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1. 发明申请

WO9821341A2 METHOD FOR THE RECOMBINANT PRODUCTION OF 1,3-PROPANEDIOL 审中-公开
标题翻译：重组1,3-丙二醇生产方法
公开(公告)号：WO9821341A2
公开(公告)日：1998-05-22
申请号：PCT/US9720873
申请日：1997-11-13
申请人： GENENCOR INT , DUNN COLEMAN NIGEL S , DIAZ TORRES MARIA , CHASE MATTHEW W , TRIMBUR DONALD
发明人： DUNN-COLEMAN NIGEL S , DIAZ-TORRES MARIA , CHASE MATTHEW W , TRIMBUR DONALD
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/02 , C12N9/04 , C12N9/16 , C12N9/88 , C12N15/52 , C12N15/53 , C12P7/18 , C12R1/22 , C12R1/85 , C12R1/865 , C12N15/55 , C12N15/60
CPC分类号： C12N9/0004 , C12N9/16 , C12N9/88 , C12N15/52 , C12P7/18 , Y10S530/824
摘要： The present invention provides an improved method for the production of 1,3-propanediol from a variety of carbon sources is an organism comprising DNA encoding protein X of a dehydratase or protein X in combination with at least one of protein 1, protein 2 and protein 3. The protein X may be isolated from a diol dehydratase or a glycerol dehydratase. The present invention also provides host cells comprising protein X that are capable of increased production of 1,3-propanediol.
摘要翻译：本发明提供了用于从各种碳源生产1,3-丙二醇的改进方法是一种生物体，其包含编码脱水酶或蛋白质X的蛋白质X的DNA，与蛋白质1，蛋白质2和蛋白质蛋白质中的至少一种组合蛋白X可以从二醇脱水酶或甘油脱水酶中分离出来。本发明还提供能够增加1,3-丙二醇生产的含有蛋白质X的宿主细胞。

2. 发明申请

WO1994005309A1 USE OF PLATELET FACTOR 4 TO INHIBIT OSTEOBLAST PROLIFERATION 审中-公开
标题翻译：使用平板因子4抑制OSTEOBLAST增殖
公开(公告)号：WO1994005309A1
公开(公告)日：1994-03-17
申请号：PCT/US1993008013
申请日：1993-08-26
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, ...
发明人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, ... , TATAKIS, Dimitris, N.
IPC分类号： A61K37/00
CPC分类号： A61K38/195 , Y10S530/824
摘要： The invention features the use of platelet factor 4 (PF4) for inhibiting proliferation of osteoblasts in a mammal in need of such inhibition. The method entails administering PF4. PF4 can be used to treat both diseases characterized by primary changes in osteoblastic cell funtion/activity (e.g., osteosarcoma) and diseases or systemic conditions affecting bone in which abnormal osteoblastic cell function/activity is a secondary effect (e.g., osteoporosis). In addition, PF4 may be used to treat diseases associated with localized changes in bone metabolism in which abnormal osteoblastic cell function/activity contributes to pathogenic bone changes, e.g., periodontal disease, rheumatoid arthritis and osteoarthritis, localized osteoporosis, mastocytosis, multiple myeloma, and bone metastases of various tumors.
摘要翻译：本发明的特征在于在需要这种抑制的哺乳动物中使用血小板因子4（PF4）来抑制成骨细胞的增殖。该方法需要施用PF4。 PF4可用于治疗特征为成骨细胞功能/活性（例如骨肉瘤）的初级变化和影响骨的疾病或全身条件的两种疾病，其中异常成骨细胞功能/活性是次要作用（例如，骨质疏松症）。此外，PF4可用于治疗与骨代谢局部变化相关的疾病，其中异常成骨细胞功能/活性有助于致病性骨变化，例如牙周病，类风湿性关节炎和骨关节炎，局部骨质疏松症，肥大细胞增多症，多发性骨髓瘤和各种肿瘤的骨转移。

3. 发明申请

WO00012537A1 PROCESS FOR THE PREPARATION OF ACTIVE SOMATOTROPIN FROM INCLUSION BODIES 审中-公开
标题翻译：从包裹体制备活性成瘾者的方法
公开(公告)号：WO00012537A1
公开(公告)日：2000-03-09
申请号：PCT/KR1999/000485
申请日：1999-08-26
IPC分类号： C07K1/113 , C07K14/61 , C12N1/21 , C07K1/36 , C12P21/02
CPC分类号： C07K1/1133 , C07K14/61 , Y10S530/824 , Y10S530/825
摘要： A process for the preparation of biologically active somatotropin from inclusion bodies of a recombinant host cell containing an inactive form of said somatotropin protein comprises the steps of: (a) contacting the inclusion bodies with an aqueous alcohol solution at an alkaline pH to solubilize said protein; and (b) bringing the solubilized protein into contact with a mild oxidizing agent to refold and form intramolecular disulfide bonds between cysteine residues of said protein.
摘要翻译：一种从包含非活性形式的所述生长激素蛋白质的重组宿主细胞的包含体制备生物活性生长激素的方法包括以下步骤：（a）使所述包涵体与碱性pH下的醇水溶液接触以溶解所述蛋白质 ; 和（b）使溶解的蛋白质与温和氧化剂接触以重折叠并在所述蛋白质的半胱氨酸残基之间形成分子内二硫键。

