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1. 发明申请

WO2009072003A2 SAMPLE PROCESSING SYSTEM AND METHODS 审中-公开
标题翻译：样本处理系统和方法
公开(公告)号：WO2009072003A2
公开(公告)日：2009-06-11
申请号：PCT/IB2008003823
申请日：2008-12-08
申请人： MILTENYI BIOTEC GMBH , MILTENYI STEFAN , SCHIMMELPFENNIG WINFRIED , LANTOW HOLGER , NEUSCHAEFER ELMAR NIKLAS , BIEHL MARTIN , KABAHA EIAD , SCHULZ JUERGEN
发明人： MILTENYI STEFAN , SCHIMMELPFENNIG WINFRIED , LANTOW HOLGER , NEUSCHAEFER ELMAR NIKLAS , BIEHL MARTIN , KABAHA EIAD , SCHULZ JUERGEN
IPC分类号： A61M1/36 , C12N5/00
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
摘要翻译：本发明涉及一种系统，包括：a）样品处理单元，包括输入端口和耦合到具有至少一个样品室的旋转容器的输出端口，所述样品处理单元配置为样品提供第一处理步骤或使容器旋转以对沉积在室中的样品施加离心力，并分离至少沉积样品的第一组分和第二组分; 以及b）样品分离单元，其耦合到所述样品处理单元的输出端口，所述细胞分离单元包括分离柱保持器，泵和多个阀，所述多个阀构造成至少部分地控制通过流体回路和分离柱定位在保持器中，分离柱构造成分离流过柱的样品的标记和未标记组分。

2. 发明申请

WO2006020100A3 CONTINUOUS BLOOD SEPARATOR 审中-公开
标题翻译：连续血液分离器
公开(公告)号：WO2006020100A3
公开(公告)日：2006-04-27
申请号：PCT/US2005025258
申请日：2005-07-18
申请人： SMART MEDICAL TECHNOLOGIES LLC , HATAMIAN MEHDI , GHALEBI MEHRTOSH A
发明人： HATAMIAN MEHDI , GHALEBI MEHRTOSH A
IPC分类号： B04B5/04 , B01L3/14
CPC分类号： A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B2005/0457 , B04B2005/0464
摘要： The disclosed inventions relate to systems and methods for separating fluids into constituent fluid components. For example, apheresis is a process by which blood is drawn from a patient, the blood is separated and/or modified, and at least a portion of the blood is returned to the patient. In some embodiments, fluid separation can be accomplished in a continuous, in-line flow. For example, the fluid can separate in a direction transverse to the general direction of flow through the system. Baffles or spiral-shaped separation chambers can be used in a rotating fluid separation device.
摘要翻译：所公开的发明涉及将流体分离成组成流体组分的系统和方法。例如，血液成像术是从患者抽取血液的过程，血液被分离和/或修饰，并且血液的至少一部分返回到患者体内。在一些实施例中，流体分离可以以连续的在线流程来完成。例如，流体可以在横向于通过系统的总体流动方向的方向上分离。挡板或螺旋形分离室可用于旋转流体分离装置。

3. 发明申请

WO0236266A3 FLUID SEPARATION DEVICES, SYSTEMS AND METHODS 审中-公开
标题翻译：流体分离装置，系统和方法
公开(公告)号：WO0236266A3
公开(公告)日：2004-06-24
申请号：PCT/US0146953
申请日：2001-11-02
申请人： GAMBRO INC
发明人： FELT THOMAS J , HLAVINKA DENNIS J
IPC分类号： A61M1/02 , A61M1/36 , A61M1/38 , B04B5/04 , B04B7/08 , B04B9/08
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal separation device (10) for use in a fluid separation system to centrifugally separate a composite fluid into the composite components thereof. This centrifugal separation device includes a centrifugal rotor housing (30) and a rotor (40) which is disposed in a freely rotatable disposition within the housing, the rotor having a fluid receiving area (42) and several fluid flow channels defined therein. A composite fluid to be separated is delivered to the fluid receiving area from which it travels through a radial fluid transport channel (44) to a circumferential fluid separation channel (46) where it is subjected to substantial centrifugal forces which separate the composite fluid into components which each then travel to distinct first and second separated fluid outlet channels (52, 54). The separated fluids then exit from these outlet channels and are then moved from the separation device to a collection bag for storage or may then be returned to the donor. The first and second fluid outlet channels also have respective first and second lengths which are related to each other so as to provide a substantial hydraulic pressure balance for the respective separated fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred relationship of the respective first and second lengths of said first and second separated fluid outlet channels to each other which provides the hydraulic balance is rho¿3
摘要翻译：一种用于流体分离系统以将复合流体离心分离成其复合部件的离心分离装置（10）。该离心分离装置包括离心转子壳体（30）和转子（40），转子（40）以可自由旋转的方式设置在壳体内，转子具有限定在其中的流体接收区域（42）和若干流体流动通道。要分离的复合流体被输送到流体接收区域，从其流过径向流体输送通道（44）到达周向流体分离通道（46），在该流体分配通道（46）处经受基本的离心力，其将复合流体分离成部件其然后各自行进到不同的第一和第二分离的流体出口通道（52,54）。分离的流体然后从这些出口通道离开，然后从分离装置移动到用于储存的收集袋中，然后可以返回给供体。第一和第二流体出口通道还具有彼此相关的相应的第一和第二长度，以便为流过其中的各个分离的流体提供实质的液压平衡。这种压力平衡控制在圆周分离通道内的分离的流体组分的界面。所述第一和第二分离的流体出口通道的相应的第一和第二长度彼此的优选关系彼此提供水力平衡。 =rho¿3？gh？3？其中第一出口通道的第一长度为h 3，第二出口通道的第二长度为h 3，其中，g是重力加速度值，表示第一出口通道中流体的密度，表示第二出口通道中流体的密度。这里使用的优选的离心驱动马达产生旋转磁场，其与设置在转子中的磁反应性材料共同作用，以使转子与旋转磁场一起旋转。因此，无孔，无密封的连续流离心机在这里是有用的。

