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1. 发明申请

WO2017014821A3 COMPOSITE ARTICLE AND METHOD OF MANUFACTURE 审中-公开
标题翻译：复合制品和制造方法
公开(公告)号：WO2017014821A3
公开(公告)日：2017-04-27
申请号：PCT/US2016030132
申请日：2016-04-29
申请人： UNIV MICHIGAN STATE
发明人： HAQ MAHMOODUL , DRZAL LAWRENCE T
IPC分类号： F41H1/04 , A42B3/06 , B29C70/60 , F41H5/04
CPC分类号： F41H5/04 , A42B3/063 , F41H1/04 , F41H1/08
摘要： A multilayer composite includes adjacent filler layers having a filler material dispersed within a first polymeric matrix and an intervening-layer disposed between the adjacent filler layers. The intervening-layer comprises nanoplatelets embedded within a second polymeric matrix and are aligned substantially parallel to the adjacent filler layers. The intervening-layer is configured to fail upon application of a force to the multilayer composite that is greater than or equal to a predetermined force threshold.
摘要翻译：多层复合材料包括具有分散在第一聚合物基体内的填充材料的邻近填充层和设置在相邻填充层之间的中间层。中间层包含嵌入第二聚合物基体内的纳米片，并基本上平行于相邻的填充层排列。插入层被配置为在施加力大于或等于预定力阈值的多层复合材料时失效。

2. 发明申请

WO2016123454A8 CRYPTIC POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：裂殖多肽及其用途
公开(公告)号：WO2016123454A8
公开(公告)日：2016-09-29
申请号：PCT/US2016015587
申请日：2016-01-29
申请人： UNIV MICHIGAN STATE
发明人： MARTINEZ-HACKERT ERIK , AYKUL SENEM
IPC分类号： C07K14/71 , C07K14/82 , C07K16/22
CPC分类号： C07K14/71 , C07K14/82
摘要： The disclosure features, among other things, polypeptides comprising a Cryptic polypeptide, a functional fragment thereof, or variants of any of the foregoing. Also featured are nucleic acids encoding the polypeptides, methods for producing of the polypeptides, and a variety of diagnostic and therapeutic applications in which the polypeptides are useful. For example, the polypeptides can be used to treat a subject having a condition associated with bone loss.
摘要翻译：本公开特征包括含有Cryptic多肽的多肽，其功能片段或任何前述的变体。其特征还在于编码多肽的核酸，用于产生多肽的方法以及多肽可用于的各种诊断和治疗应用。例如，多肽可用于治疗具有与骨丢失相关的病症的受试者。

3. 发明申请

WO2013163571A3 METHODS OF HYDROLYZING PRETREATED DENSIFIED BIOMASS PARTICULATES AND SYSTEMS RELATED THERETO 审中-公开
标题翻译：水解预处理浓缩生物质颗粒物的方法及其相关系统
公开(公告)号：WO2013163571A3
公开(公告)日：2014-03-06
申请号：PCT/US2013038452
申请日：2013-04-26
申请人： MICHIGAN BIOTECHNOLOGY INST D B A MBI , UNIV MICHIGAN STATE
发明人： BALS BRYAN , TEYMOURI FARZANEH , CAMPBELL TIMOTHY J , DALE BRUCE E
IPC分类号： C12P19/02 , C12P7/10 , C12P19/14 , D21C1/06 , D21C1/10
CPC分类号： C12P19/02 , C12P7/10 , C12P19/14 , C12P2201/00 , D21C1/06 , D21C1/10 , D21C5/005 , Y02E50/16
摘要： A method is provided in which pretreated and densified cellulosic biomass particulates can hydrolyzed at a high solids loading rate as compared with the solids loading rate of loose hydrolysable cellulosic biomass fibers. The resulting high concentration sugar-containing stream can be easily converted to biofuels or an entire suite of other useful bioproducts.
摘要翻译：提供了一种方法，其中与松散的可水解纤维素生物质纤维的固体负载速率相比，预处理和致密化的纤维素生物质颗粒可以以高固体负载速率水解。所得到的高浓度含糖流可以容易地转化为生物燃料或一整套其他有用的生物产物。

