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1. 发明申请

WO2013119552A3 CELLS AND METHODS FOR PRODUCING LUTEIN 审中-公开
标题翻译：用于生产罗廷辛的细胞和方法
公开(公告)号：WO2013119552A3
公开(公告)日：2015-06-18
申请号：PCT/US2013024746
申请日：2013-02-05
申请人： UNIV CITY NEW YORK RES FOUND
发明人： WURTZEL ELEANORE T , QUINLAN RENA
IPC分类号： C07C49/00 , C07C35/21 , C12P23/00
CPC分类号： C12P23/00 , A23L33/135 , A23L33/145 , C07C403/24 , C12N9/001 , C12N9/0073 , C12N9/0083 , C12N9/1085 , C12N9/90 , C12Y103/05006 , C12Y114/13129 , C12Y114/99045 , C12Y205/01029 , C12Y205/01032 , C12Y505/01018 , C12Y505/01019
摘要： Provided herein are recombinant cells (e.g., recombinant bacteria or plant, insect, mammalian, and yeast cells) containing a nucleic acid encoding a CYP97A protein or a nucleic acid encoding a CYP97B protein; a nucleic acid encoding a CYP97C protein; a nucleic acid encoding a geranylgeranyl pyrophosphate synthase protein; a nucleic acid encoding a phytoene synthase protein; a nucleic acid encoding a phytoene desaturase protein; a nucleic acid encoding a lycopene β-cyclase protein; and a nucleic acid encoding a lycopene ε-cyclase protein. Also provided are methods of producing lutein that include culturing these recombinant cells (e.g., recombinant bacteria and yeast cells), and methods of generating these recombinant cells (e.g., recombinant bacteria and yeast cells). Also provided is lutein produced by these methods, and pharmaceutical compositions, food supplements, food products, and cosmetic compositions that contain lutein produced by these methods.
摘要翻译：本文提供了含有编码CYP97A蛋白的核酸或编码CYP97B蛋白的核酸的重组细胞（例如重组细菌或植物，昆虫，哺乳动物和酵母细胞）编码CYP97C蛋白质的核酸; 编码香叶基香叶基焦磷酸合酶蛋白的核酸; 编码芸苔属合酶蛋白的核酸; 编码八氢番茄红素去饱和酶蛋白的核酸; 编码番茄红素β-环蛋白的核酸; 和编码番茄红素ε-环化酶蛋白质的核酸。还提供了生产包括培养这些重组细胞（例如重组细菌和酵母细胞）的叶黄素的方法以及产生这些重组细胞（例如重组细菌和酵母细胞）的方法。还提供了通过这些方法生产的叶黄素，以及含有通过这些方法生产的叶黄素的药物组合物，食品添加剂，食品和化妆品组合物。

2. 发明申请

WO2013119552A2 CELLS AND METHODS FOR PRODUCING LUTEIN 审中-公开
标题翻译：用于生产罗廷辛的细胞和方法
公开(公告)号：WO2013119552A2
公开(公告)日：2013-08-15
申请号：PCT/US2013/024746
申请日：2013-02-05
申请人： THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
发明人： WURTZEL, Eleanore, T. , QUINLAN, Rena
IPC分类号： C12P23/00
CPC分类号： C12P23/00 , A23L33/135 , A23L33/145 , C07C403/24 , C12N9/001 , C12N9/0073 , C12N9/0083 , C12N9/1085 , C12N9/90 , C12Y103/05006 , C12Y114/13129 , C12Y114/99045 , C12Y205/01029 , C12Y205/01032 , C12Y505/01018 , C12Y505/01019
摘要： Provided herein are recombinant cells (e.g., recombinant bacteria or plant, insect, mammalian, and yeast cells) containing a nucleic acid encoding a CYP97A protein or a nucleic acid encoding a CYP97B protein; a nucleic acid encoding a CYP97C protein; a nucleic acid encoding a geranylgeranyl pyrophosphate synthase protein; a nucleic acid encoding a phytoene synthase protein; a nucleic acid encoding a phytoene desaturase protein; a nucleic acid encoding a lycopene β-cyclase protein; and a nucleic acid encoding a lycopene ε-cyclase protein. Also provided are methods of producing lutein that include culturing these recombinant cells (e.g., recombinant bacteria and yeast cells), and methods of generating these recombinant cells (e.g., recombinant bacteria and yeast cells). Also provided is lutein produced by these methods, and pharmaceutical compositions, food supplements, food products, and cosmetic compositions that contain lutein produced by these methods.
摘要翻译：本文提供了含有编码CYP97A蛋白的核酸或编码CYP97B蛋白的核酸的重组细胞（例如重组细菌或植物，昆虫，哺乳动物和酵母细胞）编码CYP97C蛋白质的核酸; 编码香叶基香叶基焦磷酸合酶蛋白的核酸; 编码芸苔属合酶蛋白的核酸; 编码八氢番茄红素去饱和酶蛋白的核酸; 编码番茄红素β-环蛋白的核酸; 和编码番茄红素ε-环化酶蛋白质的核酸。还提供了生产包括培养这些重组细胞（例如重组细菌和酵母细胞）的叶黄素的方法以及产生这些重组细胞（例如重组细菌和酵母细胞）的方法。还提供了通过这些方法生产的叶黄素，以及含有通过这些方法生产的叶黄素的药物组合物，食品添加剂，食品和化妆品组合物。

