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    • 5. 发明申请
    • CHIMERIC PHAGE TAIL PROTEINS AND USES THEREOF
    • CHIMERIC PHAGE尾蛋白及其用途
    • WO2009055697A4
    • 2009-07-09
    • PCT/US2008081151
    • 2008-10-24
    • TEXAS A & M UNIV SYSSTRUCK DOUGLAS KYOUNG RYLAND F III
    • STRUCK DOUGLAS KYOUNG RYLAND F III
    • C07K14/01
    • C07K14/005C07K2319/035C12N2795/10122
    • A multi-protein pyocin-like structure derived from a bacteriophage or a bacteriocin that includes a chimeric tail fiber having a protein receptor binding domain capable of recognizing Lipid A. A multiprotein pyocin-like structure, derived from a bacteriophage or a bacteriocin that includes a chimeric tail fiber capable of recognizing and binding MurNac-L-Ala-D-Glu. A phage including a chimeric tail fiber that binds Lipid A. A plasmid encoding a chimeric ail fiber that binds MurNac-L-Ala-D-Glu. A plasmid encoding a chimeric tail fiber that binds Lipid A. A chimeric bacteriocin or bacteriophage derived tail fiber that includes the amino terminal of the human bactericidal/permeability-increasing protein (BPINTD)- A chimeric bacteriophage or bacteriocin derived tail fiber also includes a binding domain encoding the mammalian Nod2ctD- An antibacterial agent includes a bacteriocidal/permeability-increasing protein receptor domain that binds to Lipid A. An antibacterial agent also includes Nod2 carboxyl-terminus receptor domain that binds MurNac-L-Ala-D-Glu.
    • 衍生自噬菌体或细菌素的多蛋白类似脓毒素样结构,其包含具有能够识别脂质A的蛋白质受体结合结构域的嵌合尾纤维。衍生自噬菌体或细菌素的多蛋白类似脓毒素样结构,其包含 能够识别和结合MurNac-L-Ala-D-Glu的嵌合尾纤维。 包含结合脂质A的嵌合尾纤维的噬菌体。编码结合MurNac-L-Ala-D-Glu的嵌合纤维的质粒。 编码结合脂质A的嵌合尾纤维的质粒。包含人杀菌/通透性增加蛋白质(BPINTD)的氨基末端的嵌合细菌素或噬菌体衍生的尾纤维 - 嵌合噬菌体或细菌素衍生的尾纤维还包括结合 编码哺乳动物Nod2ctD的结构域。抗菌剂包括结合脂质A的杀菌/通透性增加蛋白受体结构域。抗菌剂还包括结合MurNac-L-Ala-D-Glu的Nod2羧基末端受体结构域。