4. 发明申请

WO2013090814A2 p-Coumaroyl-CoA:Monolignol Transferase 审中-公开
标题翻译：对 - 香豆酰-CoA：Monolignol转移酶
公开(公告)号：WO2013090814A2
公开(公告)日：2013-06-20
申请号：PCT/US2012069902
申请日：2012-12-14
申请人： UNIV MICHIGAN STATE , WISCONSIN ALUMNI RES FOUND , SEDBROOK JOHN
发明人： SEDBROOK JOHN , WILKERSON CURTIS , RALPH JOHN , WITHERS SAUNIA
IPC分类号： C12N15/82
CPC分类号： C12N15/8255 , C12N9/1029 , C12N15/1137 , C12N15/8218 , C12N2310/14
摘要： The invention relates to nucleic acids encoding a p-coumaroyl-CoA:monolignol transferase and to inhibitory nucleic acids adapted to inhibit the expression and/or translation of a p-coumaroyl-CoA:monolignol transferase RNA. Inhibition of p-coumaroyl-CoA:monolignol transferase in plants improves the incorporation of monolignol ferulates into the lignin of plants, giving rise to plant biomass that is more easily processed into useful products such as paper and biofuels.
摘要翻译：本发明涉及编码对香豆酰-CoA：单分子转移酶的核酸和适用于抑制对 - 香豆酰-CoA：单间醇转移酶RNA的表达和/或翻译的抑制性核酸。在植物中抑制对香豆酰-CoA：单乙醇转移酶改善了单螺旋阿魏酸向植物的木质素的引入，从而产生更容易加工成有用产物如纸和生物燃料的植物生物质。

5. 发明申请

WO2013082298A2 IMMUNOLOGICAL COMPOSITION FOR CLOSTRIDIUM DIFFICILE 审中-公开
标题翻译：枯草芽胞杆菌的免疫组合物
公开(公告)号：WO2013082298A2
公开(公告)日：2013-06-06
申请号：PCT/US2012067091
申请日：2012-11-29
申请人： UNIV MICHIGAN STATE
发明人： AMALFITANO ANDREA , SEREGIN SERGEY
IPC分类号： A61K39/08
CPC分类号： C07K14/33 , A61K38/00 , A61K39/08 , A61K2039/5256 , C12N2710/10043
摘要： The invention relates to methods and compositions for treating or inhibiting infection of Clostridium difficile. The methods and compositions generate rapid immune responses that inhibit future infection, and/or neutralize the toxicity caused by C. difficile infection.
摘要翻译：本发明涉及治疗或抑制艰难梭菌（Clostridium difficile）感染的方法和组合物。该方法和组合物产生快速免疫应答，其抑制未来感染，和/或中和由艰难梭菌感染引起的毒性。

6. 发明申请

WO2012135073A2 ADAPTIVE LASER SYSTEM FOR OPHTHALMIC USE 审中-公开
标题翻译：自适应激光系统
公开(公告)号：WO2012135073A2
公开(公告)日：2012-10-04
申请号：PCT/US2012030476
申请日：2012-03-23
申请人： UNIV MICHIGAN STATE , DANTUS MARCOS
发明人： DANTUS MARCOS
CPC分类号： A61F9/00802 , A61F9/00827 , A61F9/00831 , A61F9/00836 , A61F2009/00846 , A61F2009/00863 , A61F2009/0087 , A61F2009/00872 , G02B2207/114 , H01S3/005 , H01S3/0092 , H01S3/06733 , H01S3/1112 , H01S3/1618 , H01S3/1675
摘要： An adaptive laser system for ophthalmic use is provided. In another aspect, a relatively inexpensive laser is employed. In another aspect of the present system, non-linear optical imaging uses multiphoton fluorescences and/or second harmonic generation, to create three-dimensional mapping of a portion of the eye in combination with automated feedback to assist with a surgical operation. In a further aspect of the present system, the patient interface uses laser induced markings or indicia to aid in focusing and/or calibration. Still another aspect employs temporal focusing of the laser beam pulse.
摘要翻译：提供了一种用于眼科用途的自适应激光系统。在另一方面，采用相对便宜的激光。在本系统的另一方面，非线性光学成像使用多光子荧光和/或二次谐波产生来创建眼睛的一部分与自动反馈结合的三维映射以辅助外科手术。在本系统的另一方面，患者接口使用激光诱导标记或标记来帮助聚焦和/或校准。另一方面采用激光束脉冲的时间聚焦。

