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1. 发明申请

WO2006041940A2 COMPOSITIONS HAVING IMPROVED OSTEOGENESIS AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：具有改善的成骨作用的组合物以及制备和使用该组合物的方法
公开(公告)号：WO2006041940A2
公开(公告)日：2006-04-20
申请号：PCT/US2005035862
申请日：2005-10-04
申请人： LOSTEC INC , MALININ THEODORE I
发明人： MALININ THEODORE I
CPC分类号： A61L2/0035 , A61F2/28 , A61F2002/2835 , A61F2002/30059 , A61F2310/00359 , A61L2/0041 , A61L2/007 , A61L27/3608 , A61L27/365 , A61L27/3691 , A61N5/10
摘要： An implantable bone-containing composition and a method for making same are disclosed. The compositions includes sterilized bone, which has been exposed to a dose of radiation in excess of about 45 kGy in the absence of radio-protective agents. The sterilized bone has higher osteogenic capacity than bone sterilized at the conventional dose of between 15 kGy and 35 kGy, approaching or surpassing the osteogenic capacity of the bone prior to irradiation.
摘要翻译：公开了一种可植入的含骨组合物及其制备方法。该组合物包括无菌的骨，在无放射保护剂的情况下，该骨已经暴露于超过约45kGy的辐射剂量。经灭菌的骨具有比在15kGy与35kGy之间的常规剂量下灭菌的骨更高的成骨能力，在照射之前接近或超过骨的成骨能力。

2. 发明申请

WO2003092745A1 METHODS FOR STERILIZING TISSUES USING CRYOPRESERVATIVES 审中-公开
标题翻译：使用CRYOPRERER活性灭菌组织的方法
公开(公告)号：WO2003092745A1
公开(公告)日：2003-11-13
申请号：PCT/US2003/012827
申请日：2003-04-24
申请人： CLEARANT, INC. , GREIB, Teri , MANN, David M. , STAFFORD, Richard E. , BURGESS, Wilson H. , DROHAN, William N. , MACPHEE, Martin J.
发明人： GREIB, Teri , MANN, David M. , STAFFORD, Richard E. , BURGESS, Wilson H. , DROHAN, William N. , MACPHEE, Martin J.
IPC分类号： A61L2/08
CPC分类号： C12M37/00 , A01N1/02 , A01N1/0221 , A01N1/0226 , A01N1/0294 , A61K35/12 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/007 , A61L2/0082
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, spores, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译：公开了用于灭菌组织以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母，对于TSE和/或单细胞或多细胞寄生虫，单独或组合地负责的霉菌，真菌，孢子，朊病毒或类似物质。所述方法包括用照射对一个或多个组织进行消毒。

3. 发明申请

WO2003020325A2 METHODS FOR STERILIZING PREPARATIONS CONTAINING ALBUMIN 审中-公开
标题翻译：用于灭菌含有ALBUMIN的制剂的方法
公开(公告)号：WO2003020325A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027947
申请日：2002-09-03
申请人： CLEARANT, INC. , GRIKO, Yuri , MIEKKA, Shirley I. , BURGESS, Wilson H. , DROHAN, William N. , MACPHEE, Martin J. , KENT, Randall S. , MANN, David M.
发明人： GRIKO, Yuri , MIEKKA, Shirley I. , BURGESS, Wilson H. , DROHAN, William N. , MACPHEE, Martin J. , KENT, Randall S. , MANN, David M.
IPC分类号： A61L
CPC分类号： A61L2/007 , A61K38/38 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/0082
摘要： Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations containing albumin, such as plasma protein fractions, with irradiation.
摘要翻译：公开了用于灭菌含有白蛋白的制剂的方法，以降低其中的一种或多种活性生物污染物或病原体的水平，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母，霉菌，朊病毒或类似物质，单独或组合，用于TSEs和/或单细胞或多细胞寄生虫。这些方法包括用照射消毒含有白蛋白的制剂，例如血浆蛋白质级分。

