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1. 发明申请

WO2010149296A1 BONE SUBSTITUTE MATERIAL 审中-公开
标题翻译：骨代替材料
公开(公告)号：WO2010149296A1
公开(公告)日：2010-12-29
申请号：PCT/EP2010/003590
申请日：2010-06-15
申请人： GEISTLICH PHARMA AG , BUFLER, Michael, Alexander
发明人： BUFLER, Michael, Alexander
IPC分类号： A61L27/12 , A61L27/32 , A61L27/42 , A61L24/00 , A61L31/02 , A61L31/08 , A61L31/12
CPC分类号： A61L27/425 , A61L24/0063 , A61L27/12 , A61L27/32 , A61L27/50 , A61L31/026 , A61L31/086 , A61L31/123 , A61L2400/12 , A61L2430/02 , B33Y80/00
摘要： The invention relates to: - a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and at least one uniform and closed epitactically grown layer of nanocrystalline HAP deposited on top of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, i.e. a length of 30 to 46 nm and a width of 14 to 22 nm, - a process of preparing the above CAP/HAP bone substitute material comprising the steps of a) preparing a sintered CAP core material, b) immersing the sintered CAP core material in an aqueous solution at a temperature between 10°C and 50°C to start the transformation process of CAP to HAP whereby a uniform and closed epitactic grown layer of nanocrystalline hydroxyapatite will be formed on the CAP core material surface, the epitactically grown nanocrystals having the same size and morphology as human bone mineral, c) stopping the transformation by separating solid material from the aqueous solution at a time when a uniform and closed coating of at least one nanocrystalline layer of HAP is present but before the transformation process is finished completely, and d) optionally sterilizing the separated material coming from step c), and - the use of the above bone substitute material as implant or prosthesis for bone formation, bone regeneration, bone repair and/or bone replacement at a defect site in a human or animal.
摘要翻译：本发明涉及： - 双相磷酸钙/羟基磷灰石（CAP / HAP）骨替代材料，其包含烧结的CAP芯和沉积在烧结的CAP芯的顶部上的至少一个均匀和封闭的纳米晶体HAP的外延生长层，其中，生长的纳米晶体具有与人骨矿物相同的尺寸和形态，即30至46nm的长度和14至22nm的宽度， - 制备上述CAP / HAP骨替代材料的方法，包括以下步骤：a）制备烧结的CAP芯材料，b）将烧结的CAP芯材浸入在10℃至50℃的温度下的水溶液中以开始CAP转化为HAP，由此使纳米晶体羟基磷灰石的均匀和封闭的外延生长层将形成在CAP芯材表面上，具有与人骨矿物相同尺寸和形态的外延生长的纳米晶体，c）通过分离固体m停止转化当存在至少一个HAP的至少一个纳米晶层的均匀和封闭的涂层时，但是在转化过程完全完成之前，从水溶液中的空气，以及d）任选地对来自步骤c）的分离的材料进行灭菌，以及 - 使用上述骨替代材料作为人或动物的缺损部位的骨形成，骨再生，骨修复和/或骨置换的植入物或假体。