7. 发明申请

WO2011069008A8 CARBOXYLIC ACID RECOVERY AND METHODS RELATED THERETO 审中-公开
标题翻译：羧酸回收方法及其相关方法
公开(公告)号：WO2011069008A8
公开(公告)日：2012-06-21
申请号：PCT/US2010058787
申请日：2010-12-02
申请人： UNIV MICHIGAN STATE , ORJUELA ALVARO , YANEZ-MCKAY ABRAHAM , LIRA CARL , MILLER DENNIS
发明人： ORJUELA ALVARO , YANEZ-MCKAY ABRAHAM , LIRA CARL , MILLER DENNIS
IPC分类号： C07C67/08 , C07C51/02 , C07C55/10 , C07C69/40
CPC分类号： C07C51/02 , C07C67/08 , Y02P20/127 , C07C55/10 , C07C69/40
摘要： A method of producing an alkyl ester of a carboxylic acid is provided, the method comprising: adding an alkanol and a mineral acid to a carboxylic acid salt to provide a carboxylic acid/alkanol solution and a precipitated mineral acid salt; separating the mineral acid salt from the carboxylic acid/alkanol solution; esterifying the carboxylic acid; and isolating an alkyl ester of the carboxylic acid.
摘要翻译：提供了一种制备羧酸烷基酯的方法，所述方法包括：向羧酸盐中加入链烷醇和无机酸以提供羧酸/烷醇溶液和沉淀的无机酸盐; 从羧酸/烷醇溶液中分离无机酸盐; 酯化羧酸; 并分离出羧酸的烷基酯。

8. 发明申请

WO2011133571A3 DIGESTIBLE LIGNOCELLULOSIC BIOMASS AND EXTRACTIVES AND METHODS FOR PRODUCING SAME 审中-公开
标题翻译：可溶性线粒体生物量及其提取物及其生产方法
公开(公告)号：WO2011133571A3
公开(公告)日：2012-01-12
申请号：PCT/US2011033079
申请日：2011-04-19
申请人： UNIV MICHIGAN STATE , CHUNDAWAT SHISHIR , SOUSA LEONARDO , CHEH ALBERT M , BALAN VENKATESH , DALE BRUCE
发明人： CHUNDAWAT SHISHIR , SOUSA LEONARDO , CHEH ALBERT M , BALAN VENKATESH , DALE BRUCE
IPC分类号： C12P19/04 , C08B1/00 , C12N9/14 , C12P1/06 , C12R1/885
CPC分类号： C12P19/14 , C08B15/02 , C08B37/0003 , C08B37/0057 , C08H6/00 , C08H8/00 , C12P7/10 , C12P19/20 , C12P2201/00 , C13K1/02 , Y02E50/16
摘要： The invention relates to methods for treating lignocellulosic biomass to obtain useful products therefrom.
摘要翻译：本发明涉及用于处理木质纤维素生物质从其获得有用产物的方法。

