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1. 发明申请

WO2021139887A1 ACTIVE IMPLANTABLE STIMULATING DEVICE FOR ON-DEMAND STIMULATION OF A VAGUS NERVE 审中-公开
公开(公告)号：WO2021139887A1
公开(公告)日：2021-07-15
申请号：PCT/EP2020/050379
申请日：2020-01-09
申请人： SYNERGIA MEDICAL
发明人： DOGUET, Pascal , GARNIER, Jérôme , DELBEKE, Jean
IPC分类号： A61B5/0476 , A61B5/00 , A61N1/36 , A61N5/06 , A61B5/369 , A61B5/4094 , A61B5/686 , A61N1/36053 , A61N1/36064 , A61N1/36067 , A61N1/36135 , A61N1/36167 , A61N5/0622
摘要： The present invention concerns an active implantable stimulating device (10) comprising (a) a tissue coupling unit (40) comprising one or more electrodes (40a, 40b) suitable for being implanted directly onto a vagus nerve (Vn) of a patient, (b) an EEG-unit (70) comprising EEG-electrodes (70a-70d) configured for measuring an electroencephalogram of the patient, (c) an encapsulation unit (50) configured for being subcutaneously implanted in the patient body and enclosing an IPG (51) and an electronic unit (53), (d) an energy transfer lead (30) configured for transferring pulses of electrical and/or optical energy emitted by the IPG between the encapsulation unit and the tissue coupling unit, (e) a signal transfer lead (60) configured for transferring signals between the EEG-unit and the encapsulation unit. The EEG-electrodes (70a-70d) continuously or intermittently monitor the electric activity of the brain of a patient. The EEG-signal is conveyed to the electronic circuit (53) in the form of EEG-conditioned data. The electronic circuit analyses the EEG-conditioned data to yield analysis results. The electronic circuit takes a decision, based on the analysis results whether or not to instruct the IPG (51) to trigger energy pulses to stimulate the vagus nerve (VN), depending on whether the analysis results are representative of a coming or incipient seizure.

2. 发明申请

WO2023031457A2 ELEKTRODENANORDNUNG ZUR MESSUNG VON BIOPOTENTIALEN AN EINEM KOPF EINES MENSCHEN 审中-公开
公开(公告)号：WO2023031457A2
公开(公告)日：2023-03-09
申请号：PCT/EP2022/074614
申请日：2022-09-05
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： WOLF, Karen Insa , PÄTZOLD, Wiebke , DA SILVA SOUTO, Carlos Filipe , DEBENER, Stefan , PAUL, Marina
IPC分类号： A61B5/271 , A61B5/259 , A61B5/00 , A61B5/18 , A61B5/12 , A61B2505/07 , A61B2560/0412 , A61B2562/164 , A61B5/282 , A61B5/291 , A61B5/296 , A61B5/297 , A61B5/4094 , A61B5/4809 , A61B5/6814 , A61B5/6822 , A61B5/6823 , A61B5/6833 , A61B5/68335
摘要： Vorrichtung mit einer Elektrodenanordnung mit einer Vielzahl von Elektroden zur Messung von elektrischen Signalen an einer Gesichtsoberfläche eines Kopfes eines Nutzers und hinter einem Ohr des Nutzers; und mit einer Trägerstruktur. Die Trägerstruktur definiert zumindest teilweise eine Relativposition der Elektroden zueinander und die Trägerstruktur ist ohne äußere Krafteinwirkung eines Nutzers innerhalb eines Toleranzbereichs formstabil und unter äußerer Krafteinwirkung des Nutzers deformierbar, um einen Abstand zwischen zwei benachbart angeordneten Elektroden zu verändern und/oder sich Gesichts- und Kopfstrukturen flächendeckend anzupassen. Die Trägerstruktur ist ausgebildet, um zumindest einen Teil der Elektrodenanordnung an der Gesichtsoberfläche und hinter dem Ohr zu positionieren.

3. 发明申请

WO2022112326A2 SYSTEM ZUR ERFASSUNG VON EEG-SIGNALEN AN EINEM LEBEWESEN UND SYSTEM ZUR ELEKTRISCHEN STIMULATION VON GEWEBE EINES LEBEWESENS 审中-公开
公开(公告)号：WO2022112326A2
公开(公告)日：2022-06-02
申请号：PCT/EP2021/082817
申请日：2021-11-24
申请人： PRECISIS GMBH
发明人： JAGSCHIES, Lasse
IPC分类号： A61B5/293 , A61B5/372 , A61B5/00 , A61N1/05 , A61B5/4094 , A61N1/0529
摘要： Die Erfindung betrifft ein System zur Erfassung von EEG-Signalen an einem Lebewesen, wobei das System mehrere EEG-Elektroden zur Aufnahme elektrischer Signale am Lebewesen und wenigstens eine mit den EEG-Elektroden verbundene Auswerteeinrichtung aufweist, wobei Auswerteeinrichtung dazu eingerichtet ist, wenigstens die folgenden Schritte durchzuführen: a) Aufnehmen von EEG-Signalen von den EEG-Elektroden, b) Berechnen wenigstens von bipolaren und quadrupolaren Feldanteilen des elektrischen Feldes im Lebewesen, das ursächlich für die EEG-Signale ist, aus den EEG-Signalen, c) Bestimmen wenigstens einer physiologischen Kenngröße des Lebewesens aus den berechneten zumindest bipolaren und quadrupolaren Feldanteilen.

