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1. 发明申请

WO02057467A3 USE OF UMBRAVIRUS IN PROTECTION AGAINST POST-TRANSCRIPTIONAL GENE SILENCING 审中-公开
标题翻译： UBRRAVIRUS在抗转录基因沉默中的应用
公开(公告)号：WO02057467A3
公开(公告)日：2003-01-03
申请号：PCT/GB0200252
申请日：2002-01-21
申请人： SCOTTISH CROP RES INST , REAVY BRIAN , MACFARLANE STUART ANDREW , TALIANSKI MIKHAIL EMMANUILOVIC , RIABOV EVGUENI VITALIEVICH
发明人： REAVY BRIAN , MACFARLANE STUART ANDREW , TALIANSKI MIKHAIL EMMANUILOVIC , RIABOV EVGUENI VITALIEVICH
IPC分类号： C07K14/08 , C12N15/33 , C12N15/67 , C12N15/82 , C12N15/85 , C12N15/11 , A01H5/00 , C12N15/63 , C12N15/79
CPC分类号： C07K14/005 , C12N15/67 , C12N15/8218 , C12N15/85 , C12N2770/00022 , C12N2770/00043
摘要： The use of umbraviral proteins to protect viral vectors or transgenes from post-transcriptional gene silencing (PTGS) is described. Preferably the umbraviral protein is ORF3 and, for example, may be the ORF3 from GRV, PEMV-2, TmoV or CmoMV. Enhancement of expression in a host cell, suitably a plant or insect host cell, of a heterologous protein due to the protective presence of the umbraviral protein is also described.
摘要翻译：描述了使用尿布病毒蛋白来保护病毒载体或转基因免受转录后基因沉默（PTGS）的影响。优选地，万向节病毒蛋白质是ORF3，并且例如可以是来自GRV，PEMV-2，TmoV或CmoMV的ORF3。还描述了由于保护性存在万向节病毒蛋白而在宿主细胞，适当地植物或昆虫宿主细胞中表达异源蛋白的表达。

2. 发明申请

WO2017011815A3 CITRUS PLANTS RESISTANT TO CITRUS HUANGLONGBING (EX GREENING) CAUSED BY CANDIDATUS LIBERIBACTER ASIATICUS (LAS) AND BACTERIAL CANKER CAUSED BY (XANTHOMONAS AXONOPODIS PV. CITRI) (XAC) USING SPINACH DEFENSIN GENES IN CTV VECTORS 审中-公开
标题翻译：（CT）载体中使用菠菜防御素基因（XAC）引起的柑桔黄化病（EX绿化）和由细菌黄腐病病毒（LAS）引起的细菌性枯萎病（CAC）
公开(公告)号：WO2017011815A3
公开(公告)日：2017-03-09
申请号：PCT/US2016042672
申请日：2016-07-15
申请人： TEXAS A&M UNIV , SOUTHERN GARDENS CITRUS NURSERY LLC
发明人： MIRKOV T ERIK , KRESS RICKE
IPC分类号： A01H5/00 , C07K14/415 , C12N15/29
CPC分类号： C12N15/8279 , C12N15/8203 , C12N15/86 , C12N2770/00043 , C12N2800/22 , C12N2840/20 , C12N2840/203
摘要： Disclosed herein are viral vectors based on modifications of the Citrus Tristeza virus useful for transfecting citrus trees for beneficial purposes. Included in the disclosure are viral vectors including one or more gene cassettes that encode spinach defensin peptide(s). The gene cassettes are positioned at desirable locations on the viral genome so as to enable expression while preserving functionality of the virus. Also disclosed are methods of transfecting plants and plants transfected with viral vector embodiments.
摘要翻译：本文公开了基于对有益目的转化柑橘树木而言有用的柑橘脆皮镰孢病毒的修饰的病毒载体。本公开内容包括病毒载体，其包括编码菠菜防卫素肽的一个或多个基因盒。将基因盒定位在病毒基因组的期望位置，以便在保持病毒功能的同时进行表达。还公开了转染用病毒载体实施方案转染的植物和植物的方法。

