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1. 发明申请

WO2011086401A1 SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 审中-公开
标题翻译：自组装模块式阀门及折叠，组装和运输方法
公开(公告)号：WO2011086401A1
公开(公告)日：2011-07-21
申请号：PCT/IB2010/000049
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/24 , A61F2/2406 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/844 , A61F2210/0014 , A61F2230/0091 , A61F2250/006
摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.
摘要翻译：本发明提供了一种设计为两个或更多个装置模块的模块化假体瓣膜装置，其可以被输送到未被组装的身体腔体，然后至少部分地使用位于或靠近该组件的自组装构件瓣膜植入部位。装置模块可以包括支撑结构和阀模块。阀模块可以以未组装的折叠输送构造递送，并且经由自组装构件展开并组装成工作构型。在其组装形式中，阀模块可以是单件式叶片子结构或多个阀部分。自组装构件具有输送配置和预设配置，并且可以被触发以恢复到预设配置以组装阀模块。模块化阀装置可以以当前阀装置不可能的方式进行折叠，例如通过沿着其周向轴线在其高度方向上滚动未组装的阀模块，使得折叠的阀模块的直径可以等于一个滚动的小叶。本发明的该特征提供了一种具有比预组装阀装置更小的输送直径的经皮瓣膜装置。这又允许使用减小直径的输送装置，并且与本领域中的经皮瓣膜装置相比增加了装载的输送装置的灵活性。本发明还提供了一种用于折叠和传送这种模块化阀装置的系统和方法，并且使用自组装构件优选地在身体中组装它。

2. 发明申请

WO1988010104A1 HEART VALVE PROSTHESIS 审中-公开
标题翻译：心脏瓣膜假体
公开(公告)号：WO1988010104A1
公开(公告)日：1988-12-29
申请号：PCT/SU1988000136
申请日：1988-06-23
申请人： BUKATOV, Alexandr Semenovich , AGAFONOV, Andrei Vasilievich , KOSTRETSOV, Anatoly Stepanovich , DZEVISHEK, Elena Viktorovna , IOFIS, Naum Abramovich , SHUMAKOV, Valery Ivanovich , KAIDASH, Arnold Nikolaevich , POPOV, Leonid Leonidovich , KOZYRKIN, Boris Ivanovich , JURECHKO, Vladimir Nikolaevich , ZHAROV, Sergei Vasilievich , KOROTEEVA, Irina Viktorovna , CHARKOVSKY, Alexandr Vladimirovich
IPC分类号： A61F02/24
CPC分类号： A61F2/2406
摘要： A heart valve prosthesis comprises a valve ring (1) with an aperture (2) for passage of the blood and a valve disk (3) located in said aperture and floatably mounted between supports (4, 5) for closing and opening the valve aperture (2). The valve disk (3) has an assymmetrical variable profile consisting, for example, of a convex section (9) and a concave section (10), so that these sections, together with the valve ring (1), form zones of different hydraulic resistance to the blood flow and, as a result, provide for an angular displacement of the disk (3), thus enabling the ''life-time'' of the heart valve prosthesis to be prolonged.
摘要翻译：一种心脏瓣膜假体具有一个具有用于血液通过的孔口（2）的阀环（1）和位于所述端口中并浮动地安装在载体（4）之间的阀盘（3）。，5）用于关闭和打开阀（2）的孔口。阀（3）的盘具有例如由凸部（9）和凹部（10）构成的不对称可变轮廓，使得所述部件与阀环（1）形成与血流不同的液压阻力区域，并且因此引起盘（3）的角位移，由此延长心脏瓣膜的寿命。