4. 发明申请

WO2021188318A1 A METHOD OF EARLY DETECTION OF EPILEPTIC SEIZURES THROUGH SCALP EEG MONITORING 审中-公开
公开(公告)号：WO2021188318A1
公开(公告)日：2021-09-23
申请号：PCT/US2021/021390
申请日：2021-03-08
申请人： NCEFALON CORPORATION
发明人： CHAN, Caleb K. , CHAN, An , CHUNG, Jeffrey M. , XU, Li , TAM, Frank. K.
IPC分类号： A61B5/24 , A61B5/242 , A61B5/291 , A61B5/0006 , A61B5/369 , A61B5/4094 , A61B5/7225 , A61B5/7267
摘要： A system performs concurrent detection and early detection of epileptic seizure episodes, based on scalp electroencephalogram (EEG) of a patient collected through a data acquisition device in the course of the patient's normal daily activities. An early detection model, which is trained and retrained applying machine learning techniques at predetermined intervals on the collected data, enables issuing of an early warning of an upcoming seizure episode to allow the patient to take necessary preparatory actions (e.g., seeking a safe location for the episode to happen and alerting care-givers).

5. 发明申请

WO2021148310A1 APPARATUS FOR TASK DETERMINATION DURING BRAIN ACTIVITY ANALYSIS 审中-公开
公开(公告)号：WO2021148310A1
公开(公告)日：2021-07-29
申请号：PCT/EP2021/050748
申请日：2021-01-15
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HUIJBERS, Willem , MATTERS, Marco , LAMERICHS, Rudolf, Mathias, Johannes, Nicolaas , VAN EE, Raymond , DENISSEN, Adrianus, Johannes, Maria , WESTERINK, Joanne, Henriëtte, Desirée, Monique , LEUFKENS, Timmy, Robertus, Maria
IPC分类号： G16H50/20 , G16H30/40 , A61B5/00 , A61B2576/026 , A61B5/055 , A61B5/377 , A61B5/4064 , A61B5/4094 , G16H20/70
摘要： The present invention relates to an apparatus for task determination during brain activity analysis. The apparatus comprises an input unit (20), a processing unit (30), and an output unit (40). The input unit is configured to provide the processing unit with measurement data of the brain of a patient performing a task during brain activity analysis. The processing unit is configured to determine a measure of brain activity based on the measurement data of the brain. The processing unit is configured to determine: that the patient should perform a different task to the task they are currently performing and select the different task; or that the patient should continue performing the task that they are currently performing; or that the patient should stop performing the task; The determination comprises utilization of information relating to the task and the determined measure of brain activity and information relating to a plurality of reference tasks and associated plurality of reference measures of brain activity. The output unit is configured to output an indication that the patient should perform the different task, that the patient should continue performing the task, or that the patient should stop performing the task.

6. 发明申请

WO2021129017A1 一种高处作业监护装置审中-公开
公开(公告)号：WO2021129017A1
公开(公告)日：2021-07-01
申请号：PCT/CN2020/118351
申请日：2020-09-28
申请人：广东电网有限责任公司电力科学研究院
发明人：刘羽中 , 李华亮 , 胡巧明 , 杨志欣 , 谢庭军 , 张凯 , 沈雅利
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/11 , A61B5/318 , A61B5/4094 , A61B5/6814 , A61B5/6815 , A61B5/6824 , A61B5/746
摘要：一种高处作业监护装置，包括：场景模拟单元、症状检测单元以及处理单元；场景模拟单元用于给高处作业提供多种高处作业虚拟场景；症状检测单元用于采集作业人员的生理信号，并将采集到的信息传输至所述处理单元；处理单元用于获取症状检测单元传输的生理信号，并对生理信号进行分析处理，判断作业人员是否存在职业禁忌证。本申请通过让作业人员进入模拟的高处作业场景，对作业人员的生理信号进行实时采集，并对采集的信号进行分析，监测作业人员是否存在高处作业职业禁忌证，起到提前发现作业人员的生理状况，避免意外的发生的作用。