2. 发明申请

WO1998017330A1 CERAMIC FUSION IMPLANTS AND COMPOSITIONS CONTAINING OSTEOINDUCTIVE FACTORS 审中-公开
标题翻译：陶瓷熔融植入物和含有铁氧体因子的组合物
公开(公告)号：WO1998017330A1
公开(公告)日：1998-04-30
申请号：PCT/US1997018692
申请日：1997-10-20
申请人： SDGI HOLDINGS, INC. , MCKAY, William, F.
发明人： SDGI HOLDINGS, INC.
IPC分类号： A61L27/00
CPC分类号： A61F2/446 , A61B17/7062 , A61B17/707 , A61F2/4405 , A61F2/442 , A61F2/4465 , A61F2/447 , A61F2002/30133 , A61F2002/30153 , A61F2002/30224 , A61F2002/30261 , A61F2002/30677 , A61F2002/448 , A61F2230/0015 , A61F2230/0019 , A61F2230/0069 , A61F2230/0082 , A61F2310/00293 , A61L27/12 , A61L27/425 , A61L27/54 , A61L27/56 , A61L31/026 , A61L31/047 , A61L31/123 , A61L31/146 , A61L31/16 , A61L2430/38 , A61L27/227
摘要： Bone graft substitute compositions are provided for promoting new bone growth and arthrodesis. The compositions include a carrier for controlled delivery of osteoinductive factors. In one embodiment, the carriers include a biphasic calcium phosphate ceramic having between about 2-40 % hydroxyapatite and about 98-60 % tricalcium phosphate by volume, and a calcium/phosphorous ratio of between about 1.50 to about 1.60. The invention also includes osteoinductive compositions including the carriers and an effective amount of a bone morphogenetic protein dispersed within the ceramic. The composition has a weight ratio of protein to ceramic of no more than about 1:200. In a specific embodiment, the weight ratio of protein to ceramic is between about 1:200 and about 1:2000. Spinal implants (10) are also provided which include a body (11) having a wall (12) sized for engagement within a space (S) between adjacent vertebrae (V) to maintain the space (S) and a confining matrix (13) for confining new bone growth to the body (11).
摘要翻译：提供骨移植替代组合物用于促进新的骨生长和关节固定术。组合物包括用于受控传递成骨诱导因子的载体。在一个实施方案中，载体包括具有约2-40％羟基磷灰石和约98-60％磷酸三钙的体积的两相磷酸钙陶瓷，钙/磷比为约1.50至约1.60。本发明还包括包含载体的骨诱导组合物和分散在陶瓷内的有效量的骨形态发生蛋白。该组合物的蛋白质与陶瓷的重量比不超过约1:200。在具体实施方案中，蛋白质与陶瓷的重量比为约1:200至约1:2000。还提供了脊柱植入物（10），其包括具有壁（12）的主体（11），其尺寸适于接合在相邻椎骨（V）之间的空间（S）内，以维持空间（S）和约束矩阵（13）用于限制新骨骼生长到身体（11）。

3. 发明申请

WO2003103734A1 STRONTIUM-APATIT-ZEMENT-ZUBEREITUNGEN UND DEREN VERWENDUNGEN 审中-公开
标题翻译：锶APATIT水泥筹备工作及其用途
公开(公告)号：WO2003103734A1
公开(公告)日：2003-12-18
申请号：PCT/EP2003/005059
申请日：2003-05-14
申请人： SANATIS GMBH , WENZ, Robert
发明人： WENZ, Robert
IPC分类号： A61L24/00
CPC分类号： A61L27/54 , A61L24/0063 , A61L27/12 , A61L27/58 , A61L31/123 , A61L31/148 , A61L31/16 , A61L2430/02 , C04B12/025 , C04B28/344 , C04B2111/00836 , C04B22/062 , C04B22/064 , C04B22/10 , C04B22/16 , C04B24/00
摘要： Es werden Calcium-Strontium-Hydroxyphosphat-(Strontium-Apatit-) Zementzubereitung beschrieben mit einer Pulvermischung, die molare Mengen der Komponenten Calcium (Ca), Strontium (Sr) und Orthophosphat (P) in der Mischung in den Bereichen 1,00 3 (P0 4 ) 2 (TCP) und als SrKomponente SrHP0 4 and/oder Sr 3 (P04) 2 und gegebenenfalls zusätzlich SrC0 3 . Als wässrige Anmischlosung zur Bildung des Strontium-Apatit-Zements eignet sich eine wässrige Losung eines Alkalisalzes oder eines Ammoniumsalzes der Orthophosphorsäure.
摘要翻译：有钙 - 锶 - Hydroxyphosphat-（锶磷灰石）中描述的水泥组合物，与在1.00的区域中的混合物的粉末混合物，所述组分钙的摩尔量（Ca），锶（Sr）和正磷酸（P）

4. 发明申请

WO9600592A3 BIODEGRADABLE FRACTURE FIXATION PLATES AND USES THEREOF 审中-公开
标题翻译：可生物降解的断裂固定板及其用途
公开(公告)号：WO9600592A3
公开(公告)日：1996-02-22
申请号：PCT/US9508171
申请日：1995-06-28
申请人： UNIV TEXAS
发明人： AGRAWAL C MAULI
IPC分类号： A61L31/12 , A61L31/14 , A61L31/16 , A61L27/00 , A61L31/00
CPC分类号： A61L31/16 , A61L31/121 , A61L31/123 , A61L31/129 , A61L31/148 , A61L2300/404 , A61L2300/414 , A61L2300/602 , A61L2300/604 , A61L31/047 , A61B17/58 , C08L67/04
摘要： The present invention provides materials for use in biodegradable structural prosthetic devices with enhanced load-bearing strength and reinforced flexibility. Prosthetic devices are also provided, which comprise a biodegradable polymer layer, reinforced by a biodegradable material, and optionally, the inclusion of pharmacologically active substances, such as growth factors and anti-microbial agents. The prosthetic devices provide for gradually decreasing structural support that lessens as the implant degrades and is compensated by new bone growth. The degradation also provides for the controlled release of the pharmacologically active agents. The prosthetic devices are exemplified by bone fixation plates.

