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1. 发明申请

WO01032701A1 A NEW POLYPEPTIDE - SUBUNIT 15 OF HUMAN F1F0 ATP SYNTHASE AND A POLYNUCLEOTIDE ENCODING THE SAME 审中-公开
公开(公告)号：WO01032701A1
公开(公告)日：2001-05-10
申请号：PCT/CN2000/000403
申请日：2000-10-30
IPC分类号： A61K38/00 , C12N9/14 , C12N15/12 , C07K14/47 , C12N15/63
CPC分类号： C12Y306/03014 , A61K38/00 , C12N9/14
摘要： The present invention discloses a new polypeptide-subunit 15 of human F1F0 ATP synthase and a polynucleotide encoding the same, as well as a method of producing the polypeptide by DNA recombinant technology. The present invention also discloses methods of using the polypeptide in treatment of various disease, especially in treatment of energy metabolism and material metabolism disorder, such as DOWN syndrome, BATTEN condition, Alzheimer's disease, some tumors, some genetic disease, blood disease, and immunological disease. The present invention also discloses an antagonist against the polypeptide and the therapeutic use of the same. The present invention also discloses the use of such polynucleotide encoding the subunit 15 of human F1F0 ATP synthase.

2. 发明申请

WO2013091049A2 POLINUCLEOTÍDEO DE CANA-DE-AÇÚCAR QUE CONFERE TOLERÂNCIA A ESTRESSES ABIÓTICOS 审中-公开
标题翻译：蔗糖多糖对抗生素胁迫的抵抗力
公开(公告)号：WO2013091049A2
公开(公告)日：2013-06-27
申请号：PCT/BR2012/000499
申请日：2012-12-06
申请人： UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP
发明人： TEIXEIRA, Marcelo Menossi , DE SOUZA, Cesar Bueno , HOSHINO, Andrea Akemi , CHAGAS, Éder Bedani Ruis , SOUZA, Gláucia Mendes
IPC分类号： C12N15/29
CPC分类号： C12N15/8273 , C12N9/14 , C12N15/8271 , C12Y306/03014
摘要： As plantas são influenciadas por um grande número de fatores ambientais bióticos e abióticos e recorrentemente estresses abióticos são mais graves, afetando todas as funções da planta, resultando em redução do crescimento e da produtividade. Nesse sentido, a identificação e a compreensão dos mecanismos de tolerância abióticos são fundamentais no desenvolvimento de novas cultivares tolerantes à seca. Dessa forma, a presente invenção descreve um método de produção de plantas que contém em suas células uma sequência de nucleotídeos de cana-de-açúcar. A expressão do vetor que contém a sequencia poderá levar a planta na qual ele é inserido à maior tolerância a estresses abióticos. De uma forma mais ampla, é descrito um polinucleotídeo que codifica um polipeptídeo de cana-de-açúcar, o qual é expresso por um promotor e um terminador que funcionam em plantas e este polinucleotídeo confere tolerância a diferentes estresses abióticos.
摘要翻译：植物受到大量生物和非生物环境因素的影响，复发性非生物胁迫是最严重的并影响所有植物功能，导致生长和生产力下降。在这种情况下，识别和理解非生物抗性机制对于开发新的抗旱品种至关重要。因此，本发明描述了用含有甘蔗核苷酸序列的细胞产生植物的方法。含有序列的载体的表达可赋予对引入载体的植物的非生物胁迫更大的抗性。更一般地，描述了编码由在植物中可操作的启动子和终止子表达的甘蔗多肽的多核苷酸，该多核苷酸赋予对各种非生物胁迫的抗性。

3. 发明申请

WO2008131431A3 MODULATION OF BLOOD BRAIN BARRIER PROTEIN EXPRESSION 审中-公开
标题翻译：血脑屏障蛋白表达的调节
公开(公告)号：WO2008131431A3
公开(公告)日：2009-04-09
申请号：PCT/US2008061316
申请日：2008-04-23
申请人： UNIV ST LOUIS
IPC分类号： C07K14/705 , C12N15/11 , C12N15/113
CPC分类号： C07K14/705 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/31 , C12Y306/03014
摘要： There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
摘要翻译：公开了抑制血脑屏障蛋白（BBBP）的药物。这种药剂可用于控制进入和离开CNS的药剂。这允许药物更有效和/或允许降低药物的副作用。

