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1. 发明申请

WO2016041890A3 COMPOSITIONS, METHODS, AND SYSTEMS FOR TISSUE FIXATION 审中-公开
标题翻译：用于组织固定的组合物，方法和系统
公开(公告)号：WO2016041890A3
公开(公告)日：2016-06-09
申请号：PCT/EP2015070927
申请日：2015-09-14
申请人： VENTANA MED SYST INC , HOFFMANN LA ROCHE
发明人： CHAFIN DAVID , OTTER MICHAEL , THEISS ABBEY , BAUER DANIEL
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N1/36 , G01N2001/2873 , G01N2001/305
摘要： The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.
摘要翻译：本公开涉及使用高浓度醛基固定剂来固定组织样品。选择醛浓度显着增加固定溶液扩散到组织中的速率。当在双温固定的冷温步骤中组合时，实现了翻译后修饰的蛋白质的保存的显着改善。

2. 发明申请

WO2015193469A1 EINBETTMEDIUM FÜR BIOLOGISCHE PROBEN UND VERFAHREN ZUM HERSTELLEN VON EINGEBETTETEN BIOLOGISCHEN PROBEN SOWIE DEREN VERWENDUNG 审中-公开
标题翻译：嵌入的生物样品和方法生产嵌入式生物样品和及其用途
公开(公告)号：WO2015193469A1
公开(公告)日：2015-12-23
申请号：PCT/EP2015/063808
申请日：2015-06-19
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER , LASER ZENTRUM HANNOVER E.V.
发明人： KÜHNEL, Mark , KELLNER, Manuela , JONIGK, Danny , IZYKOWSKI, Nicole , MEYER, Heiko , LORBEER, Raoul-Amadeus , HEIDRICH, Marko
IPC分类号： G01N1/30 , G01N1/42
CPC分类号： G01N1/36 , C12Q1/68 , G01N1/286 , G01N1/30 , G01N1/44 , G01N2001/2886 , G01N2001/305 , G01N2001/364 , G06K9/00134 , G06K9/0014
摘要： In einem ersten Aspekt richtet sich die Erfindung auf die Verwendung einer UV-polymerisierbaren Zusammensetzung als Einbettmedium für biologische Proben. Diese UV-polymerisierbare Zusammensetzung ist eine mit einem Brechungsindex nach Polymerisation im Bereich von n = 1,45bis n = 1,6. In einem weiteren Aspekt richtet sich die Anmeldung auf ein Verfahren zum Herstellen von eingebetteten biologischen Proben unter Verwendung dieser UV-polymerisierbaren Zusammensetzung sowie um diese eingebetteten biologischen Proben selbst. Diese biologischen Proben sind in verschiedensten Bereichen, unter anderem der Diagnostik, einsetzbar und eignen sich insbesondere auch zur RNA basierten Diagnostik.
摘要翻译：在第一方面，本发明涉及使用可UV聚合性组合物可用作生物样品包埋介质。这些UV可聚合的组合物是一个具有n的范围聚合后的折射率= 1,45bis N = 1.6。在进一步的方面，本申请涉及一种用于使用这些UV聚合性组合物，以及那些包埋的生物样品本身包埋的生物样品中的用途。这些生物样品是在各个领域，包括诊断，可以使用和特别适合也是基于RNA的诊断。

3. 发明申请

WO0244691A3 SPUTUM FIXATIVE AND METHODS AND USES THEREFOR 审中-公开
标题翻译： SPUTUM FIXATIVE及其方法和用途
公开(公告)号：WO0244691A3
公开(公告)日：2002-09-26
申请号：PCT/CA0101674
申请日：2001-11-28
申请人： UNIV MCMASTER , COX GERARD , KELLY MARGARET , HARGREAVE FREDERICK
发明人： COX GERARD , KELLY MARGARET , HARGREAVE FREDERICK
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N2001/305
摘要： A fixative composition for preserving cell count in a sputum sample and to a method of preserving cell count and improving cellular dispersal of the sputum sample. The composition comprises a disulphide bond reducing agent, preferably DTT, and a cross-linking agent, preferably paraformaldehyde. The method of the invention involves fixing the sputum sample and then dispersing it with a proteolytic agent such as trypsin. The method and composition are used in enhancing examination of sputum samples and can be used in the diagnosis and assessment of a number of conditions, such as airway inflammatory related conditions, i.e., asthma, chronic cough, Chronic Obstructive Pulmonary Disease, cancer, aspitation of orthopharyngeal or gastric contents, including gastroesophogeal reflux, heart failure, including left heart failure such as dyspnea with combined pulmonary and cardiac disorders. This invention makes possible delayed examination of the sputum sample and enables the taking of a sample at any site and time and subsequently transporting it to an appropriate centre for examination.
摘要翻译：用于保存痰样品中细胞计数的固定剂组合物以及保存细胞计数和改善痰样品的细胞分散的方法。该组合物包含二硫键还原剂，优选DTT和交联剂，优选多聚甲醛。本发明的方法包括固定痰样，然后用蛋白水解剂如胰蛋白酶分散。该方法和组合物用于增强对痰标本的检查，并可用于诊断和评估许多病症，如气道炎症相关病症，即哮喘，慢性咳嗽，慢性阻塞性肺病，癌症，对鼻咽或胃内容物，包括胃食管反流，心力衰竭，包括左心衰竭，如伴有肺和心脏病的呼吸困难。本发明使痰液样本延迟检查成为可能，并且能够在任何地点和时间取样并随后将其运送到适当的中心进行检查。