5. 发明申请

WO2013158869A2 THIXOTROPIC PROCESSING OF MAGNESIUM COMPOSITES WITH A NANOPARTICLES-HALOED GRAIN STRUCTURE FOR BIOMEDICAL IMPLANT APPLICATIONS 审中-公开
标题翻译：具有纳米粒子的晶粒结构的镁复合材料在生物医学植入中的应用
公开(公告)号：WO2013158869A2
公开(公告)日：2013-10-24
申请号：PCT/US2013037153
申请日：2013-04-18
申请人： UNIV DREXEL , GEORGIA INST TECHNOLOGY
发明人： ZHOU GONGYAO , GONG HAIBO , YAO DONGGANG
CPC分类号： A61L31/124 , A61L27/425 , A61L27/427 , A61L31/123 , A61L2400/12 , C22B26/22 , C22C1/00 , C22C1/1036 , C22C23/00 , C22C23/02 , C22C23/06 , C22C26/00 , C22C32/00 , C22F1/06
摘要： In described embodiments, the present invention includes a magnesium-based composite material formed froma plurality of a-phase magnesium grains; and a beta-alloy phase comprising magnesium and nano-diamond and/or and phosphate containing nanoparticles, the beta-alloy phase surrounding each of the plurality of magnesium grains. A method of manufacturing a composite material is also disclosed.
摘要翻译：在所述实施例中，本发明包括由多个a相镁颗粒形成的镁基复合材料; 以及包含镁和纳米金刚石和/或含磷酸盐纳米颗粒的β合金相，所述β合金相包围所述多个镁颗粒中的每一个。还公开了一种制造复合材料的方法。

6. 发明申请

WO2004072104A2 METHODS AND MATERIALS FOR NANOCRYSTALLINE SURFACE COATINGS AND ATTACHMENT OF PEPTIDE AMPHIPHILE NANOFIBERS THEREON 审中-公开
标题翻译：纳米结构表面涂层的方法和材料及其附着于其中的肽类AMPNIPLE NANOFIBERSERS
公开(公告)号：WO2004072104A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004025
申请日：2004-02-11
申请人： NORTHWESTERN UNIVERSITY , STUPP, Samuel, I. , SPOERKE, Erik, D. , NIECE, Krista, L. , ANTHONY, Shawn, G.
发明人： STUPP, Samuel, I. , SPOERKE, Erik, D. , NIECE, Krista, L. , ANTHONY, Shawn, G.
IPC分类号： C07K
CPC分类号： A61L31/086 , A61L27/32 , A61L27/425 , A61L31/123 , C12N5/0068 , C12N2533/18 , C12N2533/50
摘要： Biocompatible composites comprising peptide amphiphiles and surface modified substrates and related methods for attachment thereon.
摘要翻译：包含肽两亲物和表面改性底物的生物相容性复合材料及其上附着的相关方法。

7. 发明申请

WO00047245A1 BIODEGRADABLE COMPOSITE MATERIAL FOR TISSUE REPAIR 审中-公开
标题翻译：用于组织修复的生物可降解复合材料
公开(公告)号：WO00047245A1
公开(公告)日：2000-08-17
申请号：PCT/GB2000/000475
申请日：2000-02-11
IPC分类号： A61L27/00 , A61L27/42 , A61L27/46 , A61L27/58 , A61L31/12 , A61L31/14
CPC分类号： A61L31/123 , A61L27/425 , A61L27/46 , A61L27/58 , A61L31/127 , A61L31/146
摘要： There is described a biodegradable composite material for tissue repair comprising a water-soluble glass, preferably as glass fibres and/or particles in the form of a matrix, impregnated with a biodegradable polymer. An especially preferred polymer is poly epsilon -caprolactone. The biodegradable composite is particularly useful for the repair of nerve and/or bone tissue, especially the bones of the skull. A method of producing the composite material is also described.
摘要翻译：描述了一种用于组织修复的可生物降解的复合材料，其包括浸渍有可生物降解的聚合物的水溶性玻璃，优选作为基质形式的玻璃纤维和/或颗粒。特别优选的聚合物是聚ε-己内酯。可生物降解的复合物特别可用于修复神经和/或骨组织，特别是颅骨的骨骼。还描述了制备复合材料的方法。