4. 发明申请

WO2003009875A1 SYSTEMS FOR, AND METHODS OF, IRRADIATING ARTICLES DISPOSED IN A CONTAINER 审中-公开
标题翻译：在集装箱中处理废物的系统和方法
公开(公告)号：WO2003009875A1
公开(公告)日：2003-02-06
申请号：PCT/US2002/023545
申请日：2002-07-23
申请人： SUREBEAM CORPORATION
发明人： ALLEN, Thomas, John , SULLIVAN, George, Michael , WILLIAMS, Colin, Brian
IPC分类号： A61L2/08
CPC分类号： A61L2/007 , A23B4/015 , A23L3/263 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/08 , A61L2202/122 , G21K5/10
摘要： Articles (40) having irregular characteristics such as an irregular geometrical configuration or an irregular density are disposed in a container (42) which is moved in a first direction past a radiation source (50). Radiation from the source (50) is directed toward the articles (40) in the container (42) in a second direction substantially perpendicular to the first direction. The radiation energy passing from the source (50) to the articles (40) at different positions in the articles (40) is absorbed in accordance with the irregularities in the characteristics of the articles (40) at the different positions to maintain the radiant energy at the different positions in the articles (40) within particular limits. For irregularities of geo metrical configuration or density in the articles (40), the absorption may be provided during the movement of the container (42) in the first direction with a fixture (44, 46) which has a geometrical configuration or density constituting the difference at every position between a substantially constant value and the geometrical configuration or density of the articles (40) at this position. The fixtures (44, 46) is disposed externally relative to the container (40).
摘要翻译：具有诸如不规则几何构型或不规则密度的不规则特征的制品（40）设置在沿第一方向移动经过辐射源（50）的容器（42）中。来自源（50）的辐射在基本上垂直于第一方向的第二方向上朝向容器（42）中的物品（40）。根据在不同位置处的物品（40）的特性的不规则性，将从源（50）到物品（40）的物质（40）中的物质（40）的辐射能量吸收，以保持辐射能在物品（40）的不同位置处于特定限度内。对于物品（40）中的地理计量结构或密度的不规则性，可以在容器（42）沿第一方向移动期间提供吸收，其中具有几何构造或密度的固定件（44,46）构成在基本上恒定的值和在该位置处的制品（40）的几何构型或密度之间的每个位置的差。固定装置（44,46）相对于容器（40）设置在外部。

5. 发明申请

WO2004009139A1 METHODS FOR STERILIZING RECOMBINANT OR TRANSGENIC MATERIAL 审中-公开
标题翻译：灭菌重组或转基因材料的灭菌方法
公开(公告)号：WO2004009139A1
公开(公告)日：2004-01-29
申请号：PCT/US2003/022450
申请日：2003-07-18
申请人： CLEARANT, INC. , MANN, David, M. , BURGESS, Wilson, H. , KENT, Randall, S. , MACPHEE, Martin, J. , DROHAN, William, N.
发明人： MANN, David, M. , BURGESS, Wilson, H. , KENT, Randall, S. , MACPHEE, Martin, J. , DROHAN, William, N.
IPC分类号： A61L2/08
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0082
摘要： Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.
摘要翻译：公开了用于灭菌生物制品以降低活性生物污染物（例如病毒，细菌，酵母，霉菌，支原体和寄生虫）的水平的方法。

6. 发明申请

WO2003065802A1 METHODS FOR STERILIZING TISSUE 审中-公开
标题翻译：消毒组织的方法
公开(公告)号：WO2003065802A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/001075
申请日：2003-01-31
申请人： CLEARANT, INC. , BURGESS, Wilson, H. , DROHAN, William, N. , MACPHEE, Martin, J. , MANN, David, M.
发明人： BURGESS, Wilson, H. , DROHAN, William, N. , MACPHEE, Martin, J. , MANN, David, M.
IPC分类号： A01N1/00
CPC分类号： A61L2/0047 , A01N1/02 , A01N1/0294 , A61K35/12 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/007 , A61L2/0082 , A61L2/0088 , C12M37/00
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译：公开了用于灭菌组织以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母，对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。所述方法包括用照射对一个或多个组织进行消毒。

