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    • 9. 发明申请
    • ENCHANCED TRANS-KERATIN DRUG DELIVERY
    • 加强的转氨酶药物递送
    • WO2010011354A2
    • 2010-01-28
    • PCT/US2009/004361
    • 2009-07-27
    • WEINFIELD, Todd, A.INNOVATION BIOMEDICAL DEVICES, INC.
    • WEINFIELD, Todd, A.
    • A61M5/14A61M37/00
    • A61K31/4402A61F7/02A61F2007/0037A61F2007/0046A61K9/0014A61K9/70A61M37/00A61M2210/086
    • The teachings provided herein are directed to a system and method for delivering an anti-infective agent through the nail of a subject having a nail infection. The system can comprise a drug delivery mechanism comprising an a nti -infective agent and a heating element and a holding mechanism for releasably attaching the drug delivery mechanism to the digit having the infected nail. The drug delivery mechanism does not comprise a nail-infection-agent-containing member or sponge for receiving and delivering the anti-infective agent to the infected nail. In addition, the holding mechanism comprises a substantially open structure that covers the infected nail and does not enclose the digit. The system facilitates an enhanced trans-keratin drug delivery of the anti-infective agent through the infected nail in a dark, warm, and moist environment that prevents the growth of fungi in the infected nail. The teachings also include a heatable bandage for treating an infected nail.
    • 本文提供的教导针对用于通过具有指甲感染的受试者的指甲递送抗感染剂的系统和方法。 该系统可以包括药物输送机构,该药物输送机构包括非感染剂和加热元件以及用于将药物输送机构可释放地附接到具有感染指甲的手指的保持机构。 药物输送机构不包括含有指甲感染剂的构件或海绵,用于接收抗感染剂并将其递送至受感染的指甲。 另外,保持机构包括覆盖感染指甲并且不包围手指的基本上敞开的结构。 该系统促进抗感染剂通过受感染的指甲在黑暗,温暖和潮湿环境中增强的反式角蛋白药物递送,该环境防止感染指甲中真菌的生长。 该教导还包括用于治疗感染指甲的可加热绷带。