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1. 发明申请

WO2020028180A1 SPECIFIC DETECTION OF RIBONUCLEIC ACID SEQUENCES USING NOVEL CRISPR ENZYME-MEDIATED DETECTION STRATEGIES 审中-公开
公开(公告)号：WO2020028180A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/043716
申请日：2019-07-26
申请人： TOKITAE LLC , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： BAUGHMAN, Ted A. , CATE, Jamie , DOUDNA, Jennifer , KNOTT, Gavin John , MADAN, Damian , NALEFSKI, Eric , LE NY, Anne-Laure M. , THORNTON, Brittney
IPC分类号： C12Q1/6825 , C12Q1/66
摘要： Embodiments disclosed herein include devices, methods, and systems for direct, selective, and sensitive detection of single-stranded target RNA sequences from various sources using a programed Cas13a protein. When activated by binding a target RNA sequence, the Cas13a cleaves a tether releasing a reporter molecule that may then be detected. In some embodiments, the systems, methods, and devices may include a filter or membrane that may help to separate the tethered and untethered reporter molecules. These devices, systems, and techniques allow a user to rapidly process samples that may contain the target RNA, without needing to amplify the target sequences. These devices and methods may be used to assay a wide variety of samples and target RNA sources, for the presence or absence of a specific target RNA sequence. Compositions and kits, useful in practicing these methods, for example detecting a target RNA in a biological sample, are also described.

2. 发明申请

WO2018191110A1 INTEGRATED DRY ICE PRODUCTION AND STORAGE SYSTEM 审中-公开
公开(公告)号：WO2018191110A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/026409
申请日：2018-04-06
申请人： TOKITAE LLC
发明人： BURKOT, Stephen, Thomas, Graves , KUIPER, Mark, K. , LIEBERMAN, Daniel, Howard , NG, Chin, Hei , SCHWAMPE, Nicholas, John , YAGER, David, J.
IPC分类号： F25D3/12 , C01B32/55
CPC分类号： F25J1/0095 , C01B32/55 , F25J1/0027 , F25J1/0275
摘要： Devices and systems for dry ice production are described, including a lid structure sized for placement over a storage container, an input tube sized to traverse a first opening in the lid structure and forming a flow conduit for pressurized carbon dioxide into the storage container, a vent tube sized to traverse a second opening in the lid structure and forming a flow conduit for gaseous carbon dioxide, a first end of the vent tube sized to fit into the storage container, a lower vent tube sized to fit in the storage container, the lower vent tube coupled to the first end of the vent tube and having openings to vent gaseous carbon dioxide from the storage container and into the vent tube.

3. 发明申请

WO2018169744A1 DEVICE FOR CONCENTRATION OF BIOLOGICAL SAMPLE PRIOR TO IMMUNOASSAY 审中-公开
公开(公告)号：WO2018169744A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/021374
申请日：2018-03-07
申请人： TOKITAE LLC
发明人： CONNELLY, John Thomas , HARSTON, Stephen Paul , WEIGL, Bernhard Hans , YILDIRIM, Ozgur Emek
IPC分类号： G01N1/20 , G01N33/53
摘要： In some embodiments, a medical-sample filtration device includes: a container including at least one wall forming an internal surface, a first aperture adjacent to a first end of the wall, and a second aperture adjacent to a second end of the wall; a movable insert positioned within the container and including an external surface of a size and shape to reversibly mate with the internal surface of the container; a positioning unit affixed to the internal surface close to the second aperture; a filter unit affixed to the second aperture; a sample conduit affixed to the filter unit; a valve unit attached to the sample conduit; and a connector operable to close the valve when the movable insert is in a predefined position relative to the container.

