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1. 发明申请

WO2019045707A1 UNIFIED DETECTION SYSTEM FOR FLUOROMETRY, LUMINOMETRY AND SPECTROMETRY 审中-公开
公开(公告)号：WO2019045707A1
公开(公告)日：2019-03-07
申请号：PCT/US2017/049388
申请日：2017-08-30
申请人： THERANOS, INC.
发明人： MOHAN, Karan , ANEKAL, Samartha
IPC分类号： G01N21/01
CPC分类号： G01N21/255 , G01N21/01 , G01N21/645 , G01N2021/1734 , G01N2021/6417
摘要： The devices and systems disclosed herein provide multiple optical capabilities in a single device or system. Methods for using these devices and systems are provided. These devices and systems are configurable for operation in each of a spectroscopy mode, a fluorescence mode, and a luminescence mode, and are capable of performing spectroscopic, fluorescence, and luminescence observations, measurements, and analyses when operated in the corresponding spectroscopy mode, fluorescence mode, or luminescence mode. These devices and systems include mirror dispersion elements having multiple faces including an optical dispersion element on one face (e.g., a diffraction grating or a prism) and a reflective element on another face (e.g., a mirror). These multiple capabilities eliminate the need to move or load a sample in multiple devices when subjecting a sample to multiple analyses, and thus provide greater accuracy, precision, and speed while reducing complexity and cost of sample analysis.

2. 发明申请

WO2016057749A1 METHODS AND DEVICES FOR REAL-TIME DIAGNOSTIC TESTING (RDT) FOR EBOLA AND OTHER INFECTIOUS DISEASES 审中-公开
标题翻译：用于EBOLA和其他感染性疾病的实时诊断测试（RDT）的方法和设备
公开(公告)号：WO2016057749A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054618
申请日：2015-10-08
申请人： THERANOS, INC.
发明人： YOUNG, Daniel , HOLMES, Elizabeth
IPC分类号： G01N33/569 , C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/6846 , C12Q1/70 , G01N33/56983 , G01N33/6854 , G01N2333/08 , G01N2469/20 , Y02A50/51 , Y02A50/52 , Y02A50/53 , Y02A50/58 , Y02A50/59 , C12Q2531/119 , C12Q2563/131 , C12Q2563/137 , C12Q2563/157 , C12Q2565/625 , C12Q2565/629
摘要： Methods, devices, systems, and kits for use in detecting and measuring infectious diseases are provided. In particular embodiments, methods, devices, systems, and kits for detecting and measuring Ebola virus, including Ebola Zaire strain virus, are provided. Devices and systems may be used within regions suffering from Ebola or other infections, providing local, rapid, and effective diagnosis of infectious diseases such as Ebola, improving treatment and reducing or preventing spread of such infectious diseases.
摘要翻译：提供了用于检测和测量传染病的方法，装置，系统和试剂盒。在特定实施例中，提供了用于检测和测量埃博拉病毒（包括埃博拉病毒扎伊尔病毒）的方法，装置，系统和试剂盒。设备和系统可以在患有埃博拉或其他感染的区域内使用，提供艾滋病病毒等传染病的局部，快速和有效的诊断，改善治疗并减少或预防这种感染性疾病的传播。

3. 发明申请

WO2016044673A1 HYBRID MULTI-STEP NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：混合多步核酸放大
公开(公告)号：WO2016044673A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050822
申请日：2015-09-17
申请人： THERANOS, INC.
发明人： PATEL, Pranav , WU, Indira , RICHARDSON, Aaron , BELHOCINE, Kamila , LEE, Josephine , TABAKMAN, Scott
IPC分类号： C12N15/00 , C12M1/00 , C12Q1/68
CPC分类号： C12Q1/707 , C12M1/00 , C12N15/00 , C12Q1/6844 , C12Q1/6858 , C12Q1/689 , C12Q1/706 , C12Q2600/156 , C12Q2600/158 , C12Q2521/501 , C12Q2525/161 , C12Q2525/307 , C12Q2531/113 , C12Q2531/119
摘要： Improved methods for amplifying target nucleic acid sequences are provided by 1) first amplifying the number of copies of target nucleic acid sequences in a sample by a first nucleic acid amplification method, and then 2) applying a second nucleic amplification method to the amplified sample, or aliquot thereof, further amplifying the number of copies of target sequences. In embodiments, a first nucleic acid amplification method is a thermocycling method, and a second nucleic acid amplification method is an isothermal method.
摘要翻译：通过1）首先通过第一种核酸扩增方法扩增样品中靶核酸序列的拷贝数，然后2）向扩增的样品应用第二种核酸扩增方法，提供扩增靶核酸序列的改进方法，或其等分试样，进一步扩增靶序列的拷贝数。在实施方案中，第一核酸扩增方法是热循环方法，第二核酸扩增方法是等温法。