3. 发明申请

WO2017011815A2 CITRUS PLANTS RESISTANT TO CITRUS HUANGLONGBING (EX GREENING) CAUSED BY CANDIDATUS LIBERIBACTER ASIATICUS (LAS) AND BACTERIAL CANKER CAUSED BY (XANTHOMONAS AXONOPODIS PV. CITRI) (XAC) USING SPINACH DEFENSIN GENES IN CTV VECTORS 审中-公开
标题翻译： CITRUS植物抵抗CITRUS HUANGLONGBING（EX GREENING）由CIDIDATATUS LIBERIBACTER ASIATICUS（LAS）和BACTERIAL CANKER引起的（XANTHOMONAS AXONOPODIS PV.CITRI）（XAC）引起的CTV VECTORS中使用SPINACH DEFENSIN基因
公开(公告)号：WO2017011815A2
公开(公告)日：2017-01-19
申请号：PCT/US2016/042672
申请日：2016-07-15
申请人： TEXAS A&M UNIVERSITY , SOUTHERN GARDENS CITRUS NURSERY, LLC
发明人： MIRKOV, T. Erik , KRESS, Ricke
IPC分类号： A01H5/00 , C12N15/86
CPC分类号： C12N15/8279 , C12N15/8203 , C12N15/86 , C12N2770/00043 , C12N2800/22 , C12N2840/20 , C12N2840/203
摘要： Disclosed herein are viral vectors based on modifications of the Citrus Tristeza virus useful for transfecting citrus trees for beneficial purposes. Included in the disclosure are viral vectors including one or more gene cassettes that encode spinach defensin peptide(s). The gene cassettes are positioned at desirable locations on the viral genome so as to enable expression while preserving functionality of the virus. Also disclosed are methods of transfecting plants and plants transfected with viral vector embodiments.
摘要翻译：本文公开了基于用于转化柑橘树以用于有益目的的柑橘属Tristeza病毒的修饰的病毒载体。本公开中包括病毒载体，包括一个或多个编码菠菜防御素肽的基因盒。将基因盒定位在病毒基因组上的期望位置，以便能够表达同时保持病毒的功能。还公开了用病毒载体实施方案转染植物和植物的方法。

4. 发明申请

WO2012116064A1 CARDIAC REPAIR BY REPROGRAMMING OF CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES 审中-公开
标题翻译： CARDIAC将CARDIAC FIBROBLASTS转录为心脏病的修复
公开(公告)号：WO2012116064A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026113
申请日：2012-02-22
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS , NAM, Young-jae , SONG, Kunhua , OLSON, Eric
发明人： NAM, Young-jae , SONG, Kunhua , OLSON, Eric
IPC分类号： C07K14/47 , A61K38/17 , A61K48/00 , C12N5/077
CPC分类号： C12N5/0657 , A61K31/7105 , A61K38/00 , A61K38/17 , A61K45/06 , C07K14/4702 , C12N2501/40 , C12N2770/00043
摘要： The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo . Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.
摘要翻译：本发明涉及使用包括Tbx5，Mef2C，Hand2，心肌素和Gata4在内的转录因子在体外和体内将心脏成纤维细胞重编程为心肌细胞。这种方法特别用于治疗心肌梗塞后的患者，以预防或限制瘢痕形成并促进心肌修复。

5. 发明申请

WO1995034668A2 THE CYTOPLASMIC INHIBITION OF GENE EXPRESSION 审中-公开
标题翻译：基因表达的CYPOPLASMIC抑制
公开(公告)号：WO1995034668A2
公开(公告)日：1995-12-21
申请号：PCT/US1995006741
申请日：1995-05-26
申请人： BIOSOURCE TECHNOLOGIES, INC.
发明人： BIOSOURCE TECHNOLOGIES, INC. , KUMAGAI, Monto, H. , DELLA-CIOPPA, Guy, R. , DONSON, Jonathan , HARVEY, Damon, A.
IPC分类号： C12N15/83
CPC分类号： C12N15/1137 , C07K14/005 , C07K14/415 , C07K14/70571 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/1085 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2799/021 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069 , G01N2333/4353
摘要： One aspect of the invention is to provide novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA. The genetic constructions of the invention are capable of replicating in the cytoplasm of a eukaryotic cell and comprise a promoter region in functional combination with an encoding polynucleotide. The genetic constructions may be designed so as to replicate in the cytoplasm of plant cells, yeast cells, and mammalian cells. When the eukaryotic cell of interest is a plant cell, the genetic construction is preferably derived from a plant RNA virus. Plant RNA virus derived genetic constructions may employ a plant virus subgenomic promoter, including subgenomic promoters from tobamoviruses in functional combination with the RNA encoding region. Another aspect of the invention is to provide cells comprising the genetic constructions of the invention and organism comprising a plurality of such cells. Another aspect of the invention is to provide methods of reducing the expression of a gene of interest in eukaryotic cells, i.e., methods of producing eukaryotic cells exhibiting reduced levels of expression of a gene of interest. The methods of the invention comprise the step of transfecting a cell with a genetic construction of the invention in which the RNA encoding region is specific for the gene of interest. Another aspect of the invention is to provide plant cells that produce elevated levels of the carotenoid phytoene. The elevated levels of phytoene are achieved by inhibiting the expression at the enzyme phytoene desaturase using the vectors of the invention.
摘要翻译：本发明的一个方面是提供用于在真核细胞的细胞质中表达抑制性RNA的新型遗传构建体。抑制性RNA可以是反义RNA或共抑制RNA。本发明的遗传结构能够在真核细胞的细胞质中复制，并且与编码多核苷酸的功能组合包含启动子区。遗传结构可以设计成在植物细胞，酵母细胞和哺乳动物细胞的细胞质中复制。当感兴趣的真核细胞是植物细胞时，遗传构建优选衍生自植物RNA病毒。植物RNA病毒衍生的遗传结构可以使用植物病毒亚基因组启动子，包括与RNA编码区域功能组合的来自烟草花叶病毒的亚基因组启动子。本发明的另一方面是提供包含本发明的遗传结构的细胞和包含多个这样的细胞的生物体。本发明的另一方面是提供减少真核细胞中目的基因表达的方法，即产生目的基因表达降低水平的真核细胞的方法。本发明的方法包括用本发明的遗传构建转染细胞的步骤，其中RNA编码区域对于感兴趣的基因是特异性的。本发明的另一方面是提供产生升高水平的类胡萝卜素八氢番茄红素的植物细胞。通过使用本发明的载体抑制酶萘乙酸去饱和酶的表达来实现提高的八氢番茄聚糖水平。