4. 发明申请

WO1998018403A1 PROCESS FOR OPERATING A BLOOD CENTRIFUGATION UNIT, AND CENTRIFUGATION UNIT FOR CARRYING OUT THE PROCESS 审中-公开
标题翻译：一种用于操作血液离心分离，离心和执行该方法
公开(公告)号：WO1998018403A1
公开(公告)日：1998-05-07
申请号：PCT/EP1997005865
申请日：1997-10-24
申请人： GEIGLE, Peter
IPC分类号： A61F02/02
CPC分类号： B04B5/0442 , A61B2090/0815 , B04B2005/0464
摘要： A process is disclosed for operating a centrifugation unit with a centrifugation container, in particular a centrifugation bowl, for separating the components of a liquid, in particular blood, containing components with different specific weights. The centrifugation container has a separation chamber, a liquid inlet into the separation chamber and an outlet for discharging the separated component from the separation chamber. The inlet and the outlet extend through a revolving passage at the upper end of the container. The inlet is in communication with an inlet duct which opens in a defined area of the container into the separation chamber. A pumping device is provided for filling and/or emptying the centrifugation container. The liquid to be centrifuged is supplied through the inlet. After a desired amount is separated, the flow direction between inlet and outlet is reversed while the centrifugation container continues to rotate at its full working speed, so that at least one of the separated components is discharged from the separation chamber through the inlet duct and the inlet. The flow direction is then reversed again, so that liquid to be separated is again supplied through the inlet. While the separated component is discharged, a compensating liquid is supplied through the outlet in communication with the separation chamber. Also disclosed is a corresponding centrifugation unit.
摘要翻译：本发明涉及一种用于操作一个离心单元，其用于从具有不同特定的含重液体组分中分离的部件，特别是血液，包括：离心分离机，特别是Zentrifugierglocke，所述离心机的分离室，用于将液体是一个入口具有用于从分离室中的分离的组分，其中所述入口和所述出口通过旋转传输引入件在容器的上端和引导的分离室和一个出口，其中所述入口是连通的入口通道，其在限定于所述容器的区域分离室打开时，以及激励装置，用于填充和/或离心，将被离心经由入口被供给的液体，其中，与进一步分离所需的量之后，续的排空 inuierlichen旋转为全速离心容器中，入口和出口之间流动的方向是相反的，从而使分离的组分中的至少一个经由所述供应通道从分离腔室，在此之后的流动方向再次反转入口排出，从而使再次经由入口被提供给separiende液体，其中通过与分离室连通的分离的组分的排放流补偿液体供给。此外，相应的离心单元中指定。

