10/20 , G16H20/17 , G16H30/20 , G16H30/40 , G16H40/67 , G16H50/30
摘要： The disclosed system receives various physiological as well as physical information concerning a patient, and operational data from a ventilation device and medication delivery device, and provides the physiological and physical information, together with the operational data, to a neural network configured to analyze the information and data. The system receives, from the neural network, an assessment classification of the patient corresponding to at least one of a pain assessment, a sepsis assessment, and a delirium assessment of the patient based on providing to the neural network the determined physiological state of the patient, the determined physical state of the patient, the determined operational mode of the ventilator, the medication delivery information, and the received diagnostic information for the patient, and adjusts, based on the assessment classification, a ventilation parameter that influences the operational mode of a ventilator providing ventilation to the patient.

5. 发明申请

WO2022169020A2 PPG 기반 스펙트로그램 및 CNN에 기반하는 통증 평가 방법 및 장치 审中-公开
公开(公告)号：WO2022169020A2
公开(公告)日：2022-08-11
申请号：PCT/KR2021/002696
申请日：2021-03-04
申请人： 전남대학교산학협력단 , 울산대학교 산학협력단 , 재단법인 아산사회복지재단
发明人： 신항식 , 임지연 , 최병문 , 노규정
IPC分类号： A61B5/00 , A61B5/024 , A61B5/02416 , A61B5/4824 , A61B5/7257 , A61B5/7264 , G06N3/0427 , G06N3/08 , G16H50/20
摘要： 본 발명은 PPG 기반 스펙트로그램 및 CNN에 기반하는 통증 평가 방법 및 장치에 관한 것이다. 본 발명의 일 실시예에 따른 PPG 기반 스펙트로그램 및 CNN에 기반하는 통증 평가 방법은 (a) 사용자의 PPG(Photoplethysmographic) 신호를 획득하는 단계; (b) 상기 획득된 PPG 신호로부터 상기 PPG 신호에 대한 스펙트로그램(spectrogram)을 생성하는 단계; 및 (c)상기 PPG 신호에 대한 스펙트로그램을 이용하여 상기 사용자의 통증을 평가하는 단계;를 포함할 수 있다.

6. 发明申请

WO2021249674A1 BIOFEEDBACK SYSTEM 审中-公开
公开(公告)号：WO2021249674A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/052512
申请日：2021-02-03
申请人： NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)
发明人： ENGEBRETSEN, Marcus Aleksander , STUBBERUD, Anker , LINDE, Mattias , OLSEN, Alexander , TRONVIK, Erling , RAMAMPIARO, Herindrasana
IPC分类号： A61B5/00 , A61B5/4094 , A61B5/4824 , A61B5/4836 , A61B5/486
摘要： A biofeedback system for headache patients comprises: a sensor system (2) for obtaining and transmitting data indicative of a plurality of physiological parameters of the patient, a personal computing device (4) arranged to receive data from the sensor system (2) and to interact with the patient via a user interface of the personal computing device (4), and a computer-implemented biofeedback agent (6). The sensor system (2) is configured for measurement of the physiological parameters of the patient, wherein the physiological parameters include at least two of muscle tension, body temperature, heart rate and heart rate variability. The personal computing device (4) together with the biofeedback agent (6) are configured to carry out the following steps: obtain data indicative of the physiological parameters from the sensor system (2); instruct the patient to control the physiological parameters; determine baseline levels for each of the physiological parameters; derive a score for each of the physiological parameters relative to the baseline levels, wherein the score increases in reaction to control of the respective physiological parameter; and use a weighting system to determine a weighting for the score associated with each of the physiological parameters and present a total score to the patient via the user interface, the total score consisting of a combination of the weighted scores, wherein the weighting system gives a higher weighting to the score for the physiological parameter that the patient most successfully controls and a lower weighting to the score for the physiological parameter that the patient least successfully controls.

7. 发明申请

WO2021188079A2 AN ARTIFICIAL INTELLIGENCE METHOD TO ENSURE THE ASSESSMENT THE LEVEL OF COMFORT AND PAIN OF BABIES 审中-公开
公开(公告)号：WO2021188079A2
公开(公告)日：2021-09-23
申请号：PCT/TR2021/050207
申请日：2021-03-09
申请人： ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ
发明人： AÇIKGÖZ, Ayfer , YİĞİT, Deniz , ÇELİK, Özer
IPC分类号： G06N3/02 , G06K9/62 , A61B5/00 , A61B2503/04 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0816 , A61B5/1128 , A61B5/14542 , A61B5/4824 , A61B5/7267 , G06N20/00
摘要： This invention is about an artificial intelligence method developed to automatically determine of the level of comfort and pain of babies and enables the assessment of comfort levels and pain levels of newborn babies and its characteristic is; being consisted of a data module (1) where to obtain data sets such as image, sound, heart rate, oxygen saturation, blood pressure, respiration rate from newborn babies, an artificial intelligence module (2) where obtained records are processed with artificial intelligence algorithms, a comfort assessment module (2.1) where the comfort level of artificial intelligence results is showed and a pain assessment module (2.2) where the pain level of artificial intelligence results is showed.