6. 发明申请

WO2015023767A1 CALCIUM FORMATE AS A SUPPLEMENT TO PREVENT NEURAL TUBE DEFECTS 审中-公开
标题翻译：钙作为补充，以防止神经管缺陷
公开(公告)号：WO2015023767A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/050917
申请日：2014-08-13
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： APPLING, Dean R. , MOMB, Jessica E.
IPC分类号： A61K9/00 , A61K31/00
CPC分类号： A61K31/19 , A23K20/174 , A23K20/24 , A23L7/117 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K9/00 , A61K31/14 , A61K31/519 , A61K31/714 , A61K33/26 , A61K45/06 , C12N15/86 , C12N2760/00043 , C12N2760/00051 , C12N2770/00043 , C12N2770/00051 , A61K2300/00 , A23V2250/00 , A23V2250/034 , A23V2250/7056
摘要： Compositions and method for treating a folate-resistant disease in a subject are disclosed. The methods involve administering to the subject an effective amount of a composition containing a formate. For example, the method can be used to reducing the risk of neural tube defects during pregnancy. The method can also be used to treat other conditions normally treatable by folate supplementation.
摘要翻译：公开了用于治疗受试者中叶酸耐药性疾病的组合物和方法。所述方法涉及向受试者施用有效量的含有甲酸盐的组合物。例如，该方法可用于降低怀孕期间神经管缺陷的风险。该方法也可用于治疗通常用叶酸补充剂治疗的其它病症。

7. 发明申请

WO2014074509A1 PRODUCTION OF AN IMMUNOGEN USING A PLANT VIRUS 审中-公开
标题翻译：使用植物病毒生产免疫球蛋白
公开(公告)号：WO2014074509A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068486
申请日：2013-11-05
申请人： VACPLANTA LIMTED
发明人： GASANOVA, Tatiana Vladimirovna , IVANOV, Petr Alexeevich , PETUKHOVA, Natalia Vitalievna
IPC分类号： C07K14/00 , C12N7/01
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/58 , C07K2319/40 , C12N7/00 , C12N15/8258 , C12N2760/16134 , C12N2770/00023 , C12N2770/00043
摘要： Provided herein is a recombinant rod-shaped viral particle comprising a fusion protein comprising a coat protein for a rod-shaped plant virus and a epitope from a human and/or human pathogen, where the epitope is disposed on the outer surface of the viral particle. In certain cases, the amino acid sequence of the coat protein is at least 40% identical to the amino acid sequence of the Tobacco Mosaic Virus (TMV) coat protein.
摘要翻译：本文提供了一种重组棒状病毒颗粒，其包含融合蛋白，其包含用于棒状植物病毒的外壳蛋白和来自人和/或人类病原体的表位，其中所述表位置于病毒颗粒的外表面上。在某些情况下，外壳蛋白的氨基酸序列与烟草花叶病毒（TMV）外壳蛋白的氨基酸序列至少40％相同。