3. 发明申请

WO2014170870A2 A PROSTHETIC HEART VALVE 审中-公开
标题翻译：一个先天性心脏瓣膜
公开(公告)号：WO2014170870A2
公开(公告)日：2014-10-23
申请号：PCT/IB2014060816
申请日：2014-04-17
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS PTY LTD
发明人： PARK KENNETH STUART , APPA HARISH , VISAGIE CLAUDE , BEZUIDENHOUT DEON , ZILLA PETER PAUL
CPC分类号： A61F2/2418 , A61F2/2406 , A61F2/2412 , A61F2/2415
摘要： A prosthetic heart valve (10) which includes a stent (14) having three leaflets (12) attached thereto is provided. The stent (14) is compressible so as to be capable of being introduced into a patient's body through a minimally invasive procedure and has a ring-like body (16) defining in its height three arch-shaped elements (18). Each element (18) includes an arc (20) and a pair of haunches (22) extending from opposite sides thereof, with three commissural posts (26) formed by the haunches (22) of adjacent elements (18). The leaflets (12) each have an attachment edge (28) and a free edge (30) with a belly (32) extending therebetween. The leaflets (12) are movable between a coapted condition, in which the free edges (30) abut and prevent fluid flow through the valve (10), and an open condition, in which fluid flow through the valve (10) is permitted. The leaflets (12) are made from a polymeric material and are moulded directly onto the stent (14) so as to provide for continuous attachment thereof.
摘要翻译：提供了一种假体心脏瓣膜（10），其包括具有附接到其上的三个小叶（12）的支架（14）。支架（14）是可压缩的，以便能够通过微创程序被引入到患者体内，并且具有在其高度上限定三个拱形元件（18）的环形体（16）。每个元件（18）包括弧形（20）和一对从其相对侧延伸的一对托架（22），由相邻元件（18）的托架（22）形成的三个连合柱（26）。传单（12）各自具有附接边缘（28）和具有在其间延伸的腹部（32）的自由边缘（30）。小叶（12）可以在其中自由边缘（30）抵接并防止流体流过阀门（10）的着色状态和允许通过阀门（10）的流体流动的打开状态之间移动。传单（12）由聚合材料制成，并直接模制在支架（14）上，以便提供连续的连接。

4. 发明申请

WO1988010105A1 HEART VALVE PROSTHESIS 审中-公开
标题翻译：心脏瓣膜预防
公开(公告)号：WO1988010105A1
公开(公告)日：1988-12-29
申请号：PCT/SU1988000137
申请日：1988-06-23
申请人： BUKATOV, Alexandr Semenovich , IOFIS, Naum Abramovich , EGOROV, Jury Grigorievich , DOBROVA, Natalya Borisovna , KOSTRETSOV, Anatoly Stepanovich , AGAFONOV, Andrei Vasilievich
IPC分类号： A61F02/24
CPC分类号： A61F2/2406
摘要： A heart valve prosthesis comprises a valve ring (1) with an aperture (2) for passage of the blood. A disk (3) is mounted in said aperture (2) for closing and opening the aperture. The disk (3) is provided, on its upper or distal side (6), with an annular curved groove (9) reducing the mass of the disk (3). The disk (3) is floatably mounted between limiters (4, 5) of its movement.

5. 发明申请

WO2013096548A1 METHODS AND APPARATUS FOR REGULATING BLOOD PRESSURE 审中-公开
标题翻译：调节血压的方法和装置
公开(公告)号：WO2013096548A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/070803
申请日：2012-12-20
申请人： VOLCANO CORPORATION , SHEEHAN, David , KINGHORN, Curt
发明人： SHEEHAN, David
IPC分类号： A61F2/06 , A61B5/0215 , A61B5/021
CPC分类号： A61B5/4836 , A61B5/0215 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B2017/00212 , A61B2017/00893 , A61F2/2403 , A61F2/2406 , A61F2/82 , A61F2002/068
摘要： A blood pressure control apparatus, system, and methods of modifying intravascular blood flow of a patient is disclosed. In one aspect, the blood pressure control apparatus comprises an intravascular flow-modifying device including an expandable, hollow, stent-like support member configured for implantation within the vasculature, which includes an upstream sensor, a downstream sensor, and a flow restrictor. The flow restrictor is configured to partially occlude a vessel lumen and thereby artificially create back pressure upstream of the device, which causes dilation of the vessel wall and activation of the baroreceptors upstream of the device. Activation of the baroreceptors may depress the activity of the sympathetic nervous system, thereby contributing to a decrease in systemic blood pressure. The flow restrictor is also configured to partially occlude the renal vein lumen, thereby artificially increasing renal perfusion and depressing the baroreceptor-mediated sympathetic and neurohormonal efforts to raise blood pressure.
摘要翻译：公开了一种血压控制装置，系统和改善患者血管内血流的方法。一方面，血压控制装置包括血管内流动改变装置，其包括被构造用于植入脉管系统内的可扩张的，中空的支架状支撑构件，其包括上游传感器，下游传感器和限流器。流量限制器构造成部分地封闭血管内腔，从而人为地在装置的上游产生背压，这导致血管壁的扩张和装置上游的压力感受器的激活。压力感受器的激活可能会抑制交感神经系统的活动，从而有助于全身血压的降低。流量限制器还构造成部分闭塞肾静脉管腔，从而人为地增加肾脏灌注并抑制压力感受器介导的交感神经和神经激素作用以提高血压。

