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1. 发明申请

WO0244691A3 SPUTUM FIXATIVE AND METHODS AND USES THEREFOR 审中-公开
标题翻译： SPUTUM FIXATIVE及其方法和用途
公开(公告)号：WO0244691A3
公开(公告)日：2002-09-26
申请号：PCT/CA0101674
申请日：2001-11-28
申请人： UNIV MCMASTER , COX GERARD , KELLY MARGARET , HARGREAVE FREDERICK
发明人： COX GERARD , KELLY MARGARET , HARGREAVE FREDERICK
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N2001/305
摘要： A fixative composition for preserving cell count in a sputum sample and to a method of preserving cell count and improving cellular dispersal of the sputum sample. The composition comprises a disulphide bond reducing agent, preferably DTT, and a cross-linking agent, preferably paraformaldehyde. The method of the invention involves fixing the sputum sample and then dispersing it with a proteolytic agent such as trypsin. The method and composition are used in enhancing examination of sputum samples and can be used in the diagnosis and assessment of a number of conditions, such as airway inflammatory related conditions, i.e., asthma, chronic cough, Chronic Obstructive Pulmonary Disease, cancer, aspitation of orthopharyngeal or gastric contents, including gastroesophogeal reflux, heart failure, including left heart failure such as dyspnea with combined pulmonary and cardiac disorders. This invention makes possible delayed examination of the sputum sample and enables the taking of a sample at any site and time and subsequently transporting it to an appropriate centre for examination.
摘要翻译：用于保存痰样品中细胞计数的固定剂组合物以及保存细胞计数和改善痰样品的细胞分散的方法。该组合物包含二硫键还原剂，优选DTT和交联剂，优选多聚甲醛。本发明的方法包括固定痰样，然后用蛋白水解剂如胰蛋白酶分散。该方法和组合物用于增强对痰标本的检查，并可用于诊断和评估许多病症，如气道炎症相关病症，即哮喘，慢性咳嗽，慢性阻塞性肺病，癌症，对鼻咽或胃内容物，包括胃食管反流，心力衰竭，包括左心衰竭，如伴有肺和心脏病的呼吸困难。本发明使痰液样本延迟检查成为可能，并且能够在任何地点和时间取样并随后将其运送到适当的中心进行检查。

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