4. 发明申请

WO99009390A1 A HIGH QUALITY, CONTINUOUS THROUGHPUT, TISSUE FIXATION-DEHYDRATION-FAT REMOVAL-IMPREGNATION METHOD 审中-公开
标题翻译：高质量，连续性，组织固定 - 脱脂 - 脂肪去除方法
公开(公告)号：WO99009390A1
公开(公告)日：1999-02-25
申请号：PCT/US1998/016463
申请日：1998-08-19
IPC分类号： G01N33/48 , B01L9/00 , G01N1/06 , G01N1/28 , G01N1/30 , G01N1/31 , G01N1/36 , G01N1/44
CPC分类号： B01L9/50 , G01N1/06 , G01N1/30 , G01N1/312 , G01N1/36 , G01N1/44 , G01N2001/305 , G01N2001/315
摘要： A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.
摘要翻译：公开了用于组织快速，连续流组织学处理的方法和装置。固定，脱水，清洗和浸渍的步骤在不到一小时的时间内完成; 这允许病理学家在收到后不久评估样本，也许在患者仍在手术室时。通过减少组织切片的厚度，使用由溶液的混合物组成的非水溶液，在升高的温度和搅拌下的溶液交换以及在真空压力下的浸渍来实现快速和连续的加工。因此，手术中的患者提供了点护理手术病理学。

5. 发明申请

WO1986006479A1 METHOD OF IMPREGNATING A TISSUE SPECIMEN WITH PARAFFIN 审中-公开
标题翻译：用PARAFFIN印染组织样本的方法
公开(公告)号：WO1986006479A1
公开(公告)日：1986-11-06
申请号：PCT/SE1986000185
申请日：1986-04-22
申请人： RENVALL, Henrik, Gerhard
IPC分类号： G01N01/28
CPC分类号： G01N1/30 , G01N2001/305
摘要： In a method of impregnating a tissue specimen with paraffin either directly after an optional treatment of the tissue specimen with a fixing agent or after the tissue specimen optionally has been treated with a fixing agent and/or a dehydrating agent an immersion of the tissue specimen into a bath of liquid paraffin takes place. The bath is kept below a predetermined temperature at which thermolabile components and properties of the tissue specimen undergo changes. The pressure of the bath is then lowered from atmospheric pressure to a predetermined pressure at which water present in the tissue specimen and/or, when appropriate, the dehydrating agent vaporizes, the pressure of the bath then being increased again to atmospheric pressure.
摘要翻译：在使用固定剂任选处理组织标本之后或在组织样本任选地用定影剂和/或脱水剂处理后，将组织标本浸入组织样本中的方法中，发生液体石蜡浴。将浴保持在组织样本的不耐热组分和性质变化的预定温度以下。然后将浴的压力从大气压降至组织样本中存在的水的预定压力和/或当适当时，脱水剂蒸发时，浴的压力再次升高至大气压。

6. 发明申请

WO2018160513A1 DRIED CELLULOSE-TREATED TISSUE FOR IN-VITRO COMPLEMENT ACTIVATION ASSAYS AND DIAGNOSTIC KITS 审中-公开
公开(公告)号：WO2018160513A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/019821
申请日：2018-02-27
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： ASHWORTH, Paul E.
IPC分类号： A61K35/12
CPC分类号： G01N33/564 , A61K35/12 , G01N1/30 , G01N2001/305 , G01N2333/4716
摘要： Methods of preparing a solid reference material so as to elicit a positive control response when tested for in-vitro complement activation include providing biological tissue; treating the tissue with an aqueous cellulose solution for a rime sufficient to allow fluid in the tissue to be replaced by the aqueous cellulose solution; drying the cellulose-treated tissue by a vacuum-drying process or a lyophilization process to form dried tissue; and storing the dried tissue in a dry, ambient environment. The tissue prepared by these methods and its use in an in-vitro complement assay and diagnostic kit are also described.