6. 发明申请

WO2007054078A3 ARTIFICIAL HEART VALVE 审中-公开
标题翻译：人工心脏瓣膜
公开(公告)号：WO2007054078A3
公开(公告)日：2007-09-07
申请号：PCT/DE2006001961
申请日：2006-11-09
申请人： ATRIMED MEDIZINTECHNIK GMBH , KROGMANN MICHAEL , OTTO CORDELIA
发明人： KROGMANN MICHAEL , OTTO CORDELIA
IPC分类号： A61F2/24
CPC分类号： A61F2/2406 , A61F2/2403
摘要： The invention relates to a heart valve (1) with an annular member (2) to anchor the heart valve (1) in the human body along with a lumen (5) that is mounted in the center thereof by means of the annular member (2). At least one closing element (8) which can be rotated about a pivoting axis (13) from an open position into a closed position is mounted in the annular member (5). The closing element (8) is equipped with at least one bearing piece (16) and is mounted on the annular member (2) with the aid thereof, each bearing piece (16) being disposed in a bearing recess (14) of the annular member (2) allocated to the bearing piece (16). Each bearing recess (14) comprises a bearing bottom (9) on which the bearing piece (16) glides and which is embodied as a convex or concave surface rather than in a planar manner. The position of the pivoting axis of the closing element in relation to the annular member depends on the opening angle (lower case omega) of the closing element.
摘要翻译：心脏瓣膜（1）的环形本体（2）锚定在人体内心脏瓣膜（1）与所述环形体（2）夹持在其中心内腔（5）中的一个。在环状体（5）至少一个封闭体（8）被安装时，它可绕的汾位置的枢转轴线（13）运动到闭合位置。封闭体（8）具有至少一个支承件（16）并且其特征在于在所述环形本体（2）被安装时，各支承件（16）设置在所述环形主体的相关联的他容纳凹部（14）（2）。每个轴承凹部（14）具有一个轴承座（9），在其上，其中，所述轴承基座被形成为凸形或凹形表面（9）的支承件（16）滑动时，是不平坦的，而是。相对于所述封闭体的开度角（小的ω）的所述环形体的封闭构件的枢转轴线的位置依赖。

7. 发明申请

WO1984000882A1 PROSTHETIC HEART VALVE WITH PLANO-CONVEX DISK OCCLUDER 审中-公开
标题翻译： PROSTHETIC心脏瓣与PLANO-CONVEX DISK OCCLUDER
公开(公告)号：WO1984000882A1
公开(公告)日：1984-03-15
申请号：PCT/US1983001368
申请日：1983-09-06
申请人： ANGICOR LIMITED
发明人： ANGICOR LIMITED , KASTER, Robert, L.
IPC分类号： A61F01/04
CPC分类号： A61F2/2406
摘要： In a prosthetic heart valve having a free floating, rotatable, pivotable disk occluder for blocking a flow of fluid therethrough, an improvement comprising the provision of a disk occluder (12) having a substantially convex distal surface (39) and a substantially planar proximal surface (38) having a concentrically disposed well (42) formed therein. A proximal positioned control unit (21) and a distal positioned control unit (22) are provided for cooperative interaction with the disk occluder (12) to support the disk occluder (12) in the occlude and non-occlude mode and to provide a pivot guide for transition between the occlude to non-occlude mode and for the transition between the non-occlude to the occlude mode.
摘要翻译：在具有自由浮动的，可旋转的，可枢转的盘封闭器的假体心脏瓣膜中，用于阻止流体通过其中，改进包括提供具有基本上凸起的远侧表面（39）和基本平坦的近侧表面（30）的盘闭塞器（38）具有形成在其中的同心设置的孔（42）。提供近端定位的控制单元（21）和远侧定位的控制单元（22），用于与盘闭塞器（12）的协同相互作用，以将闭塞器（12）支撑在闭塞和非闭塞模式中，并提供枢轴在闭塞到非闭塞模式之间以及不闭塞到闭塞模式之间的转换的指导。