4. 发明申请

WO2015138818A1 SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION 审中-公开
标题翻译：用于体液样品收集的系统，装置和方法
公开(公告)号：WO2015138818A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020307
申请日：2015-03-12
申请人： THERANOS, INC.
发明人： HOLMES, Elizabeth , CHEN, Michael , KO, Pey-Jiun , BURD, Tammy , LATH, Adrit , MCHALE, Patricia , ROY, Joy
IPC分类号： A61J1/05 , G01N1/10
CPC分类号： A61B5/150946 , A61B5/150022 , A61B5/15003 , A61B5/150099 , A61B5/150213 , A61B5/150343 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/15074 , A61B5/150755 , A61B5/150763 , A61B5/150786 , A61B5/150992 , A61B5/15117 , A61B5/154 , A61B5/155 , A61B10/0045 , A61B2010/008 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2300/041 , B01L2300/0838 , B01L2300/0861 , B01L2300/16 , B01L2400/0406 , B01L2400/0487 , G01N1/10 , G01N1/14 , G01N2001/149
摘要： Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
摘要翻译：提供了体液样品收集系统，装置和方法。该装置可以包括第一部分，该第一部分至少包括样品收集通道，该样品收集通道经配置以经由第一类型的动力将流体样品吸入样品收集通道。样品收集装置可以包括第二部分，其包括用于接收收集在样品收集通道中的体液样品的样品容器，样品容器可操作地可接合以与收集通道流体连通，于是当建立流体连通时，容器提供不同于第一动力的第二动力，以将大部分体液样品从通道移动到容器中。

5. 发明申请

WO2015130828A1 SYSTEMS, DEVICES, AND METHODS FOR SAMPLE INTEGRITY VERFICATION 审中-公开
标题翻译：用于样品完整性验证的系统，设备和方法
公开(公告)号：WO2015130828A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017581
申请日：2015-02-25
申请人： THERANOS, INC.
发明人： MORRISON, Zachary , YOUNG, Daniel , BALWANI, Sunny
IPC分类号： G06K9/20 , G01N21/00
CPC分类号： G02B21/367 , G01N21/03 , G01N35/00732 , G01N35/00871 , G01N2035/00891 , G01N2201/12 , G02B7/1821 , G02B21/0004 , G02B21/06 , G02B21/34 , G02B21/361 , G02B21/362 , G02B21/365
摘要： The devices, systems, and methods disclosed herein provide sample verification capabilities in a single device or system. Devices are disclosed herein. Systems including these devices are also provided. These devices and systems may be configured for verifying sample integrity prior to a subject leaving a sample collection site so that any further samples or other corrective action can occur without having to make a separate visit.
摘要翻译：本文公开的装置，系统和方法在单个装置或系统中提供样本验证能力。本文公开了装置。还提供了包括这些设备的系统。这些设备和系统可以被配置用于在对象离开样本采集站点之前验证样本完整性，使得可以发生任何进一步的样本或其他校正动作而不必单独访问。

6. 发明申请

WO2015035256A3 DEVICES, SYSTEMS, METHODS AND KITS FOR RECEIVING A SWAB 审中-公开
标题翻译：用于接收SWAB的设备，系统，方法和工具
公开(公告)号：WO2015035256A3
公开(公告)日：2015-07-16
申请号：PCT/US2014054419
申请日：2014-09-05
申请人： THERANOS INC
发明人： LUI CLARISSA , HOLMES ELIZABETH
IPC分类号： G01N33/48 , B01J19/00 , B01L1/00 , G01N1/02
CPC分类号： B01L3/508 , A61B10/007 , A61B10/0096 , B01L3/5029 , B01L2200/026 , B01L2200/10 , B01L2300/0627 , B01L2300/0832 , B01L2300/087 , B01L2300/123 , G01N1/02 , G01N1/10 , G01N2001/028
摘要： Methods, devices, systems, and kits useful for the collection and analysis of samples obtained by swabs are disclosed. Swab containers configured for receiving a swab containing a sample; cartridges for holding one or more of: a swab container, a swab, assay units, pipette tips, vessels, transport units, and implements; systems (which may include a sample processing device); kits; and methods for their use are disclosed. A swab container may include an entry port; an assay chamber having an assay port; a conduit comprising an interior channel connecting the entry port; and an interior channel providing fluidic communication between the entry port and assay chamber. An interior channel may be configured to squeeze a portion of a swab placed in or through the conduit. A cartridge may include a cartridge frame configured to receive one or more of swab containers, assay units, transport units, pipette tips, vessels or implements.
摘要翻译：公开了用于收集和分析由拭子获得的样品的方法，装置，系统和试剂盒。擦拭容器，配置用于接收含有样品的拭子; 用于容纳一个或多个的药筒：拭子容器，拭子，测定单元，移液器吸头，容器，运输单元和器具; 系统（其可以包括样品处理装置）; 包; 并公开了它们的使用方法。拭子容器可以包括入口; 具有测定端口的测定室; 导管，其包括连接入口的内部通道; 以及在入口和分析室之间提供流体连通的内部通道。内部通道可以被配置为挤压置于或穿过导管的拭子的一部分。药筒可以包括被配置为接收一个或多个拭子容器，测定单元，运输单元，移液管尖端，容器或器具的药筒框架。