9. 发明申请

WO2010099445A3 NON-COVALENT INHIBITION OF THE 26S PROTEASOME AND USES THEREOF 审中-公开
标题翻译： 26S蛋白质的非共价抑制及其用途
公开(公告)号：WO2010099445A3
公开(公告)日：2011-01-27
申请号：PCT/US2010025590
申请日：2010-02-26
申请人： UNIV MICHIGAN STATE , TEPE JETZE , LANSDELL THERESA , KARIN MICHAEL
发明人： TEPE JETZE , LANSDELL THERESA , KARIN MICHAEL
IPC分类号： A61K31/4168 , A61K31/417 , A61K31/4172 , A61P29/00 , A61P35/00
CPC分类号： A61K31/4168 , A61K31/417 , A61K31/4172
摘要： The present inventions relate to compositions and methods for treating inflammatory diseases and cancer by administering proteasome inhibitors. In particular, the present inventions provide a new class of orally available non-covalent proteasome inhibitors capable of reducing NF-kappaB for mediating cytokine production in vivo. Further, the use of a small molecular weight inhibitor of the 26S proteasome via a non-covalent type inhibition is contemplated for use as a means to treat NF -kB mediated diseases, including but not limited to multiple myeloma and rheumatoid arthritis.
摘要翻译：本发明涉及通过施用蛋白酶体抑制剂治疗炎性疾病和癌症的组合物和方法。特别地，本发明提供了一类能够减少NF-κB以介导体内细胞因子产生的口服可用的非共价蛋白酶体抑制剂。此外，预期通过非共价型抑制使用26S蛋白酶体的小分子量抑制剂用作治疗NF-kB介导的疾病的手段，包括但不限于多发性骨髓瘤和类风湿性关节炎。

10. 发明申请

WO2009094571A3 TERNARY THERMOELECTRIC MATERIALS AND METHODS OF FABRICATION 审中-公开
标题翻译：三种热电材料和制造方法
公开(公告)号：WO2009094571A3
公开(公告)日：2010-01-28
申请号：PCT/US2009031875
申请日：2009-01-23
申请人： UNIV OHIO STATE RES FOUND , UNIV MICHIGAN STATE
发明人： HEREMANS JOSEPH , JOVOVIC VLADIMIR , MORELLI DONALD T
IPC分类号： C01B19/00 , H01L35/16 , H01L35/34
CPC分类号： C01B19/007 , C01B19/002 , C01P2006/40 , H01L35/16 , H01L35/34 , Y02P20/129
摘要： A thermoelectric material and a method of fabricating a thermoelectric material are provided. The thermoelectric material includes a compound having an elemental formula of A 1 -xB 1 +yC2+z and having a coefficient of thermal expansion greater than 20 parts-per-million per degree Celsius in at least one direction at one or more operating temperatures. The A component of the compound includes at least one element selected from the group consisting of: at least one Group Ia element and at least one Group Ib element, the B component of the compound includes at least one element selected from the group consisting of: at least one Group V element and at least one Group VIII element, and the C component of the compound includes at least one Group VI element. In addition, x is between -0.2 and 0.3, y is between -0.2 and 0.4, and z is between -0.2 and 0.8. Furthermore, the A component includes no more than 95 atomic % silver when the B component includes antimony and the C component includes tellurium, the B component includes no more than 95 atomic % antimony when the A component includes silver and the C component includes tellurium, and the C component includes no more than 95 atomic % tellurium when the A component includes silver and the B component includes antimony.
摘要翻译：提供热电材料和制造热电材料的方法。热电材料包括具有A 1 -xB 1 + yC 2 + z的元素分子式并且在一个或多个操作温度下在至少一个方向上具有大于百万分之20每百万摄氏度的热膨胀系数的化合物。所述化合物的A组分包括选自由至少一种Ia族元素和至少一种Ib族元素组成的组中的至少一种元素，所述化合物的B组分包括选自以下的至少一种元素：至少一种V族元素和至少一种VIII族元素，并且该化合物的C组分包括至少一种VI族元素。另外，x在-0.2和0.3之间，y在-0.2和0.4之间，并且z在-0.2和0.8之间。另外，A成分在B成分含有锑且C成分含有碲时含有95原子％以下的银，A成分含有银时含有95原子％以下锑，C成分含有碲，并且当A组分包括银并且B组分包括锑时，C组分包括不超过95原子％的碲。

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