4. 发明申请

WO2017007762A1 LOCALIZED EXCESS PROTONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：本地化的过程原理及其制备方法和使用方法
公开(公告)号：WO2017007762A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/040978
申请日：2016-07-05
申请人： LEE, James
发明人： LEE, James
IPC分类号： C25B1/04
CPC分类号： C25B1/06 , C12P19/32 , C12Y306/03014 , C23F1/14 , C25B1/10 , Y02E60/366 , Y02P20/129
摘要： Localized excess protons are created with an open-circuit water electrolysis process using a pair of anode and cathode electrodes for a special excess proton production and proton-utilization system to treat a substrate material plate/film by forming and using an excess protons-substrate-hydroxyl anions capacitor-like system. The technology enables protonation and/or proton-driven oxidation of plate/film and/or membrane materials in a pure water environment. The present invention does not require the use of any conventional acid chemicals including nitric and sulfuric acids for the said industrial applications. The application of localized excess protons provides a special energy recycling and renewing technology function to extract latent heat including molecular thermal motion energy at ambient temperature for generating local proton motive force (equivalent to Gibbs free energy) to do useful work such as driving ATP synthesis and proton-driven oxidation of certain substrate metal atoms.
摘要翻译：使用一对阳极和阴极用于特殊的过量质子生成和质子利用系统的开放水电解方法产生局部过量质子，以通过形成和使用过量的质子 - 衬底 - 羟基阴离子电容器系统。该技术可在纯水环境中使板/膜和/或膜材料进行质子化和/或质子驱动氧化。本发明不需要使用任何常规的酸性化学品，包括硝酸和硫酸用于所述工业应用。局部过量质子的应用提供了特殊的能量回收和更新技术功能，用于提取包括分子热运动能在环境温度下的潜热，以产生局部质子动力（相当于吉布斯自由能）来进行有用的工作，如驱动ATP合成和某些底物金属原子的质子驱动氧化。

5. 发明申请

WO2008131431A8 MODULATION OF BLOOD BRAIN BARRIER PROTEIN EXPRESSION 审中-公开
标题翻译：血脑屏障蛋白表达调控
公开(公告)号：WO2008131431A8
公开(公告)日：2009-07-16
申请号：PCT/US2008061316
申请日：2008-04-23
申请人： UNIV ST LOUIS
IPC分类号： C07K14/705 , C12N15/11 , C12N15/113
CPC分类号： C07K14/705 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/31 , C12Y306/03014
摘要： There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
摘要翻译：已经公开了抑制血脑屏障蛋白（BBBP）的药剂。这些试剂可用于控制进入和离开CNS的试剂。这允许药物更有效和/或允许降低药物的副作用。

6. 发明申请

WO2007071962A1 POLYPEPTIDE TARGETING TO MITOCHONDRIA 审中-公开
标题翻译：多肽针对麻醉药
公开(公告)号：WO2007071962A1
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004755
申请日：2006-12-19
申请人： MEDICAL RESEARCH COUNCIL , MINCZUK, Michal , PAPWORTH, Monika, A. , KLUG, Aaron
发明人： MINCZUK, Michal , PAPWORTH, Monika, A. , KLUG, Aaron
IPC分类号： C12N15/11 , C12N15/79 , C07K19/00
CPC分类号： A61K38/1709 , A61K38/45 , A61K38/46 , C07K14/47 , C07K2319/07 , C07K2319/095 , C07K2319/81 , C12N9/1007 , C12N9/14 , C12Y201/01072 , C12Y306/03014
摘要： Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA- binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
摘要翻译：提供了将线粒体蛋白递送至线粒体的方法。还提供了包含编码与线粒体靶向序列（MTS）和核出口信号（NES）融合的DNA结合多肽的编码序列和编码的蛋白质的核酸构建体。该构建体成功地将DNA结合蛋白递送至线粒体。基于上述构建体的嵌合甲基化酶被成功地递送至线粒体，导致mtDNA的修饰。

7. 发明申请

WO2017210764A1 PLANT RESISTANT TO PEST INSECT 审中-公开
标题翻译：植物抗虫害昆虫
公开(公告)号：WO2017210764A1
公开(公告)日：2017-12-14
申请号：PCT/BR2017/050146
申请日：2017-06-07
申请人： EMBRAPA - EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA
发明人： LIMA ARAGÃO, Francisco José , BABA IBRAHIM, Abdulrazak
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , C12N9/14 , C12N15/8218 , C12Y306/03014 , Y02A40/162
摘要： The present invention belongs to the field of plant genetics and describes a method of producing plants resistant to pest insects. The invention further provides molecules, nucleic acid constructs and other elements that refer to the induction of greater resistance of the plant to pest insect. A plant that incorporating such elements, as well as a method of controlling pest by using molecules in different presentation forms are also provided.
摘要翻译：本发明属于植物遗传学领域，并且描述了一种产生抗虫害植物的方法。本发明进一步提供分子，核酸构建体和涉及诱导植物对害虫的较大抗性的其它元件。还提供了包含这些元素的植物，以及通过使用不同呈递形式的分子来控制害虫的方法。