7. 发明申请

WO2015070247A1 METHODS AND SYSTEMS FOR A SAMPLE COLLECTION DEVICE WITH A NOVELTY EXTERIOR 审中-公开
标题翻译：用于具有外部特征的样品收集装置的方法和系统
公开(公告)号：WO2015070247A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/065087
申请日：2014-11-11
申请人： THERANOS, INC.
发明人： KO, Pey-Jiun , HOLMES, Elizabeth
IPC分类号： A61B5/15 , G01N1/02
CPC分类号： A61B5/150839 , A61B5/150022 , A61B5/15003 , A61B5/150076 , A61B5/150236 , A61B5/150244 , A61B5/150312 , A61B5/150343 , A61B5/150389 , A61B5/150503 , A61B5/151 , A61B5/1535 , A61B10/0045 , A61B10/02
摘要： Methods for obtaining a sample from a subject include providing a sample collection device having a novelty exterior. The sample collection device can be used to collection liquid sample such as but not limited to blood, capillary blood, interstitial fluid, or other liquid sample. Samples may be provide by a small wound such as by a finger-stick and the sample may be analyzed in a short period of time, e.g., in less than five hours, or less than four hours.
摘要翻译：从受试者获得样品的方法包括提供具有新颖外观的样品收集装置。样品收集装置可用于收集液体样品，例如但不限于血液，毛细管血液，间质液或其它液体样品。样品可以通过例如通过手指棒的小伤口提供，并且可以在短时间内（例如在少于5小时或小于4小时内）分析样品。

8. 发明申请

WO2015039039A1 METHODS, DEVICES, AND SYSTEMS HAVING MULTIPLE PASSWORDS 审中-公开
标题翻译：具有多个密码的方法，设备和系统
公开(公告)号：WO2015039039A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/055687
申请日：2014-09-15
申请人： THERANOS, INC.
发明人： BALWANI, Ramesh
IPC分类号： G06F21/46 , H04L9/32
CPC分类号： G06F19/322 , G06F19/00 , G06F21/31 , G06F21/6245 , G16H10/60 , H04L9/088 , H04L9/3226 , H04L63/083 , H04L63/105 , Y02A90/26
摘要： Password-protected methods, systems, and devices are disclosed in which a first password provides access to a first (limited) level, and a second password provides access to a second level, where the second level provides an operation, communication, or information not available at the first level. A system or device may include a processor (e.g., a computer, telephone, tablet, or other device). In embodiments, activities using the second level may include activities available at the first level. The existence of the second level is not detectable at the first level, nor are the operation, communication, or information not available at the first level detectable at the second level. A first-level password may be shared with family or friends while maintaining exclusivity and confidentiality for information and operations available at the second level. Further passwords, associated with further levels, may be provided.
摘要翻译：公开了密码保护的方法，系统和设备，其中第一密码提供对第一（受限）级别的访问，并且第二密码提供对第二级别的访问，其中第二级别提供操作，通信或信息在第一级可用。系统或设备可以包括处理器（例如，计算机，电话，平板电脑或其他设备）。在实施例中，使用第二级别的活动可以包括在第一级别可用的活动。第二级别的存在在第一级不能被检测到，第二级别的第一级的操作，通信或信息也不可检测到。一级密码可以与家人或朋友共享，同时保持第二级可用的信息和操作的排他性和机密性。可以提供与进一步的级别相关联的进一步的密码。

9. 发明申请

WO2014145330A3 METHODS AND DEVICES FOR SAMPLE COLLECTION AND SAMPLE SEPARATION 审中-公开
标题翻译：样品采集和样品分离的方法和设备
公开(公告)号：WO2014145330A3
公开(公告)日：2015-01-08
申请号：PCT/US2014030070
申请日：2014-03-15
申请人： THERANOS INC
发明人： SLOAN DEBORAH , HOLMES ELIZABETH A , KO PEY-JIUN , LAI EDWINA
IPC分类号： G01N1/10 , G01N1/28
CPC分类号： B01L3/502753 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150343 , A61B5/150358 , B01L3/502715 , B01L2200/028 , B01L2300/021 , B01L2300/0672 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0874 , B01L2300/161 , B01L2400/0406 , B01L2400/049
摘要： Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.
摘要翻译：提供了样品收集和样品分离的方法和装置。在一个实施例中，提供了用于与形成的部件液体样品一起使用的装置，该装置包括用于接收所述样品的至少一个样品入口; 至少第一出口，用于仅输出所形成的成分液体样品的液体部分; 至少第二出口，用于输出形成的组分液体样品至少混合在其中的第一材料。

10. 发明申请

WO2014160903A3 BIOLOGICAL SAMPLE PROCESSING 审中-公开
公开(公告)号：WO2014160903A3
公开(公告)日：2014-10-02
申请号：PCT/US2014/032092
申请日：2014-03-27
申请人： THERANOS, INC.
发明人： HOLMES, Elizabeth, A. , LATH, Adrit
IPC分类号： G01N1/28 , G01N35/02
摘要： Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge from at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.

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