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    • 3. 发明申请
    • STABLE PACKAGED DOSAGE FORM AND PROCESS THEREFOR
    • 稳定的包装剂型及其过程
    • WO2007109824A1
    • 2007-10-04
    • PCT/AU2006/000397
    • 2006-03-24
    • TRACTON, Ian, Simon
    • TRACTON, Ian, Simon
    • A61K36/05A23L3/3418A23L3/3427A23L3/3436B65B25/22B65B31/02B65D81/26
    • A61K36/05A23L3/3436A23L17/60
    • The present invention relates to a process for preparing a stabilised packaged dosage form, said dosage form comprising an oxidation-sensitive material, for example carotenes and carotenoids in whole dried algae of the genus Dunaliella , said method comprising: a) providing said oxidation-sensitive material and placing it in a sealable container with an oxygen scavenger, or a desiccant, or both an oxygen scavenger and a desiccant; b) sealing said container and storing said oxidation-sensitive material with said oxygen scavenger, or desiccant, or oxygen scavenger and desiccant in said sealed container for a sufficient period of time to allow for removal of substantially all free oxygen, or free moisture or substantially all free oxygen and free moisture from the environment inside said container and the environment of said oxidation-sensitive material; and c) removing said oxidation-sensitive material from said container and sealing it in substantially air-tight packaging. The present invention also relates to a stable packaged oral dosage form comprising whole dried algae, but substantially no antioxidants exogenous to said whole dried algae and a dosage form consisting essentially of whole dried Dunaliella in encapsulated, tableted or single dosage sachet form, and also relates to a method of treatment or prophylaxis of various conditions, a method for supplementing the diet of a subject, a method for maintaining or improving the general health of a subject, and a method for promoting a fake suntan on a subject, wherein said methods comprise administering to a subject an effective amount of whole dried Dunaliella rich in carotenes.
    • 本发明涉及一种制备稳定的包装剂型的方法,所述剂型包含氧化敏感性材料,例如胡萝卜素属的全干藻类中的胡萝卜素和类胡萝卜素,所述方法包括:a)提供所述氧化敏感的 将其放置在具有除氧剂或干燥剂的密封容器中,或者除氧剂和干燥剂; b)密封所述容器并将所述氧化敏感材料与所述除氧剂或干燥剂或除氧剂和干燥剂一起储存在所述密封容器中足够的时间,以允许除去基本上所有的游离氧或游离水分或基本上 所有容器内的环境中的所有游离氧气和游离水分以及所述氧化敏感材料的环境; 以及c)从所述容器中除去所述氧化敏感材料并将其密封在基本上不透气的包装中。 本发明还涉及一种稳定包装的口服剂型,其包含全部干燥的藻类,但基本上没有对所述全部干燥的藻类外源的抗氧化剂,以及基本上由包封的,压片的或单一的剂量小袋形式的全部干燥的杜氏盐藻组成的剂型, 涉及治疗或预防各种病症的方法,补充受试者饮食的方法,维持或改善受试者的总体健康的方法以及促进受试者的假晒黑的方法,其中所述方法包括 向受试者施用有效量的富含胡萝卜素的干燥的杜氏盐藻。