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1. 发明申请

WO2006113914A3 METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS, AND ORGANISMS 审中-公开
标题翻译：制备方法，组合物和制品提高细胞，组织，器官和有机体的存活率
公开(公告)号：WO2006113914A3
公开(公告)日：2007-04-19
申请号：PCT/US2006015158
申请日：2006-04-20
申请人： HUTCHINSON FRED CANCER RES , ROTH MARK B , MORRISON MIKE , GOLDMARK JESSE , BLACKSTONE ERIC
发明人： ROTH MARK B , MORRISON MIKE , GOLDMARK JESSE , BLACKSTONE ERIC
IPC分类号： A61K33/04 , A01N1/00 , C12N5/00
CPC分类号： A61K33/04 , A01N1/02 , A01N1/0226 , A61K31/095 , A61K31/165 , A61K31/185 , A61K31/21 , A61K31/26 , A61K31/275 , A61K31/555 , A61K31/66 , A61K45/06 , Y10S514/921 , A61K2300/00
摘要： The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.
摘要翻译：本发明涉及氧还原剂和其它活性化合物在体内或整个生物体中的细胞，组织和/或器官中的用途，除了提高其生存性之外。它包括组合物，方法，制品和用于提高生存能力的装置，以及用于在这些生物材料中的任何一种中实现淤滞或止血，从而保护和/或保护它们。在具体实施方案中，还使用所述活性化合物进行器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停搏，神经变性，低温和癌症的治疗方法和装置。

2. 发明申请

WO2003066067A2 METHOD FOR TREATING A MAMMAL BY ADMINISTRATION OF A COMPOUND HAVING THE ABILITY TO RELEASE CO, COMPOUNDS HAVING THE ABILITY TO RELEASE CO AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：通过管理具有释放CO的能力的化合物，具有释放CO的能力的化合物和其药物组合物来治疗哺乳动物的方法
公开(公告)号：WO2003066067A2
公开(公告)日：2003-08-14
申请号：PCT/IB2003/000932
申请日：2003-02-03
申请人： HAAS, Werner , ROMAO, Carlos , ROYO, Beatriz , FERNANDES, Ana, Cristina , GONCALVES, Isabel
发明人： HAAS, Werner , ROMAO, Carlos , ROYO, Beatriz , FERNANDES, Ana, Cristina , GONCALVES, Isabel
IPC分类号： A61K31/7048
CPC分类号： C07F17/00 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/52 , C07F11/005 , C07F13/005 , C07F15/02 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/879 , Y10S514/886 , Y10S514/887 , Y10S514/894 , Y10S514/903 , Y10S514/921 , Y10S514/929 , Y10S514/95 , Y10S514/958 , Y10S514/959 , Y10S514/964 , A61K2300/00
摘要： Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g. rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
摘要翻译：几类体内释放一氧化碳的化合物可用于治疗和/或预防疾病，例如慢性炎症性疾病。类风湿性关节炎和具有强烈炎症成分的疾病，例如动脉粥样硬化，中风，冠状动脉疾病和阿尔茨海默病。体内释放一氧化碳的化合物可以连接到已知的药物载体和/或已知的抗炎药物，例如阿司匹林。

3. 发明申请

WO0119356A3 HIGH LIPID DIET 审中-公开
标题翻译：高脂饮料
公开(公告)号：WO0119356A3
公开(公告)日：2001-05-17
申请号：PCT/EP0008731
申请日：2000-09-07
申请人： NESTLE SA , TURINI MARCO , ROESSLE CLAUDIA , BREUILLE DENIS , CROZIER WILLI GAYLE , FINOT PAUL ANDRE , RICHELLE MYRIAM , DUTOT GUY
发明人： TURINI MARCO , ROESSLE CLAUDIA , BREUILLE DENIS , CROZIER-WILLI GAYLE , FINOT PAUL-ANDRE , RICHELLE MYRIAM , DUTOT GUY
IPC分类号： A23L33/00 , A23L33/12 , A23L33/15 , A23L33/16 , A61K31/00 , A61K31/202 , A61K31/23 , A61K47/00 , A61P3/00 , A61P29/00 , A61P43/00 , A23L1/30
CPC分类号： A61K31/23 , A23L33/12 , A23L33/15 , A23L33/16 , A23L33/40 , Y10S514/921
摘要： A composition for use as a medicament or nutritional product is described which comprises at least one lipid wherein the lipid provides greater than 35 % total energy of the composition. A prefered embodiment comprises a n-6/n-3 fatty acid ratio of about 2/1 to 7/1. In addition, a method of preparing the composition; use of the composition in the manufacture of a medicament or nutritional product; and a method of treatment or prevention of sepsis or inflammatory shock which comprises administering an effective amount of the composition are described.
摘要翻译：描述了用作药物或营养产品的组合物，其包含至少一种脂质，其中所述脂质提供组合物的总能量的35％以上。优选的实施方案包括约2/1至7/1的n-6 / n-3脂肪酸比。另外，制备组合物的方法; 在制备药物或营养产品中使用该组合物; 以及治疗或预防败血症或炎性休克的方法，其包括施用有效量的组合物。

