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    • 1. 发明申请
    • OMNIPHOBIC MATERIALS FOR BIO-APPLICATIONS
    • 用于生物应用的OMNIPHOBIC材料
    • WO2017165411A1
    • 2017-09-28
    • PCT/US2017/023401
    • 2017-03-21
    • MASSACHUSETTS INSTITUTE OF TECHNOLOGYTHE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    • LANGER, Robert, S.TRAVERSO, Carlo, GiovanniZHANG, ShiyiLEE, Young-Ah, Lucy
    • A61B8/12A61B18/24A61K9/48
    • B32B27/06B32B3/26B32B3/30B32B5/16B32B5/30B32B2255/04B32B2255/24B32B2264/02B32B2264/025B32B2307/538B32B2307/70B32B2535/00
    • Compositions and articles comprising omniphobic materials for bio-related and other applications are generally provided. In some embodiments, the compositions and articles described herein may be introduced internally of a subject (e.g., in the esophagus, in the gastrointestinal tract, in the rectum). In some aspects, the compositions and articles comprise a releasable therapeutic agent In some embodiments, the compositions and articles described herein may be configured to have a relatively short retention time at the location internal of the subject (e.g., less than 2 seconds) such as a capsule comprising an omniphobic coating. In alternative embodiments, the compositions and articles described herein may be configured to have relative long retention times at the location internal of the subject (e.g., greater than 10 minutes) and include a mucoadhesive portion as well as an omniphobic portion. Such articles may have an omniphobic portion which resists adhesion and/or fouling (e.g., by foodstuffs and/or other materials present internal of the subject) of the article, such that the mucoadhesive portion maintains adhesion to the location internal of the subject for relatively long retention times. In some such embodiments, the article may be a Janus-type device.
    • 通常提供包含用于生物相关和其他应用的全部材料的组合物和制品。 在一些实施方案中,本文所述的组合物和制品可以引入受试者内部(例如,在食道中,在胃肠道中,在直肠中)。 在一些方面,组合物和制品包含可释放的治疗剂。在一些实施方案中,本文所述的组合物和制品可以被配置为在受试者内部位置处具有相对短的保留时间(例如小于2秒),例如 包含全憎性涂层的胶囊。 在替代实施方案中,本文所述的组合物和制品可以被配置为在受试者内部位置处具有相对较长的保留时间(例如,大于10分钟),并且包括粘膜粘附部分以及全portion部分。 这样的制品可具有抵制制品的粘附和/或结垢(例如,通过食品和/或存在于受试者体内的其它材料)的全面性部分,使得粘膜粘附部分保持与受试者内部的相对位置 保留时间长。 在一些这样的实施例中,该物品可以是Janus型设备。