3. 发明申请

WO2019126777A1 PRODUCTION OF (R)-(E)-(+)-ALPHA-IONONE IN RECOMBINANT SACCHAROMYCES CEREVISIAE 审中-公开
公开(公告)号：WO2019126777A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/067332
申请日：2018-12-21
申请人： ADVANCED BIOTECH INC.
发明人： AGOSIN TRUMPER, Eduardo Esteban , SAITUA PEREZ, Francisco Javier , LOPEZ SALINAS, Javiera Cecilia , DOMARADZKI, Maciej , IBACETA ACEVEDO, Maximiliano , ARENAS FRIGOLETT, Natalia
IPC分类号： C12P23/00 , C12N15/63 , C12N1/18
CPC分类号： C12P7/26 , C12N9/0069 , C12N9/1085 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y113/11071 , C12Y205/01029 , C12Y505/01018
摘要： This invention provides improved biological synthesis of the apocarotenoid α-ionone in Saccharomyces cerevisiae. The final native step involved in the natural apocarotenoid pathway depends on an endogenous farnesyl pyrophosphate synthase (FPPs). From there, heterologous geranylgeranyl pyrophosphate synthase (crtE), phytoene synthase (crtB), phytoene desaturase (crtl), lycopene ε-cyclase (LycE) and a Carotenoid Cleavage Dioxygenase (CCD1) are required to complete the synthesis of α-ionone. Lycopene ε-cyclase from lettuce (Lactuca sativa ) or modified cyclase from Arabidopsis thaliana was used to overproduce lycopene which was then cleaved by the carotenoid cleavage dioxygenase from Petunia hybrida (Ph-CCD1).

4. 发明申请

WO2014140924A2 BIOLOGICAL DEVICES AND METHODS FOR INCREASING THE PRODUCTION OF LYCOPENE FROM PLANTS 审中-公开
标题翻译：生物装置和方法，用于增加从植物生产的叶绿素
公开(公告)号：WO2014140924A2
公开(公告)日：2014-09-18
申请号：PCT/IB2014/001232
申请日：2014-03-11
申请人： INTERNATIONAL PARK OF CREATIVITY
发明人： CUERO RENGIFO, Raul , ALEJANDRA CABRERA DELGADO, Maria
IPC分类号： C12N15/52
CPC分类号： C12N15/8279 , C12N9/0073 , C12N9/90 , C12P5/007 , C12Y114/13129 , C12Y505/01018
摘要： Described herein are devices and methods for enhancing the physiological properties of plants. For example, the devices and methods described herein increase the production of lycopene, which has industrial and economic value. The lycopene produced by the devices and methods does not require the ultra purification that is common in conventional or commercial methods. The devices and methods described herein also enhance the growth rate of plants.
摘要翻译：本文描述了用于增强植物生理特性的装置和方法。例如，本文所述的装置和方法增加了具有工业和经济价值的番茄红素的生产。由装置和方法生产的番茄红素不需要在常规或商业方法中常见的超纯化。本文所述的装置和方法还增强了植物的生长速率。

5. 发明申请

WO2016154314A1 COMPOSITIONS AND METHODS OF BIOSYNTHESIZING CAROTENOIDS AND THEIR DERIVATIVES 审中-公开
标题翻译：生物降解CAROTENOIDS及其衍生物的组合物和方法
公开(公告)号：WO2016154314A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023784
申请日：2016-03-23
申请人： ARCH INNOTEK, LLC
发明人： WANG, Yechun
IPC分类号： C12N1/19 , C12N1/21 , C12N15/70 , C12N15/80 , C12N15/81 , C12N9/02 , C12N9/10 , C12N9/90 , C12P23/00
CPC分类号： C12N15/52 , C12N9/001 , C12N9/0069 , C12N9/1085 , C12N9/90 , C12N15/70 , C12N15/81 , C12N15/815 , C12P5/026 , C12P7/26 , C12P23/00 , C12Y101/01034 , C12Y103/99 , C12Y113/11051 , C12Y205/01 , C12Y205/01001 , C12Y205/0101 , C12Y505/01018 , C12Y505/01019
摘要： The present invention relates to compositions and methods of producing carotenoids and carotenoid derivatives.
摘要翻译：本发明涉及生产类胡萝卜素和类胡萝卜素衍生物的组合物和方法。

6. 发明申请

WO2014140924A3 BIOLOGICAL DEVICES AND METHODS FOR INCREASING THE PRODUCTION OF LYCOPENE FROM PLANTS 审中-公开
标题翻译：生物装置和方法，用于增加从植物生产的叶绿素
公开(公告)号：WO2014140924A3
公开(公告)日：2015-02-19
申请号：PCT/IB2014001232
申请日：2014-03-11
申请人： INTERNAT PARK OF CREATIVITY
发明人： CUERO RENGIFO RAUL , ALEJANDRA CABRERA DELGADO MARIA
IPC分类号： C12N15/52 , A01H5/00 , C12N5/04 , C12N15/63 , C12P23/00
CPC分类号： C12N15/8279 , C12N9/0073 , C12N9/90 , C12P5/007 , C12Y114/13129 , C12Y505/01018
摘要： Described herein are devices and methods for enhancing the physiological properties of plants. For example, the devices and methods described herein increase the production of lycopene, which has industrial and economic value. The lycopene produced by the devices and methods does not require the ultra purification that is common in conventional or commercial methods. The devices and methods described herein also enhance the growth rate of plants.
摘要翻译：本文描述了用于增强植物生理特性的装置和方法。例如，本文所述的装置和方法增加了具有工业和经济价值的番茄红素的生产。由装置和方法生产的番茄红素不需要在常规或商业方法中常见的超纯化。本文所述的装置和方法还增强了植物的生长速率。

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