4. 发明申请

WO1997042966A1 THERAPEUTIC USES OF BPI PROTEIN PRODUCTS FOR HUMAN MENINGOCOCCEMIA 审中-公开
标题翻译： BPI蛋白质产品对人类肉鸡的治疗用途
公开(公告)号：WO1997042966A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008016
申请日：1997-05-09
申请人： XOMA CORPORATION , GIROIR, Brett, P. , SCANNON, Patrick, J.
发明人： XOMA CORPORATION
IPC分类号： A61K38/17
CPC分类号： C07K14/4742 , A61K38/1751 , Y10S514/898 , Y10S514/921 , Y10S530/829 , Y10S530/83 , A61K2300/00
摘要： Methods and materials for the treatment of human meningococcemia are provided in which therapeutically effective amounts of BPI protein products are administered.
摘要翻译：提供用于治疗人脑膜炎球菌病的方法和材料，其中施用治疗有效量的BPI蛋白质产品。

5. 发明申请

WO1996029973A2 COMPOSITIONS AND METHODS FOR INHIBITING THROMBOGENESIS 审中-公开
标题翻译：用于抑制血液发生的组合物和方法
公开(公告)号：WO1996029973A2
公开(公告)日：1996-10-03
申请号：PCT/CA1996000190
申请日：1996-03-29
申请人： HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT INC.
发明人： HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT INC. , Weitz, Jeffrey, I. , HIRSH, Jack , YOUNG, Edward
IPC分类号： A61K00/00
CPC分类号： C08B37/0078 , Y10S514/921
摘要： The present invention provides compositions and methods for inactivating thrombin bound to fibrin within a thrombus or clot, whereby the ability of clot-bound thrombin to catalytically promote further clot accretion is substantially diminished or eliminated. The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accident (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.
摘要翻译：本发明提供用于灭活血栓或凝块内与纤维蛋白结合的凝血酶的组合物和方法，其中凝块结合的凝血酶催化促进进一步凝块增生的能力基本上减少或消除。本发明的组合物和方法特别可用于预防心脏旁路装置和经历肾透析的患者的血液循环中的血栓形成，并且用于治疗患有血栓相关心血管病症或患有血栓相关心血管病症的患者，例如不稳定型心绞痛，急性心肌梗死（心脏病发作），脑血管意外（中风），肺栓塞，深静脉血栓形成，动脉血栓形成等。

6. 发明申请

WO1996025174A1 MUSCLE PROTEIN DECOMPOSITION INHIBITOR CONTAINING IL-6 RECEPTOR ANTIBODY 审中-公开
标题翻译：包含IL-6受体抗体的肌肉蛋白分解抑制剂
公开(公告)号：WO1996025174A1
公开(公告)日：1996-08-22
申请号：PCT/JP1996000310
申请日：1996-02-13
申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA , TSUJINAKA, Toshimasa , EBISUI, Chikara , FUJITA, Junya
发明人： CHUGAI SEIYAKU KABUSHIKI KAISHA
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2319/00 , Y10S514/907 , Y10S514/921
摘要： A muscle protein decomposition inhibitor containing an interleukin-6 receptor antibody (IL-6R antibody) exemplified by antibodies of animals other than man, such as mouse or rat, chimeric antibodies comprising the above antibodies and human antibodies, and reconstituted human antibodies. The inhibitor is useful for inhibiting muscle protein decomposition occurring in such disease as cancerous cachexia, severe septicemic trauma and muscular dystrophy.
摘要翻译：含有白细胞介素-6受体抗体（IL-6R抗体）的肌肉蛋白分解抑制剂，例如除人以外的动物（例如小鼠或大鼠），包含上述抗体和人抗体的嵌合抗体和重构人抗体。抑制剂可用于抑制在诸如癌性恶病质，严重的败血性创伤和肌营养不良的疾病中发生的肌肉蛋白分解。