8. 发明申请

WO2007054078A2 KÜNSTLICHE HERZKLAPPE 审中-公开
标题翻译：人工心脏瓣膜
公开(公告)号：WO2007054078A2
公开(公告)日：2007-05-18
申请号：PCT/DE2006/001961
申请日：2006-11-09
申请人： ATRIMED MEDIZINTECHNIK GMBH , KROGMANN, Michael , OTTO, Karl-Heinz
发明人： KROGMANN, Michael , OTTO, Karl-Heinz
IPC分类号： A61F2/24
CPC分类号： A61F2/2406 , A61F2/2403
摘要： Eine künstliche Herzklappe (1) soll eine Durchflusscharakteristik mit möglichst hohen laminaren Strömungsanteilen aufweisen und für den Träger eine geringere Thrombosegefahr bergen. Dazu weist die Herzklappe (1) einen ringförmigen Körper (2) zur Verankerung der Herzklappe (1) im menschlichen Körper auf mit einem von dem ringförmigen Körper (2) in seinem Zentrum aufgespannten Lumen (5). In dem ringförmigen Körper (5) ist mindestens ein Schließkörper (8) gelagert, der um eine Schwenkachse (13) von einer Offen-Stellung in eine Geschlossen-Stellung, drehbar ist. Der Schließkörper (8) weist zumindest ein Lagerstück (16) auf und ist dadurch am ringförmigen Körper (2) gelagert, wobei jedes Lagerstück (16) in einer ihm zugeordneten Lagervertiefung (14) des ringförmigen Körpers (2) angeordnet ist. Jede Lagervertiefung (14) weist einen Lagergrund (9) auf, auf dem das Lagerstück (16) gleitet, wobei der Lagergrund (9) nicht eben, sondern als konvexe oder konkave Fläche ausgebildet ist.
摘要翻译：人造心脏瓣膜（1）是具有与最高可能的层流部分的流动特性和姿势血栓形成为佩戴者的风险较低。为了这个目的，心脏瓣膜（1）的环形本体（2）锚定在人体内心脏瓣膜（1）与所述环形体（2）夹持在其中心内腔（5）中的一个。在环状体（5）至少一个封闭体（8）被安装时，大约从打开位置到关闭位置的枢转轴线（13），是可旋转的。封闭体（8）具有至少一个支承件（16）并且其特征在于在所述环形本体（2）被安装时，各支承件（16）设置在所述环形主体的相关联的他容纳凹部（14）（2）。每个轴承凹部（14）具有一个轴承座（9），在其上，其中，所述轴承基座被形成为凸形或凹形表面（9）的支承件（16）滑动时，是不平坦的，而是。

9. 发明申请

WO01034068A1 PROSTHETIC HEART VALVE 审中-公开
标题翻译：前置心脏瓣膜
公开(公告)号：WO01034068A1
公开(公告)日：2001-05-17
申请号：PCT/IB1999/001816
申请日：1999-11-10
IPC分类号： A61F2/24
CPC分类号： A61F2/2406
摘要： A multi-leaflet cardiovascular valve having a generally annular valve body (1) and at least two leaflets (4, 5) mounted within the valve body such that the leaflets rotate around a central axis (11) and a transverse pivoting axis (12) between an open configuration wherein blood is permitted to flow through the annular valve body and a closed configuration wherein blood is prevented from flowing in at least one direction through the annular valve body. During the open configuration, the leaflets rotate around the flow axis.
摘要翻译：一种具有大致环形的阀体（1）和安装在阀体内的至少两个小叶（4,5）的多瓣瓣心血管瓣，使得小叶围绕中心轴线（11）和横向枢转轴线（12）旋转，在允许血液流过环形阀体的打开构造和其中防止血液在至少一个方向上流过环形阀体的封闭构造之间。在打开配置期间，传单围绕流轴旋转。

10. 发明申请

WO1995033501A1 METHOD OF IMPROVING MECHANICAL HEART VALVE PROSTHESES AND OTHER MEDICAL INSERTS, AND PRODUCTS MANUFACTURED IN ACCORDANCE WITH THE METHOD 审中-公开
标题翻译：改善机械心脏瓣膜及其他医疗器械的方法以及根据该方法制造的产品
公开(公告)号：WO1995033501A1
公开(公告)日：1995-12-14
申请号：PCT/SE1995000530
申请日：1995-05-12
申请人： OLIN, Christian , JOHANSSON, Erik
IPC分类号： A61L27/00
CPC分类号： C23C8/24 , A61F2/24 , A61F2/2406 , A61L27/06 , A61L27/30 , A61L33/02
摘要： A method of improving mechanical heart valve prostheses and other mechanical parts implanted in the human body, by reducing their tendency to contribute to the formation of thrombi and by improving their mechanical and biocompatible properties. The products, such as heart valve prostheses, are made of titanium or a titanium alloy which has been treated with pure nitrogen gas under vacuum at high temperature, so that a surface layer of titanium nitride is formed. The invention also relates to products, such as heart valve prostheses, made of titanium or titanium alloy having a surface layer of titanium nitride.
摘要翻译：通过减少机械心脏瓣膜假体和植入人体内的其它机械部件，减少其有助于形成血栓的倾向并改善其机械和生物相容性质的方法。诸如心脏瓣膜假体的产品由在高温真空下用纯氮气处理的钛或钛合金制成，从而形成氮化钛的表面层。本发明还涉及具有氮化钛表面层的由钛或钛合金制成的产品，例如心脏瓣膜假体。

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