7. 发明申请

WO2016010858A1 METHOD AND APPARATUS FOR CELL BLOCK PREPARATION OF CYTOLOGY SPECIMENS 审中-公开
标题翻译：细胞生物学标本细胞块的制备方法与装置
公开(公告)号：WO2016010858A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040008
申请日：2015-07-10
申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
发明人： LINDSEY, Kathryn , SHOTSBERGER, Wanda , HOUSER, Patricia, M. , YANG, Jack
IPC分类号： G01N1/28 , G01N1/30 , G01N1/31 , G01N1/36
CPC分类号： G01N1/36 , G01N1/286 , G01N1/30 , G01N2001/305 , G01N2001/364
摘要： Embodiments disclosed herein relate to methods and apparatus for cell block preparation of cytology specimens. Specific embodiments relate to methods and apparatus for formalin fixed paraffin embedded cell block preparation of cytology specimens.
摘要翻译：本文公开的实施方案涉及细胞学标本的细胞块制备的方法和装置。具体实施方案涉及福尔马林固定石蜡包埋细胞块制备细胞学标本的方法和装置。

8. 发明申请

WO2015041755A1 METHODS FOR PHENOTYPING OF INTACT WHOLE TISSUES 审中-公开
标题翻译：用于定位全身组织的方法
公开(公告)号：WO2015041755A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/048985
申请日：2014-07-30
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRADINARU, Viviana , YANG, Bin
IPC分类号： G01N33/533
CPC分类号： G01N1/30 , G01N33/57492 , G01N2001/302 , G01N2001/305
摘要： In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches PACT, a protocol for passive tissue clearing and immunostaining of intact organs. In other embodiments, the present application teaches RIMS, a refractive index matching media for imaging thick tissue. In yet other embodiments, the application teaches PARS, a method for whole-body clearing and immunolabeling.
摘要翻译：在各种实施方案中，本申请教导了组织清除的方法和组合物，其中整个器官和身体被赋予大分子可渗透性和光学透明性，从而以完整的连接性暴露其细胞结构。在一些实施方案中，本申请教导了PACT，用于完整器官的被动组织清除和免疫染色的方案。在其他实施例中，本申请教导了RIMS，用于成像厚组织的折射率匹配介质。在其它实施方案中，该应用教导了PARS，全身清除和免疫标记的方法。

9. 发明申请

WO2012177656A3 DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION 审中-公开
标题翻译：设备，解决方案和样品收集方法
公开(公告)号：WO2012177656A3
公开(公告)日：2013-04-25
申请号：PCT/US2012043176
申请日：2012-06-19
申请人： ABOGEN INC , BIADILLAH YOUSSEF , ANDREWS STEPHEN DOUGLAS
发明人： BIADILLAH YOUSSEF , ANDREWS STEPHEN DOUGLAS
IPC分类号： C12M1/24 , G01N1/10 , G01N33/48 , G01N35/10
CPC分类号： G01N1/30 , A01N1/0273 , A61B10/0051 , A61B10/007 , A61B10/0096 , B01L3/502 , B01L3/5021 , B01L3/50825 , B01L2200/025 , B01L2200/0689 , B01L2200/085 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0832 , B01L2400/0683 , G01N1/10 , G01N2001/002 , G01N2001/305
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
摘要翻译：本公开涉及用于收集和处理含有细胞的体液样品（以及用于收集，加工和/或分析其它流体包括有毒和/或有害物质/流体的实施方案）的装置，解决方案和方法。此外，本公开一般涉及功能基因组研究以及从唾液和其他体液（例如尿液）分离和保存细胞用于细胞分析。关于用于收集体液的装置，一些实施例包括两个配合体，帽和管（例如），其中在一些实施例中，帽包括用于保持样品防腐剂溶液的封闭内部空间并与管构成（封闭）样品采集装置。在交配时，保存溶液流入封闭的内部空间以将细胞保存在体液中。管被配置为接收体液（例如，唾液，尿液）的供体样品，然后可以进行处理以提取多个细胞。可以进一步处理多个细胞以从其中分离出一种和/或另一种细胞类型。可以分析多个细胞以及分离的细胞类型用于功能基因组和表观遗传学研究以及生物标志物发现。

10. 发明申请

WO2006113523A2 ANALYTIC SUBSTRATE COATING APPARATUS AND METHOD 审中-公开
标题翻译：分析底漆涂料和方法
公开(公告)号：WO2006113523A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014230
申请日：2006-04-14
申请人： ANGROS, Lee, H.
发明人： ANGROS, Lee, H.
IPC分类号： B05D3/02
CPC分类号： G01N1/30 , B01L3/0258 , B01L3/508 , B01L99/00 , B01L2200/12 , B01L2300/0822 , B01L2300/16 , B01L2300/161 , B05C1/025 , B05C9/06 , B05C9/14 , B05C11/028 , B05C13/02 , B05D1/02 , B05D1/20 , B05D1/28 , B05D7/5483 , B05D2252/04 , G01N2001/305 , Y10T156/179 , Y10T156/1798
摘要： An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates "on demand" for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.
摘要翻译：使用位于实验室设置中的紧凑且便携式的自动化仪器来生产涂覆的分析基底的装置和方法，其可以在“使用”上一致地产生一个或多个涂覆的分析基底，以便立即使用分析底物优选在使用前没有漂洗涂覆的分析底物的步骤。该设备优选地使用具有包含用于形成涂层的涂料组合物的储存器的涂布器盒。优选地，盒是可移除的和可互换的，以便于生产具有不同涂层或不同涂层图案的各个分析基底。这些涂布的分析基材由于涂覆设备施加的涂层质量的提高以及涂层分析基材在生产后可以在实验室中使用的快速性而具有优异的样品粘附特性。

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