7. 发明申请

WO1995021180A1 SUBSTITUTED LACTOSE DERIVATIVES AS CELL ADHESION INHIBITORS 审中-公开
标题翻译：取代的乳糖衍生物作为细胞粘附抑制剂
公开(公告)号：WO1995021180A1
公开(公告)日：1995-08-10
申请号：PCT/US1995001295
申请日：1995-02-01
申请人： GLYCOMED INCORPORATED
发明人： GLYCOMED INCORPORATED , ABBAS, Saeed, A. , DASGUPTA, Falguni , ASA, Darwin , MUSSER, John, H. , NASHED, Mina, A.
IPC分类号： C07H03/06
CPC分类号： C07H11/00 , C07H3/04 , C07H3/06 , C07H15/18 , C07H23/00 , Y10S514/825 , Y10S514/885 , Y10S514/886 , Y10S514/921
摘要： Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In said formula each R is independently H or lower alkyl (1-4C); R is H, OH or lower alkyl (1-4C), or a lipophilic group such as a higher alkyl group (5-15C), alkylaryl or one or more additional saccharide residues; R is a negatively charged moiety including SO4 -, PO4 -, or related group; Y is H or lower alkyl (1-4C); and X is H or -CHR (CHOR )2CHR OR wherein R and R are each independently H, lower alkyl (1-4C), or taken together result in a five- or six-membered ring optionally containing a heteroatom selected from the group consisting of O, S, and NR ; said five- or six-membered ring optionally substituted with one substituent selected from the group consisting of R , CH2OR , OR , OOCR , NR 2, NHCOR , and SR with the proviso that if X represents a hexose substituent R and R , taken together, cannot provide a hexose substituent.
摘要翻译：描述了制备它们具有式（I）的化合物和方法，其结合选择素受体，从而通过调节细胞粘附事件来调节炎症，癌症和相关疾病的过程。在所述式中，R 1独立地为H或低级烷基（1-4C）; R 2是H，OH或低级烷基（1-4C），或亲脂基团如高级烷基（5-15C），烷基芳基或一个或多个另外的糖残基; R 3是带负电荷的部分，包括SO 4 2-，PO 4 2-或相关基团; Y为H或低级烷基（1-4C）; 并且X是H或-CHR 4（CHOR 1）2 CHR 5 OR 1其中R 4和R 5各自独立地为H，低级烷基（1-4C）或一起导致任选地含有选自O，S和NR 1的杂原子的五元或六元环; 所述五元或六元环任选被一个选自R 1，CH 2 OR 1，OR 1，OOCR 1，NR 12，NHCOR 1，和SR 1，条件是如果X表示己糖取代基R 3和R 4一起不能提供己糖取代基。

8. 发明申请

WO1995010266A1 NITROGEN MONOXIDE SYNTHESIS INHIBITOR 审中-公开
标题翻译：硝酸一氧化氮合成抑制剂
公开(公告)号：WO1995010266A1
公开(公告)日：1995-04-20
申请号：PCT/JP1994001695
申请日：1994-10-11
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , MORITOKI, Hideki , TAKAISHI, Yoshihisa , ADACHI, Masakazu , ONO, Yukihisa
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/085
CPC分类号： C07D307/77 , C07C43/215 , C07C45/513 , C07C45/68 , C07C47/575 , C07C49/747 , C07C49/755 , C07C50/34 , C07C50/38 , C07C62/32 , C07C62/34 , C07C62/38 , C07C323/65 , C07C2603/26 , C07D207/16 , C07F7/1804 , C07F9/532 , Y10S514/921
摘要： A nitrogen monoxide synthesis inhibitor containing as the active ingredient at least one member selected from phenanthrene derivatives represented by the compounds of general formula (1) and salts thereof; it is useful for preventing and treating various diseases caused by nitrogen monoxide, such as endotoxin shock.
摘要翻译：一种一氧化氮合成抑制剂，含有选自由通式（1）的化合物及其盐表示的菲衍生物中的至少一种作为活性成分; 可用于预防和治疗由一氧化氮引起的各种疾病，如内毒素休克。

9. 发明申请

WO1986005692A2 TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME 审中-公开
标题翻译：治疗呼吸道感染综合征
公开(公告)号：WO1986005692A2
公开(公告)日：1986-10-09
申请号：PCT/US1986000659
申请日：1986-03-31
申请人： RAFFIN, Thomas, A. , STEVENS, John, H.
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K38/00 , Y10S514/921

10. 发明申请

WO2005086814A3 METHODS AND COMPOSITIONS RELATED TO REGULATION OF CYTOKINE PRODUCTION BY GLYCOGEN SYNTHASE KINASE 3 (GSK-3) 审中-公开
标题翻译：通过GLYCOGEN SYNTHASE KINASE 3（GSK-3）调控细胞因子生产相关的方法和组合
公开(公告)号：WO2005086814A3
公开(公告)日：2006-11-02
申请号：PCT/US2005007586
申请日：2005-03-09
申请人： UAB RESEARCH FOUNDATION , MARTIN MICHAEL
发明人： MARTIN MICHAEL
IPC分类号： A61K33/14 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/20
CPC分类号： A61K33/14 , Y10S514/921
摘要： This invention relates generally to a method of treating inflammation and associated diseases and disorders by administering an agent that inhibits glycogen synthase kinase 3 activity.
摘要翻译：本发明一般涉及通过施用抑制糖原合酶激酶3活性的药物来治疗炎症和相关疾病和病症的方法。

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