4. 发明申请

WO9614408A3 NUCLEOTIDE SEQUENCE ENCODING THE ENZYME I-SCEI ANDNUCLEOTIDE SEQUENCE ENCODING THE ENZYME I-SCEI AND THE USES THEREOF THE USES THEREOF 审中-公开
标题翻译：编码酶编码序列的编码序列编码EN酶I-SCEI及其用途
公开(公告)号：WO9614408A3
公开(公告)日：1996-08-29
申请号：PCT/EP9504351
申请日：1995-11-06
申请人： PASTEUR INSTITUT , UNIV PARIS CURIE
发明人： CHOULIKA ANDRE , PERRIN ARNAUD , DUJON BERNARD , NICOLAS JEAN-FRANCOIS
IPC分类号： A01K67/027 , C07H21/02 , C07H21/04 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N9/16 , C12N9/22 , C12N15/00 , C12N15/09 , C12N15/55 , C12N15/63 , C12N15/66 , C12N15/74 , C12N15/82 , C12N15/86 , C12P21/02 , C12P21/06 , C12Q1/68 , C12R1/865 , C12R1/91 , C12N15/11
CPC分类号： C12Q1/683 , A01K2217/05 , C12N9/22 , C12N15/66 , C12Q1/6841 , Y10S530/824
摘要： An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site directed insertion of genes.

5. 发明申请

WO1996014408A2 NUCLEOTIDE SEQUENCE ENCODING THE ENZYME I-SCEI AND THE USES THEREOF 审中-公开
标题翻译：编码ENZYME I-SCEI的核苷酸序列及其用途
公开(公告)号：WO1996014408A2
公开(公告)日：1996-05-17
申请号：PCT/EP1995004351
申请日：1995-11-06
申请人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE
发明人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE , CHOULIKA, André , PERRIN, Arnaud , DUJON, Bernard , NICOLAS, Jean-François
IPC分类号： C12N15/11
CPC分类号： C12Q1/683 , A01K2217/05 , C12N9/22 , C12N15/66 , C12Q1/6841 , Y10S530/824
摘要： An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site directed insertion of genes.
摘要翻译：提供编码酶I-SceI的分离的DNA。 DNA序列可以并入克隆和表达载体，转化细胞系和转基因动物中。载体可用于基因作图和基因定点插入。

6. 发明申请

WO2005096823A1 VACCINE FOR NONTYPEABLE HAEMOPHILUS INFLUENZAE INFECTION 审中-公开
标题翻译：疫苗用于非特异性HAEMOPHILUS INFLUENZAE感染
公开(公告)号：WO2005096823A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/011069
申请日：2005-04-01
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK AT BUFFALO , HILTKE, Thomas , MURPHY, Timothy, F. , SETHI, Sanjay
发明人： HILTKE, Thomas , MURPHY, Timothy, F. , SETHI, Sanjay
IPC分类号： A01N63/00
CPC分类号： A61K39/102 , A61K2039/52 , A61K2039/545 , A61K2039/70 , Y10S530/824
摘要： This invention provides a method for identifying strains of nontypeable Haemophilus influenzae that can be used as immunogenic compositions having specificity against a plurality of Haemophilus influenzae strains. The invention also provides compositions comprising whole cell bacteria or outer membrane protein P2 obtained from the strains for use as vaccines.
摘要翻译：本发明提供了一种用于鉴定不可分型流感嗜血杆菌菌株的方法，其可用作对多种流感嗜血杆菌菌株具有特异性的免疫原性组合物。本发明还提供包含从用作疫苗的菌株获得的全细胞细胞或外膜蛋白P2的组合物。

7. 发明申请

WO1998021339A1 METHOD FOR THE PRODUCTION OF 1,3-PROPANEDIOL BY RECOMBINANT ORGANISMS 审中-公开
标题翻译：通过重组有机物生产1,3-丙二醇的方法
公开(公告)号：WO1998021339A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020292
申请日：1997-11-10
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , GENENCOR INTERNATIONAL, INC. , GATENBY, Anthony, Arthur , HAYNIE, Sharon, Loretta , NAGARAJAN, Vasantha , NAIR, Ramesh, V. , NAKAMURA, Charles, E. , PAYNE, Mark, Scott , PICATAGGIO, Stephen, Kenneth , DIAS-TORRES, Maria , HSU, Amy, Kuang-Hua , LAREAU, Richard, D. , TRIMBUR, Donald, E. , WHITED, Gregory, M.
发明人： E.I. DU PONT DE NEMOURS AND COMPANY , GENENCOR INTERNATIONAL, INC.
IPC分类号： C12N15/53
CPC分类号： C12N9/0004 , C12N9/16 , C12N9/88 , C12N15/52 , C12P7/18 , Y10S530/824
摘要： Recombinant organisms are provided comprising genes encoding glycerol-3-phosphate dehydrogenase, glycerol-3-phosphatase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for the production of 1,3-propanediol from a variety of carbon substrates.
摘要翻译：提供重组生物，其包含编码甘油-3-磷酸脱氢酶，甘油-3-磷酸酶，甘油脱水酶和1,3-丙二醇氧化还原酶活性的基因，其可用于从各种碳底物生产1,3-丙二醇。