8. 发明申请

WO2023277589A1 활동성 갑상선 눈병증 진료를 위한 내원 안내 방법 및 이를 수행하는 시스템 审中-公开
公开(公告)号：WO2023277589A1
公开(公告)日：2023-01-05
申请号：PCT/KR2022/009356
申请日：2022-06-29
申请人： 주식회사 타이로스코프
发明人： 신규보 , 박재민 , 김종찬
IPC分类号： G16H50/50 , G16H30/40 , G16H30/20 , G16H50/20 , G16H10/20 , A61B5/00 , A61B3/10 , A61B3/14 , A61B5/4227 , A61B5/445 , A61B5/4824 , A61B5/4878 , G06T2207/20021 , G06T2207/20132 , G06T2207/30041 , G06T2207/30201 , G06T7/0012 , G06T7/12 , G06T7/70
摘要： 본 출원에 의하면, 퓨터로 실행가능한 갑상선 안병증의 예측방법이 개시된다. 상기 방법은, 결막 충혈 예측 모델, 결막 부종 예측 모델, 눈물언덕 부종 예측 모델, 눈꺼풀 발적 예측 모델 및 눈꺼풀 부종 예측 모델을 준비하고, 대상의 얼굴 이미지를 획득하고, 상기 얼굴 이미지로부터 제1 처리된 이미지(first processed image) 및 제2 처리된 이미지(second processed image)를 획득하고 - 이때, 상기 제1 처리된 이미지는 상기 제2 처리된 이미지와 상이함 -, 상기 제1 처리된 이미지를 상기 결막 충혈 예측 모델, 상기 결막 부종 예측 모델 및 상기 눈물언덕 부종 예측 모델에 입력하여 결막 충혈, 결막 부종 및 눈물언덕 부종 각각에 대한 예측값들을 획득하고, 상기 제2 처리된 이미지를 상기 눈꺼풀 발적 예측 모델 및 상기 눈꺼풀 부종 예측 모델에 입력하여 눈꺼풀 발적 및 눈꺼풀 부종 각각에 대한 예측값들을 획득하고, 상기 결막 충혈에 대한 상기 예측값, 상기 결막 부종에 대한 상기 예측값, 상기 눈물언덕 부종에 대한 상기 예측값, 상기 눈꺼풀 발적에 대한 상기 예측값 및 상기 눈꺼풀 부종에 대한 상기 예측값에 기초하여, 상기 대상이 갑상선 안병증 (thyroid eye disease)을 가지고 있을 가능성(possibility)을 판단하는 것을 포함한다.

9. 发明申请

WO2022271706A1 CLOUD-BASED PATIENT MONITORING SYSTEM 审中-公开
公开(公告)号：WO2022271706A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034353
申请日：2022-06-21
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： SRIVASTAVA, Kyle, Harish , MCDONALD, Matthew, Lee , WOON, Rex, James
IPC分类号： G16H20/30 , G16H40/63 , G16H50/50 , A61B5/00 , A61N1/36 , G08B1/00 , G08B21/18 , G08B21/24 , H02J7/00 , A61B2562/0219 , A61B5/0022 , A61B5/1118 , A61B5/4809 , A61B5/4824 , A61B5/7264 , A61B5/7275 , A61B5/743 , A61N1/36062 , A61N1/36071 , A61N1/36139 , A61N1/37252 , A61N1/37258 , A61N1/37282 , G08B21/0446 , G08B21/0453 , G16H15/00 , G16H40/67 , G16H50/30
摘要： Systems, devices, and methods for remote monitoring and managing of patients with chronic pain are discussed. A remote monitoring system comprises a cloud-computing device and a remote device. The cloud-computing device receives patient data including physiological or functional information sensed by sensors, and provides on-demand cloud-based services including establishing a correspondence between one or more physiological or functional states and one or more pain levels, detecting patient physiological or functional state, predicting a pain level, detecting a patient behavior, generating a recommendation for adjusting sensor operations based on the patient behavior, and storing patient data and other information in a cloud storage. The remote device can access the cloud storage and the cloud-based services, provide the stored information to an authorized user or the patient, control an implantable device to initiate or adjust a neuromodulation therapy, or adjust sensor operations.

10. 发明申请

WO2021201353A1 통증 분석 장치 审中-公开
公开(公告)号：WO2021201353A1
公开(公告)日：2021-10-07
申请号：PCT/KR2020/013479
申请日：2020-10-05
申请人： 유승구
发明人： 유승구 YU, Seung Ku
IPC分类号： A61B5/00 , A61B5/0051 , A61B5/0053 , A61B5/0077 , A61B5/4824 , A61B5/483 , A61B5/4884
摘要： 통증 분석 장치는 복수의 통증자극을 제공할 수 있는 복수의 통증자극부, 복수의 통증자극부를 구동하는 통증자극구동부, 복수의 통증자극부의 복수의 통증자극 각각에 대한 생체신호를 감지하는 복수의 생체신호감지부 및 다수의 피검사자에게 복수의 통증자극을 증가시켜 제공하며, 복수의 통증자극에 대한 복수의 통증역치와 복수의 통증역치에 대한 복수의 생체신호를 저장하고, 이 후 복수의 생체신호감지부로부터 피검사자의 복수의 생체신호를 수신하면 복수의 생체신호에 기초하여 통증도를 결정하는 제어부를 포함한다.

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