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    • 3. 发明申请
    • METHOD FOR TREATING WASTE CONTAINING TECHNETIUM
    • 用于处理含有废物的技术的方法
    • WO00003398A1
    • 2000-01-20
    • PCT/GB1999/002077
    • 1999-07-01
    • C01G99/00G21C19/46G21F9/06G21F9/30
    • C01G99/006G21C19/46G21F9/06Y02W30/883
    • A process for the treatment of an aqueous medium comprising technetium in the form of dissolved pertechnetate comprises bringing the medium into contact with a metal to thereby reduce the dissolved pertechnetate to at least one non-metallic technetium species of lower oxidation state. Aluminium is a preferred metal, and the reduced technetium (VI) and (V) species plate out thereon, facilitating the removal of the technetium. When the aluminium is exhausted, it may be rejuvenated by acid treatment. The process may be used in conjunction with known process for the removal of other ingredients from radioactive waste.
    • 用于处理含有以高锝酸盐溶解的锝的含水介质的方法包括使介质与金属接触,从而将溶解的高锝酸盐还原成至少一种较低氧化态的非金属锝物质。 铝是优选的金属,还原的锝(VI)和(V)物质在其上平板化,便于锝的除去。 当铝耗尽时,可以通过酸处理来恢复活力。 该方法可以与用于从放射性废物中除去其它成分的已知方法结合使用。
    • 7. 发明申请
    • METHOD FOR THE PREPARATION OF FACIAL METAL TRICARBONYL COMPOUNDS AND THEIR USE IN THE LABELLING OF BIOLOGICALLY ACTIVE SUBSTRATES
    • 制备金属金属化合物的方法及其在生物活性基材标签中的应用
    • WO98048848A1
    • 1998-11-05
    • PCT/US1998/007979
    • 1998-04-21
    • C07D233/26A61K51/00A61K51/04C01G45/04C01G47/00C01G99/00C07B59/00C07D213/53C07D213/72C07D471/04C07F13/00C07J43/00C07K1/13C07K7/08C07K16/00
    • A61K51/0476A61K51/0478C01G45/04C01G99/006C01P2006/88C07B59/004C07F13/005
    • The invention relates to a method of preparing a compound of the general formula (I): fac-[M(CO)3(OH2)3] wherein M is Mn, Tc, Re or Re, by reacting a metal in the permetallate form with carbon monoxide and a reducing agent, characterized in that a mixture of a base, a reducing agent soluble in water but not substantially decomposed by water, and optionally a stabilizing agent is solved in a water containing solvent system containing a solution of the metal in the permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide and optionally in the presence of a halide. The invention further relates to a method of preparing a labeled compound with the aid of the compound of general formula (I), to a method of direct preparation of labeled compounds, to a method of labeling of substrates such as amino acids, peptides, proteins, sugars, small receptor binding molecules and body cells with the aid of compound of general formula (I) and to a kit for the preparation of a labeling composition and a kit for the preparation of a diagnostic of therapeutic pharmaceutical composition.
    • 本发明涉及制备通式(I)化合物的方法:fac- [M(CO)3(OH 2)3] +,其中M为Mn,99m Tc, 通过使多金属盐形式的金属与一氧化碳和还原剂反应,其特征在于,将碱,可溶于水但基本上不被水分解的还原剂和任选的稳定剂的混合物溶解在 含有溶剂体系的水,其含有金属在高锰酸盐溶液中,高锰酸盐或高铼酸盐形式,在一氧化碳存在下,任选地在卤化物存在下。 本发明还涉及借助于通式(I)的化合物制备标记化合物的方法,直接制备标记的化合物的方法,用于标记底物如氨基酸,肽,蛋白质的方法 ,糖,小受体结合分子和体细胞,以及用于制备标记组合物的试剂盒和用于制备治疗性药物组合物诊断的试剂盒。