8. 发明申请

WO2015001336A2 CONTROL OF VARROA MITE INFESTATION 审中-公开
标题翻译：变异型螨虫感染的控制
公开(公告)号：WO2015001336A2
公开(公告)日：2015-01-08
申请号：PCT/GB2014052004
申请日：2014-07-02
申请人： UNIV ABERDEEN , SEC DEP FOR ENVIRONMENT FOOD AND RURAL AFFAIRS ACTING THROUGH THE FOOD AND ENVIRONMENT RES AGENCY FE
发明人： BOWMAN ALAN STUART , CAMPBELL EWAN MCINNES , BUDGE GILES ELLIOT
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A01N57/16 , A23K20/153 , A23K50/90 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/51 , C12N2320/30 , C12N2320/31 , C12Y104/03004 , C12Y204/01016 , C12Y205/01018 , C12Y207/0104 , C12Y301/01007 , C12Y306/01003 , C12Y306/03014
摘要： Nucleic acid agents for reducing or removing infestations of the Varroa destructor mite are described. Compositions comprising the nucleic acid agents and methods for controlling mite infestations using the nucleic acid agents and compositions are also disclosed.
摘要翻译：描述了用于减少或去除瓦氏螨虫侵害的核酸试剂。还公开了包含核酸试剂的组合物和使用该核酸试剂和组合物控制螨侵染的方法。

9. 发明申请

WO2013091049A3 METHOD FOR PRODUCING GENETICALLY MODIFIED PLANTS WITH INCREASED RESISTANCE TO SALT STRESS AND DROUGHT 审中-公开
标题翻译：用于生产具有抗盐胁迫和耐旱性的基因改良植物的方法
公开(公告)号：WO2013091049A3
公开(公告)日：2013-11-07
申请号：PCT/BR2012000499
申请日：2012-12-06
申请人： UNICAMP
发明人： TEIXEIRA MARCELO MENOSSI , DE SOUZA CESAR BUENO , HOSHINO ANDREA AKEMI , CHAGAS EDER BEDANI RUIS , SOUZA GLAUCIA MENDES
IPC分类号： C12N15/29 , A01H1/00 , C12N15/82
CPC分类号： C12N15/8273 , C12N9/14 , C12N15/8271 , C12Y306/03014
摘要： Plants are influenced by a large number of biotic and abiotic environmental factors, recurrent abiotic stresses being the most serious and affecting all plant functions, leading to reduced growth and productivity. In this context, identifying and understanding abiotic resistance mechanisms are crucial for developing new drought-resistant cultivars. Thus, the present invention describes a method for producing plants with cells that contain a sugar cane nucleotide sequence. Expression of the sequence-containing vector can impart greater resistance to abiotic stresses to the plant into which the vector is introduced. More generally, a polynucleotide is described that encodes a sugarcane polypeptide expressed by a promoter and a terminator that are operational in plants, this polynucleotide imparting resistance to various abiotic stresses.
摘要翻译：植物受到大量生物和非生物环境因素的影响，复发性非生物胁迫是最严重的并影响所有植物功能，导致生长和生产力下降。在这种情况下，识别和理解非生物抗性机制对于开发新的抗旱品种至关重要。因此，本发明描述了用含有甘蔗核苷酸序列的细胞产生植物的方法。含有序列的载体的表达可赋予对引入载体的植物的非生物胁迫更大的抗性。更一般地，描述了编码由在植物中可操作的启动子和终止子表达的甘蔗多肽的多核苷酸，该多核苷酸赋予对各种非生物胁迫的抗性。

10. 发明申请

WO9959620A9 ANGIOSTATIN RECEPTOR 审中-公开
标题翻译：抗生素受体
公开(公告)号：WO9959620A9
公开(公告)日：2000-02-03
申请号：PCT/US9910957
申请日：1999-05-19
申请人： UNIV DUKE , UNIV NORTHWESTERN , STACK MARY S
发明人： STACK MARY S , MOSER TAMMY L , PIZZO SALVATORE V
IPC分类号： G01N33/53 , A61K38/00 , A61K38/46 , A61K45/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P19/02 , A61P27/02 , A61P35/00 , A61P43/00 , C07K14/705 , C07K16/28 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N15/09 , G01N33/543 , G01N33/554 , G01N33/68 , G01N33/74 , A61K38/17 , A61K38/43 , C07H21/04 , C07K14/435
CPC分类号： C12N9/14 , A61K38/00 , C07K16/40 , C12Y306/03014 , G01N33/68 , G01N33/6872 , G01N33/74 , G01N2500/00
摘要： The present invention relates, in general, to an angiostatin receptor and, in particular, to an angiostatin receptor present on cellular plasma membranes. More particularly, the present invention relates to the human angiostatin receptor, ATP synthase, or subunit or portion thereof, and to the use thereof in assays designed to screen compounds for their ability to serve as agonists or antagonists of human angiostatin. The invention further relates to nucleic acid sequences encoding ATP synthase, or subunit or portion thereof, and to host cells transformed therewith. The invention also relates to antibodies specific for ATP synthase.
摘要翻译：本发明一般涉及血管抑素受体，尤其涉及存在于细胞质膜上的血管抑素受体。更具体地说，本发明涉及人体血管抑素受体，ATP合成酶或其亚单位或其部分，以及其用于筛选化合物作为人类血管生成抑制素的激动剂或拮抗剂的能力的分析中的用途。本发明还涉及编码ATP合成酶或亚单位或其部分的核酸序列以及用其转化的宿主细胞。本发明还涉及对ATP合成酶特异的抗体。

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