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    • 1. 发明申请
    • MICROWAVE REACTOR
    • 微波反应器
    • WO2009048642A1
    • 2009-04-16
    • PCT/US2008/011779
    • 2008-10-09
    • ACCELBEAM DEVICES LLCBROWNELL, James, HaydenZHILKOV, Stanislav
    • BROWNELL, James, HaydenZHILKOV, Stanislav
    • F26B21/06
    • B01J19/126B01J2219/00029B01J2219/00033B01J2219/0871B01J2219/1209B01J2219/1227H05B6/802
    • A microwave reactor for processing a flow of a mixture, said reactor comprising a reaction chamber having an unpressurized interior and a reaction block disposed within the interior of the reaction chamber, with at least one antenna disposed within the interior of the chamber; and at least one generator of electromagnetic radiation connected to the antenna so that the flow may circulate through said reaction block, and the generator generates a radiation that is uniformly and homogeneously propagated in the chamber and is evenly absorbed by the mixture. The present invention provides embodiments of microwave reactors capable of processing reaction volumes normally found in early stage drug development and pre-clinical studies, as well as embodiments sufficient for commercial production, the designs disclosed incorporate process controls as well as high microwave field uniformity. The reactor may process batches, or may be a flow through design, or a 'stop flow' design whereby flow is admitted, a batch is processed and the flow is re-started.
    • 一种用于处理混合物流的微波反应器,所述反应器包括具有未加压内部的反应室和设置在反应室内部的反应块,至少一个天线设置在室内; 以及连接到天线的至少一个电磁辐射发生器,使得流动可以循环通过所述反应块,并且发生器产生均匀均匀地传播到室中并被混合物均匀吸收的辐射。 本发明提供能够处理早期药物开发和临床前研究中通常发现的反应体积的微波反应器的实施方案,以及足以进行商业生产的实施方案,所公开的设计包括工艺控制以及高微波场均匀性。 反应器可以处理批次,或者可以是流动式设计,或者是“停止流动”设计,从而允许流动,处理批次并重新开始流程。
    • 6. 发明申请
    • PRESSURE SENSING REACTION VESSEL FOR MICROWAVE ASSISTED CHEMISTRY
    • 用于微波辅助化学品的压力感测反应容器
    • WO99013979A1
    • 1999-03-25
    • PCT/US1998/019011
    • 1998-09-14
    • G01L11/00B01J19/00B01J19/12G01L9/00G01N1/28G01N1/44H05B6/80
    • H05B6/806B01J19/126B01J2219/1209B01J2219/1215B01J2219/1218G01L9/0051G01N1/44
    • A microwave vessel system for external and noninvasive pressure monitoring and control is disclosed. The system comprises a reaction vessel (21) formed of a material that is transparent to microwave radiation, with the reaction vessel (21) including a portion that is movable (22) under pressure generated by a chemical reaction inside the vessel while maintaining the reaction sealed inside the vessel. A sensor (30) is adjacent to the movable portion (22) of the vessel (21) for detecting the motion of the movable portion as the portion responds to pressure generated inside the vessel. The system includes means for maintaining the sensor (30) against the movable portion while microwaves are applied to the vessel (21) so that the movement of the movable portion (22) under pressure is detected by the sensor (30).
    • 公开了一种用于外部和无创压力监测和控制的微波容器系统。 该系统包括由对微波辐射透明的材料形成的反应容器(21),反应容器(21)包括在保持反应的同时在容器内通过化学反应产生的压力可移动的部分(22) 密封在船内。 传感器(30)邻近容器(21)的可移动部分(22),用于检测可移动部分的运动,因为该部分响应于容器内产生的压力。 该系统包括用于在将微波施加到容器(21)的同时将传感器(30)保持在可移动部分上的装置,使得可动部分(22)在压力下的运动由传感器(30)检测。