7. 发明申请

WO2002070024A1 METHOD FOR STERILIZING BIOACTIVE MATERIALS 审中-公开
标题翻译：消毒生物材料的方法
公开(公告)号：WO2002070024A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/000102
申请日：2002-01-04
申请人： OSTEOTECH, INC. , SHIMP, Lawrence, A.
发明人： SHIMP, Lawrence, A.
IPC分类号： A61L2/08
CPC分类号： A61L2/0041 , A23L3/263 , A61L2/0011 , A61L2/0035 , A61L2/007 , A61L2/10 , A61L2/20
摘要： A method is provided for sterilizing a bioactive material which comprises contacting the bioactive material with hydrogen gas and while the bioactive material is in contact with hydrogen gas, irradiating the bioactive material with ionizing radiation to sterilize the material.
摘要翻译：提供了一种消毒生物活性物质的方法，包括使生物活性材料与氢气接触，同时生物活性材料与氢气接触，用电离辐射照射生物活性材料以消毒该材料。

8. 发明申请

WO01070279A1 METHODS FOR STERILIZING BIOLOGICAL MATERIALS 审中-公开
标题翻译：消毒生物材料的方法
公开(公告)号：WO01070279A1
公开(公告)日：2001-09-27
申请号：PCT/US2001/009361
申请日：2001-03-23
IPC分类号： A61L2/08 , A61L2/00 , A61M1/36
CPC分类号： A61L2/0041 , A61L2/0011 , A61L2/0029 , A61L2/0035 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/007 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M1/3686
摘要： Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.
摘要翻译：公开了用于灭菌生物制品以降低活性生物污染物（例如病毒，细菌，酵母，霉菌，支原体和寄生虫）的水平的方法。

9. 发明申请

WO2013078396A3 RADIATION-STERILIZED BIODEGRADABLE DRUG DELIVERY COMPOSITIONS 审中-公开
标题翻译：辐射灭菌生物可降解药物组合物
公开(公告)号：WO2013078396A3
公开(公告)日：2015-06-11
申请号：PCT/US2012066375
申请日：2012-11-21
申请人： DURECT CORP
发明人： SEKAR MICHAEL , YUM SU IL , THEEUWES FELIX , VAN OSDOL WILLIAM W
IPC分类号： A61K47/00
CPC分类号： A61K47/48246 , A61K9/0019 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1647 , A61K9/19 , A61K31/198 , A61K31/7052 , A61K38/17 , A61K38/22 , A61K38/26 , A61K38/27 , A61K41/0019 , A61K45/06 , A61K47/48015 , A61K47/52 , A61K47/64 , A61L2/0035 , A61L2/0041 , A61L2/007 , A61L2202/21 , C07K14/575 , C07K14/61 , A61K2300/00
摘要： The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided.
摘要翻译：本公开涉及通过组合车辆（例如单相载体）和包含有益剂的不溶性组分制备组合物的方法，并且在使用之前使用电离辐射对组合物进行灭菌，其中有益剂是稳定的在暴露于灭菌剂量的电离辐射之后。提供了相关的组合物和方法。

10. 发明申请

WO2014194931A1 PATHOGEN REDUCTION TREATMENT 审中-公开
标题翻译：病态减少治疗
公开(公告)号：WO2014194931A1
公开(公告)日：2014-12-11
申请号：PCT/EP2013/061399
申请日：2013-06-03
申请人： ONDERZOEKS- EN ONTWIKKELINGSFONDS RODE KRUIS-VLAANDEREN
发明人： FEYS, Hendrik B. , VANDEKERCKHOVE, Philippe , COMPERNOLLE, Veerle
IPC分类号： A61K41/00 , A61L2/00 , A61L2/14 , A61L2/16
CPC分类号： A61K41/0019 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0076
摘要： The present invention relates to method for reducing a risk to the occurrence of unwanted side reactions in a substrate that is subjected to a pathogen reduction treatment, wherein a sensitizing compound capable of targeting said pathogen is added to the substrate and the sensitizing compound is activated for targeting of the pathogen. In advance of activating the sensitizing compound, the substrate is subjected to an oxygen reduction treatment with the purpose of reducing a concentration of dissolved oxygen present in the substrate. Preferred examples of substrates include whole blood, blood products or blood components.
摘要翻译：本发明涉及一种减少在经过病原体还原处理的底物中发生不希望的副反应的风险的方法，其中将能够靶向所述病原体的敏化化合物加入到基质中，并使敏化化合物活化靶向病原体。在激活敏化化合物之前，为了降低基材中存在的溶解氧的浓度，对基板进行氧还原处理。底物的优选实例包括全血，血液制品或血液成分。

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