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1. 发明申请

WO2006124895A3 MUTATIONS FOR ENHANCED TYROSINE PRODUCTION 审中-公开
标题翻译：增强酪氨酸生产的突变
公开(公告)号：WO2006124895A3
公开(公告)日：2007-09-13
申请号：PCT/US2006018912
申请日：2006-05-16
申请人： MASSACHUSETTS INST TECHNOLOGY , STEPHANOPOULIOS GREGORY , LUTKE-EVERSLOH TINA
发明人： STEPHANOPOULIOS GREGORY , LUTKE-EVERSLOH TINA
IPC分类号： C12N1/00 , C12N1/12
CPC分类号： C12P13/225 , C07K14/435 , C12N9/001 , C12P13/22 , C12Y103/01012 , C12Y504/99005
摘要： The present invention provides cells genetically engineered to express mutated chorismate mutase/prephenate dehydrogenase (CM/PDH), the nucleic acid coding for each mutated CM/PDH and similar nucleic acids and methods for utilizing cells expressing mutated CM/PDH to produce tyrosine.
摘要翻译：本发明提供了基因工程改造以表达突变的酸碱性变位酶/预苯酸脱氢酶（CM / PDH）的细胞，编码每种突变的CM / PDH的核酸和类似的核酸以及利用表达突变的CM / PDH的细胞产生酪氨酸的方法。

2. 发明申请

WO2011076889A1 PLANTS TOLERANT TO HPPD INHIBITOR HERBICIDES 审中-公开
标题翻译：适用于HPPD抑制剂除草剂的植物
公开(公告)号：WO2011076889A1
公开(公告)日：2011-06-30
申请号：PCT/EP2010/070575
申请日：2010-12-22
申请人： BAYER CROPSCIENCE AG , POREE, Fabien , LABER, Bernd , KNITTEL-OTTLEBEN, Nathalie , LANGE, Gudrun , SCHULZ, Arno , HAIN, Ruediger
发明人： POREE, Fabien , LABER, Bernd , KNITTEL-OTTLEBEN, Nathalie , LANGE, Gudrun , SCHULZ, Arno , HAIN, Ruediger
IPC分类号： C12N9/02 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8274 , C12N9/001 , C12N9/0069 , C12Y103/01012 , C12Y113/11027
摘要： The present invention relates to nucleic acid sequences encoding a hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, abbreviated herein as HPPD) obtained from bacteria belonging to the genus Kordia, as well as the proteins encoded thereby, and to a chimeric gene which comprises such nucleic acid sequence, and to the use of such nucleic acid sequences, proteins or chimeric genes for obtaining plants which are tolerant to HPPD inhibitor herbicides.
摘要翻译：本发明涉及从属于科迪亚属的细菌获得的编码羟基苯基丙酮酸双加氧酶（EC 1.13.11.27，本文缩写为HPPD）的核酸序列，以及由此编码的蛋白质以及包含该核酸的嵌合基因序列，以及使用这种核酸序列，蛋白质或嵌合基因来获得对HPPD抑制剂除草剂具有耐受性的植物。

3. 发明申请

WO2006124895A2 MUTATIONS FOR ENHANCED TYROSINE PRODUCTION 审中-公开
标题翻译：增强酪氨酸生产的突变
公开(公告)号：WO2006124895A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018912
申请日：2006-05-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , STEPHANOPOULIOS, Gregory , LUTKE-EVERSLOH, Tina
发明人： STEPHANOPOULIOS, Gregory , LUTKE-EVERSLOH, Tina
IPC分类号： C12P13/22
CPC分类号： C12P13/225 , C07K14/435 , C12N9/001 , C12P13/22 , C12Y103/01012 , C12Y504/99005
摘要： The present invention provides cells genetically engineered to express mutated chorismate mutase/prephenate dehydrogenase (CM/PDH), the nucleic acid coding for each mutated CM/PDH and similar nucleic acids and methods for utilizing cells expressing mutated CM/PDH to produce tyrosine.
摘要翻译：本发明提供了基因工程改造以表达突变的酸碱性变位酶/预苯酸脱氢酶（CM / PDH）的细胞，编码每种突变的CM / PDH的核酸和类似的核酸以及利用表达突变的CM / PDH的细胞产生酪氨酸的方法。

4. 发明申请

WO2013033652A1 METABOLIC ENGINEERING OF THE SHIKIMATE PATHWAY 审中-公开
标题翻译：代表路线的代谢工程
公开(公告)号：WO2013033652A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/053547
申请日：2012-08-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JUMINAGA, Darmawi , KEASLING, Jay, D.
发明人： JUMINAGA, Darmawi , KEASLING, Jay, D.
IPC分类号： C12N9/88 , C12N15/63 , C12N15/67
CPC分类号： C12N15/70 , C12N9/001 , C12N9/88 , C12N15/52 , C12P7/42 , C12P13/22 , C12P13/225 , C12P13/227 , C12Y103/01012 , C12Y401/02 , Y02P20/52
摘要： The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom.
摘要翻译：本公开涉及产生氨基酸和氨基酸中间体的工程微生物。特别地，本公开涉及编码增加芳族氨基酸的产生和芳香族氨基酸中间体莽草酸的操纵子的重组核酸; 芳香族氨基酸生产微生物和芳香族氨基酸中间体莽草酸; 以及与芳香族氨基酸的生成，芳香族氨基酸中间体莽草酸以及从其衍生的商品化学品有关的方法。