5. 发明申请

WO2015030443A1 원심 분리기용 바울 및 그를 포함한 원심 분리기 审中-公开
标题翻译：用于离心和离心的包装盒
公开(公告)号：WO2015030443A1
公开(公告)日：2015-03-05
申请号：PCT/KR2014/007879
申请日：2014-08-25
申请人： 주식회사 아이쎌 , 김주태 , 한현희 , 박연아
发明人： 김주태 , 한현희 , 박연아 , 김해권 , 박세아 , 주환수 , 김용수
IPC分类号： B04B7/08 , B04B5/00
CPC分类号： B04B7/08 , B04B5/0442 , B04B2005/0464
摘要： 본 발명은 원심 분리기용 바울 및 그를 포함한 원심 분리기에 관한 것으로, 보다 상세하게는, 원심력을 이용하여 조직내 물질을 분리하는 원심 분리기용 바울에 사용되는 원심 분리기용 바울로서, 소정의 조직이 수용되는 수용부를 가지며 회전력의 인가에 따라 회전되는 용기; 상기 수용부 내에 배치되고 상기 수용부를 직경 방향 내공간과 외공간으로 구분하되 상기 용기의 바닥면과 소정 거리 이격되어 상기 조직이 상기 내공간과 상기 외공간 사이로 이동할 수 있는 간극이 형성된 격벽; 및 상기 내공간에 배치되며 조직의 출입이 이루어지는 관부; 를 포함하며, 상기 용기의 바닥면 중심부에는 상기 조직이 적치되는 함몰부가 형성되며, 상기 격벽에는 상기 간극을 통해 이동하는 조직의 분할이 이루어지도록 하는 복수의 절단부가 구비되고, 상기 복수의 절단부는 상기 격벽의 둘레방향을 따라 소정의 간격을 갖고 이격되게 배치되는 원심 분리기용 바울 및 그를 포함한 원심 분리기에 관한 것이다.
摘要翻译：本发明涉及一种用于离心机的碗和离心机，更具体地说，涉及用于离心机的碗和包括该离心机的离心机，以及用于离心机的碗，其用于离心机的碗通过使用离心力分离组织内的材料，包括：具有容纳部分的容器，容纳部分具有容纳在其中的预定组织，并随着施加旋转力而旋转; 分隔壁，其布置在容纳部分的内部并且将容纳部分分隔成内径和直径方向的外部空间，其中间隙与容器的底表面以预定距离间隔开，使得组织能够在内部空间和外部空间之间移动; 以及布置在所述内部空间中以便能够进入所述组织的管部，其中在所述容器的底面的中心形成有存储有所述组织的凹部，所述分隔壁设置有多个切割用于分割移动通过间隙的组织的部分，并且多个切割部分在分隔壁的圆周方向上以预定间隔隔开。

6. 发明申请

WO2009131659A1 SINGLE USE CENTRIFUGE SYSTEM 审中-公开
标题翻译：单一使用中心系统
公开(公告)号：WO2009131659A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/002464
申请日：2009-04-21
申请人： BOSTON TECHNOLOGY CONSULTANTS GROUP, INC.
发明人： KESSLER, Stephen, B.
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0464 , C12M33/10 , C12M47/02
摘要： An improved centrifuge system having a single means for both feeding and collecting liquid streams aseptically from rotating components is provided. Also methods and apparatus for centrifugal separation of cells from cell culture media of large cell culture batches by processing a large volume within a few hours, using pre-sterilized, single-use fluid path components. The apparatus uses a sealing approach that improves reliability while avoiding air contamination as well as shedding from mechanical seals. The risk of process liquid leaks is minimized.
摘要翻译：提供了一种改进的离心机系统，其具有用于从旋转部件无菌地进料和收集液流的单个装置。还有用于使用预消毒的一次性流体路径组分在几小时内通过加工大体积离心分离细胞与大细胞培养物批次的细胞培养基的方法和装置。该设备采用密封方式，提高可靠性，同时避免空气污染以及从机械密封件脱落。处理液体泄漏的风险最小化。

7. 发明申请

WO2009072006A3 A CENTRIFUGE FOR SEPARATING A SAMPLE INTO AT LEAST TWO COMPONENTS 审中-公开
标题翻译：将样品分离成至少两个组分的离心机
公开(公告)号：WO2009072006A3
公开(公告)日：2009-08-06
申请号：PCT/IB2008003845
申请日：2008-12-08
申请人： MILTENYI BIOTEC GMBH , MILTENYI STEFAN , SCHIMMELPFENNIG WINFRIED , LANTOW HOLGER , NEUSCHAEFER ELMAR NIKLAS , BIEHL MARTIN , KABAHA EIAD , SCHULZ JUERGEN
发明人： MILTENYI STEFAN , SCHIMMELPFENNIG WINFRIED , LANTOW HOLGER , NEUSCHAEFER ELMAR NIKLAS , BIEHL MARTIN , KABAHA EIAD , SCHULZ JUERGEN
IPC分类号： B04B5/04 , B04B13/00 , G01N15/04
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.
摘要翻译：本发明涉及一种用于将样品分离成至少两个组分的离心机，包括用于接收要离心的样品的室。根据本发明，离心机还包括用于控制样品分离进度位于腔室的装置。

8. 发明申请

WO2008006237A1 一种由多个相对独立分离室构成的离心杯审中-公开
公开(公告)号：WO2008006237A1
公开(公告)日：2008-01-17
申请号：PCT/CN2006/001312
申请日：2006-06-13
申请人：王晓进
发明人：王晓进
IPC分类号： B04B5/04 , A61M1/00
CPC分类号： B04B5/0442 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B04B2005/0464
摘要： A centrifugal cup is composed of cup body (1), blood/washing liquid inlet (2), guide tube (3), deceleration ring (4), and washing liquid outlet (5). It features that said cup body (1) is radially divided into multiple individual separation chambers by multiple isolating grates.