8. 发明申请

WO1997047334A1 METHOD FOR PREPARING AN IMPLANTABLE COMPOSITE MATERIAL, RESULTING MATERIAL, IMPLANT INCLUDING SAID MATERIAL, AND KIT THEREFOR 审中-公开
标题翻译：用于制备可植入材料的材料，材料，包括所述材料的植入物及其制品的方法
公开(公告)号：WO1997047334A1
公开(公告)日：1997-12-18
申请号：PCT/FR1997001045
申请日：1997-06-11
申请人： BIOLAND , LERCH, Alain , FRAYSSINET, Patrick
发明人： BIOLAND
IPC分类号： A61L27/00
CPC分类号： A61L27/425 , A61F2310/00293 , A61L27/12 , A61L31/026 , A61L31/123 , Y10S623/92
摘要： A method for preparing a composite material for implantation into a biological medium, by preparing at least one block of solid porous matrix including at least one calcium salt; preparing a liquid solution hardenable into a solid composition including at least one calcium salt; dipping the matrix block into the liquid solution; and drying and hardening the liquid solution. The resulting composite material, an implant including said material, and a kit for extemporaneously carrying out the method, are also disclosed.
摘要翻译：一种通过制备至少一块包含至少一种钙盐的固体多孔基质块来制备用于植入生物培养基的复合材料的方法; 制备可硬化成包含至少一种钙盐的固体组合物的液体溶液; 将基质块浸入液体溶液中; 并干燥并硬化液体溶液。还公开了所得到的复合材料，包括所述材料的植入物和用于临时实施该方法的试剂盒。

9. 发明申请

WO2014201763A1 一种用于人体骨骼固定的复合植入物审中-公开
公开(公告)号：WO2014201763A1
公开(公告)日：2014-12-24
申请号：PCT/CN2013/081786
申请日：2013-08-19
申请人：王惠
发明人：王惠 , 王磊
IPC分类号： A61L31/06 , A61L31/04 , A61L31/02
CPC分类号： A61L31/123 , C08L33/10 , C08L77/02
摘要：一种用于人体骨骼固定的复合植入物，其由多种原料通过热压制备而成。所述多种原料中各组分所占的质量百分比为：聚酰胺6纤维23-24%、甲基丙烯酸甲酯与N-乙烯基吡咯烷酮共聚物45%-65%以及羟基磷灰石微粉2%-15%。该复合植入物化学性质稳定、生物相容性好，在体内不降解，且具有较佳的弯曲、抗压、抗冲击及断裂疲劳强度等性能。

10. 发明申请

WO2010147687A1 BIODEGRADABLE MEDICAL DEVICE WITH HYDROXYAPATITE FILAMENTS AND BIODEGRADABLE POLYMER FIBERS 审中-公开
标题翻译：可生物降解的医用设备，具有羟基磷酸酯纤维和可生物降解的聚合物纤维
公开(公告)号：WO2010147687A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/027336
申请日：2010-03-15
申请人： MEDTRONIC VASCULAR INC. , BILGE, Iskender
发明人： BILGE, Iskender
IPC分类号： A61F2/82 , A61L27/12 , A61L27/58 , A61L27/14 , A61M29/02
CPC分类号： A61L31/028 , A61F2/82 , A61F2/90 , A61F2/958 , A61F2210/0004 , A61F2250/003 , A61L31/026 , A61L31/06 , A61L31/123 , A61L31/127 , A61L31/148 , A61L31/16 , Y10T442/105 , Y10T442/2525 , C08L67/04
摘要： A system for treating a vascular condition includes a stent including hydroxyapatite fibers interwoven to define a stent lumen. Another aspect of the invention is a method of manufacturing a stent by forming hydroxyapatite fibers and biodegradable polymeric fibers, and interweaving the fibers to form a stent wall. The hydroxyapatite fibers can be formed by a sol-gel process, followed by spinning of the gel to form the hydroxyapatite fibers.
摘要翻译：用于治疗血管病症的系统包括支架，其包括交织以固定支架内腔的羟基磷灰石纤维。本发明的另一方面是通过形成羟基磷灰石纤维和可生物降解的聚合物纤维来制造支架的方法，并且交织纤维以形成支架壁。羟基磷灰石纤维可以通过溶胶 - 凝胶法形成，然后旋转凝胶以形成羟基磷灰石纤维。

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