5. 发明申请

WO2011076877A1 PLANTS TOLERANT TO HPPD INHIBITOR HERBICIDES 审中-公开
标题翻译：适用于HPPD抑制剂除草剂的植物
公开(公告)号：WO2011076877A1
公开(公告)日：2011-06-30
申请号：PCT/EP2010/070561
申请日：2010-12-22
申请人： BAYER CROPSCIENCE AG , POREE, Fabien , LABER, Bernd , KNITTEL-OTTLEBEN, Nathalie , LANGE, Gudrun , SCHULZ, Arno , HAIN, Ruediger
发明人： POREE, Fabien , LABER, Bernd , KNITTEL-OTTLEBEN, Nathalie , LANGE, Gudrun , SCHULZ, Arno , HAIN, Ruediger
IPC分类号： C12N9/02 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8274 , C12N9/001 , C12N9/0069 , C12Y103/01012 , C12Y113/11027
摘要： The present invention relates to nucleic acid sequences encoding a hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, abbreviated herein as HPPD) obtained from bacteria belonging to the subfamily Synechococcoideae, as well as the proteins encoded thereby, and to a chimeric gene which comprises such nucleic acid sequence, and to the use of such nucleic acid sequences, proteins or chimeric genes for obtaining plants which are tolerant to HPPD inhibitor herbicides.
摘要翻译：本发明涉及从属于亚科孢子虫科的细菌获得的编码羟基苯基丙酮酸双加氧酶（EC 1.13.11.27，本文缩写为HPPD）的核酸序列以及由此编码的蛋白质以及包含这种核酸的嵌合基因序列，以及使用这种核酸序列，蛋白质或嵌合基因来获得对HPPD抑制剂除草剂具有耐受性的植物。

6. 发明申请

WO0246441A2 NOVEL TARGETS FOR HERBICIDES AND TRANSGENIC PLANTS RESISTANT TO SAID HERBICIDES 审中-公开
标题翻译：用于除草剂和抗转基因植物的新靶标抗除草剂
公开(公告)号：WO0246441A2
公开(公告)日：2002-06-13
申请号：PCT/FR0103832
申请日：2001-12-05
申请人： AVENTIS CROPSCIENCE SA , MATRINGE MICHEL , RIPPERT PASCAL
发明人： MATRINGE MICHEL , RIPPERT PASCAL
IPC分类号： C07K14/415 , C12N1/19 , C12N1/21 , C12N9/02 , C12N9/10 , C12N15/53 , C12N15/55 , C12N15/82
CPC分类号： C12N9/001 , C07K14/415 , C12N9/1096 , C12N15/8274 , C12Y103/01012 , C12Y103/01013 , Y02P20/582
摘要： The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic pathway of tyrosine biosynthesis, and constitute, as such, potential targets of herbicides. Hence the invention also concerns a method for identifying herbicide compounds targeting said enzymes, said herbicide compounds preventing tyrosine biosynthesis by being fixed on said enzymes. The invention further concerns transgenic plants tolerant to herbicide compounds targeting an enzyme involved in the tyrosine biosynthesis pathway, in particular an enzyme involved in the transformation of L-tyrosine prephenate, in particular an arogenate dehydrogenase enzyme. Said plants become tolerant by expression in their tissues of a prephenate dehydrogenase enzyme, said enzyme being insensitive to said herbicide compounds and enabling the plant to synthetize tyrosine despite being treated with said herbicide compounds.
摘要翻译：本发明涉及具有雄激素脱氢酶活性的新型酶，特别是植物的氢化脱氢酶，以及编码所述酶的基因。本发明的雄激素脱氢酶催化酪氨酸生物合成的代谢途径的最后阶段，并且构成除草剂的潜在靶标。因此，本发明还涉及用于鉴定靶向所述酶的除草剂化合物的方法，所述除草剂化合物通过固定在所述酶上来预防酪氨酸生物合成。本发明还涉及对涉及酪氨酸生物合成途径的酶的除草剂化合物具有耐受性的转基因植物，特别是涉及转化L-酪氨酸预苯酸酯，特别是雄激素脱氢酶的酶。所述植物通过在其预组酸脱氢酶的组织中表达而变得耐受，所述酶对所述除草剂化合物不敏感，并且能够使植物合成酪氨酸，尽管用所述除草剂化合物进行处理。

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