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    • 1. 发明申请
    • SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY
    • 自组装模块式阀门及折叠,组装和运输方法
    • WO2011086401A1
    • 2011-07-21
    • PCT/IB2010/000049
    • 2010-01-13
    • VALVE MEDICAL LTDRICHTER, YoramRICHTER, JacobWEISZ, Ety
    • RICHTER, YoramRICHTER, JacobWEISZ, Ety
    • A61F2/24
    • A61F2/2415A61F2/24A61F2/2406A61F2/2409A61F2/2412A61F2/2418A61F2/2427A61F2/844A61F2210/0014A61F2230/0091A61F2250/006
    • The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.
    • 本发明提供了一种设计为两个或更多个装置模块的模块化假体瓣膜装置,其可以被输送到未被组装的身体腔体,然后至少部分地使用位于或靠近该组件的自组装构件 瓣膜植入部位。 装置模块可以包括支撑结构和阀模块。 阀模块可以以未组装的折叠输送构造递送,并且经由自组装构件展开并组装成工作构型。 在其组装形式中,阀模块可以是单件式叶片子结构或多个阀部分。 自组装构件具有输送配置和预设配置,并且可以被触发以恢复到预设配置以组装阀模块。 模块化阀装置可以以当前阀装置不可能的方式进行折叠,例如通过沿着其周向轴线在其高度方向上滚动未组装的阀模块,使得折叠的阀模块的直径可以等于 一个滚动的小叶。 本发明的该特征提供了一种具有比预组装阀装置更小的输送直径的经皮瓣膜装置。 这又允许使用减小直径的输送装置,并且与本领域中的经皮瓣膜装置相比增加了装载的输送装置的灵活性。 本发明还提供了一种用于折叠和传送这种模块化阀装置的系统和方法,并且使用自组装构件优选地在身体中组装它。
    • 7. 发明申请
    • INVERTING TEMPORARY VALVE SHEATH
    • 反转临时阀门
    • WO2017199085A2
    • 2017-11-23
    • PCT/IB2017/000630
    • 2017-05-12
    • VALVE MEDICAL LTD.
    • RICHTER, YoramWEISZ, EtyKREIZLER, Mark
    • A61M25/00
    • A percutaneous device including a temporary valve attached to a sheath, the sheath having an inverting section for delivery and removal thereof from a blood vessel. The sheath is inverted for delivery, housing the valve between inverted layers thereof. To deploy said valve, the sheath is everted to position the temporary valve on an outer surface thereof. The temporary valve and sheath are reversibly movable between inverted and deployed configurations. Upon eversion, the temporary valve assumes a radially expanded canopy shape having an outer diameter selected to contact the vessel wall and allow blood flow in only one direction. The temporary valve may be removed by releasing one end of the valve from the sheath, flattening the temporary valve along the longitudinal axis of the sheath. Also provided is a temporary valve system comprising a dilator for inverting and everting the sheath, said dilator being removably connected to the sheath.
    • 包括临时瓣膜的经皮装置,所述临时瓣膜附接到护套,所述护套具有用于将其从血管递送和移除的翻转部分。 为了递送护套被翻转,将阀容纳在其翻转层之间。 为了展开所述阀,护套翻转以将临时阀定位在其外表面上。 临时阀和护套在倒置和展开配置之间可逆地移动。 外翻时,临时瓣膜呈现径向扩张的顶盖形状,其外径选择为接触血管壁并且仅允许血液沿一个方向流动。 通过从护套释放阀的一端来移除临时阀,沿着护套的纵向轴线使临时阀变平。 还提供了一种临时瓣膜系统,其包括用于翻转和翻转鞘管的扩张器,所述扩张器可移除地连接到鞘管。
    • 9. 发明申请
    • TEMPORARY VALVE AND VALVE-FILTER
    • 临时阀和阀过滤器
    • WO2014177935A2
    • 2014-11-06
    • PCT/IB2014/001564
    • 2014-03-13
    • VALVE MEDICAL LTD.
    • RICHTER, YoramWEISZ, EtySCHWARZ, Boaz
    • A61F2/013A61B17/1204A61B17/12109A61B17/12131A61B17/12177A61F2/2427
    • A temporary percutaneous valve-filter device having valve portions non-porous to blood and filter portions non-porous to emboli but at least in part porous to blood. In one embodiment, the device has a substantially flat valve unit and a substantially flat filter unit. In another embodiment, the device has at least one open umbrella deployed configuration. In one aspect, the device has a unitary construction with one umbrella canopy with one or more filter areas with flaps allowing unidirectional blood flow. In another aspect, the device has a valve unit and filter unit, the umbrella canopies oriented in opposite directions, and the valve unit "closes" and opens to allow blood to flow to one direction. Also provided is a temporary valve system, including a core having an inverted delivery configuration and everted deployed configuration, that may be used with or without a filter unit, and a method of deployment.
    • 一种临时经皮瓣膜过滤装置,其具有对血液无孔的阀部分和对栓塞无孔但对血液至少部分多孔的过滤部分。 在一个实施例中,该装置具有基本平坦的阀单元和基本平坦的过滤器单元。 在另一个实施例中,该设备具有至少一个开放的伞部署配置。 在一个方面,该装置具有一体式结构,其具有一个伞形伞盖,其具有一个或多个具有允许单向血液流动的翼片的过滤区域。 在另一方面,该装置具有阀单元和过滤器单元,伞形突出部朝向相反方向,并且阀单元“关闭”并打开以允许血液向一个方向流动。 还提供了一种临时阀系统,其包括具有反向输送配置的核心和可以与过滤器单元一起使用或不使用过滤单元的永久展开配置,以及部署方法。