9. 发明申请

WO1998008611A1 SORTING CENTRIFUGING SYSTEM 审中-公开
标题翻译： SORTIERZENTRIFUGATIONSSYSTEM
公开(公告)号：WO1998008611A1
公开(公告)日：1998-03-05
申请号：PCT/EP1997004539
申请日：1997-08-21
申请人： KOMANNS, Aribert , KOMANNS, Anke
IPC分类号： B04B05/04
CPC分类号： B04B11/06 , B04B5/0442 , B04B9/08 , B04B2005/0464
摘要： The invention concerns a method and device for separating the components of mixtures or suspensions in the centrifugal acceleration field of a centrifuge, flow-through centrifuge or ultra-centrifuge. During centrifugation, mixtures or suspensions are continuously or discontinuously fed into a centrifuge rotor system (5, 6, 12, 13) pre-filled with a fluid medium, and excess fluid and/or separated components are continuously discharged. The inflow of the mixtures or suspensions and the discharge of the separated components occur spatially separately in the region of the central axis of rotation, either via sliding sealing systems (4) or by means of processes which do not involve sliding seals. To that end, the flow direction of the incoming mixtures or suspensions is guided to a peripheral fixed point of the rotating centrifuge rotor system. Under the effect of centrifugal force, directed sedimentation of the components to be separated occurs in the fluid medium. At the same time, the components settled out in the fluid medium. At the same time, the components settled out in a directed manner are deflected in a circular manner via a deflection device in the centrifuge rotor system, which deflection device can move in a circular manner. In a final step, the separated components are deflected into the collection container in the region of the peripheral circumference of the centrifuge rotor system.
摘要翻译：在Zentrifugalbeschleunigungsfeld离心机流离心机或超离心分离混合物或悬浮液的部件的方法和装置。混合物或悬浮液离心期间在连续或不连续引入预填充有液体介质离心机转子系统（5，6，12，13），并且还为上清液和/或分离的组分，而不是一个连续的排斥反应。混合物或悬浮液，并在空间上分离的分离的组分的排出的流入通过gleitdichtungsfreie方法要么Gleitdichtungssysteme（4）或发生在旋转的中心轴的区域中。在此，流入的混合物或悬浮液的流动方向被引导到旋转的离心转子系统的周边固定点。在离心力的作用在液体介质中发生时将被分离的成分的定向沉降。同时，被寻址的沉降成分的圆形偏转发生在在离心转子系统圆可动偏转器和在最后步骤中，将分离的组分被引导到在所述离心机转子系统的外围圆周的区域内的收集容器。

10. 发明申请

WO1986001426A1 CLOSED HEMAPHERESIS SYSTEM AND METHOD 审中-公开
标题翻译：关闭HEMAPHERESIS系统和方法
公开(公告)号：WO1986001426A1
公开(公告)日：1986-03-13
申请号：PCT/US1985001569
申请日：1985-08-19
申请人： HEMASCIENCE LABORATORIES, INC. , McLAUGHLIN, William, Francis
发明人： HEMASCIENCE LABORATORIES, INC. , SCHOENDORFER, Donald, Walter
IPC分类号： B01D13/00
CPC分类号： B04B5/0442 , A61M1/262 , A61M1/3496 , A61M1/3693 , A61M1/3696 , B01D61/08 , B01D63/062 , B01D63/16 , B01D69/043 , B01D2315/02 , B04B2005/0464 , B04B2005/0471
摘要： A hemapheresis system and method comprises a stationary closed housing (12) concentric about a central axis and a feed system that moves blood upwardly from the housing lower end toward an outlet (30) port adjacent a substantially closed upper end. Within the stationary housing (12) is a double walled rotor (14) concentric with the housing (12) and rotatable magnetically within the housing (12) on sealed end bearings. The space between the rotor walls defines a centrifugation gap into which whole blood is passed and within which centrifugal separation takes place as the rotor (14) is spun at a relatively low rate. At the upper end of the rotor (14), lighter matter such as plasma rich in platelets passes continuously inwardly to a central lengthwise passageway (68) leading to an outlet port (24) coaxial with the central axis, while heavier central matter flows through apertures (60) in the outer rotor wall to the upper outlet port (30). In one example the differential impedence is established by housing (12) and rotor (14) configurations which diverge outwardly with compound curvatures, and with space between rotor (14) and housing (12) leading to a closed end. In another example the housing-rotor space is of restricted cross section and an opposing flow of compatible fluid is introduced in an intermediate region of the flow path. These systems are biologically closed and permit continuous return of packed cells to a donor as plasma is collected.

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