4. 发明申请

WO2018064364A1 DEVICES FOR USE WITH REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 审中-公开
标题翻译：用于制冷设备的设备，包括温度控制集装箱系统
公开(公告)号：WO2018064364A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/054065
申请日：2017-09-28
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , HINMAN, Roderick T. , HU, Jennifer Ezu , LARUSSON, Fridrik , LIU, Shieng , PAL, Brian L. , PETERS, Matthew W. , PETERSON, Nels R.
IPC分类号： F25D11/00 , F25D19/00 , F25D17/04 , F25D29/00 , F28D15/02
摘要： A refrigeration device includes a thermal transfer unit with an evaporative region, an adiabatic region, and a condensing region with a reversible valve attached to the adiabatic region. The device includes a container sealed around PCM, with a set of refrigeration coils of a compressor unit in thermal contact with the PCM. A storage region is in thermal contact with the evaporative region of the thermal transfer unit. A controller is operably connected to the reversible valve and the refrigeration compressor unit. The storage region can be used to store cold packs within a predetermined temperature range for medical outreach.
摘要翻译：制冷设备包括具有蒸发区域，绝热区域和具有连接到绝热区域的可逆阀的冷凝区域的热传递单元。该装置包括密封在PCM周围的容器，压缩机单元的一组制冷盘管与PCM热接触。存储区域与热转印单元的蒸发区域热接触。控制器可操作地连接到可逆阀和制冷压缩机单元。存储区域可用于存储预定温度范围内的冷包以进行医疗外展。

5. 发明申请

WO2017180500A1 PORTABLE DEVICE FOR COLD CHAIN STORAGE 审中-公开
标题翻译：用于冷链储存的便携式装置
公开(公告)号：WO2017180500A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/026771
申请日：2017-04-10
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , FOWLER, Lawrence Morgan , LARUSSON, Fridrik , LIU, Shieng , PETERSON, Nels R. , YAGER, David J.
IPC分类号： F25D3/08 , F25D3/00 , F25D11/00 , F25D19/00 , F25D23/06 , F25D29/00
摘要： Disclosed embodiments include portable devices for cold chain storage and methods of fabricating portable devices for cold chain storage. In an illustrative embodiment, a portable device for cold chain storage includes a container defining therein a storage region. The container includes an inner cylinder, and the storage region is defined coaxially inwardly of the inner cylinder. The inner cylinder includes phase change material disposed therein, and the phase change material is in thermal communication with the storage region. The inner cylinder also includes evaporative coils disposed therein. The evaporative coils are embedded in the phase change material. The container also includes a thermally insulated outer cylinder. An outer wall of the outer cylinder is disposed radially outwardly of an outer wall of the inner cylinder.
摘要翻译：所公开的实施例包括用于冷链存储的便携式设备和制造用于冷链存储的便携式设备的方法。在说明性实施例中，用于冷链存储的便携式装置包括在其中限定存储区域的容器。容器包括内筒，并且存储区域被限定在内筒的同轴内侧。内筒包括设置在其中的相变材料，并且相变材料与储存区域热连通。内筒还包括设置在其中的蒸发盘管。蒸发盘管嵌入在相变材料中。该容器还包括绝热外筒。外筒的外壁设置在内筒外壁的径向外侧。

6. 发明申请

WO2016200775A1 PACKAGING MULTI-MONODOSE CONTAINERS 审中-公开
标题翻译：包装多单体容器
公开(公告)号：WO2016200775A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036157
申请日：2016-06-07
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , NATARAJAN, Krishnan , PETERSON, Nels R. , WOOD, Lowell L., Jr.
IPC分类号： B65B11/50 , B65B31/02 , B65B51/10 , A61J1/05
CPC分类号： A61J1/16 , A61J1/1406 , A61J2205/30 , B65B5/045 , B65B5/06 , B65B5/067 , B65B31/00 , B65B51/10 , B65B51/146 , B65B61/04 , B65B63/04 , B65B2220/16
摘要： Methods and devices are described for packaging a multi-monodose container including covering a molded structure with a hermetically-sealable overwrap, the molded structure including a first portion and a second portion, the first portion including a row of interconnected monodose pharmaceutical vials, each of the interconnected monodose pharmaceutical vials enclosing a dose of at least one pharmaceutical agent, the second portion affixed to the first portion and including a textured surface pattern positioned to direct gas flow between the first portion and a region adjacent to the second portion; evacuating at least a portion of air from around the molded structure, the evacuated air at least partially flowing over the textured surface pattern of the second portion; forming a hermetic seal around the row of interconnected monodose pharmaceutical vials; and separating the second portion of the molded structure from the first portion of the molded structure.
摘要翻译：描述了用于包装多单体容器的方法和装置，包括用可密封的外包装覆盖模制结构，所述模制结构包括第一部分和第二部分，所述第一部分包括一排互连的单糖药物小瓶，每个所述相互连接的单糖药瓶包围剂量的至少一种药剂，所述第二部分固定在所述第一部分上，并且包括纹理表面图案，其被定位成引导所述第一部分与邻近所述第二部分的区域之间的气流; 从模制结构周围抽空至少一部分空气，抽空的空气至少部分地流过第二部分的纹理表面图案; 围绕相互连接的单糖药瓶的一排形成气密密封; 以及将模制结构的第二部分与模制结构的第一部分分开。