8. 发明申请

WO1994018240A1 FILAMENTOUS FUNGUS PROTEINS FOR BINDING AND TRANSPORTING LIPIDS, PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开
标题翻译：用于结合和运输脂肪的真菌真菌蛋白，其制备方法及其用途
公开(公告)号：WO1994018240A1
公开(公告)日：1994-08-18
申请号：PCT/FR1994000151
申请日：1994-02-10
申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE-INRA , RECORD, Eric , LESAGE, Laurence , MARION, Didier , CAHAGNIER, Bernard , RICHARD-MOLARD, Daniel , ASTHER, Marcel
发明人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE-INRA
IPC分类号： C07K15/00
CPC分类号： C07K14/37 , A61K38/00 , Y10S435/911 , Y10S435/913 , Y10S435/939 , Y10S530/824
摘要： A family of lipid binding and transporting proteins, a method for preparing same from fungi, and their use in cosmeticology, the agri-foodstuffs industry and pharmacology, are disclosed. Said proteins are capable of binding, transporting and/or rearranging lipids between membranes, optionally in combination with active principles. Furthermore, the proteins are hydrophobic and acidic, have a molecular weight of under 50 kDa, and may be prepared from a non-toxic filamentous fungus capable of developing on a lipid-enriched medium, particularly from raw extracts of said fungi.
摘要翻译：公开了一种脂质结合和转运蛋白质，其从真菌中制备其的方法及其在美容学，农业食品工业和药理学中的应用。所述蛋白质能够在膜之间结合，运输和/或重新排列脂质，任选地与活性成分组合。此外，蛋白质是疏水性的和酸性的，具有低于50kDa的分子量，并且可以由能够在富含脂质的培养基，特别是所述真菌的粗提取物上发育的无毒丝状真菌制备。

9. 发明申请

WO1994007919A1 INSULIN RECEPTOR-LIKE PROTEIN 审中-公开
标题翻译：胰岛素受体样蛋白
公开(公告)号：WO1994007919A1
公开(公告)日：1994-04-14
申请号：PCT/US1993009486
申请日：1993-10-05
申请人： McKENZIE, Maureen, A.
IPC分类号： C07K15/04
CPC分类号： C07K14/72 , C07K14/39 , G01N2333/62 , G01N2333/72 , G01N2333/9121 , Y10S530/824
摘要： An insulin-like polypeptide isolated from yeast cultures is described. The protein elicits in yeast upon binding to a specific receptor many of the physiologic responses characteristic of those observed in mammalian cells upon binding of insulin to the mammalian insulin receptor.
摘要翻译：描述从酵母培养物分离的胰岛素样多肽。蛋白质在结合特异性受体时引发了许多在胰岛素与哺乳动物胰岛素受体结合时在哺乳动物细胞中观察到的那些特征的生理反应。

10. 发明申请

WO99016881A1 ANTIGEN PROTEIN AND NUCLEIC ACID CODING FOR SAID PROTEIN 审中-公开
标题翻译：抗原蛋白和核酸编码蛋白
公开(公告)号：WO99016881A1
公开(公告)日：1999-04-08
申请号：PCT/JP1998/004326
申请日：1998-09-28
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K49/00 , A61P13/02 , A61P15/00 , A61P31/04 , C07K14/40 , C07K16/14 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/68 , G01N33/53 , G01N33/569
CPC分类号： C07K14/40 , A61K38/00 , A61K39/00 , Y10S530/824
摘要： A novel antigen protein which is useful for treatment and diagnosis of diseases derived from fungi including Candida albicans; and a nucleic acid coding for the antigen protein. The antigen protein is characterized by being recognized by an antiserum derived from a Candida albicans infection resistant mammal and the nucleic acid codes for an antigen protein recognized by an antiserum derived from a Candida albicans infection resistant mammal.
摘要翻译：一种新型抗原蛋白，可用于治疗和诊断来自真菌的疾病，包括白色念珠菌; 和编码抗原蛋白质的核酸。抗原蛋白的特征在于由来自白色念珠菌感染抗性哺乳动物的抗血清识别，核酸编码由来自白色念珠菌感染抗性哺乳动物的抗血清识别的抗原蛋白。

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