8. 发明申请

WO2008136253A1 ウイルスベクターおよびその利用审中-公开
标题翻译： VIRAL VECTOR及其使用
公开(公告)号：WO2008136253A1
公开(公告)日：2008-11-13
申请号：PCT/JP2008/057170
申请日：2008-04-11
申请人：独立行政法人科学技術振興機構 , 森正之 , 土肥浩二
发明人：森正之 , 土肥浩二
IPC分类号： C12N15/09 , A01H5/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C12N15/8203 , C12N15/8257 , C12N2770/00043
摘要：　ウイルスの塩基配列を含むポリヌクレオチドであって、該ウイルスの塩基配列は、ウイルスの複製タンパク質をコードする第１の塩基配列およびウイルスの移行タンパク質をコードする第２の塩基配列を含み、第２の塩基配列は第１の塩基配列の下流に位置しており、かつ発現させるべきポリペプチドをコードする外来塩基配列を連結するための連結部位を、第２の塩基配列の下流に有しており、第２の塩基配列は、ウイルス由来のネイティブな配列に対してさらなる塩基配列が挿入、置換または付加されたポリヌクレオチドを提供する。これにより、ウイルスの塩基配列を含むベクターを構築し、当該ベクターを含む宿主細胞の生育状態を低下させることなく、タンパク質を効率よく生産すること。
摘要翻译：旨在提供含有病毒核苷酸序列的多核苷酸，其中病毒核苷酸序列含有编码病毒复制蛋白的第一核苷酸序列和编码病毒运动蛋白的第二核苷酸序列，第二核苷酸序列位于第一核苷酸的下游序列，其具有用于连接编码在第二核苷酸序列下游表达的多肽的外源核苷酸序列的连接位点，第二核苷酸序列通过进一步插入，取代或添加源自病毒。通过使用该方法构建含有病毒核苷酸序列的载体，能有效地生成蛋白质，而不会降低含有载体的宿主细胞的生长条件。

9. 发明申请

WO2008058396A1 PAPAYA MOSAIC VIRUS-BASED VACCINES FOR INFLUENZA 审中-公开
公开(公告)号：WO2008058396A1
公开(公告)日：2008-05-22
申请号：PCT/CA2007/002069
申请日：2007-11-15
申请人： LECLERC, Denis
发明人： LECLERC, Denis
IPC分类号： C12N15/62 , A61K39/12 , A61K39/145 , A61K39/295 , A61K39/39 , A61K47/48 , A61P31/16 , A61P37/04 , C07K14/08 , C07K14/11 , C07K19/00 , C12N15/40 , C12N15/44 , C12N7/01
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/55516 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134 , C12N2770/00022 , C12N2770/00023 , C12N2770/00043
摘要： An antigen-presenting system (APS) comprising one or more antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. Specifically an APS comprising one or more influenza virus antigens is provided. The APS can be used, for example, as a vaccine against influenza. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PaPMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP). Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.
摘要翻译：提供了包含与番木瓜花叶病毒（PapMV）或源自番木瓜花叶病毒的病毒样颗粒（VLP））组合的一种或多种抗原的抗原呈递系统（APS）。具体地提供了包含一种或多种流感病毒抗原的APS。 APS可以用作例如针对流感的疫苗。由APS包含的一种或多种抗原可以与PapMV或PaPMV VLP的外壳蛋白缀合，或者它们可以是非共轭的（即与PapMV或PapMV VLP分离）。缀合可以是例如通过与外壳蛋白的遗传融合，或通过共价，非共价或亲和手段结合。

10. 发明申请

WO0066743A9 VIRAL EXPRESSION VECTORS 审中-公开
标题翻译：病毒表达载体
公开(公告)号：WO0066743A9
公开(公告)日：2002-03-14
申请号：PCT/US0012380
申请日：2000-05-04
申请人： LARGE SCALE BIOLOGY CORP , FITZMAURICE WAYNE P , POGUE GREGORY P , LINDBO JOHN A
发明人： FITZMAURICE WAYNE P , POGUE GREGORY P , LINDBO JOHN A
IPC分类号： A01H5/00 , C07K14/08 , C12N5/10 , C12N15/09 , C12N15/40 , C12N15/82 , C12N15/86 , C12N5/14
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8257 , C12N15/86 , C12N2770/00022 , C12N2770/00043
摘要： The present invention provides nucleic acid sequences having an altered viral movement protein and 126/183kDa replicase proteins further characterized in its ability to stabilize a transgene contained in a virus that expresses the altered movement protein. The present invention also provides viral vectors expressing the altered movement protein, cells transformed with the vectors, and host plants infected by the viral vectors.
摘要翻译：本发明提供具有改变的病毒运动蛋白质和126 / 183kDa复制酶蛋白质的核酸序列，其进一步特征在于其稳定包含在表达改变的运动蛋白质的病毒中的转基因的能力。本发明还提供表达改变的运动蛋白的病毒载体，用载体转化的细胞，以及被病毒载体感染的宿主植物。

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