7. 发明申请

WO2016137758A1 PHOTOTHERMAL SPECTROSCOPY SYSTEMS FOR OFFSET SYNCHRONOUS TESTING OF FLOW ASSAYS AND METHODS OF USING SAME 审中-公开
标题翻译：用于偏移同步测试流动测定的光热谱系统及其使用方法
公开(公告)号：WO2016137758A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/017678
申请日：2016-02-12
申请人： TOKITAE LLC
发明人： GASPERINO, David , HORNING, Matthew P. , NICHOLS, Kevin Paul Flood , RUTSCHMAN, Phillip , WILSON, Benjamin K. , YILDIRIM, Ozgur Emek
IPC分类号： G01N21/31 , G01N21/17
CPC分类号： G01N21/63 , G01N21/171 , G01N33/54373 , G01N2021/1714 , G01N2201/0697
摘要： Embodiments disclosed herein are directed to photothermal spectroscopy apparatuses and systems for offset synchronous testing of flow assays. Methods of using and operating such photothermal spectroscopy systems are also disclosed.
摘要翻译：本文公开的实施例涉及用于流动测定的偏移同步测试的光热分析装置和系统。还公开了使用和操作这种光热光谱系统的方法。

8. 发明申请

WO2015191920A8 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A8
公开(公告)日：2016-02-04
申请号：PCT/US2015035423
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , TOKITAE LLC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

9. 发明申请

WO2015160958A1 PHOTONIC FENCE 审中-公开
公开(公告)号：WO2015160958A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/025981
申请日：2015-04-15
申请人： TOKITAE LLC , PEGRAM, Nathan John
发明人： PEGRAM, Nathan John , HYDE, Roderick A. , JOHANSON, 3ric , KARE, Jordin T. , MAKAGON, Artyom , MULLEN, Emma Rae , MYHRVOLD, Nathan P. , NUGENT, Thomas J., Jr. , PETERSON, Nels R. , RUTSCHMAN, Phillip , WOOD, Lowell L., Jr.
IPC分类号： A01M23/00 , A01M1/00 , A01M1/10 , A01M1/22
CPC分类号： A01M1/226 , A01M1/02 , A01M1/026 , A01M1/106
摘要： A system for tracking airborne organisms includes an imager, a backlight source (such as a retroreflective surface) in view of the imager, and a processor configured to analyze one or more images captured by the processor to identify a biological property of an organism.
摘要翻译：用于跟踪空中生物的系统包括成像器，鉴于成像器的背光源（例如回射表面）以及被配置为分析由处理器捕获的一个或多个图像以识别生物体的生物学特性的处理器。

10. 发明申请

WO2014194022A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS WITH REGULATED COOLING 审中-公开
标题翻译：温度稳定的储存系统与调节冷却
公开(公告)号：WO2014194022A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/039899
申请日：2014-05-29
申请人： TOKITAE LLC
发明人： BLOEDOW, Jonathan , CALDERON, Ryan , GASPERINO, David , GATES, William , HYDE, Roderick A. , JUNG, Edward K.Y. , LIU, Shieng , MYHRVOLD, Nathan P. , PEGRAM, Nathan John , TEGREENE, Clarence T. , WHITMER, Charles , WOOD, Lowell L., Jr. , YILDIRIM, Ozgur Emek
IPC分类号： B65D81/38
CPC分类号： F25B21/02 , F25D3/06 , F25D2201/14
摘要： Regulated cooling devices are described herein that are sized, shaped and calibrated for use with a substantially thermally sealed storage container. In some embodiments, the regulated cooling devices include a cooling region, an adiabatic region, a lid region, and an electronics unit attached to the lid region.
摘要翻译：本文描述了调节冷却装置，其尺寸，形状和校准用于与基本上热密封的储存容器一起使用。在一些实施例中，调节的冷却装置包括冷却区域，绝热区域，盖子区域和附接到盖子区域的电子单元。

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