7. 发明申请

WO2018013884A1 NEUROMODULATION APPARATUS, METHOD AND SYSTEM 审中-公开
公开(公告)号：WO2018013884A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042043
申请日：2017-07-14
申请人： CORTERA NEUROTECHNOLOGIES, INC.
发明人： MULLER, Rikky , JOHNSON, Benjamin , IZYUMIN, Igor
IPC分类号： A61B5/00 , A61B5/04 , A61F11/04 , A61N1/05 , A61N1/36 , H02J7/00 , H04R25/00 , A61B5/291 , A61B5/4094 , A61B5/4836 , A61B5/6868 , A61N1/36125 , A61N1/36139 , A61N1/36157 , A61N1/36167 , A61N1/37223 , H02J1/00 , H02J1/082 , H02J2007/0067 , H02J2207/20 , H02J50/20 , H02J7/0063
摘要： Representative methods, apparatus and systems are disclosed for providing concurrent electrical stimulation and electrical recording in a human or non-human subject, such as for neuromodulation, with the apparatus coupleable to an electrode array. A representative apparatus is typically an integrated circuit including: stimulation circuits, recording circuits, and blocking circuits responsive to control signals to block the stimulation voltage or current on an electrode from a corresponding recording circuit, while other recording circuits may simultaneously record electrical signals from other electrodes and generate recorded data. A representative stimulation circuit may include current sources; a first multiplexer for current source selection; a second multiplexer for electrode selection; a switchable voltage offset circuit; a switchable grounding circuit; and a stimulation controller providing control signals to provide the electrical stimulation, such as biphasic or monophasic stimulation, and bipolor or unipolar stimulation. Off-chip communication, control, along with power and voltage level control, are also provided.

8. 发明申请

WO2022029445A1 DEEP BRAIN STIMULATION 审中-公开
公开(公告)号：WO2022029445A1
公开(公告)日：2022-02-10
申请号：PCT/GB2021/052039
申请日：2021-08-06
申请人： OXFORD UNIVERSITY INNOVATION LIMITED
发明人： WEERASINGHE, Gihan , BOGACZ, Rafal
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05 , A61B5/00 , A61B5/11 , A61B2562/0219 , A61B5/1101 , A61B5/293 , A61B5/37 , A61B5/4088 , A61B5/4094 , A61B5/4836 , A61B5/686 , A61B5/6868 , A61N1/0476 , A61N1/0534 , A61N1/36067 , A61N1/36139
摘要： There is provided a method of generating deep brain stimulation signals, the method comprising receiving a plurality of sensor signals from a corresponding plurality of sensors on or in a subject, and using the received sensor signals to generate a plurality of stimulation signals for application at a corresponding plurality of target sites in the brain of the subject. There is further provided a method of generating stimulation signals, the method comprising receiving a plurality of sensor signals from a corresponding plurality of sensors on or in a subject, and using the received sensor signals to generate a plurality of stimulation signals for application at a corresponding plurality of target sites on or in the subject using a model of the response of neurons in the subject to the stimulation signals that models neural tissue as a plurality of coupled populations of neurons.

9. 发明申请

WO2022020433A1 SEIZURE DETECTION VIA ELECTROOCULOGRAPHY (EOG) 审中-公开
公开(公告)号：WO2022020433A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042517
申请日：2021-07-21
申请人： EYSZ INC.
发明人： KUPERMAN, Rachel , AMIN, Parth
IPC分类号： A61B5/398 , A61B5/00 , A61B5/24 , A61B5/316 , A61B5/163 , A61B5/369 , A61B5/4094 , A61B5/4836 , A61B5/7267 , A61B5/746
摘要： This invention incorporates analysis of electrooculographic (EOG) data into a methods and apparatus for reporting, alarming and intervening events and conditions. More particularly, EOG signals are analyzed separately from EEG signals, with the EOG signals used as a distinct source of information. The approach can identify patterns associated or predictive of seizures, syncope, drowsiness and loss of consciousness during night or day through the analysis of eye-movements recorded using just the EOG.

10. 发明申请

WO2021249674A1 BIOFEEDBACK SYSTEM 审中-公开
公开(公告)号：WO2021249674A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/052512
申请日：2021-02-03
申请人： NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)
发明人： ENGEBRETSEN, Marcus Aleksander , STUBBERUD, Anker , LINDE, Mattias , OLSEN, Alexander , TRONVIK, Erling , RAMAMPIARO, Herindrasana
IPC分类号： A61B5/00 , A61B5/4094 , A61B5/4824 , A61B5/4836 , A61B5/486
摘要： A biofeedback system for headache patients comprises: a sensor system (2) for obtaining and transmitting data indicative of a plurality of physiological parameters of the patient, a personal computing device (4) arranged to receive data from the sensor system (2) and to interact with the patient via a user interface of the personal computing device (4), and a computer-implemented biofeedback agent (6). The sensor system (2) is configured for measurement of the physiological parameters of the patient, wherein the physiological parameters include at least two of muscle tension, body temperature, heart rate and heart rate variability. The personal computing device (4) together with the biofeedback agent (6) are configured to carry out the following steps: obtain data indicative of the physiological parameters from the sensor system (2); instruct the patient to control the physiological parameters; determine baseline levels for each of the physiological parameters; derive a score for each of the physiological parameters relative to the baseline levels, wherein the score increases in reaction to control of the respective physiological parameter; and use a weighting system to determine a weighting for the score associated with each of the physiological parameters and present a total score to the patient via the user interface, the total score consisting of a combination of the weighted scores, wherein the weighting system gives a higher weighting to the score for the physiological parameter that the patient most successfully controls and a lower weighting to the score for the physiological parameter that the patient least successfully controls.

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